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Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 3001-3025 out of 3519.

<< < 116 | 117 | 118 | 119 | 120 | 121 | 122 | 123 | 124 | 125 > >>

Public Release: 23-Dec-2013
Gene therapy method targets tumor blood vessels
Working in mice, researchers at Washington University School of Medicine in St. Louis report developing a gene delivery method long sought in the field of gene therapy: a deactivated virus carrying a gene of interest that can be injected into the bloodstream and make its way to the right cells. In this early proof-of-concept study, the scientists have shown that they can target tumor blood vessels in mice without affecting healthy tissues.
National Institutes of Health

Contact: Julia Evangelou Strait
Washington University School of Medicine

Public Release: 23-Dec-2013
Proceedings of the National Academy of Sciences
Researchers identify gene that influences the ability to remember faces
New findings suggest the oxytocin receptor, a gene known to influence mother-infant bonding and pair bonding in monogamous species, also plays a special role in the ability to remember faces. This research has important implications for disorders in which social information processing is disrupted, including autism spectrum disorder. In addition, the finding may lead to new strategies for improving social cognition in several psychiatric disorders.
NIH/National Institute of Mental Health, Marks Family Foundation

Contact: Lisa Newbern
Emory Health Sciences

Public Release: 23-Dec-2013
European Heart Journal
Study shows value of calcium scan in predicting heart attack, stroke among those considered at risk
A new study shows that coronary artery calcium (CAC) screening, an assessment tool that is not currently recommended for people considered at low risk, should play a more prominent role in helping determine a person's risk for heart attack and heart disease-related death, as well as the need for angioplasty or bypass surgery. CAC screening provides a direct measure of calcium deposits in heart arteries and is easily obtained on a computed tomography scan.
National Institutes of Health

Contact: Ellen Beth Levitt
Johns Hopkins Medicine

Public Release: 23-Dec-2013
Both real and 'sham' acupuncture help ease side effects of widely used breast cancer drug
Breast cancer patients experience fewer side effects while being treated with a widely used drug called an aromatase inhibitor when they get acupuncture -- either the real treatment or a "sham" procedure, according to a new study led by researchers at the University of Maryland Marlene and Stewart Greenebaum Cancer Center. Their findings are published online in Cancer, a peer-reviewed journal of the American Cancer Society.
American Society of Clinical Oncology, Susan G. Komen, NIH/National Cancer Institute, Breast Cancer Research Foundation, and others

Contact: Karen Warmkessel
University of Maryland Medical Center

Public Release: 22-Dec-2013
Nature Chemical Biology
Innovative screening strategy swiftly uncovers new drug candidates, new biology
Scientists at The Scripps Research Institute have demonstrated a drug-discovery strategy with a double payoff -- it enables the rapid selection of chemical compounds that have a desired effect on cells and also highlights how the compounds work. To illustrate the power of the innovative technique, the TSRI researchers used it to identify a compound that shows promise for treating obesity-linked diabetes.
National Institutes of Health, American Diabetes Association, National Health and McDonald's Center for Type 2 Diabetes & Obesity

Contact: Mika Ono
Scripps Research Institute

Public Release: 22-Dec-2013
Nature Neuroscience
Study shows Where Alzheimer's starts and how it spreads
Using high-resolution fMRI imaging in patients with Alzheimer's disease and in mouse models of the disease, researchers have clarified three fundamental issues about Alzheimer's: where it starts, why it starts there, and how it spreads. In addition to advancing understanding of Alzheimer's, the findings could improve early detection of the disease, when drugs may be most effective. The study was published today in the online edition of the journal Nature Neuroscience.
National Institutes of Health

Contact: Karin Eskenazi
Columbia University Medical Center

Public Release: 20-Dec-2013
Kessler Foundation collaborates with UNH on NIDRR Rehabilitation Research and Training Center grant
Kessler Foundation scientists John O'Neill, Ph.D., CRC and Amanda Botticello, Ph.D., M.P.H., were awarded a subcontract on the University of New Hampshire's (UNH) Rehabilitation Research and Training Center grant on Disability Statistics and Demographics. The goal of the 5-year NIDRR-funded grant is to bridge the divide between producers and end users of disability statistics. Andrew Houtenville, Ph.D., of UNH, is project director for the grant, which totals $4.3 million. The Kessler subcontract is valued at $398,115.
NIH/National Institute on Disability and Rehabilitation Research

Contact: Carolann Murphy
Kessler Foundation

Public Release: 20-Dec-2013
Journal of Infectious Diseases
Staph stoppers
University of Iowa researchers have developed a new vaccine that protects against lethal pneumonia caused by Staphylococcus aureus bacteria, including drug-resistant strains like MRSA. The new vaccine, tested in animal models, works by targeting the toxins secreted by staph bacteria. Results appear in the Journal of Infectious Disease.
National Institutes of Health

Contact: Richard Lewis
University of Iowa

Public Release: 20-Dec-2013
Icahn School of Medicine at Mount Sinai named to new NIH Stroke Research Network
The Icahn School of Medicine at Mount Sinai is an inaugural member of the NIH's Stroke Trials Network. It will receive a 5-year, $1.3 million grant to build a collaborative research infrastructure for a NYC regional coordinating stroke center.
National Institutes of Health

Contact: Laura Newman
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 20-Dec-2013
Genome Research
Common disorders: It's not the genes themselves, but how they are controlled
Many rare disorders are caused by gene mutation. Yet until now the underlying genetic cause of more common conditions has evaded scientists for years. New research from Case Western Reserve University to appear in Genome Research finds that six common diseases arise from DNA changes located outside genes. The study from the laboratory of Peter Scacheri, PhD, shows that multiple DNA changes, or variants, work in concert to affect genes, leading to autoimmune diseases.
National Institutes of Health

Contact: Jessica Studeny
Case Western Reserve University

Public Release: 20-Dec-2013
Journal of Clinical Investigation
Dysfunctional TGF-beta signaling contributes to Loeys-Dietz syndrome-associated aortic aneurysm
In this issue of the Journal of Clinical Investigation, Harry Dietz and colleagues at Johns Hopkins School of Medicine developed a mouse model of LDS, in which transgenic animals expressing Tgfbr1 or Tgfbr2 with LDS-associated mutations recapitulated human phenotypes.
National Institutes of Health, Howard Hughes Medical Institute

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 20-Dec-2013
Journal of Clinical Investigation
Angiogenic factor secretion by melanocytes associated with pigmentation leve
In this issue of the Journal of Clinical Investigation, Irit Adini and colleagues at the Harvard Medical School determined that melanocytes from light-skinned humans and albino mice secrete high levels of fibromodulin and that fibromodulin promotes angiogenesis.
National Institutes of Health

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 20-Dec-2013
Journal of Clinical Investigation
Fungal surface protein promotes host cell
In this issue of the Journal of Clinical Investigation, Ashraf Ibrahim and colleagues at the University of California, Los Angeles identified spore coat protein homologues on the surface of Mucorales fungi as the ligand for GRP78 and that gene encoding these proteins are unique to Mucorales.
National Institutes of Health, University of California - Los Angeles

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 19-Dec-2013
UT Southwestern neuroscience researchers identify gene involved in response to cocaine
UT Southwestern neuroscience researchers have identified a gene that controls the response to cocaine by comparing closely related strains of mice often used to study addiction and behavior patterns.
NIH/National Institute on Drug Abuse, National Institutes of Health, Howard Hughes Medical Institute

Contact: Deborah Wormser
UT Southwestern Medical Center

Public Release: 19-Dec-2013
Classic signaling pathway holds the key to prostate cancer progression
University of Houston researchers published a study investigating the processes through which androgen receptors affect prostate cancer progression. The publication, "Androgens Regulate Prostate Cancer Cell Growth via an AMPK-PGC-1α-Mediated Metabolic Switch," featured in Oncogene, illuminates a known metabolic pathway as a potential novel therapeutic target. Daniel Frigo and his team at the Center for Nuclear Receptors and Cell Signaling demonstrate that androgens take control of the AMPK signaling cascade to increase prostate cancer cell growth.
National Institutes of Health, Department of Defense, Texas Emerging Technology Fund

Contact: Emily Merrell
University of Houston

Public Release: 19-Dec-2013
Dual catalysts help synthesize alpha-olefins into new organic compounds
Boston College chemists have developed a method to convert chemicals known as alpha-olefins into new organic compounds. Combining a pair of catalytic reactions in sequence converted inexpensive chemicals into new organic compounds that are highly sought after by researchers in medicine and the life sciences.
NIH/National Institute of General Medical Sciences

Contact: Ed Hayward
Boston College

Public Release: 19-Dec-2013
Journal of the National Comprehensive Cancer Network
Saving fertility not priority at most cancer centers
Infertility is one of the most distressing long-term side effects of cancer treatment for adolescents and young adults. Yet the leading National Cancer Institute-designated comprehensive cancer centers -- which should be leaders in fertility preservation -- aren't doing an adequate job of helping patients protect their fertility. Most of these centers do not have policies to consistently identify which patients may be at risk for fertility loss, inform patients of this risk or refer them to fertility specialists.
NIH/National Institute on Child Health and Human Development

Contact: Marla Paul
Northwestern University

Public Release: 19-Dec-2013
Mating is the kiss of death for certain female worms
The presence of male sperm and seminal fluid causes female worms to shrivel and die after giving birth, Princeton University researchers reported this week in the journal Science. The demise of the female appears to benefit the male worm by removing her from the mating pool for other males.
National Institutes of Health

Contact: Catherine Zandonella
Princeton University

Public Release: 19-Dec-2013
TB bacteria mask their identity to intrude into deeper regions of lungs
TB-causing bacteria appear to mask their identity to avoid recognition by infection-killing cells in the well-patrolled upper airways. The bacteria call up more permissive white blood cells in the deeper regions of the lungs and hitch a ride inside them to get into parts of the host's lungs that are under less surveillance.
National Science Foundation, American Lung Association, American Cancer Society, National Institutes of Health

Contact: Leila Gray
University of Washington

Public Release: 19-Dec-2013
Cell Reports
How cells remodel after UV radiation
Researchers at the University of California, San Diego School of Medicine, with colleagues in The Netherlands and United Kingdom, have produced the first map detailing the network of genetic interactions underlying the cellular response to ultraviolet radiation.
National Institutes of Health, Netherlands Organization for Scientific Research

Contact: Scott LaFee
University of California - San Diego

Public Release: 19-Dec-2013
Nutrition influences metabolism through circadian rhythms, UCI study finds
A high-fat diet affects the molecular mechanism controlling the internal body clock that regulates metabolic functions in the liver, UC Irvine scientists have found. Disruption of these circadian rhythms may contribute to metabolic distress ailments, such as diabetes, obesity and high blood pressure.
National Institutes of Health, National Science Foundation, Merieux Research Institute, Sirtiris/GSK

Contact: Tom Vasich
University of California - Irvine

Public Release: 19-Dec-2013
American Journal of Public Health
Lactation consultant visits spur breastfeeding among women who usually resist it
In two separate clinical trials, researchers at Albert Einstein College of Medicine of Yeshiva University have found that periodic meetings with a lactation consultant encourages women traditionally resistant to breastfeeding to do so, at least for a few months--long enough for mother and child to gain health benefits. The results of the trials were published online today in American Journal of Public Health.
National Institutes of Health

Contact: Kim Newman
Albert Einstein College of Medicine

Public Release: 19-Dec-2013
Study confirms target of potent chronic leukemia drug
A new study helps confirm that a molecule targeted by the experimental drug ibrutinib is critical for the development of chronic lymphocytic leukemia, the most common form of adult leukemia.
Leukemia and Lymphoma Society, D. Warren Brown Foundation, NIH/National Cancer Institute

Contact: Darrell E. Ward
Ohio State University Wexner Medical Center

Public Release: 19-Dec-2013
PLOS Genetics
Protein links liver cancer with obesity, alcoholism, and hepatitis
A new study identifies an unexpected molecular link between liver cancer, cellular stress, and risk factors for developing this cancer -- obesity, alcoholism, and viral hepatitis. In the study by University of Iowa researchers and published in the journal PLOS Genetics, researchers show that a protein called CHOP, which had previously been thought to generally protect against cancer, actually promotes liver cancer in mice.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases, Carver Medical Research Trust Initiative, NIH/National Cancer Institute

Contact: Jennifer Brown

Public Release: 19-Dec-2013
Scientists look to tackle bacterium that is major cause of diarrhea, vomiting
Scientists want to make a chink in the armor of a bacterium that has little name recognition yet is the number-one bacterial cause of the diarrhea, vomiting and stomach pain Americans experience annually.
National Institutes of Health

Contact: Toni Baker
Medical College of Georgia at Georgia Regents University

Showing releases 3001-3025 out of 3519.

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