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Department of Health and Human Services

News from the National Institutes of Health

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Key: Meeting M      Journal J      Funder F

Showing releases 3126-3150 out of 3474.

<< < 121 | 122 | 123 | 124 | 125 | 126 | 127 | 128 | 129 | 130 > >>

Public Release: 6-Oct-2013
Nature Genetics
International coalition of researchers finds 6 new Sjögren's syndrome genes
Six new Sjögren's syndrome-related genes have been discovered by an international group of researchers in a genome-wide association study. Previously, only one Sjögren's gene was known.
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH/National Institute of Allergy and Infectious Diseases, NIH/National Institute of Dental and Craniofacial Research, Sjögren's Syndrome Foundation

Contact: Greg Elwell
greg-elwell@omrf.org
405-271-8955
Oklahoma Medical Research Foundation

Public Release: 6-Oct-2013
Nature
CSHL neuroscientists identify class of cortical inhibitory neurons that specialize in disinhibition
New research now reveals that one class of inhibitory neurons -- called VIP interneurons -- specializes in inhibiting other inhibitory neurons in multiple regions of cortex, and does so under specific behavioral conditions. The new research finds that VIP interneurons, when activated, release principal cells from inhibition, thus boosting their responses. This provides an additional layer of control over cortical processing, much like a dimmer switch can fine-tune light levels.
NIH/National Institute of Neurological Disorders and Stroke, Klingenstein Foundation, John Merck Foundation, Sloan Foundation, Swartz Foundation, Curie Fellowship

Contact: Peter Tarr
tarr@cshl.edu
917-435-5068
Cold Spring Harbor Laboratory

Public Release: 6-Oct-2013
Nature Genetics
Massive DNA study points to new heart drug targets and a key role for triglycerides
A global hunt for genes that influence heart disease risk has uncovered 157 changes in human DNA that alter the levels of cholesterol and other blood fats -- a discovery that could lead to new medications. Each of the changes points to genes that can modify levels of cholesterol and other blood fats and are potential drug targets. Many of the changes point to genes not previously linked to blood fats, also called lipids.
National Institutes of Health, National Science Foundation

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 4-Oct-2013
Genome Research
Nano-dissection identifies genes involved in kidney disease
A new method developed by researchers at Princeton University and the University of Michigan called "in silico nano-dissection" uses computers rather than scalpels to separate and identify genes from specific cell types, enabling the systematic study of genes involved in diseases.
National Institutes of Health

Contact: Catherine Zandonella
czandone@princeton.edu
Princeton University

Public Release: 4-Oct-2013
Journal of Clinical Investigation
IU researchers, collaborators discover new therapeutic agents that may benefit leukemia patients
An Indiana University cancer researcher and his colleagues have discovered new therapeutic targets and drugs that may someday benefit people with certain types of leukemia or blood cancer.
National Institutes of Health

Contact: Michael Schug
maschug@iupui.edu
317-278-0953
Indiana University

Public Release: 4-Oct-2013
Blood
Stem cells engineered to become targeted drug factories
A group of Brigham and Women's Hospital, and Harvard Stem Cell Institute researchers and collaborators at MIT and MGH have found a way to use stem cells as drug delivery vehicles. The researchers inserted modified strands of messenger RNA into connective tissue stem cells -- called mesenchymal stem cells -- which stimulated the cells to produce adhesive surface proteins and secrete interleukin-10, an anti-inflammatory molecule.
National Institutes of Health

Contact: B. D. Colen
bd_colen@harvard.edu
617-413-1224
Harvard University

Public Release: 4-Oct-2013
ACS Chemical Biology
Rutgers scientists discover molecules that show promise for new anti-flu medicines
A new way to attack flu viruses is taking shape in laboratories at Rutgers University, where scientists have identified chemical agents that block the virus's ability to replicate itself in cell culture. These novel compounds show promise for a new class of antiviral medicines to fight much-feared pandemic influenza such as the looming "bird flu" threats caused by the H5N1 influenza A virus and the new H7N9 virus.
National Institutes of Health

Contact: Carl Blesch
cblesch@ucm.rutgers.edu
732-932-7084 x616
Rutgers University

Public Release: 4-Oct-2013
Cancer
High Medicare spending on prostate cancer screenings, but little benefit for older men
Prostate cancer screening has little benefit for men aged 75 and older, yet over three years, the Medicare fee-for-service program spent $447 million annually on PSA-based screenings -- one-third of which was for men in the over 75 age group, according to study by researchers at the Yale Cancer Outcomes, Public Policy, and Effectiveness Research Center.
National Institutes of Health

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University

Public Release: 4-Oct-2013
Cancer Epidemiology, Biomarkers & Prevention
Cancer survivors in rural areas forgo health care because of cost
Older cancer survivors living in rural areas were more likely to forgo medical and dental care because of financial concerns compared with older cancer survivors living in urban areas, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
NIH/National Cancer Institute

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 3-Oct-2013
Science
How an aggressive fungal pathogen causes mold in fruits and vegetables
A research team led by a University of California, Riverside molecular plant pathologist has discovered the mechanism by which an aggressive fungal pathogen infects almost all fruits and vegetables. The team discovered a novel virulence mechanism of Botrytis cinerea, a pathogen that can infect more than 200 plant species, causing serious gray mold disease on almost all fruits and vegetables that have been around, even at times in the refrigerator, for more than a week.
National Institutes of Health, National Science Foundation

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside

Public Release: 3-Oct-2013
Cell Stem Cell
Researchers unveil method for creating 're-specified' stem cells for disease modeling
A team led by researchers in the Boston Children's Hospital's Stem Cell Transplantation Program reports a new approach for turning induced pluripotent stem cells into hematopoietic stem and progenitor cells for in vivo disease modeling.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases, NIH/National Heart, Lung and Blood Institute

Contact: Meghan Weber
meghan.weber@childrens.harvard.edu
617-919-3110
Boston Children's Hospital

Public Release: 3-Oct-2013
Menopause
New study suggests changing bacterial mix may lead to painful sex after menopause
The mix of bacteria in the vagina changes as women go through menopause. And a certain mix is typical after menopause in women who have vulvovaginal atrophy, a common cause of vaginal dryness and sexual pain, finds a team at Johns Hopkins and the University of Maryland. They suspect these bacteria may play a role in causing VVA.
National Institutes of Health

Contact: Eileen Petridis
epetridis@fallscommunications.com
216-696-0229
The North American Menopause Society (NAMS)

Public Release: 3-Oct-2013
Kessler Foundation's Krch awarded $600,000 NIDRR grant for virtual reality study in TBI
Denise Krch, PhD, research scientist at Kessler Foundation was awarded a 3-year, $600,000 NIDRR Field-Initiated Grant titled "The development of a virtual reality program to improve executive functioning in individuals with traumatic brain injury (TBI)." Scientists will develop a virtual reality-based intervention that targets problem solving, mental flexibility, and divided attention, and to pilot test the completed prototype in a small sample of individuals with TBI who have moderate to severe impairment in executive function.
NIH/National Institute on Disability & Rehabilitation Research

Contact: Carolann Murphy
CMurphy@KesslerFoundation.org
973-324-8382
Kessler Foundation

Public Release: 3-Oct-2013
PLOS Neglected Tropical Diseases
Innovative approach could ultimately end deadly disease of sleeping sickness
A tag team of two bacteria, one of them genetically modified, has a good chance to reduce or even eliminate the deadly disease African trypanosomiasis, or sleeping sickness, researchers at Oregon State University conclude in a recent mathematical modeling study.
National Institutes of Health

Contact: Jan Medlock
jan.medlock@oregonstate.edu
541-737-6874
Oregon State University

Public Release: 3-Oct-2013
Public Library of Science
Stem cells help repair traumatic brain injury by building a 'biobridge'
University of South Florida researchers suggest a new view of how stem cells may help repair the brain following trauma.
SanBio Inc, James and Esther King Biomedical Research Foundation, National Institutes of Health, Celgene Cellular Therapeutics

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3303
University of South Florida (USF Health)

Public Release: 3-Oct-2013
DNA nanotechnology opens new path to super-high-resolution molecular imaging
A team at the Wyss Institute for Biologically Inspired Engineering at Harvard University has been awarded a special $3.5 million grant from the National Institutes of Health to develop an inexpensive and easy-to-use new microscopy method that uses blinking DNA probes to spot many tiny components of cells simultaneously. The method could potentially lead to new ways of diagnosing disease and new insights into how the cell's components carry out their work.
National Institutes of Health

Contact: Dan Ferber
dan.ferber@wyss.harvard.edu
617-432-1547
Wyss Institute for Biologically Inspired Engineering at Harvard

Public Release: 3-Oct-2013
CHOP genetics expert co-leads NIH grant on psychiatric illness in patients with deletion syndrome
Genetics experts from The Children's Hospital of Philadelphia are among the top leaders of a major international collaboration researching why patients with chromosome 22q11.2 deletion syndrome have an elevated risk of schizophrenia and other psychiatric illnesses. Discovering genes implicated in the deletion syndrome, a multisystem disorder, may offer important clues to the biological causes of mental illness in the general population.
NIH/National Institute of Mental Health

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia

Public Release: 3-Oct-2013
Penn co-leads $12 M NIH grant to study genetics of mental illnesses in deletion syndrome patients
A major international consortium co-led by Penn Medicine has received a $12 million National Institute of Mental Health grant for a large-scale genetics study investigating why patients with chromosome 22q11.2 deletion syndrome have an increased risk of schizophrenia and other psychiatric disorders.
NIH/National Institute of Mental Health

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine

Public Release: 3-Oct-2013
PLOS ONE
LSUHSC researcher discovers target for new Rx class for inflammatory disorders
Research led by Charles Nichols, Ph.D., Associate Professor of Pharmacology at LSU Health Sciences Center New Orleans, describes a powerful new anti-inflammatory mechanism that could lead to the development of new oral medications for atherosclerosis and inflammatory bowel disorders. The findings are published in PLOS ONE, available online at http://dx.plos.org/10.1371/journal.pone.0075426.
NIH/National Heart, Lung, Blood Institute

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center

Public Release: 3-Oct-2013
Cell
Blocking nerve cells could prevent symptoms of eczema
UC Berkeley research is leading to a new picture of how the nervous system interacts with the immune system to cause the itch and inflammation of eczema, a chronic skin disease. The new findings by neuroscientists Diana Bautista and Sarah Wilson could lead to new therapies for the condition, which afflicts 10 percent of the population at some point in their lives. In children, dry and itchy skin can progress to rashes, nasal allergies and asthma.
National Institutes of Health

Contact: Robert Sanders
rlsanders@berkeley.edu
510-643-6998
University of California - Berkeley

Public Release: 3-Oct-2013
Journal of Biological Chemistry
Scripps Florida scientists identify potential new drug for inherited cancer
Scientists from the Florida campus of The Scripps Research Institute have identified a new drug candidate for an inherited form of cancer with no known cure.
National Institutes of Health, American Cancer Society, Afraxis, Inc.

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute

Public Release: 3-Oct-2013
Cancer Cell
Triple-negative breast cancer target for drug development identified
Often deadly "triple-negative" breast cancers might be effectively treated in many cases with a drug that targets a previously unknown vulnerability in the tumors, according to a UC San Francisco researcher who described her discovery in a study published online October 3, 2013 in the journal Cancer Cell.
National Institutes of Health, Bay Area Breast Cancer Specialized Program Of Research Excellence, Durra Family Fund, Mount Zion Health Fund, Prospect Creek Foundation

Contact: Jeffrey Norris
jeffrey.norris@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 3-Oct-2013
Science Express
Possible culprits in congenital heart defects identified
Mitochondria are the power plants of cells, manufacturing fuel so a cell can perform its many tasks. Mitochondria also are well known for their role in cell suicide. Now, researchers at Washington University School of Medicine in St. Louis and the University of Padua-Dulbecco Telethon Institute in Italy have shown that mitochondria also orchestrate events that determine a cell's future. The study identifies new potential genetic culprits in the origins of some congenital heart defects.
National Institutes of Health, Italian Telethon, ISHR-ES/SERVIER, Oncosuisse, AIRC, ERC

Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine

Public Release: 3-Oct-2013
Science
Silencing sudden death
Hypertrophic cardiomyopathy -- a disease in which cardiac muscle thickens, weakening the heart -- can be prevented from developing for several months in mice by reducing production of a mutant protein.
NIH/National Heart, Lung, and Blood Institute

Contact: David J Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School

Public Release: 3-Oct-2013
Molecular Cell
How a 'mistake' in a single-cell organism is actually a rewrite essential to life
A tiny but unexpected change to a segment of RNA in a single-cell organism looks a lot like a mistake, but is instead a change to the genetic information that is essential to the organism's survival.
National Institutes of Health

Contact: Juan Alfonzo
Alfonzo.1@osu.edu
614-292-0004
Ohio State University

Showing releases 3126-3150 out of 3474.

<< < 121 | 122 | 123 | 124 | 125 | 126 | 127 | 128 | 129 | 130 > >>

     
   

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