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Key: Meeting M      Journal J      Funder F

Showing releases 3076-3100 out of 3512.

<< < 119 | 120 | 121 | 122 | 123 | 124 | 125 | 126 | 127 | 128 > >>

Public Release: 16-Dec-2013
Journal of Clinical Investigation
A mouse model to evaluate potential age-promoting compounds
Recently, a mouse strain (p16LUC mice) was developed that can be used to evaluate the transcription of p16INK4, which is increasingly expressed during aging and in age-associated diseases. In this issue of the Journal of Clinical Investigation, Norman Sharpless and colleagues at the University of North Carolina evaluated potential age-promoting compounds, including arsenic, a high-fat diet, UV light, and cigarette smoke in p16LUC mice.
National Institutes of Health, Howard Hughes Medical Institute

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 15-Dec-2013
Nature Medicine
Pitt study: Lung lesions of TB variable, independent whether infection is active or latent
The lung lesions in an individual infected with tuberculosis are surprisingly variable and independent of each other, despite whether the patient has clinically active or latent disease, according to a new animal study led by researchers at the University of Pittsburgh School of Medicine. The findings, published online today in Nature Medicine, could point the way to new vaccines to prevent the hard-to-treat infection.
Bill & Melinda Gates Foundation, Otis Childs Trust, Children's Hospital of Pittsburgh Foundation, National Institutes of Health, Howard Hughes Medical Institute, Burroughs Wellcome Foundation, and others

Contact: Anita Srikameswaran
University of Pittsburgh Schools of the Health Sciences

Public Release: 13-Dec-2013
Journal of Biological Chemistry
UI researcher studies evolution on the molecular level
UI researchers describe the evolution of various forms of the enzyme "dihydrofolate reductase" as it occurred from bacteria to humans. Their paper, which appears in the Dec. 13 issue of the Journal of Biological Chemistry, may prove useful to scientists in the design of future drugs and catalysts.
National Science Foundation, National Institutes of Health

Contact: Gary Galluzzo
University of Iowa

Public Release: 13-Dec-2013
UTHealth named one of nation's NIH stroke network centers
The University of Texas Health Science Center at Houston has been named one of 25 regional stroke centers by the National Institutes of Health and the only one in Texas.
National Institutes of Health

Contact: Deborah Lake
University of Texas Health Science Center at Houston

Public Release: 13-Dec-2013
Nature Neuroscience
No 2 people smell the same
With about 400 odor receptors in the human nose, and more than 900,000 variations on the genes that build those receptors, it would appear that no two humans smell things the same way. Between any two individuals, they may vary by at least 30 percent in the population of receptors they have, according to a Duke University team led by Hiroaki Matsunami.
National Institutes of Health

Contact: Karl Leif Bates
Duke University

Public Release: 13-Dec-2013
American Journal of Kidney Diseases
UCSF research finds new link between obesity, early decline in kidney function
A new UCSF-led study of nearly 3,000 individuals links obesity to the development of kidney disease.
NIH/National Institute of Diabetes and Digestive and Kidney Disease, NIH/National Institute on Minority Health and Health Disparities

Contact: Peter Farley
University of California - San Francisco

Public Release: 13-Dec-2013
Journal of Infectious Diseases
Plaque composition, immune activation explain cardiovascular risk in HIV-infected women
A Massachusetts General Hospital research team has discovered a possible mechanism behind the elevated risk of cardiovascular disease in women infected with HIV, a risk even higher than that of HIV-infected men.
Bristol-Myers Squibb, National Institutes of Health

Contact: Cassandra Aviles
Massachusetts General Hospital

Public Release: 13-Dec-2013
Advanced Functional Materials
Duke engineers make strides toward artificial cartilage
A Duke research team has developed a better recipe for synthetic replacement cartilage in joints, calling for a newly designed durable hydrogel to be poured over a three-dimensional fabric "scaffold."
National Institutes of Health, National Science Foundation, Arthritis Foundation, Collaborative Research Center, AO Foundation

Contact: Ken Kingery
Duke University

Public Release: 13-Dec-2013
Proceedings of the National Academy of Sciences
Breakthrough could lead to protection from fatal infections
Researchers at UTMB have found a way to protect against what can be a fatal rickettsial infection.
National Institutes of Health

Contact: Raul Reyes
University of Texas Medical Branch at Galveston

Public Release: 13-Dec-2013
Pathogen study explores blocking effect of E. coli O157:H7 protein
Philip Hardwidge, associate professor at the College of Veterinary Medicine at Kansas State University, is studying how pathogens such as E. coli use proteins to block a host's innate immune system. His work is being supported by a multiyear grant from the National Institutes of Health.
National Institutes of Health

Contact: Philip Hardwidge
Kansas State University

Public Release: 13-Dec-2013
2013 CTRC-AACR San Antonio Breast Cancer Symposium
New presurgery treatment combination more effective for women with triple-negative breast cancer
Adding the chemotherapy drug carboplatin and/or the antibody therapy bevacizumab to standard presurgery chemotherapy increased the number of women with triple-negative breast cancer who had no residual cancer detected at surgery, according to results of a randomized, phase II clinical trial presented here at the 2013 San Antonio Breast Cancer Symposium, held Dec. 10-14.
National Institutes of Health, Genentech, the Breast Cancer Research Foundation

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 13-Dec-2013
2013 CTRC-AACR San Antonio Breast Cancer Symposium
Changing chemo not beneficial for metastatic B.C. patients with elevated circulating tumor cells
For women with metastatic breast cancer who had elevated amounts of circulating tumor cells in their blood after a first line of chemotherapy, switching immediately to a different chemotherapy did not improve overall survival or time to progression, according to the results of a phase III clinical trial presented here at the 2013 San Antonio Breast Cancer Symposium, held Dec. 10-14.
NIH/National Cancer Institute, Veridex

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 12-Dec-2013
Cancer Research
Researchers hope newly discovered gene interaction could lead to novel cancer therapies
Scientists from Virginia Commonwealth University Massey Cancer Center have revealed how two genes interact to kill a wide range of cancer cells. Originally discovered by the study's lead investigator Paul B. Fisher, M.Ph., Ph.D., the genes known as mda-7/IL-24 and SARI could potentially be harnessed to treat both primary and metastatic forms of brain, breast, colon, lung, ovary, prostate, skin and other cancers.
National Institutes of Health

Contact: John Wallace
Virginia Commonwealth University

Public Release: 12-Dec-2013
The Journal of Neuroscience
Scientists improve human self-control through electrical brain stimulation
If you have ever said or done the wrong thing at the wrong time, you should read this. Neuroscientists at The University of Texas Health Science Center at Houston and the University of California, San Diego, have successfully demonstrated a technique to enhance a form of self-control through a novel form of brain stimulation.
NIH/National Institutes of Health Center for Clinical and Translational Sciences

Contact: Robert Cahill
University of Texas Health Science Center at Houston

Public Release: 12-Dec-2013
2013 CTRC-AACR San Antonio Breast Cancer Symposium
Cell Reports
New models of drug-resistant breast cancer point to better treatments
Human breast tumors transplanted into mice are excellent models of metastatic cancer and are providing insights into how to attack breast cancers that no longer respond to the drugs used to treat them, according to research from Washington University School of Medicine in St. Louis.
Susan G. Komen for the Cure, National Institutes of Health

Contact: Julia Evangelou Strait
Washington University School of Medicine

Public Release: 12-Dec-2013
Wayne State discovers potential treatment for skin and corneal wound healing in diabetics
A team of Wayne State University researchers recently developed several diabetic models to study impaired wound healing in diabetic corneas. Using a genome-wide cDNA array analysis, the group identified genes, their associated pathways and the networks affected by DM in corneal epithelial cells and their roles in wound closure. Their findings may bring scientists one step closer to developing new treatments that may slow down or thwart the impact on vision.
NIH/National Eye Institute

Contact: Julie O'Connor
Wayne State University - Office of the Vice President for Research

Public Release: 12-Dec-2013
Sniffing out danger: Rutgers scientists say fearful memories can trigger heightened sense of smell
Neuroscientists at Rutgers University studying the olfactory -- sense of smell -- system in mice have discovered that fear reaction can occur at the sensory level, even before the brain has the opportunity to interpret that the odor could mean trouble.
NIH/National Institute of Mental Health, NIH/National Institute on Deafness and Other Communication Disorders

Contact: Robin Lally
732-932-7084 x652
Rutgers University

Public Release: 12-Dec-2013
Blind cavefish offer evidence for alternative mechanism of evolutionary change
In a blind fish that dwells in deep, dark Mexican caves, scientists have found evidence for a long-debated mechanism of evolutionary change that is distinct from natural selection of spontaneously arising mutations, as reported this week in the journal Science.
National Institutes of Health

Contact: Diana Kenney
Marine Biological Laboratory

Public Release: 12-Dec-2013
Speeding up gene discovery
MIT researchers develop a new gene-editing system that enables large-scale studies of gene function.
National Institutes of Health, NIH/National Human Genome Research Institute, Broad Institute, National Science Foundation, Klarman Cell Observatory, Simons Center, and others

Contact: Sarah McDonnell
Massachusetts Institute of Technology

Public Release: 12-Dec-2013
San Antonio Breast Cancer Symposium
Mayo Clinic: First in-human trial of endoxifen shows promise as breast cancer treatment
A Phase I trial of endoxifen, an active metabolite of the cancer drug tamoxifen, indicates that the experimental drug is safe, with early evidence for anti-tumor activity, a Mayo Clinic study has found. The findings indicate that Z-endoxifen, co-developed by Mayo Clinic Cancer Center and the National Cancer Institute, may provide a new and better treatment for some women with estrogen positive breast cancer and, in particular, for those women who do not respond to tamoxifen and aromatase inhibitors.
National Institutes of Health

Contact: Joe Dangor
Mayo Clinic

Public Release: 12-Dec-2013
Scientists discover double meaning in genetic code
Scientists have discovered a second code hiding within DNA. The second code contains information that changes how scientists read the instructions contained in DNA and interpret mutations to make sense of health and disease. Genomes use the genetic code to write two separate languages. One describes how proteins are made, and the other instructs the cell on how genes are controlled. One language is written on top of the other.
National Institutes of Health, NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Contact: Leila Gray
University of Washington

Public Release: 12-Dec-2013
Rapid evolution of novel forms: Environmental change triggers inborn capacity for adaptation
In this week's edition of the journal Science, a team of researchers from Harvard Medical School and Whitehead Institute report that, at least in the case of one variety of cavefish, one agent of evolutionary change is the heat shock protein known as HSP90.
National Institutes of Health and the Damon Runyon Cancer Research Foundation

Contact: Matt Fearer
Whitehead Institute for Biomedical Research

Public Release: 12-Dec-2013
First step of metastasis halted in mice with breast cancer
Cell biologists at Johns Hopkins have identified a unique class of breast cancer cells that lead the process of invasion into surrounding tissues. Because invasion is the first step in the deadly process of cancer metastasis, the researchers say they may have found a weak link in cancer's armor and a possible new target for therapy.
NIH/National Cancer Institute, NIH/National Institute of Environmental Health Sciences, US Department of Defense CDMRP Breast Cancer Program, Avon Foundation, Mary Kay Foundation, Safeway Foundation, Cindy Rosencrans Fund for Triple Negative Breast Cancer

Contact: Catherine Kolf
Johns Hopkins Medicine

Public Release: 12-Dec-2013
American Journal of Pathology
Enzyme BACE1 may be important in predicting onset of Alzheimer disease
The critical enzyme beta-secretase1 (BACE1) is known to be elevated in brains with sporadic Alzheimer disease (AD). Scientists have now found increased levels of BACE1 in brains with mild cognitive impairment, suggesting that BACE1 activity is important for conversion of mild cognitive impairment to AD and may be an early indicator of AD. The results are published in the January issue of The American Journal of Pathology.
National Institutes of Health, Alzheimer Association, National Natural Science Foundation of China

Contact: Eileen Leahy
Elsevier Health Sciences

Public Release: 12-Dec-2013
Salmonella jams signals from bacteria-fighting mast cells
A protein in Salmonella inactivates mast cells -- critical players in the body's fight against bacteria and other pathogens -- rendering them unable to protect against bacterial spread in the body, according to researchers at Duke Medicine and Duke-National University of Singapore.
National Institutes of Health, Duke-NUS

Contact: Rachel Harrison
Duke University Medical Center

Showing releases 3076-3100 out of 3512.

<< < 119 | 120 | 121 | 122 | 123 | 124 | 125 | 126 | 127 | 128 > >>


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