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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 3126-3150 out of 3525.

<< < 121 | 122 | 123 | 124 | 125 | 126 | 127 | 128 | 129 | 130 > >>

Public Release: 10-Dec-2013
Prevalence of chronic fatigue syndrome in youth is focus of Chicago-based study
The prevalence of chronic fatigue syndrome in children and the significant impairment it causes to their physical functioning, school attendance and performance, and extracurricular activities, are at the root of a new Chicago-based study led by DePaul University psychologist Leonard A. Jason.
NIH/Eunice Kennedy Shriver National Institute of Children Health and Human Development

Contact: Carol Hughes
DePaul University

Public Release: 10-Dec-2013
Cell Metabolism
SIRT5 regulation has dramatic effect on mitochondrial metabolism
The Sirtuin family of protein deacylases has received considerable attention due to its links to longevity, diabetes, cancer, and metabolic regulation. In a new study researchers identified widespread regulation of proteins involved in metabolism by the mitochondrial sirtuin, SIRT5. Using a novel method scientists identified hundreds of proteins that undergo modification by lysine succinylation and its subsequent regulation by SIRT5. These findings have widespread implications for understanding metabolic function in both normal and disease states.
National Institutes of Health

Contact: Kris Rebillot
Buck Institute for Age Research

Public Release: 10-Dec-2013
55th American Society of Hematology Annual Meeting
Less painful drug delivery for pediatric leukemia patients is safe, effective
Children with acute lymphoblastic leukemia, the most common form of pediatric cancer, can safely receive intravenous infusions of a reformulated mainstay of chemotherapy that has been delivered via painful intramuscular injection for more than 40 years, research suggests.
NIH/National Cancer Institute, Enzon Pharmaceuticals

Contact: Irene Sege
Dana-Farber Cancer Institute

Public Release: 10-Dec-2013
American Journal of Preventive Medicine
Strong state alcohol policies protective against binge drinking
According to a new study, a novel composite measure consisting of 29 alcohol policies demonstrates that a strong alcohol policy environment is a protective factor against binge drinking in the U.S. The study was led by researchers at the Boston University Schools of Medicine and Public Health and Boston Medical Center, and is published in the current issue of the American Journal of Preventive Medicine.
National Institutes of Health

Contact: Gina DiGravio
Boston University Medical Center

Public Release: 9-Dec-2013
Cancer Cell
Gene sequencing project finds family of drugs with promise for treating childhood tumor
Drugs that enhance a process called oxidative stress were found to kill rhabdomyosarcoma tumor cells growing in the laboratory and possibly bolstered the effectiveness of chemotherapy against this aggressive tumor of muscle and other soft tissue. The findings are the latest from the St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project and appear in the Dec. 9 edition of the scientific journal Cancer Cell.
Pediatric Cancer Genome Project, Kay Jewelers, NIH/National Cancer Institute, Howard Hughes Medical Institute, Tully Family Foundation, American-Lebanese-Syrian Associated Charities

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

Public Release: 9-Dec-2013
Proceedings of the National Academy of Sciences
OHSU researchers develop new drug approach that could lead to cures for wide range of diseases
A team led by a longtime Oregon Health & Science University researcher has demonstrated in mice what could be a revolutionary new technique to cure a wide range of human diseases -- from cystic fibrosis to cataracts to Alzheimer's disease -- that are caused by "misfolded" protein molecules.
National Institutes of Health, Ben F. Love Endowment, American Heart Association

Contact: Todd Murphy
Oregon Health & Science University

Public Release: 9-Dec-2013
Proceedings of the National Academy of Sciences
New sensor tracks zinc in cells
Shifts in zinc's location could be exploited for early diagnosis of prostate cancer.
NIH/National Institute of General Medical Sciences

Contact: Andrew Carleen
Massachusetts Institute of Technology

Public Release: 9-Dec-2013
Kids movies send mixed messages about eating habits and obesity
Many of the most popular children's movies from recent years feature both "obesogenic" behaviors and weight-related stigmatizing content, a study by University of North Carolina at Chapel Hill researchers finds.
N.C. Children's Promise, National Institutes of Health

Contact: Tom Hughes
University of North Carolina Health Care

Public Release: 9-Dec-2013
Grant supports creation of patient-derived stem cell lines for Alzheimer's research
Researchers at UC Irvine's Institute for Memory Impairments and Neurological Disorders have received a two-year, $600,000 grant from the National Institute on Aging to develop and study patient-derived stem cell lines.
NIH/National Institute on Aging

Contact: Tom Vasich
University of California - Irvine

Public Release: 9-Dec-2013
Biological Psychiatry
How a concussion can lead to depression years later
A head injury can lead immune-system brain cells to go on "high alert" and overreact to later immune challenges by becoming excessively inflammatory -- a condition linked with depressive complications, a new animal study suggests.
NIH/National Institute on Aging, Howard Hughes Medical Institute

Contact: Jonathan Godbout
Ohio State University

Public Release: 9-Dec-2013
Proceedings of the National Academy of Sciences
The smoking gun: Fish brains and nicotine
In researching neural pathways, it helps to establish an analogous relationship between a region of the human brain and the brains of more-easily studied animal species. New work from a team led by Carnegie's Marnie Halpern hones in on one particular region of the zebrafish brain that could help us understand the circuitry underlying nicotine addiction.
European Molecular Biology Organization, University of Virginia, National Institutes of Health

Contact: Marnie Halpern
Carnegie Institution

Public Release: 9-Dec-2013
Innovative drug-dispensing contact lens delivers glaucoma medication continuously for a month
Researchers at Massachusetts Eye and Ear/Harvard Medical School Department of Ophthalmology, Boston Children's Hospital, and the Massachusetts Institute of Technology are one step closer to an eye drop-free reality with the development of a drug-eluting contact lens designed for prolonged delivery of latanoprost, a common drug used for the treatment of glaucoma, the leading cause of irreversible blindness worldwide.
NIH/National Eye Institute, Massachusetts Eye Lions Research Fund, New England Cornea Transplant Fund, NIH/National Institute of General Medical Sciences

Contact: Mary Leach
Massachusetts Eye and Ear Infirmary

Public Release: 9-Dec-2013
JAMA Pediatrics
Communities across US reduce teen smoking, drinking, violence and crime
Fewer high school students across the US started drinking alcohol, smoking cigarettes, committing crimes and engaging in violence before graduation when their towns used the Communities That Care prevention system during the teens' middle school years. A University of Washington study found that the positive influence of this community-led system was sustained through high school.
National Institutes of Health

Contact: Molly McElroy
University of Washington

Public Release: 9-Dec-2013
Proceedings of the National Academy of Sciences
How 'sunshine vitamin' D may be helpful in fighting multiple sclerosis
In mice with a rodent form of multiple sclerosis, vitamin D appears to block damage-causing immune cells from migrating to the central nervous system, offering a potential explanation for why the so-called "sunshine vitamin" may prevent or ease symptoms of the neurodegenerative disease, according to results of a study at Johns Hopkins.
NIH/National Institute of Neurological Disorders and Stroke

Contact: Stephanie Desmon
Johns Hopkins Medicine

Public Release: 9-Dec-2013
Journal of Clinical Investigation
Choloroquine reduces formation of bone resorbing cells in murine osteoporosis
In this issue of the Journal of Clinical Investigation, Brendan Boyce and colleagues at the University of Rochester evaluated the role of TNF receptor–associated receptor 3 in promoting osteoclast formation.
NIH/National Institute for Arthritis, Musculoskeletal and Skin Diseases

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 9-Dec-2013
Journal of Clinical Investigation
Breast cancer prognosis associated with oncometabolite accumulation
In this issue of the Journal of Clinical Investigation Stefan Ambs and colleagues at the National Cancer Institute discovered an association between the oncometabolite 2-hydroxyglutarate levels, DNA methylation patterns, and breast cancer prognosis.
National Institutes of Health, NIH/National Cancer Institute, CCR

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 8-Dec-2013
52nd Annual Meeting of the American College of Neuropsychopharmacology
Aging and gene expression -- possible links to autism and schizophrenia in offspring
Advanced paternal age has been associated with greater risk for psychiatric disorders, such as schizophrenia and autism. With an increase in paternal age, there is a greater frequency of certain types of mutations that contribute to these disorders in offspring. Recent research, however, looks beyond the genetic code to "epigenetic effects," which do not involve changes in the genes themselves, but rather in how they are expressed to determine one's characteristics.
NIH/National Institute of Mental Health, Simon Foundation, Brain and Behavior Research Foundation/NARSAD Young Investigator Award

Contact: Laura Hill
American College of Neuropsychopharmacology

Public Release: 8-Dec-2013
From common colds to deadly lung diseases, 1 protein plays key role
An international team of researchers has zeroed in on a protein that plays a key role in many lung-related ailments, from seasonal coughing and hacking to more serious diseases such as MRSA infections and cystic fibrosis. The finding advances knowledge about this range of illnesses and may point the way to eventually being able to prevent infections such as MRSA. The key protein is called MUC5B.
National Institutes of Health

Contact: Dan Meyers
University of Colorado Denver

Public Release: 8-Dec-2013
55th American Society of Hematology Annual Meeting
Flipping a gene switch reactivates fetal hemoglobin, may reverse sickle cell disease
Hematology researchers have manipulated key biological events in adult blood cells to produce a form of hemoglobin normally absent after the newborn period. Because fetal hemoglobin is unaffected by the genetic defect in sickle cell disease, these cell culture findings may open the door to a new therapy for the debilitating blood disorder.
National Institutes of Health, American Heart Association

Contact: Rachel Salis-Silverman
Children's Hospital of Philadelphia

Public Release: 8-Dec-2013
Nature Neuroscience
Extensive variability in olfactory receptors influences human odor perception
Researchers from the Monell Center and collaborating institutions have found that as much as 30 percent of the large array of human olfactory receptor differs between any two individuals. This substantial variation is in turn reflected by variability in how each person perceives odors.
NIH/National Institute on Deafness and Other Communication Disorders

Contact: Leslie Stein
Monell Chemical Senses Center

Public Release: 8-Dec-2013
Nature Methods
Novel method could help bring cancer biomarkers to clinic
International study demonstrates protein-measurement technique's potential to standardize quantification of the entire human proteome.
National Institutes of Health, NIH/National Cancer Institute

Contact: Deborah Bach
Fred Hutchinson Cancer Research Center

Public Release: 7-Dec-2013
55th American Society of Hematology Annual Meeting
Penn Medicine team reports on study of first 59 leukemia patients who received cell therapy
Three and a half years after beginning a clinical trial which demonstrated the first successful and sustained use of genetically engineered T cells to fight leukemia, a research team from the University of Pennsylvania will announce the latest data on 59 adults and children with advanced blood cancers that have failed to respond to standard therapies. Results in patients who received this investigational, personalized cellular therapy, known as CTL019, will be presented during the American Society of Hematology's Annual Meeting and Exposition.
NIH/National Cancer Institute, Leukemia and Lymphoma Society, Alliance for Cancer Gene Therapy, Novartis

Contact: Holly Auer
University of Pennsylvania School of Medicine

Public Release: 7-Dec-2013
55th American Society of Hematology Annual Meeting
International gene therapy trial for 'bubble boy' disease shows promising early results
Researchers reported promising outcomes data for the first group of boys with X-linked severe combined immunodeficiency syndrome, a fatal genetic immunodeficiency also known as "bubble boy" disease, who were treated in an international clinical study of a new form of gene therapy. The mechanism that delivered the gene therapy is designed to prevent the leukemia that arose a decade ago in a similar trial in Europe, when one-quarter of boys treated developed the blood cancer.
NIH/National Institute of Allergy & Infectious Diseases, NIH/National Heart Lung & Blood Institute

Contact: Irene Sege
Dana-Farber Cancer Institute

Public Release: 7-Dec-2013
Sixth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities
Genetic mutations and molecular alterations may explain racial differences in head and neck cancers
A team of scientists at Johns Hopkins and in Texas has identified a handful of genetic mutations in black Americans, in addition to some chemical alterations affecting gene activity, which may help explain why the death rate among African-Americans from the most common form of head and neck cancer continues to hover some 18 percent higher above the death rate of whites with the same cancer.
NIH/National Cancer Institute, NIH/National Institute of Dental and Craniofacial Research

Contact: David March
Johns Hopkins Medicine

Public Release: 6-Dec-2013
Archives of Psychiatric Nursing
To improve foster care, add a psychiatric nurse to treatment team
Mental health nurses are a valuable addition to the team that treats teens who have psychiatric problems and are in the foster care system.
NIH/National Institute of Mental Health

Contact: Nancy Solomon
Saint Louis University

Showing releases 3126-3150 out of 3525.

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