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Key: Meeting M      Journal J      Funder F

Showing releases 3101-3125 out of 3479.

<< < 120 | 121 | 122 | 123 | 124 | 125 | 126 | 127 | 128 | 129 > >>

Public Release: 11-Nov-2013
Journal of Allergy & Clinical Immunology
First genetic mutations linked to atopic dermatitis identified in African-American children
Two specific genetic variations in people of African descent are responsible for persistent atopic dermatitis, an itchy, inflammatory form of the skin disorder eczema. A new report by researchers in the Perelman School of Medicine at the University of Pennsylvania found that loss-of-function mutations to Filaggrin-2, a gene that creates a protein responsible for retaining moisture and protecting the skin from environmental irritants, were associated with atopic dermatitis in African American children.
NIH/National Institute of Arthritis Musculoskeletal and Skin Diseases

Contact: Kim Menard
University of Pennsylvania School of Medicine

Public Release: 11-Nov-2013
New England Journal of Medicine
APOL1 gene speeds kidney disease progression and failure in blacks, regardless of diabetes status
A large study co-authored by Penn Medicine researchers published this week in the New England Journal of Medicine found that African Americans with the APOL1 gene variant experience faster progression of chronic kidney disease and have a significantly increased risk of kidney failure, regardless of their diabetes status.
National Institutes of Health

Contact: Steve Graff
University of Pennsylvania School of Medicine

Public Release: 11-Nov-2013
Nature Neuroscience
Signal found to enhance survival of new brain cells
A specialized type of brain cell that tamps down stem cell activity ironically, perhaps, encourages the survival of the stem cells' progeny, Johns Hopkins researchers report. Understanding how these new brain cells "decide" whether to live or die and how to behave is of special interest because changes in their activity are linked to neurodegenerative diseases such as Alzheimer's, mental illness and aging.
NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute of Environmental Health Sciences, NIH/National Institute of Child Health and Human Development, Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, and others

Contact: Shawna Williams
Johns Hopkins Medicine

Public Release: 11-Nov-2013
Journal of Clinical Investigation
New cause found for muscle-weakening disease myasthenia gravis
An antibody to a protein critical to enabling the brain to talk to muscles has been identified as a cause of myasthenia gravis, researchers report.
National Institutes of Health, Muscular Dystrophy Association

Contact: Toni Baker
Medical College of Georgia at Georgia Regents University

Public Release: 11-Nov-2013
CWRU team building an MRI-guided robotic heart catheter
Case Western Reserve University researchers are developing technologies to enable a doctor to see real-time images of a patient's beating heart and steer a robotic catheter through its chambers and ablate trouble spots using the push and pull of magnetic fields while the patient lies inside a magnetic resonance imager. The four-year project is funded with a $1.3 million grant from the National Institutes of Health.
National Institutes of Health

Contact: Kevin Mayhood
Case Western Reserve University

Public Release: 11-Nov-2013
Neuroscience 2013
Nature Neuroscience
What are you scared of?
What do bullies and sex have in common? Based on work by scientists at EMBL Monterotondo, it seems that the same part of the brain reacts to both. In a study published today in Nature Neuroscience, the researchers found that -- at least in mice -- different types of fear are processed by different groups of neurons. The findings could have implications for addressing phobias and panic attacks in humans.
National Institutes of Health, German Research Foundation, Chica and Heinz Schaller Research Foundation

Contact: Sonia Furtado Neves
European Molecular Biology Laboratory

Public Release: 11-Nov-2013
Brainstem abnormalities found in 'SIDS' infants, in both safe and unsafe sleep environments
Investigators at Boston Children's Hospital report that infants dying suddenly and unexpectedly, in both safe and unsafe sleep environments, have underlying brainstem abnormalities and are not all normal prior to death.
National Institutes of Health, NIH/National Institute of Child Health and Development

Contact: Andrea Duggan
Boston Children's Hospital

Public Release: 11-Nov-2013
Circulation: Journal of the American Heart Association
Device may help doctors diagnose lethal heart rhythm in womb
A device that records the natural magnetic activity of the heart helped researchers identify abnormal heart rhythms in unborn babies. It's the first sizable study to document the electrical aspects of long QT syndrome in the womb. The condition is a common cause of sudden death in early life and stillbirth.
National Institutes of Health

Contact: Bridgette McNeill
American Heart Association

Public Release: 10-Nov-2013
Nature Structural & Molecular Biology
Un-junking junk DNA
A study led by researchers at the University of California, San Diego School of Medicine shines a new light on molecular tools our cells use to govern regulated gene expression.
National Institutes of Health

Contact: Debra Kain
University of California - San Diego

Public Release: 10-Nov-2013
Philosophical Transactions of the Royal Society B
Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits
What does it mean to be human? According to scientists the key lies, ultimately, in the billions of lines of genetic code that comprise the human genome. The problem, however, has been deciphering that code. But now, researchers at the Gladstone Institutes have discovered how the activation of specific stretches of DNA control the development of uniquely human characteristics -- and tell an intriguing story about the evolution of our species.
NIH/National Institute of General Medical Sciences, NIH/National Heart, Lung and Blood Institute

Contact: Anne Holden
Gladstone Institutes

Public Release: 10-Nov-2013
Nature Medicine
Hope for transplant patients as study finds key to organ scarring
Patients with damaged organs could be helped by new treatments after scientists have discovered how tissues scar. Researchers say that the finding could pave the way for new drugs and eventually reduce the number of patients on organ transplant waiting lists.
Wellcome Trust, Medical Research Council, National Institutes of Health

Contact: Eleanor Cowie
University of Edinburgh

Public Release: 10-Nov-2013
Nature Medicine
Research by Saint Louis University scientists offers way to disrupt fibrosis
Scientists have identified a pathway that regulates fibrosis, suggesting a possible pharmacologic approach to treat patients with a broad range of fibrotic diseases.
National Institutes of Health

Contact: Nancy Solomon
Saint Louis University

Public Release: 10-Nov-2013
Nature Biotechnology
Single-cell genome sequencing gets better
Researchers led by bioengineers at the University of California, San Diego have generated the most complete genome sequences from single E. coli cells and individual neurons from the human brain. Preliminary data suggest that individual neurons from the same brain have different genetic compositions. The breakthrough, published in Nature Biotechnology, comes from a new single-cell genome sequencing technique that confines genome amplification to fluid-filled wells with a volume of just 12 nanoliters.
National Institutes of Health, US National Science Foundation

Contact: Daniel Kane
University of California - San Diego

Public Release: 9-Nov-2013
Psychological Science
You want fries with that? Don't go there
A new Dartmouth neuroimaging study suggests chronic dieters overeat when the regions of their brain that balance impulsive behavior and self-control become disrupted, decreasing their capacity to resist temptation.
NIH/National Institute on Drug Abuse, NIH/National Heart, Lung, and Blood Institute

Contact: John Cramer
Dartmouth College

Public Release: 9-Nov-2013
ASN Kidney Week 2013
New England Journal of Medicine
Genetic variation increases risk of kidney disease progression in African-Americans
New research provides direct evidence that genetic variations in some African Americans with chronic kidney disease contribute to a more rapid decline in kidney function compared with white Americans. The research, led by investigators from the University of Maryland School of Medicine and Johns Hopkins University, may help explain, in part, why even after accounting for differences in socioeconomic background, end-stage kidney disease is twice as prevalent among blacks as whites.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Contact: Bill Seiler
University of Maryland Medical Center

Public Release: 9-Nov-2013
Neuroscience 2013
Simple dot test may help gauge the progression of dopamine loss in Parkinson's disease
Could figuring out how much dopamine a patient with Parkinson's disease has lost be as simple as completing a dot test? Researchers hope the easy task might lead to ways of improving clinical treatment of Parkinson's patients. "It is very difficult now to assess the extent of dopamine loss…," says lead author Katherine R. Gamble. "Use of this test may provide some help for physicians who treat people with Parkinson's disease..."
National Institutes of Health

Contact: Karen Mallet
Georgetown University Medical Center

Public Release: 8-Nov-2013
Proceedings of the National Academy of Sciences
New therapeutic target identified for ALS and frontotemporal degeneration
A team of scientists led by researchers from the University of California, San Diego School of Medicine and Ludwig Institute for Cancer Research have identified a novel therapeutic approach for the most frequent genetic cause of ALS, a disorder of the regions of the brain and spinal cord that control voluntary muscle movement, and frontal temporal degeneration, the second most frequent dementia.
National Institutes of Health, Target ALS, Amyotrophic Lateral Sclerosis Association

Contact: Debra Kain
University of California - San Diego

Public Release: 8-Nov-2013
Penn study identifies new trigger for breast cancer metastasis
For years, scientists have observed that tumor cells from certain breast cancer patients with aggressive forms of the disease contained low levels of mitochondrial DNA. But, until recently, no one was able to explain how this characteristic influenced disease progression. Now, University of Pennsylvania researchers have revealed how a reduction in mitochondrial DNA content leads human breast cancer cells to take on aggressive, metastatic properties.
National Institutes of Health, Harriet Ellison Woodward Trust

Contact: Katherine Unger Baillie
University of Pennsylvania

Public Release: 8-Nov-2013
Neuroscience 2013
Brain, Behavior and Immunity
In animal study, 'cold turkey' withdrawal from drugs triggers mental decline
Can quitting drugs without treatment trigger a decline in mental health? That appears to be the case in an animal model of morphine addiction. Georgetown University Medical Center researchers say their observations suggest that managing morphine withdrawal could promote a healthier mental state in people. The study will be presented at Neuroscience 2013, the annual meeting of the Society for Neuroscience.
NIH/National Institute on Drug Abuse

Contact: Karen Mallet
Georgetown University Medical Center

Public Release: 8-Nov-2013
Arthritis & Rheumatism
Mother's immunosuppressive medications not likely to put fetus at risk
Women with chronic autoimmune diseases who take immunosuppressive medications during their first trimester of pregnancy are not putting their babies at significantly increased risk of adverse outcomes, according to a Vanderbilt study released online by the journal Arthritis and Rheumatism.
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases, Agency for Healthcare Research and Quality, Food and Drug Administration

Contact: Craig Boerner
Vanderbilt University Medical Center

Public Release: 8-Nov-2013
Journal of Biological Chemistry
TGen-led study reveals TWEAK-Fn14 as key drug target
A cellular pathway interaction known as TWEAK-Fn14, often associated with repair of acute injuries, also is a viable target for drug therapy that could prevent the spread of cancer, especially brain cancer, according to a study led by the Translational Genomics Research Institute.
Ben and Catherine Ivy Foundation, NIH/National Cancer Institute

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Public Release: 8-Nov-2013
Development and Psychopathology
Depression therapy effective for poor, minority moms
Faced with the dual demands of motherhood and poverty, as many as one-fourth of low-income minority mothers struggle with major depression. Now a new study shows that screening for the disorder and providing short-term, relationship-focused therapy through weekly home visits can relieve depression among minority mothers, even in the face of poverty and personal histories of abuse or violence.
NIH/National Institute of Mental Health

Contact: Susan Hagen
University of Rochester

Public Release: 8-Nov-2013
ASN Kidney Week 2013
New England Journal of Medicine
Repurposed drug may be first targeted treatment for serious kidney disease
A team led by Massachusetts General Hospital researchers is reporting that treatment with abatacept appeared to halt the course of focal segmental glomerulosclerosis in five patients, preventing four from losing transplanted kidneys and achieving disease remission in the fifth.
National Institutes of Health, Boston Area Diabetes Endocrinology Research Center, American Society for Nephrology

Contact: Mike Morrison
Massachusetts General Hospital

Public Release: 8-Nov-2013
Nature Communications
Edited RNA + invasive DNA add individuality
A study in Nature Communications finds that an enzyme that edits RNA may loosen the genome's control over invasive snippets of DNA that affect how genes are expressed. In fruit flies, that newly understood mechanism appears to contribute to differences among individuals such as eye color and life span.
NIH/National Institute on Aging, Ellison Medical Foundation

Contact: David Orenstein
Brown University

Public Release: 8-Nov-2013
Journal of Clinical Investigation
Researchers identify a histone demethylase associated with non-small cell lung cancer
In this issue of the Journal of Clinical Investigation, MinGyu Lee and colleagues at MD Anderson Cancer Center evaluated histone methylation modifications in NSCLS cell lines and determined that the histone demethylase KDM2A was upregulated in NSCLC cell lines.
National Institutes of Health, Center for Cancer Epigenetics at the UT MD Anderson Cancer Center

Contact: Corinne Williams
Journal of Clinical Investigation

Showing releases 3101-3125 out of 3479.

<< < 120 | 121 | 122 | 123 | 124 | 125 | 126 | 127 | 128 | 129 > >>


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