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Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 3101-3125 out of 3690.

<< < 120 | 121 | 122 | 123 | 124 | 125 | 126 | 127 | 128 | 129 > >>

Public Release: 8-Dec-2014
56th American Society of Hematology Annual Meeting
Disorder in gene-control system is a defining characteristic of cancer, study finds
The genetic tumult within cancerous tumors is more than matched by the disorder in one of the mechanisms for switching cells' genes on and off, scientists at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard report in a new study. Their findings, published online today in the journal Cancer Cell, indicate that the disarray in the on-off mechanism -- known as methylation -- is one of the defining characteristics of cancer and helps tumors adapt to changing circumstances.
NIH/National Cancer Institute, NIH/National Heart Lung and Blood Institute, Blavatnik Family Foundation, Stand Up to Cancer, Melton and Rosenbach Funds, American Cancer Society, National Science Foundation, Leukemia and Lymphoma Society

Contact: Anne Doerr
Dana-Farber Cancer Institute

Public Release: 8-Dec-2014
Proceedings of the National Academy of Sciences
Heat-shock protein enables tumor evolution and drug resistance in breast cancer
Long known for its ability to help organisms successfully adapt to environmentally stressful conditions, the highly conserved molecular chaperone heat-shock protein 90 also enables estrogen receptor-positive breast cancers to develop resistance to hormonal therapy.
National Institutes of Health, National Cancer Institute, Susan G. Komen Foundation, Howard Hughes Medical Institute

Contact: Matt Fearer
Whitehead Institute for Biomedical Research

Public Release: 8-Dec-2014
Genetic errors linked to aging underlie leukemia that develops after cancer treatment
New research at Washington University School of Medicine in St. Louis challenges the view that cancer treatment in itself is a direct cause of a fatal form of leukemia that can develop several years after a patient receives chemotherapy or radiation therapy.
NIH/National Human Genome Research Institute, Leukemia & Lymphoma Society.

Contact: Diane Duke Williams
Washington University School of Medicine

Public Release: 8-Dec-2014
Proceedings of the National Academy of Sciences
New therapy holds promise for restoring vision
UC Berkeley scientists developed a therapy to restore light sensitivity to retinas blinded by the death of photoreceptors, as in retinitis pigmentosa. They use a virus to insert a gene for an ion channel into surviving retinal cells. An injected chemical binds to the receptor and opens it when hit with light, making these cells respond to light. It works in mice and now dogs at PennVet, while mice see enough to follow visual cues.
National Institutes of Health, Foundation Fighting Blindness

Contact: Robert Sanders
University of California - Berkeley

Public Release: 8-Dec-2014
Proceedings of the National Academy of Sciences
Vaccine holds hope of preventing antibiotic resistant skin infections
LA BioMed researchers find a new investigational vaccine, NDV-3, employing the recombinant protein Als3, can mobilize the immune system to fight off MRSA skin infections in an experimental model.
National Institutes of Health, US Department of Defense, NovaDigm Therapeutics, Inc.

Contact: Laura Mecoy
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)

Public Release: 8-Dec-2014
Journal of Cell Biology
Macrophages chase neutrophils away from wounds to resolve inflammation
Macrophages are best known for their Pac Man-like ability to gobble up cellular debris and pathogens in order to thwart infection. A new study describes how these immune cells also help resolve inflammation by inducing white blood cells called neutrophils to leave wounded tissue.
American Heart Association, National Institutes of Health

Contact: Rita Sullivan King
Rockefeller University Press

Public Release: 7-Dec-2014
56th American Society of Hematology Annual Meeting
Penn researchers announce latest results of investigational cellular therapy
The latest results of clinical trials of more than 125 patients testing a personalized cellular therapy known as CTL019 will be presented by University of Pennsylvania researchers at the 56th American Society of Hematology Annual Meeting and Exposition. Highlights of the new trial results will include a response rate of more than 90 percent among pediatric acute lymphoblastic leukemia patients, and results from the first lymphoma trials testing the approach.
National Institutes of Health, The Leukemia & Lymphoma Society's Specialized Centers of Research, Stand Up To Cancer-St. Baldrick's Pediatric Dream Team Trans

Contact: Holly Auer
University of Pennsylvania School of Medicine

Public Release: 7-Dec-2014
56th American Society of Hematology Annual Meeting
Young adults with ALL benefit from therapies developed for children
A large, prospective clinical trial adds to mounting evidence that adolescent and young adult patients -- aged 16 to 39 with acute lymphoblastic leukemia -- fare better when treated with high-intensity pediatric protocols than previous patients treated on adult regimens.
National Institutes of Health

Contact: John Easton
University of Chicago Medical Center

Public Release: 6-Dec-2014
56th American Society of Hematology Annual Meeting
New England Journal of Medicine
Immunotherapy achieves breakthrough result in patients with Hodgkin lymphoma
Eighty-seven percent of Hodgkin lymphoma patients who participated in an early-phase immunotherapy clinical trial experienced cancer remission.
Bristol Myers Squibb, National Institutes of Health, Miller Family Fund

Contact: Teresa M. Herbert
Dana-Farber Cancer Institute

Public Release: 5-Dec-2014
Molecular Cell
CSHL team finds a way to make shRNA gene knockdown more effective
Scientists at Cold Spring Harbor Laboratory have devised a powerful algorithm that improves the effectiveness of an important research technology harnessing RNA interference, or RNAi.
Howard Hughes Medical Institute, National Institutes of Health, Kathryn W. Davis, Hope Funds for Cancer Research, Boehringer Ingelheim Foundation

Contact: Peter Tarr
Cold Spring Harbor Laboratory

Public Release: 5-Dec-2014
Proceedings of the National Academy of Sciences
Promising compound rapidly eliminates malaria parasite
An international research collaborative has determined that a promising anti-malarial compound tricks the immune system to rapidly destroy red blood cells infected with the malaria parasite but leave healthy cells unharmed. St. Jude Children's Research Hospital scientists led the study, which appears in the current online early edition of the Proceedings of the National Academy of Sciences.
NIH/National Institutes of Allergy and Infectious Diseases, Medicines for Malaria Venture, Australian National Health

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

Public Release: 5-Dec-2014
Journal of the American College of Surgeons
Malnutrition is predictor of long-term survival in patients undergoing Whipple procedure
Malnutrition is an important factor predicting long-term survival in older patients undergoing pancreaticoduodenectomy (PD) -- commonly called the Whipple procedure -- to treat benign tumors and cysts of the pancreas as well as pancreatitis, according to new study results published in the December issue of the Journal of the American College of Surgeons.
NIH/National Cancer Institute

Contact: Sally Garneski
American College of Surgeons

Public Release: 5-Dec-2014
Penicillin tactics revealed
One of the oldest and most widely used antibiotics, penicillin attacks enzymes that build the bacterial cell wall. Researchers from Harvard Medical School have now shown that penicillin and its variants also set in motion a toxic malfunctioning of the cell's wall-building machinery, dooming the cell to a futile cycle of building and then immediately destroying that wall.
NIH/National Institute of Allergy and Infectious Diseases

Contact: David Cameron
Harvard Medical School

Public Release: 5-Dec-2014
Annals of Neurology
Study shows more patients with ALS have genetic origin than previously thought
Genetics may play a larger role in causing Lou Gehrig's disease than previously believed, potentially accounting for more than one-third of all cases, according to one of the most comprehensive genetic studies to date of patients who suffer from the condition also known as amyotrophic lateral sclerosis, or ALS.
National Institutes of Health, Genetics Epidemiology Training, Genome Technology Access Center

Contact: Sandy Van
Cedars-Sinai Medical Center

Public Release: 4-Dec-2014
Frontiers in Immunology
Predicting the storm: Can computer models improve stem cell transplantation?
Is the human immune system similar to the weather, a seemingly random yet dynamical system that can be modeled based on past conditions to predict future states? Scientists at VCU Massey Cancer Center's award-winning Bone Marrow Transplant Program believe it is.
NIH/National Cancer Institute

Contact: John Wallace
Virginia Commonwealth University

Public Release: 4-Dec-2014
Journal of the Acoustical Society of America
Quiet as a mouse, but so much to hear
Micheal L. Dent, a University at Buffalo psychologist, listens to what is inaudible to others. And what she's hearing might one day help us better understand human hearing loss.
NIH/National Institute on Deafness and Other Communication Disorders.

Contact: Bert Gambini
University at Buffalo

Public Release: 4-Dec-2014
IU collaboration to develop computational model of acetaminophen-induced liver failure
Three Indiana University professors have received $2.1 million to develop a computational model of acetaminophen-induced liver failure -- the leading cause of liver failure in the United States -- by using advanced microscopic and computational technologies that allow scientists to see into the liver of a living animal.
National Institutes of Health, National Science Foundation, Food and Drug Administration, National Aeronautical and Space Administration, Department of Defense and the Department of Energy

Contact: Steve Chaplin
Indiana University

Public Release: 4-Dec-2014
Joint Commission Journal on Quality and Patient Safety
Coordinating care of older adults moving across treatment still a problem
In what is believed to be the first interview-style qualitative study of its kind among health care providers in the trenches, a team led by a Johns Hopkins geriatrician has further documented barriers to better care of older adults as they are transferred from hospital to rehabilitation center to home, and too often back again.
Robert Wood Johnson Foundation, NIH/National Institute on Aging, Atlantic Philanthropies, John A. Hartford Foundation, Association of Subspecialty Professors, Health in Aging Foundation

Contact: Karen Tong
Johns Hopkins Medicine

Public Release: 4-Dec-2014
Bradley Hasbro Research Center to study drug treatment program for girls in court system
Marina Tolou-Shams, Ph.D., a psychologist from the Bradley Hasbro Children's Research Center, has received a $2 million grant to study the efficacy of a drug use intervention for court-involved, non-incarcerated girls who use illicit substances. The study, funded by the National Institute on Drug Abuse, will compare the gender-responsive program's effect on reducing drug use and sexual risk behaviors relative to other community-based services that girls are typically referred to by the court.
NIH/National Institute on Drug Abuse

Contact: Jill Reuter

Public Release: 4-Dec-2014
UH team fights antibiotic-resistant bacteria with NIH grant
Addressing the relentless game of cat and mouse played between antibiotics and bacteria, a pair of University of Houston professors recently received a $519,000 grant from the National Institutes of Health. Longtime collaborators on combating drug-resistant bacteria, chemical and biomolecular engineering professor Mike Nikolaou and clinical sciences pharmacy professor Vincent Tam produced a patented equation to assess the effects of antibiotics on bacteria.
National Institutes of Health

Contact: Lisa Merkl
University of Houston

Public Release: 4-Dec-2014
AIDS Patient Care and STDs
People with mental illness more likely to be tested for HIV, Penn Medicine study finds
People with mental illness are more likely to have been tested for HIV than those without mental illness, according to a new study from a team of researchers at Penn Medicine and the US Centers for Disease Control and Prevention published online this week in AIDS Patient Care and STDs.
National Institutes of Health, Centers for Disease Control and Prevention

Contact: Steve Graff
University of Pennsylvania School of Medicine

Public Release: 4-Dec-2014
Chemistry and Biology
A poisonous cure
Take two poisonous mushrooms, and call me in the morning. While no doctor would ever write this prescription, toxic fungi may hold the secrets to tackling deadly diseases.
National Institutes of Health

Contact: Layne Cameron
Michigan State University

Public Release: 4-Dec-2014
IEEE Transactions on Robotics
UT Dallas engineer applies robot control theory to improve prosthetic legs
Research led by Dr. Robert Gregg of the Erik Jonsson School of Engineering and Computer Science enables powered prosthetics to dynamically respond to the wearer's environment and help amputees walk. Wearers of the robotic leg could walk on a treadmill almost as fast as an able-bodied person.
US Army Medical Research Acquisition Activity, Burroughs Wellcome Fund, NIH/National Institute of Child Health and Human Development

Contact: LaKisha Ladson
University of Texas at Dallas

Public Release: 4-Dec-2014
Genetics in Medicine
Genome sequencing for newborns: What do new parents think?
A study published this week in Genetics in Medicine is the first to explore new parents' attitudes toward newborn genomic testing. The findings suggest that if newborn genomic testing becomes available, there would be robust interest among new parents, regardless of their demographic background.
Brigham and Women's Biomedical Research Institute, Galactosemia Foundation, National PKU Alliance, National Institutes of Health

Contact: Lori J. Schroth
Brigham and Women's Hospital

Public Release: 4-Dec-2014
PLOS Genetics
A novel role for Ranbp9 in regulating alternative splicing in spermatogenic cells
A group of researchers led by professor Wei Yan, at the University of Nevada School of Medicine has discovered that a loss of function of Ranbp9 leads to severely reduced male fertility due to disruptions in sperm development.
National Institutes of Health

Contact: Wei Yan

Showing releases 3101-3125 out of 3690.

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