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Department of Health and Human Services

News from the National Institutes of Health

Funded News


Key: Meeting M      Journal J      Funder F

Showing releases 3176-3200 out of 3508.

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Public Release: 25-Nov-2013
Nature Biotechnology
First large-scale PheWAS study using EMRs provides systematic method to discover new disease association
Vanderbilt University Medical Center researchers and co-authors from four other US institutions from the Electronic Medical Records and Genomics Network are repurposing genetic data and electronic medical records to perform the first large-scale phenome-wide association study, released today in Nature Biotechnology.
National Institutes of Health

Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center

Public Release: 25-Nov-2013
Proceedings of the National Academy of Sciences
UCI, Northwestern researchers create compounds that boost antibiotics' effectiveness
Inhibitor compounds developed by UC Irvine structural biologists and Northwestern University chemists have been shown to bolster the ability of antibiotics to treat deadly bacterial diseases such as MRSA and anthrax.
National Institutes of Health

Contact: Andrea Burgess
andrea.burgess@uci.edu
949-824-6282
University of California - Irvine

Public Release: 25-Nov-2013
PLOS ONE
2-way traffic enables proteins to get where needed, avoid disease
It turns out that your messenger RNA may catch more than one ride to get where it's going.
National Institutes of Health

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University

Public Release: 25-Nov-2013
Oncogene
UNC scientists find potential cause for deadly breast cancer relapse
Adriana S. Beltran, Ph.D., a research assistant professor in the UNC School of Medicine, found that the protein Engrailed 1 is overexpressed in basal-like carcinomas, and she designed a chain of amino acids to shut down the protein and kill basal-like tumors in the lab.
National Institutes of Health, US Department of Defense

Contact: Mark Derewicz
mark.derewicz@unch.unc.edu
919-923-0959
University of North Carolina Health Care

Public Release: 25-Nov-2013
American Journal of Medicine
Obesity associated with higher risk of hearing loss in women
New research shows that a higher body mass index and larger waist circumference are each associated with higher risk of hearing loss, while a higher level of physical activity is associated with lower risk of hearing loss in women.
National Institutes of Health, Vanderbilt University School of Medicine

Contact: Lori J Schroth
ljschroth@partners.org
617-525-6374
Brigham and Women's Hospital

Public Release: 25-Nov-2013
American Journal of Cardiology
'Rare' gene is common in african descendants and may contribute to risk of heart disease
Researchers at Weill Cornell Medical College have found that a genetic variation that is linked to increased levels of triglycerides -- fats in the blood associated with disorders such as heart disease, type 2 diabetes, obesity and stroke -- is far more common than previously believed and disproportionally affects people of African ancestry. Investigators say their discovery, reported in the American Journal of Cardiology, reinforces the need to screen this population for high levels of triglycerides to stave off disease.
Weill Cornell Medical College-Qatar, Qatar Foundation, Doha, Qatar, National Institutes of Health

Contact: Jennifer Gundersen
jeg2034@med.cornell.edu
646-317-7402
Weill Cornell Medical College

Public Release: 25-Nov-2013
Journal of School Violence
Study finds 1 in 10 high school students hurt by dating partners
One in 10 high school youth in the US reports having been hit or physically hurt by a dating partner in the past year, according to a new study led by a Boston University School of Public Health researcher.
NIH/National Institute on Alcohol Abuse and Alcoholism

Contact: Emily Rothman
erothman@bu.edu
617-763-5557
Boston University Medical Center

Public Release: 25-Nov-2013
Biomacromolecules
Researchers use nanoscale 'patches' to sensitize targeted cell receptors
Researchers have developed nanoscale "patches" that can be used to sensitize targeted cell receptors, making them more responsive to signals that control cell activity. The finding holds promise for promoting healing and facilitating tissue engineering research.
National Science Foundation, NIH/National Institute of Biomedical Imaging and Bioengineering

Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University

Public Release: 25-Nov-2013
JAMA Pediatrics
UTMB researchers find ear infections down, thanks to vaccine
Researchers from the University of Texas Medical Branch at Galveston have discovered that, during recent years, several interventions have been introduced aiming to decrease the otitis media burden -- and they've been successful. The researchers found there was a downward trend in visits from 2004 to 2011, with a significant drop in children younger than 2 years that coincided with the advent of the 13-valent vaccine, or PCV-13, in 2010.
National Institutes of Health

Contact: Kristen Hensley
k.hensley@utmb.edu
409-771-7863
University of Texas Medical Branch at Galveston

Public Release: 25-Nov-2013
Journal of Biological Chemistry
Study shows marijuana's potential for treating autoimmune disorders
A new study from researchers at the University of South Carolina provides evidence that THC (tetrahydrocannabinol), a principal ingredient in marijuana, may be beneficial in treating those with autoimmune disorders. The study is the first to explore how tiny, yet powerful molecules called microRNAs are influenced by THC. The ability to alter microRNA expression could hold the key to successful treatments for a whole host of autoimmune diseases, including arthritis and multiple sclerosis.
National Institutes of Health, VA Merit Award

Contact: Jeff Stensland
stenslan@mailbox.sc.edu
803-777-3686
University of South Carolina

Public Release: 25-Nov-2013
Developmental Cell
Dysfunctional mitochondria may underlie resistance to radiation therapy
The resistance of some cancers to the cell-killing effects of radiation therapy may be due to abnormalities in the mitochondria -- the cellular structures responsible for generating energy, according to an international team of researchers. Their findings are published in the Nov. 25 issue of Developmental Cell.
National Institutes of Health, Leukemia & Lymphoma Society, Natural Sciences and Engineering Research Council of Canada, Spanish Ministry

Contact: Sharon Parmet
sparmet@uic.edu
312-413-2695
University of Illinois at Chicago

Public Release: 25-Nov-2013
Proceedings of the National Academy of Sciences
Using microRNA fit to a T (cell)
Researchers at the University of California, San Diego School of Medicine have successfully targeted T lymphocytes -- which play a central role in the body's immune response -- with another type of white blood cell engineered to synthesize and deliver bits of non-coding RNA or microRNA.
National Institutes of Health

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 25-Nov-2013
JAMA Neurology
Brain imaging differences in infants at genetic risk for Alzheimer's
Researchers at Brown University and Banner Alzheimer's Institute have found that infants who carry a gene associated with an increased risk for Alzheimer's disease tend to have differences in brain development compared to infants who do not carry the gene. The findings do not mean that these infants will get Alzheimer's, but they may be a step toward understanding how this gene confers risk much later in life.
NIH/National Institute of Mental Health, NIH/National Institute on Aging

Contact: Kevin Stacey
kevin_stacey@brown.edu
401-863-3766
Brown University

Public Release: 25-Nov-2013
Journal of Clinical Investigation
Breaking the brain clock predisposes nerve cells to neurodegeneration
As we age, our body rhythms lose time before they finally stop. Breaking the body clock by genetically disrupting a core clock gene, Bmal1, in mice has long been known to accelerate aging, causing arthritis, hair loss, cataracts, and premature death. New research now reveals that the nerve cells of these mice with broken clocks show signs of deterioration before the externally visible signs of aging are apparent, raising the possibility of novel approaches to staving off or delaying neurodegeneration.
NIH/National Institute of Neurological Disorders and Stroke, NIH/National Heart, Lung, and Blood Institute

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 25-Nov-2013
Journal of Clinical Oncology
Nurse navigators help cancer patients cope early in care
When Group Health patients received support from a nurse navigator, or advocate, soon after a cancer diagnosis, they had better experiences and fewer problems with their care -- particularly in health information, care coordination, and psychological and social care -- according to a randomized controlled trial in the Journal of Clinical Oncology.
NIH/National Cancer Institute

Contact: Rebecca Hughes
hughes.r@ghc.org
206-287-2055
Group Health Research Institute

Public Release: 25-Nov-2013
Journal of General Physiology
Controlling our circadian rhythms
Most people have experienced the effects of circadian-rhythm disruption, after traveling across time zones or adjusting to a new schedule. To have any hope of modulating our biological "clocks," we need to first understand the physiology at play. A new study in the Journal of General Physiology helps explain some of the biophysical processes underlying regulation of circadian rhythms.
National Institutes of Health, National Science Foundation, American Physiological Society

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

Public Release: 25-Nov-2013
Journal of Clinical Investigation
Identification of a genetic mutation associated with steroid-resistant nephritic syndrome
In this issue of the Journal of Clinical Investigation, Friedhelm Hildebrandt and colleagues at Boston Children's Hospital identified mutations in gene encoding the aarF domain containing kinase 4 (ADCK4) in 15 individuals with steroid-resistant nephritic syndrome from eight different families.
National Institutes of Health, Kidney Foundation of Canada and Nephcure Canada, National Research Foundation

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 25-Nov-2013
Journal of Clinical Investigation
Balancing T cell populations
In this issue of the Journal of Clinical Investigation, Yun-Cai Lu and colleagues at the La Jolla Institute for Allergy and Immunology investigated the role of the mTOR regulator tuberous sclerosis 1 in maintaining immune homeostasis.
NIH/National Institute of Allergy and Infectious Diseases, National Research Foundation of Korea

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 25-Nov-2013
Journal of Clinical Investigation
Identifying targets of autoantibodies
In this issue of the Journal of Clinical Investigation, Jordan Price and colleagues at Stanford University developed a microarray to identify cytokines, chemokines, and other circulating proteins as potential targets of the autoantibodies produced by SLE patients.
National Science Foundation, National Institutes of Health, Canadian Institutes of Health, National Organization for Rare Disorders

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 25-Nov-2013
Journal of Clinical Investigation
Circadian clock proteins maintain neuronal cell function
In this issue of the Journal of Clinical Investigation, Erik Musiek and colleagues at Washington University School of Medicine asked whether BMAL1 and the rest of the core clock contribute to the maintenance of healthy neurons.
National Institutes of Health, Ellison Medical Foundation, American Academy of Neurology

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 24-Nov-2013
Neuron
Meat, egg and dairy nutrient essential for brain development
"The cells of the body can do without it because they use asparagine provided through diet. Asparagine, however, is not well transported to the brain via the blood-brain barrier," said senior co-author of the study Dr. Jacques Michaud, who found that brain cells depend on the local synthesis of asparagine to function properly.
Fonds de recherche du Québec -- Santé, Canadian Institutes of Health Research, National Institutes of Health, and others

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal

Public Release: 24-Nov-2013
Nature Immunology
Study identifies protein essential for immune recognition, response to viral infection
A Massachusetts General Hospital-led research team has identified an immune cell protein that is critical to setting off the body's initial response against viral infection. They found that a protein called GEF-H1 is essential to the ability of macrophages -- major contributors to the innate immune system -- to respond to viral infections like influenza.
National Institutes of Health

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital

Public Release: 24-Nov-2013
Nature
How living cells solved a needle in a haystack problem to produce electrical signals
Scientists have figured out how cells do the improbable: pick the charged calcium ions out of vast sodium sea to generate electrical signals. The speed and accuracy of this selection is crucial to the beating of the heart and the flow of nerve impulses in the brain. The finding is likely to assist the development of new drugs, such as safer medications for chronic pain.
National Insittutes of Health, NIH/National Institute of Neurological Disorders and Stroke, NIH/National Heart, Lung, and Blood Institute, Howard Hughes Medical Institute

Contact: Leila Gray
leilag@uw.edu
206-685-0831
University of Washington

Public Release: 22-Nov-2013
Nature Immunology
Paths not taken: Notch signaling pathway keeps immature T cells on the right track
One protein called Notch, which has well-known roles in the development of multiple tissues, plays an essential role in triggering T-cell development. Notch signaling induces expression of genes that promote the maturation of T cells and discourage alternative cell fates. Deficiency of the Notch target gene Hes1 in blood stem cells results in extremely low T-cell numbers, and could shed light on how normal cells are transformed in the context of cancer.
NIH/National Institute of Allergy and Infectious Disease, NIH/National Cancer Institute, NIH/National Institute of General Medical Sciences

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 22-Nov-2013
American Journal of Hematology
Study finds link between allergies and increased risk of blood cancers in women
A team of scientists looking into the interplay of the immune system and cancer have found a link between a history of airborne allergies -- in particular to plants, grass and trees -- with risk of blood cancers in women.
NIH/National Cancer Institute

Contact: Kristen Woodward
media@fredhutch.org
206-667-2210
Fred Hutchinson Cancer Research Center

Showing releases 3176-3200 out of 3508.

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