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Key: Meeting M      Journal J      Funder F

Showing releases 3126-3150 out of 3685.

<< < 121 | 122 | 123 | 124 | 125 | 126 | 127 | 128 | 129 | 130 > >>

Public Release: 28-Jan-2015
PLOS Computational Biology
Dartmouth investigators conduct systematic testing of deimmunized biotherapeutic agents
By establishing protein design algorithms that simultaneously optimize drug candidates for both decreased immunogenic epitope content and high level stability and activity, researchers have established a novel testing platform. Published in PLOS Computational Biology, the paper, titled, 'Mapping the Pareto Optimal Design Space for a Functionally Deimmunized Biotherapeutic Candidate,' guides biotechnologists toward protein designs that function appropriately using sophisticated design algorithms.
National Institutes of Health

Contact: Kirk Cassels
The Geisel School of Medicine at Dartmouth

Public Release: 28-Jan-2015
UNC researcher co-leads effort to map genomic changes in head and neck cancer
A study co-led by a UNC Lineberger Comprehensive Cancer Center researcher has identified genomic changes in head and neck cancers linked to the sexually transmitted disease HPV -- the latest finding of a collaborative scientific effort designed to map out the genomic changes driving cancer.
NIH/National Cancer Institute, NIH/National Human Genome Research Institute

Contact: Laura Oleniacz
University of North Carolina Health Care

Public Release: 28-Jan-2015
Nature Communications
Damaged DNA may stall patrolling molecule to initiate repair
Sites where DNA is damaged may cause a molecule that slides along the DNA strand to scan for damage to slow on its patrol, delaying it long enough to recognize and initiate repair. The finding suggests that the delay itself may be the key that allows the protein molecule to find its target, according to researchers at the University of Illinois at Chicago.
UIC's Chancellor's Discovery Fund, Chicago Biomedical Consortium's Catalyst Award, Searle Funds at The Chicago Community Trust, National Institutes of Health. National Science Foundation, UIC startup fund

Contact: Jeanne Galatzer-Levy
University of Illinois at Chicago

Public Release: 28-Jan-2015
Journal of the Royal Society Interface
'Friending' your way thin
This is the first study to explore the power of online social networks in the battle of the bulge. Dieters who engaged the most lost more than 8 percent of body weight in six months. Scientists used data from's online weight-loss community. 'I was very surprised by how ... social connectedness translated into greater weight loss,' the researcher says.
National Institutes of Health

Contact: Erin White
Northwestern University

Public Release: 28-Jan-2015
Cerebral Cortex
Why upper motor neurons degenerate in ALS
Scientists have revealed a mechanism underlying the cellular degeneration of the upper motor neurons that die in ALS, and developed a model system that will allow further research on the degeneration.
National Institutes of Health, Les Turner Foundation

Contact: Marla Paul
Northwestern University

Public Release: 28-Jan-2015
Animal Behaviour
Chimps with higher-ranking moms do better in fights
For chimpanzees, just like humans, teasing, taunting and bullying are familiar parts of playground politics. An analysis of twelve years of observations of playground fights between young chimpanzees in East Africa finds that chimps with higher-ranked moms are more likely to win.
National Institutes of Health, National Science Foundation, Leo S. Guthman Foundation

Contact: Robin Ann Smith
Duke University

Public Release: 28-Jan-2015
What's happening with your donated specimen?
When donating blood, plasma, human tissue or any other bodily sample for medical research, most people might not think about how it's being used. But if you were told, would you care? A new Michigan State University study indicates that most people are willing to donate just knowing that their contribution is going toward research. But, when specific scenarios are brought into the equation, that willingness changes.
National Institutes of Health

Contact: Sarina Gleason
Michigan State University

Public Release: 28-Jan-2015
Large study catalogs genetic culprits in head and neck cancers
Scientists publish the first comprehensive catalog of genetic mutations and other abnormal changes found in 279 cancers of the head and neck, identifying several broken molecular pathways that might be targeted by existing and future cancer drugs.
National Institutes of Health

Contact: Teresa Herbert
Dana-Farber Cancer Institute

Public Release: 28-Jan-2015
Customized soap bubbles set to transform drug and vaccine delivery
At a University of Maryland start-up called SD Nanosciences, scientists are covering soap bubbles with biomolecules that act as a disguise, tricking the body's cells into mistaking the capsule for a bacterium, a cancer cell or almost any other disease-causing cell. Because the technology is flexible, cost-effective and highly efficient, it is drawing a lot of attention from both public and private funders for drug delivery and vaccine production.
MedImmune, National Institutes of Health, National Science Foundation, DuPont, Maryland Industrial Partnerships

Contact: Abby Robinson
University of Maryland

Public Release: 28-Jan-2015
Cancer Research
Moffitt researchers discover protein pathway involved in lung cancer metastasis
Smoking is the leading cause of lung cancer, and it is estimated that more than 159,000 people in the United States died from the disease last year. Most of these deaths were because the cancer had spread to other organ sites. Following their recent discovery of a protein pathway, Moffitt Cancer Center researchers are one step closer to understanding how lung cancer cells metastasize.
NIH/National Cancer Institute

Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 28-Jan-2015
LSU Health New Orleans research finds novel compound switches off epilepsy development
Researchers at the LSU Health New Orleans Neuroscience Center of Excellence have found that a novel compound they discovered helps curtail the onset and progression of temporal lobe epilepsy. The finding may contribute to the development of anti-epileptic therapies.
National Institutes of Health

Contact: Leslie Capo
Louisiana State University Health Sciences Center

Public Release: 28-Jan-2015
Journal of Gerontology: Psychological Sciences and Social Sciences
Communication is key when dealing with aging parents
Headstrong elderly parents and their adult children may be able to find common ground with proper intervention, according to researchers in human development.
NIH/National Institute on Aging, MacArthur Foundation

Contact: A'ndrea Elyse Messer
Penn State

Public Release: 28-Jan-2015
New England Journal of Medicine
First trial results show GSK/NIH Ebola candidate vaccine has acceptable safety profile
The first results from a trial of a candidate Ebola vaccine at Oxford University suggest the vaccine has an acceptable safety profile at the doses tested, and is able to generate an immune response. Larger trials in West Africa are needed to tell whether immune responses are large enough to protect against Ebola infection and disease.
The Wellcome Trust, Medical Research Council, Department for International Development, National Institutes of Health

Contact: Stephen Rouse
University of Oxford

Public Release: 28-Jan-2015
Earlier menopause linked to everyday chemical exposures
Women whose bodies have high levels of chemicals found in plastics, personal-care products, common household items and the environment experience menopause two to four years earlier than women with lower levels of these chemicals, according to a new study at Washington University School of Medicine in St. Louis. The findings are reported online Jan. 28 in the journal PLOS ONE.
National Institutes of Health

Contact: Diane Duke Williams
Washington University School of Medicine

Public Release: 28-Jan-2015
New cells may help treat diabetes
Starting from human skin cells, researchers at the University of Iowa have created human insulin-producing cells that respond to glucose and correct blood-sugar levels in diabetic mice. The findings may represent a first step toward developing patient-specific cell replacement therapy for type 1 diabetes.
NIH/National Heart Lung and Blood Institute, NIH/National Institute of Diabetes and Digestive and Kidney Diseases, US Department of Veterans Affairs

Contact: Jennifer Brown
University of Iowa Health Care

Public Release: 28-Jan-2015
Epigenetic drug boosts chemotherapy's efficacy in some lung cancers
An existing drug may help some patients with non-small-cell lung cancer whose tumors have become resistant to chemotherapy, finds a study from Boston Children's Hospital and the Dana-Farber Cancer Institute. The findings, in human cancer cells and in mice, suggest a window of vulnerability in NSCLC, the leading cause of cancer-related deaths worldwide. The work was published online today by the journal Nature.
Veterans of Foreign Wars, American Cancer Society, Boston University, National Institutes of Health

Contact: Irene Sege
Boston Children's Hospital

Public Release: 28-Jan-2015
New England Journal of Medicine
New hypertension guidelines could save lives and money
Full implementation of new hypertension guidelines could prevent 56,000 cardiovascular disease events -- mostly heart attacks and strokes -- and 13,000 deaths each year, without increasing overall health care costs, an analysis conducted by researchers at Columbia University Medical Center found. The paper was published today in the online edition of the New England Journal of Medicine.
NIH/National Heart, Lung, and Blood Institute, American Heart Association Founder's Affiliate Clinical Research Program Award, NIH/National Institute for Neurological Disorders and Stroke, Columbia University Irving

Contact: Karin Eskenazi
Columbia University Medical Center

Public Release: 27-Jan-2015
Cell mechanism discovered that may cause pancreatic cancer
Researchers at Huntsman Cancer Institute at the University of Utah have found that defects in how cells are squeezed out of overcrowded tissue to die, a process called extrusion, may be a mechanism by which pancreatic cancer begins. From these findings, they may have identified an effective way to reverse the defective extrusion's effects without destroying normal tissues nearby. The results were published in the latest edition of the journal eLife.
National Institutes of Health

Contact: Linda Aagard
University of Utah Health Sciences

Public Release: 27-Jan-2015
Proceedings of the National Academy of Sciences
Researchers identify natural plant compounds that work against insects
'Insect-specific growth regulators' are compounds that regulate the growth of insects. One hormone in insects, called juvenile hormone, is a particularly attractive target for insect growth regulators because this hormone, which regulates development, exists only in insects. An international team of scientists, including an entomologist at the University of California, Riverside, has discovered potent compounds in plants that counteract the action of juvenile hormone -- a finding that could lead to the development of novel insecticides.
National Institutes of Health

Contact: Iqbal Pittalwala
University of California - Riverside

Public Release: 27-Jan-2015
Journal of Biological Chemistry
Drug combo suppresses growth of late-stage prostate cancer tumors
Low doses of metformin, a widely used diabetes medication, and a gene inhibitor known as BI2536 can successfully halt the growth of late-stage prostate cancer tumors, a Purdue University study finds.
National Institutes of Health, National Science Foundation, American Cancer Society, China Scholarship Council

Contact: Natalie van Hoose
Purdue University

Public Release: 27-Jan-2015
PLOS Genetics
Infant failure to thrive linked to lysosome dysfunction
Neonatal intestinal disorders that prevent infants from getting the nutrients they need may be caused by defects in the lysosomal system -- or cell recycling center -- that occur before weaning. Scientists provide a new target for research and future therapies to help infants unable to absorb milk nutrients and gain weight.
National Institutes of Health

Contact: Marla Paul
Northwestern University

Public Release: 27-Jan-2015
EMBO Journal
Prostate cancer: Androgen receptor activates different genes when bound to antiandrogens
The androgen receptor in prostate cancer cells can activate different sets of genes depending on whether it binds with an androgen hormone or an antiandrogen drug, according to a new study led by researchers at The Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
NIH/National Cancer Institute, US Department of Defense, V Foundation, Ohio State University, Howard Hughes Medical Institute

Contact: Darrell E. Ward
Ohio State University Wexner Medical Center

Public Release: 27-Jan-2015
Liver Transplantation
Low sodium levels increases liver transplant survival benefit in the sickest patients
Researchers report that low levels of sodium in the blood, known as hyponatremia, increase the risk of dying for patients on the liver transplant waiting list. The study published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, showed an increase in survival benefit for patients with hyponatremia and a Model for End Stage Liver Disease (MELD) score of 12 or more.
National Institutes of Health, American College of Gastroenterology

Contact: Dawn Peters

Public Release: 27-Jan-2015
Journal of Pediatrics
Study shows salivary biomarkers predict oral feeding readiness in preterm newborns
Results from a study published online in The Journal of Pediatrics hold the potential to substantially improve clinical decision-making to determine when a premature newborn is ready for oral feeding. The study describes developmental salivary biomarkers associated with feeding success in newborns, markers that could lead to development of objective assessment tools for caregivers.
NIH/National Institute of Child Health and Human Development, Gerber Foundation, Richard B. Saltonstall Charitable Fund, National Institutes of Health

Contact: Julie Jette
Tufts Medical Center

Public Release: 27-Jan-2015
Journal of Medicinal Chemistry
Scientists find drug candidates can block cell-death pathway associated with Parkinson's
In a pair of related studies, scientists from the Florida campus of The Scripps Research Institute have shown their drug candidates can target biological pathways involved in the destruction of brain cells in Parkinson's disease. The studies suggest it is possible to design highly effective and highly selective (targeted) drug candidates that can protect the function of mitochondria, ultimately preventing brain cell death.
Department of Defense, National Institutes of Health

Contact: Eric Sauter
Scripps Research Institute

Showing releases 3126-3150 out of 3685.

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