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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 3126-3150 out of 3604.

<< < 121 | 122 | 123 | 124 | 125 | 126 | 127 | 128 | 129 | 130 > >>

Public Release: 24-Apr-2014
Cell Reports
New type of protein action found to regulate development
Johns Hopkins researchers report they have figured out how the aptly named protein Botch blocks the signaling protein called Notch, which helps regulate development. In a report on the discovery, to appear online April 24 in the journal Cell Reports, the scientists say they expect the work to lead to a better understanding of how a single protein, Notch, directs actions needed for the healthy development of organs as diverse as brains and kidneys.
NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute on Drug Abuse, Maryland Stem Cell Research Fund, McKnight Endowment Fund for Neuroscience Brain Disorders

Contact: Shawna Williams
Johns Hopkins Medicine

Public Release: 24-Apr-2014
Clinical Infectious Diseases
Use of frozen material for fecal transplant successfully treats C. difficile infection
A pilot study by Massachusetts General Hospital investigators may lead to greater availability and acceptability of an unusual treatment for a serious medical problem -- use of fecal material from healthy donors to treat recurrent diarrhea caused by the Clostridium difficile bacteria. The researchers report that use of prescreened frozen material from donors unrelated to patients was as successful in curing recurrent C. difficile as was the use of fresh fecal material reported in previous studies.
NIH/National Institute for Allergy and Infectious Diseases

Contact: Kristen Chadwick
Massachusetts General Hospital

Public Release: 24-Apr-2014
Fruit fly study identifies brain circuit that drives daily cycles of rest, activity
Researchers describe a circuit in the brain of fruit flies that controls their daily, rhythmic behavior of rest and activity. They also found that the fly version of the human brain protein known as corticotrophin releasing factor is a major coordinating molecule in this circuit.
NIH/National Institute of Neurological Disorders and Stroke, Howard Hughes Medical Institute

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 24-Apr-2014
Cell Reports
Researchers pinpoint protein crucial for development of biological rhythms in mice
Johns Hopkins researchers report that they have identified a protein essential to the formation of the tiny brain region in mice that coordinates sleep-wake cycles and other so-called circadian rhythms. By disabling the gene for that key protein in test animals, the scientists were able to home in on the mechanism by which that brain region, known as the suprachiasmatic nucleus or SCN, becomes the body's master clock while the embryo is developing.
NIH/National Institute of Mental Health, Johns Hopkins Brain Science Institute

Contact: Shawna Williams
Johns Hopkins Medicine

Public Release: 24-Apr-2014
Researchers create comprehensive map of human B cell development
A Columbia and Stanford team describes a new method for mapping cellular development at the single cell level. By combining emerging technologies with a new, advanced computational algorithm, they created the most comprehensive map ever made of human B cell development. The approach will improve the ability to investigate development in cells of all types, help identify rare aberrations that lead to disease, and guide the next generation of research in regenerative medicine.
National Science Foundation, National Institutes of Health, Packard

Contact: Christopher Williams
Columbia University

Public Release: 23-Apr-2014
New study links inflammation in those with PTSD to changes in microRNA
With a new generation of military veterans returning home from Iraq and Afghanistan, post-traumatic stress disorder (PTSD) has become a prominent concern in American medical institutions and the culture at-large. Estimates indicate that as many as 35 percent of personnel deployed to Iraq and Afghanistan suffer from PTSD. New research from the University of South Carolina School of Medicine is shedding light on how PTSD is linked to other diseases in fundamental and surprising ways.
National Institutes of Health

Contact: Jeff Stensland
University of South Carolina

Public Release: 23-Apr-2014
Games for Health Journal
Cyber buddy is better than 'no buddy'
A Michigan State University researcher is looking to give exercise enthusiasts the extra nudge they need during a workout, and her latest research shows that a cyber buddy can help.
National Institutes of Health

Contact: Sarina Gleason
Michigan State University

Public Release: 23-Apr-2014
BMC Pregnancy and Childbirth
Pollutants from coal-burning stoves strongly associated with miscarriages in Mongolia
Burning coal for domestic heating may contribute to early fetal death according to a new study by experts from the Saban Research Institute of Children's Hospital Los Angeles and Ulaanbaatar, Mongolia -- the coldest capital city in the world.
NIH/Fogarty International Center, NIH/National Institute of Environmental Health Sciences

Contact: Ellin Kavanagh
Children's Hospital Los Angeles

Public Release: 23-Apr-2014
Molecular Cell
Study identifies enzymes that help fix cancer-causing DNA defects
Purdue University researchers have identified an important enzyme pathway that helps prevent new cells from receiving too many or too few chromosomes, a condition that has been directly linked to cancer and other diseases.
National Institutes of Health, Purdue University Center for Cancer Research

Contact: Natalie van Hoose
Purdue University

Public Release: 23-Apr-2014
Novel compound halts cocaine addiction and relapse behaviors
A novel compound that targets an important brain receptor has a dramatic effect against a host of cocaine addiction behaviors, including relapse behavior, a University at Buffalo animal study has found.
National Institutes of Health

Contact: Ellen Goldbaum
University at Buffalo

Public Release: 23-Apr-2014
Psychological Science
ADHD drug may help preserve our self-control resources
Methylphenidate, also known as Ritalin, may prevent the depletion of self-control, according to research published in Psychological Science, a journal of the Association for Psychological Science.
National Institutes of Health, John Templeton Foundation

Contact: Anna Mikulak
Association for Psychological Science

Public Release: 23-Apr-2014
UH biomedical engineer works to make blood transfusions safer
A biomedical engineer at the University of Houston is working to develop highly innovative technology to make blood transfusions safer. His work is supported by a $1.8 million grant from the National Institutes of Health. Sergey Shevkoplyas' goal is to develop a simple device to separate healthy, well-preserved red blood cells from all the other material in the blood bag just before transfusion.
National Institutes of Health

Contact: Lisa Merkl
University of Houston

Public Release: 23-Apr-2014
Quality control guidelines for genomics studies
How do doctors pinpoint the genetic changes that really cause disease? A policy paper proposes guidelines for researchers studying the effects of rare genetic variants. The recommendations focus on several key areas, such as study design, gene- and variant-level implication, databases and implications for diagnosis.
NIH/National Human Genome Research Institute

Contact: Quinn Eastman
Emory Health Sciences

Public Release: 23-Apr-2014
New target for prostate cancer resistant to anti-hormone therapies
Researchers have found a new target that could remain sensitive even when prostate cancer becomes resistant to current treatments.
Prostate Cancer Foundation, NIH/National Cancer Institute, Doris Duke Charitable Foundation, American Cancer Society

Contact: Nicole Fawcett
University of Michigan Health System

Public Release: 23-Apr-2014
Stem cells in circulating blood affect cardiovascular health, study finds
New research suggests that attempts to isolate an elusive adult stem cell from blood to understand and potentially improve cardiovascular health -- a task considered possible but very difficult -- might not be necessary.
National Institutes of Health

Contact: Nicanor Moldovan
Ohio State University

Public Release: 23-Apr-2014
Science Translational Medicine
Study shows aspirin can reduce colorectal cancer risks for those with specific gene
The humble aspirin may have just added another beneficial effect beyond its ability to ameliorate headaches and reduce the risk of heart attacks: lowering colon cancer risk among people with high levels of a specific type of gene.
NIH/National Cancer Institute, National Institutes of Health

Contact: Amanda Petrak
Case Western Reserve University

Public Release: 23-Apr-2014
Genome Research
Hundreds of genetic mutations found in healthy blood of a supercentenarian
Genetic mutations are commonly studied because of links to diseases such as cancer; however, little is known about mutations occurring in healthy individuals. In a study published online in Genome Research, researchers detected over 400 mutations in healthy blood cells of a 115-year-old woman, suggesting that lesions at these sites are largely harmless over the course of a lifetime.
National Institutes of Health, Life Technologies, Scripps Health Dickinson Fellowship

Contact: Laura DeMare
Cold Spring Harbor Laboratory

Public Release: 23-Apr-2014
From liability to viability: Genes on the Y chromosome prove essential for male survival
The human Y chromosome has over the course of millions of years of evolution preserved a small set of genes that has ensured not only its own survival but also the survival of men. Moreover, the vast majority appear to have little if any role in sex determination or sperm production. Taken together, these remarkable findings suggest that these Y-linked genes may actually be contributing to differences in disease susceptibility and severity observed between men and women.
National Institutes of Health, Howard Hughes Medical Institute

Contact: Matt Fearer
Whitehead Institute for Biomedical Research

Public Release: 23-Apr-2014
American Academy of Neurology's 66th Annual Meeting
People with mild cognitive impairment may die at higher rate than people without condition
Mayo Clinic research studying the relationship between death and the two types of mild cognitive impairment (MCI) suggests that people who have these conditions die at a higher rate than people without MCI. The research was released today and will be presented at the American Academy of Neurology's 66th Annual Meeting in Philadelphia, April 26-May 3, 2014.
NIH/National Institute on Aging, Rochester Epidemiology Project

Contact: Duska Anastasijevic
Mayo Clinic

Public Release: 22-Apr-2014
Cell Death & Disease
Scientists pinpoint protein that could improve small cell lung cancer therapies
Approximately 15 percent of all lung cancers are small cell lung cancers, which grow rapidly and often develop resistance to chemotherapy. However, researchers at Virginia Commonwealth University Massey Cancer Center have revealed new insights into the mechanisms leading to this resistance that may lead to improved therapies.
National Institutes of Health, NIH/National Cancer Institute

Contact: Alaina Schneider
Virginia Commonwealth University

Public Release: 22-Apr-2014
PLOS Biology
Bioinformatics profiling identifies a new mammalian clock gene
Over 15 mammalian clock proteins have been identified, but researchers surmise there are more. Could big data approaches help find them? To accelerate clock-gene discovery, the investigators used a computer-assisted approach to identify and rank candidate clock components, which they liken to online Netflix-like profiling of movie suggestions for customers. This approach found a new core clock gene, which the team named CHRONO.
NIH/National Institute of Neurological Disorders and Stroke

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 22-Apr-2014
Scientists identify critical new protein complex involved in learning and memory
Scientists from the Florida campus of the Scripps Research Institute have identified a protein complex that plays a critical but previously unknown role in learning and memory formation.
National Institutes of Health, Spanish Ministry of Education and Science, CONSOLIDER

Contact: Eric Sauter
Scripps Research Institute

Public Release: 22-Apr-2014
Scientists alter fat metabolism in animals to prevent most common type of heart disease
Working with mice and rabbits, Johns Hopkins scientists have found a way to block abnormal cholesterol production, transport and breakdown, successfully preventing the development of atherosclerosis, the main cause of heart attacks and strokes and the number-one cause of death among humans. The condition develops when fat builds inside blood vessels over time and renders them stiff, narrowed and hardened, greatly reducing their ability to feed oxygen-rich blood to the heart muscle and the brain.
NIH/National Heart, Lung and Blood Institute

Contact: Ekaterina Pesheva
Johns Hopkins Medicine

Public Release: 22-Apr-2014
Nano Letters
First size-based chromatography technique for the study of living cells
Using nanodot technology, Berkeley Lab researchers demonstrated the first size-based form of chromatography for studying the membranes of living cells. This unique physical approach to probing cellular membrane structures reveals critical information that can't be obtained through conventional microscopy.
NIH/National Institute of Allergy and Infectious Diseases

Contact: Lynn Yarris
DOE/Lawrence Berkeley National Laboratory

Public Release: 22-Apr-2014
PLOS Medicine
Researchers identify link between fetal growth and risk of stillbirth
Researchers from the University of Texas Medical Branch and the Stillbirth Collaborative Research Network have identified a link between stillbirth and either restricted or excessive fetal growth. Findings from the study are online in the April 22 issue of PLOS Medicine.
NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development

Contact: Molly Dannenmaier
University of Texas Medical Branch at Galveston

Showing releases 3126-3150 out of 3604.

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