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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 3076-3100 out of 3530.

<< < 119 | 120 | 121 | 122 | 123 | 124 | 125 | 126 | 127 | 128 > >>

Public Release: 22-Jan-2014
Study identifies gene tied to motor neuron loss in ALS
Columbia University Medical Center researchers have identified a gene, called matrix metalloproteinase-9 (MMP-9), that appears to play a major role in motor neuron degeneration in amyotrophic lateral sclerosis, also known as Lou Gehrig's disease. The findings, made in mice, explain why most but not all motor neurons are affected by the disease and identify a potential therapeutic target for this still-incurable neurodegenerative disease. The study was published today in the online edition of the journal Neuron.
P2ALS, Target ALS, Tow Foundation, SMA Foundation, NIH/National Institute of Neurological Disorders and Stroke, National Science Foundation

Contact: Karin Eskenazi
Columbia University Medical Center

Public Release: 22-Jan-2014
Nature Communications
Study shows 1 in 5 women with ovarian cancer has inherited predisposition
A new study conservatively estimates that one in five women with ovarian cancer has inherited genetic mutations that increase the risk of the disease, according to research at Washington University School of Medicine in St. Louis.
NIH/National Cancer Institute, NIH/National Human Genome Research Institute

Contact: Caroline Arbanas
Washington University School of Medicine

Public Release: 22-Jan-2014
World's dangerous neighborhoods produce aggressive children
Across the globe, children growing up in dangerous neighborhoods exhibit more aggressive behavior, says a new Duke University study that is the first to examine the topic across a wide range of countries. The effect may be indirect: dangerous neighborhoods may influence parents' behavior, and harsh parenting practices may in turn promote aggressive behavior in children.
National Institutes of Health, NIH/National Institute of Child Health and Human Development, NIH/Fogarty International Center

Contact: Alison Jones
Duke University

Public Release: 22-Jan-2014
Journal of Visualized Experiments
Scripps Florida scientists offer new insight into neuron changes brought about by aging
A new study from the Florida campus of the Scripps Research Institute offers insights into how aging affects the brain's neural circuitry, in some cases significantly altering gene expression in single neurons. These discoveries could point the way toward a better understanding of how aging affects our cognitive ability and new therapeutic targets for the treatment of neurodegenerative disease, including Alzheimer's and Parkinson's disease.
National Institutes of Health

Contact: Eric Sauter
Scripps Research Institute

Public Release: 22-Jan-2014
Proceedings of the National Academy of Sciences
Drug discovery potential of natural microbial genomes
Scientists at the University of California, San Diego have developed a new genetic platform that allows efficient production of naturally occurring molecules, and have used it to produce a novel antibiotic compound. Their study, published this week in PNAS, may open new avenues for natural product discoveries and drug development.
National Institutes of Health

Contact: Debra Kain
University of California - San Diego

Public Release: 22-Jan-2014
Obstetrics and Gynecology
Vulvar condition causing painful sex strikes twice as many Hispanic women
The prevalence and incidence rates of vulvodynia were substantial among all ethnic groups.
NIH/National Institute of Child Health and Human Development

Contact: Beata Mostafavi
University of Michigan Health System

Public Release: 22-Jan-2014
Proceedings of the National Academy of Sciences
Better protein capture a boon for drug manufacturers
Rice University scientists have created a way to fine tune a process critical to the pharmaceutical industry that could save time and money.
National Science Foundation, National Institutes of Health, Welch Foundation

Contact: David Ruth
Rice University

Public Release: 22-Jan-2014
Unprecedented structural insights: NMDA receptors can be blocked to limit neurotoxicity
Structural biologists at Cold Spring Harbor Laboratory and collaborators at Emory University have obtained important scientific results likely to advance efforts to develop new drugs targeting NMDA receptors in the brain.
National Institutes of Health, Robertson Research Fund, Japan Promotion of Science

Contact: Peter Tarr
Cold Spring Harbor Laboratory

Public Release: 22-Jan-2014
Neuroimage: Clinical
Hearing loss linked to accelerated brain tissue loss
Although the brain becomes smaller with age, the shrinkage seems to be fast-tracked in older adults with hearing loss, according to the results of a study by researchers from Johns Hopkins and the National Institute on Aging. The findings add to a growing list of health consequences associated with hearing loss, including increased risk of dementia, falls, hospitalizations, and diminished physical and mental health overall.
NIH/National Institute on Aging, NIH/National Institute on Deafness and Other Communication Disorders

Contact: Stephanie Desmon
Johns Hopkins Medicine

Public Release: 22-Jan-2014
International Journal of Men's Health
Health disparities among US African-American and Hispanic men cost economy more than $450 billion
African-American men incurred $341.8 billion in excess medical costs due to health inequalities between 2006 and 2009, and Hispanic men incurred an additional $115 billion over the four-year period, according to a new study by researchers at the Johns Hopkins Bloomberg School of Public Health. The study looks at the direct and indirect costs associated with health inequalities and projects the potential cost savings of eliminating these disparities for minority men in the US.
NIH/National Center for Minority Health and Health Disparities

Contact: Tim Parsons
Johns Hopkins University Bloomberg School of Public Health

Public Release: 22-Jan-2014
Case Western Reserve wins $12.7 million for AIDS research and clinical trials
AIDS researchers from Case Western Reserve University and University Hospitals Case Medical Center have received a seven-year funding award from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. This award includes $12.7 million for core research funding and the potential of an additional $9 million to support clinical trials of promising treatments.
NIH/National Institute of Allergy and Infectious Diseases

Contact: Jessica Studeny
Case Western Reserve University

Public Release: 22-Jan-2014
Number of cancer stem cells might not predict outcome in HPV-related oral cancers
New research from the Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute suggests that it may be the quality of cancer stem cells rather than their quantity that leads to better survival in certain patients with oral cancer.
National Institutes of Health, Mary E. and John W. Alford Cancer Research Endowment Fund, Joan Bisesi Fund for Head and Neck Oncology

Contact: Amanda J. Harper
Ohio State University Wexner Medical Center

Public Release: 22-Jan-2014
JAMA Internal Medicine
Regenstrief, IU study: Half of hospitalized adults over 65 need surrogate decision-makers
Nearly half of hospitalized American adults age 65 and older require decision-making assistance from family members or other surrogates because the patient is too impaired to make decisions independently, according to a new study from the Regenstrief Institute and the Indiana University Center for Aging Research.
NIH/National Institute on Aging

Contact: Cindy Fox Aisen
Indiana University

Public Release: 22-Jan-2014
Lancet Oncology
Long-term follow-up shows need for new chemotherapy strategies for rectal cancer
Appearing in Lancet Oncology, long-term results of EORTC trial 22921 with 10.4 years median follow-up show that 5-FU-based adjuvant chemotherapy after preoperative (chemo)-radiotherapy for patients with cT3-resectable T4 M0 rectal cancer does not improve survival or disease-free survival.
European Organization for Research and Treatment of Cancer, NIH/National Cancer Institute, Ligue contre le Cancer Comité du Doubs

Contact: John Bean
European Organisation for Research and Treatment of Cancer

Public Release: 22-Jan-2014
Scientists find that estrogen promotes blood-forming stem cell function
Scientists have known for years that stem cells in male and female sexual organs are regulated differently by their respective hormones. In a surprising discovery, researchers at the Children's Medical Center Research Institute at UT Southwestern and Baylor College of Medicine have found that stem cells in the blood-forming system -- which is similar in both sexes -- also are regulated differently by hormones, with estrogen proving to be an especially prolific promoter of stem cell self-renewal.
Cancer Prevention and Research Institute of Texas, NIH/National Heart, Lung, and Blood Institute, Howard Hughes Medical Institute, Children's Medical Center Foundation

Contact: Connie Piloto
UT Southwestern Medical Center

Public Release: 22-Jan-2014
New studies show that many rare mutations contribute to schizophrenia risk
Researchers from the Broad Institute and several partnering institutions have taken a closer look at the human genome to learn more about the genetic underpinnings of schizophrenia. In two studies published this week in Nature, scientists analyzed the exomes, or protein-coding regions, of people with schizophrenia and their healthy counterparts, pinpointing the sites of mutations and identifying patterns that reveal clues about the biology underlying the disorder.
NIH/National Institute of Mental Health, NIH/National Human Genome Research Institute

Contact: Haley Bridger
Broad Institute of MIT and Harvard

Public Release: 22-Jan-2014
Mount Sinai research underscores the genetic complexity in schizophrenia
The genetic complexity of schizophrenia in schizophrenia is revealed in two large studies, which re the largest sequencing efforts to date on schizophrenia.
National Institutes of Health, NIH/National Human Genome Research Institute

Contact: Glenn Farrell
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 22-Jan-2014
Parental exposure to THC Linked to drug addiction, compulsive behavior in unexposed offspring
Adolescent marijuana use may have adverse impacts in adult progeny not directly exposed to marijuana. Mount Sinai study finds increased compulsive behaviors and neurobiological changes in animals.
National Institutes of Health

Contact: NewsMedia
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 21-Jan-2014
Osteoporosis International
Guys: Get married for the sake of your bones, but wait until you're 25
Researchers found evidence that men who married when they were younger than 25 had lower bone strength than men who married for the first time at a later age. Also, men in stable marriages or marriage-like relationships who had never previously divorced or separated had greater bone strength than men whose previous marriages had fractured. And those in stable relationships also had stronger bones than men who never married.
MacArthur Foundation, NIH/National Institute on Aging

Contact: Enrique Rivero
University of California - Los Angeles Health Sciences

Public Release: 21-Jan-2014
Journal of Clinical Oncology
Cancer diagnosis doesn't increase a child's risk of post-traumatic stress disorder
A St. Jude Children's Research Hospital study found that despite being diagnosed with life-threatening illnesses, childhood cancer patients are no more likely than their healthy peers to develop post-traumatic stress disorder.
National Institutes of Health, ALSAC

Contact: Summer Freeman
St. Jude Children's Research Hospital

Public Release: 21-Jan-2014
Journal of Neuroscience
New avenue to treat diabetes-related vision problems
Dopamine-restoring drugs already used to treat Parkinson's disease may also be beneficial for the treatment of diabetic retinopathy, a leading cause of blindness in adults.
NIH/National Eye Institute, NIh/National Institute of Diabetes & Digestive & Kidney Diseases, Research to Prevent Blindness, Juvenile Diabetes Research Foundation

Contact: Quinn Eastman
Emory Health Sciences

Public Release: 21-Jan-2014
Journal of Ophthalmology
Mayo Clinic research finds risk of glaucoma blindness drops by half
A comparative long-range study by Mayo Clinic ophthalmology researchers shows that the probability of blindness from glaucoma 20 years after diagnosis has dropped by half in the last generation. The findings appear online in the "in press" section of the journal Ophthalmology.
Research to Prevent Blindness, National Institutes of Health

Contact: Bob Nellis
Mayo Clinic

Public Release: 21-Jan-2014
Common blood cancer may be initiated by single mutation in bone cells
AML is a blood cancer, but for many patients the cancer may originate from an unusual source: a mutation in their bone cells. In a study published today in the online edition of Nature, researchers at Columbia University Medical Center found that a mutation in the bone cells called osteoblasts, which build new bone, causes AML in mice. The mutation was found in nearly 40 percent of patients with AML or myelodysplastic syndrome, a precursor condition, who were examined as part of the study.
National Institutes of Health

Contact: Karin Eskenazi
Columbia University Medical Center

Public Release: 21-Jan-2014
Reducing liver protein SIRT1 levels
A new study led by Boston University School of Medicine demonstrates that the abnormal metabolism linked to obesity could be regulated in part by the interaction of two metabolic regulators, called the NAD-dependent deacetylase SIRT1 and fibroblast growth factor 21. Using experimental models, the researchers found that a lack of SIRT1 protein in the liver led to lower levels of a liver secreted protein FGF21, which resulted in an increased likelihood of developing fatty liver disease and obesity.
National Institutes of Health, Robert Dawson Evans Faculty Merit Award, Wing Tat Lee Award

Contact: Jenny Eriksen Leary
Boston University Medical Center

Public Release: 21-Jan-2014
Cerebral Cortex
New Penn index detects early signs of deviation from normal brain development
Researchers at Penn Medicine have generated a brain development index from MRI scans that captures the complex patterns of maturation during normal brain development. This index will allow clinicians and researchers for the first time to detect subtle, yet potentially critical early signs of deviation from normal development during late childhood to early adult.
National Institutes of Health

Contact: Steve Graff
University of Pennsylvania School of Medicine

Showing releases 3076-3100 out of 3530.

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