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Showing releases 3101-3125 out of 3164.

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Public Release: 13-Dec-2011
PLOS ONE
Molecular markers can predict spread of cancer, guide treatment
Molecular markers found in cancer cells that have spread from a primary tumor to a limited number of distant sites can help physicians predict which patients with metastatic cancer will benefit from targeted radiation therapy. If cells from metastatic tumors have high levels of one type of microRNA then aggressive local treatment will not help. But if the cells have lower levels of that marker, then focused treatment could be effective, even curative.
National Institutes of Health, Ludwig Cancer Center, others

Contact: John.easton@uchospitals.edu
john.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center

Public Release: 13-Dec-2011
Journal of Neuroscience
A novel mechanism regulating stress is identified
A new study from Tufts researchers reports that the action of neurosteroids on a specific type of receptor is responsible for the physiological response to stress. Further, stress-induced anxiety-like behaviors in mice can be prevented by blocking the synthesis of these neurosteroids.
American Federation for Aging Research, NIH/National Institute of Neurological Disorders and Stroke

Contact: Siobhan E. Gallagher
617-636-6586
Tufts University, Health Sciences Campus

Public Release: 12-Dec-2011
GW researcher awarded NIH grant to identify molecular mechanisms to predict neurological and psychiatric diseases
Anthony-Samuel LaMantia, Ph.D., professor in the Department of Pharmacology and Physiology and Director of the GW Institute for Neuroscience in the School of Medicine and Health Sciences has been awarded a grant from the National Institutes of Health to identify molecular mechanisms that define embryonic olfactory epithelium stem cells.
National Institutes of Health

Contact: Anne Banner
abanner@gwumc.edu
202-994-2261
George Washington University Medical Center

Public Release: 12-Dec-2011
2011 ASH Annual Meeting and Exposition
Bone marrow and blood stem cell transplant survival rates equal, when donor is unrelated to patient
Patients who receive a blood stem cell transplant from a donor outside of their family to treat leukemia and other blood diseases are more likely to have graft failure but less likely to experience graft-versus-host disease, a condition caused by the donor cells attacking the recipient's body, if the transplanted blood cells come directly from a donor's bone marrow, rather than from blood stem cells circulating in the donor's bloodstream (PBSCs), according to new research.
NIH/National Heart, Lung, and Blood Institute, NIH/National Cancer Institute, National Marrow Donor Program

Contact: Maureen Mack
mmack@mcw.edu
414-955-4700
Medical College of Wisconsin

Public Release: 12-Dec-2011
Autism Speaks Autism Genetic Resource Exchange joins NIH National Database for Autism Research
Autism Speaks Autism Genetic Resource Exchange (AGRE) joins the National Database for Autism Research (NDAR), helping to create the largest multidisciplinary source of autism research data. NDAR, supported by the NIH, brings together different data resources, allowing researchers to pool larger datasets. This repository contains genetic, phenotypic, clinical, and medical data. AGRE contributes genetic, medical, developmental, morphological, demographic, and behavioral information from multiplex families who have more than one child on the autism spectrum.
National Institutes of Health, Autism Speaks

Contact: Jane E. Rubinstein
jrubinstein@rubenstein.com
212-843-8287
Autism Speaks

Public Release: 12-Dec-2011
Circulation
Researchers identify agent responsible for protection against early stages of atherosclerosis
Researchers from Boston University School of Medicine have identified for the first time the A2b adenosine receptor as a possible new therapeutic target against atherosclerosis resulting from a diet high in fat and cholesterol. The findings, which appear online in Circulation, may have significant public health implications.
NIH/National Heart, Lung and Blood Institute

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center

Public Release: 12-Dec-2011
Brain
Test for Alzheimer's disease predicts cognitive decline in Parkinson's disease
A method of classifying brain atrophy patterns in Alzheimer's disease patients using MRIs can also detect cognitive decline in Parkinson's disease, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania. Researchers also found that higher baseline Alzheimer's patterns of atrophy predicted long-term cognitive decline in cognitively normal Parkinson's patients. The study is published online in Brain.
NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute of Aging, Department of Health of the Commonwealth of Pennsylvania

Contact: Kim Menard
kim.menard@uphs.upenn.edu
215-662-6183
University of Pennsylvania School of Medicine

Public Release: 12-Dec-2011
Journal of Allergy and Clinical Immunology
Improved medication use could reduce severe asthma attacks
Researchers at Henry Ford Hospital have found that one-quarter of severe asthma attacks could be prevented if only patients consistently took their medication as prescribed. Moreover, an asthma attack was only significantly reduced when patients used at least 75 percent of their prescribed dose, according to the study.
NIH/National Institute of Allergy and Infectious Diseases, National Institutes of Health

Contact: David Olejarz
dolejar1@hfhs.org
313-874-4094
Henry Ford Health System

Public Release: 12-Dec-2011
Nature Immunology
Researchers use new finding to clear bloodstream malaria infection in mice
University of Iowa researchers and colleagues have discovered how malaria manipulates the immune system to allow the parasite to persist in the bloodstream. By rescuing this immune system pathway, the research team was able to cure mice of bloodstream malaria infections.
National Institutes of Health

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
University of Iowa Health Care

Public Release: 12-Dec-2011
Addiction Biology
New strain of lab mice mimics human alcohol consumption patterns
A line of laboratory mice developed by a researcher from the School of Science at Indiana University-Purdue University Indianapolis drinks more alcohol than other animal models and consumes it in a fashion similar to humans: choosing alcohol over other options and binge drinking.
NIH/National Institute on Alcohol Abuse and Alcoholism, School of Science at IUPUI

Contact: Cindy Fox Aisen
caisen@iupui.edu
317-274-7722
Indiana University-Purdue University Indianapolis School of Science

Public Release: 12-Dec-2011
Archives of Neurology
Widespread brain atrophy detected in Parkinson's disease with newly developed structural pattern
Atrophy in the hippocampus, the region of the brain known for memory formation and storage, is evident in Parkinson's disease patients with cognitive impairment, including early decline known as mild cognitive impairment, according to a study by researchers in the Perelman School of Medicine at the University of Pennsylvania. The study is published in the December issue of the Archives of Neurology, one of the JAMA/Archives journals.
NIH/National Institute of Neurological Disorders and Strokes, NIH/National Institute of Aging, Department of Health of the Commonwealth of Pennsylvania

Contact: Kim Menard
kim.menard@uphs.upenn.edu
215-662-6183
University of Pennsylvania School of Medicine

Public Release: 12-Dec-2011
AIDS
RI Hospital study analyzes link between HIV infection and overdose risk
A Rhode Island Hospital study is the first to systematically review and analyze the literature on the association between HIV infection and overdose risk. The findings show a 74 percent greater risk of overdose among drug users if they are HIV-infected. The researchers found that reasons for the increased risk are biological and behavioral, but may also include environmental and structural factors. The study is now available online in advance of print in the journal AIDS.
US Centers for Disease Control and Prevention, National Institutes of Health, NIH/National Institute on Drug Abuse, NIH Center for AIDS Research

Contact: Nancy Jean
njean@lifespan.org
Lifespan

Public Release: 12-Dec-2011
PLOS ONE
Tiny protein helps bacteria 'talk' and triggers defensive response in plants
Scientists have discovered a new signal that helps invading bacteria communicate but also helps targeted rice plants coordinate defensive attacks on the disease-causing invaders, a finding that could lead to new methods of combating infection not just in plants, but in humans.
US Department of Agriculture, National Institutes of Health

Contact: Patricia Bailey
pjbailey@ucdavis.edu
530-752-9843
University of California - Davis

Public Release: 12-Dec-2011
PLOS ONE
New communication code discovered in disease-causing bacteria
Single-celled bacteria communicate with each other using coded messages to coordinate attacks on their targets. Until now, the diversity of codes employed by these invading bacteria was thought to be extremely limited. However, a new report published Dec. 12 in PLoS ONE reveals bacterial communication by a novel, previously undescribed signal type.
National Institutes of Health, Next-Generation BioGreen 21 Program, Mid-Career Researcher Program

Contact: Yael Franco
yfranco@plos.org
415-568-3169
Public Library of Science

Public Release: 12-Dec-2011
Proceedings of the National Academy of Sciences
Scientists develop vaccine that attacks breast cancer in mice
Researchers from the University of Georgia and the Mayo Clinic in Arizona have developed a vaccine that dramatically reduces tumors in a mouse model that mimics 90 percent of human breast and pancreatic cancer cases -- including those that are resistant to common treatments. The vaccine, described this week in the early edition of the journal Proceedings of the National Academy of Sciences, reveals a promising new strategy for treating cancers that share the same distinct carbohydrate signature, including ovarian and colorectal cancers.
NIH/National Cancer Institute, Mayo Breast SPORE Grant, Mayo Pancreas SPORE Grant

Contact: Sam Fahmy
sfahmy@uga.edu
706-542-6049
University of Georgia

Public Release: 12-Dec-2011
Fish may provide key to stopping disease spread, Wayne State University researcher says
A small fish may prove useful to understanding a worldwide health problem, if a Wayne State University researcher is correct.
National Institutes of Health

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research

Public Release: 12-Dec-2011
Proceedings of the National Academy of Sciences
Discovery could lead to treatment for eye diseases that cause blindness
A new study has identified a gene that plays a major role in maintaining clarity of the cornea in humans and mice -- and could possibly be used as gene therapy to treat diseases that cause blindness.
National Institutes of Health, Canadian Institutes of Health Research

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University

Public Release: 12-Dec-2011
2011 ASH Annual Meeting and Exposition
Gene mutation signals a high risk of recurrence in some older acute-leukemia patients
Older people with acute myeloid leukemia and normal looking chromosomes in their cancer cells have a higher risk of recurrence if they have mutations in the ASXL1gene, according to a new study. The study is the first to investigate the influence of these gene mutations on prognosis in these patients and in conjunction with other prognostic gene mutations. The findings could lead to more effective targeted therapies and improved cure rates for these patients.
NIH/National Cancer Institute, Coleman Leukemia Research Foundation, John B. and Jane T. McCoy Chair in Cancer Research

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center

Public Release: 12-Dec-2011
Journal of Clinical Investigation
Disease progression halted in rat model of Lou Gehrig’s disease
Amyotrophic lateral sclerosis is an incurable adult neurodegenerative disorder that progresses to paralysis and death. Genetic mutations cause ALS in five percent of patients. In a rat model of ALS linked to mutations in the gene that templates the protein TDP-43, researchers have found it is possible to halt the progressive neuron degeneration that causes paralysis and death.
National Institutes of Health

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation

Public Release: 10-Dec-2011
2011 ASH Annual Meeting and Exposition
New England Journal of Medicine
Gene therapy achieves early success against hereditary bleeding disorder
Symptoms improved significantly in adults with the bleeding disorder hemophilia B following a single treatment with gene therapy developed by researchers at St. Jude Children's Research Hospital in Memphis and demonstrated to be safe in a clinical trial conducted at the University College London in the U.K.
National Institutes of Health, Assisi Foundation of Memphis, ALSAC, Katherine Dormandy Trust, Medical Research Council, Wellcome Trust, NHS Blood and Transplant and the UCLH/UCL NIHR Biomedical Research Centre

Contact: Carrie Strehlau
media@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Public Release: 9-Dec-2011
Biological Psychiatry
Scripps research study underlines potential of anti-stress peptide to block alcohol dependence
New research by scientists at the Scripps Research Institute has underlined the power of an endogenous anti-stress peptide in the brain to prevent and even reverse some of the cellular effects of acute alcohol and alcohol dependence in animal models. The work could lead to the development of novel drugs to treat alcoholism.
Pearson Center for Alcoholism and Addiction Research, NIH/National Institute on Alcohol Abuse and Alcoholism

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute

Public Release: 9-Dec-2011
2011 CTRC-AACR San Antonio Breast Cancer Symposium
Why women quit breast cancer drugs early
Why do so many postmenopausal women who are treated for estrogen-sensitive breast cancer quit using drugs that help prevent the disease from recurring? The first study to ask the women themselves reports 36 percent of women quit early because of the medications' side effects, which are more severe and widespread than previously known. The research also reveals a big gap between what women tell their doctors about side effects and what they actually experience.
NIH/National Cancer Institute

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University

Public Release: 8-Dec-2011
Cell
Suppression of protein critical to cell division stops cancer cells from dividing, kills them
Suppressing a newly identified and characterized protein involved in regulating cell division could be a novel strategy to fight certain cancers because it stops the malignant cells from dividing and causes them to die quickly.
National Institutes of Health, Genentech, Leukemia & Lymphoma Society, V Foundation for Cancer Research

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences

Public Release: 8-Dec-2011
Cell Stem Cell
Penn study unlocks origins of blood stem cells
A research team led by Nancy Speck, Ph.D., professor of Cell and Developmental Biology at the Perelman School of Medicine at the University of Pennsylvania, has discovered a molecular marker for the immediate precursors of hematopoietic stem cells in the developing embryo, which provides much-needed insights for making these cells from engineered precursors.
NIH/National Heart, Lung, and Blood Institute

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 8-Dec-2011
Brigham and Women's Hospital awarded $9.6 million to study whole genome sequencing
Brigham and Women's Hospital has been awarded $9.6 million over four years from the National Human Genome Research Institute to fund the Medical Sequencing Research Project.
NIH/National Human Genome Research Institute

Contact: Tom Langford
tlangford@partners.org
617-534-1605
Brigham and Women's Hospital

Showing releases 3101-3125 out of 3164.

<< < 120 | 121 | 122 | 123 | 124 | 125 | 126 | 127 > >>