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News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 3201-3225 out of 3512.

<< < 124 | 125 | 126 | 127 | 128 | 129 | 130 | 131 | 132 | 133 > >>

Public Release: 24-Nov-2013
Nature Immunology
Study identifies protein essential for immune recognition, response to viral infection
A Massachusetts General Hospital-led research team has identified an immune cell protein that is critical to setting off the body's initial response against viral infection. They found that a protein called GEF-H1 is essential to the ability of macrophages -- major contributors to the innate immune system -- to respond to viral infections like influenza.
National Institutes of Health

Contact: Sue McGreevey
Massachusetts General Hospital

Public Release: 24-Nov-2013
How living cells solved a needle in a haystack problem to produce electrical signals
Scientists have figured out how cells do the improbable: pick the charged calcium ions out of vast sodium sea to generate electrical signals. The speed and accuracy of this selection is crucial to the beating of the heart and the flow of nerve impulses in the brain. The finding is likely to assist the development of new drugs, such as safer medications for chronic pain.
National Insittutes of Health, NIH/National Institute of Neurological Disorders and Stroke, NIH/National Heart, Lung, and Blood Institute, Howard Hughes Medical Institute

Contact: Leila Gray
University of Washington

Public Release: 22-Nov-2013
Nature Immunology
Paths not taken: Notch signaling pathway keeps immature T cells on the right track
One protein called Notch, which has well-known roles in the development of multiple tissues, plays an essential role in triggering T-cell development. Notch signaling induces expression of genes that promote the maturation of T cells and discourage alternative cell fates. Deficiency of the Notch target gene Hes1 in blood stem cells results in extremely low T-cell numbers, and could shed light on how normal cells are transformed in the context of cancer.
NIH/National Institute of Allergy and Infectious Disease, NIH/National Cancer Institute, NIH/National Institute of General Medical Sciences

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 22-Nov-2013
American Journal of Hematology
Study finds link between allergies and increased risk of blood cancers in women
A team of scientists looking into the interplay of the immune system and cancer have found a link between a history of airborne allergies -- in particular to plants, grass and trees -- with risk of blood cancers in women.
NIH/National Cancer Institute

Contact: Kristen Woodward
Fred Hutchinson Cancer Research Center

Public Release: 22-Nov-2013
Journal of American College of Surgeons
Extent of obesity not strongest factor for patients when choosing weight loss operation
A new study investigating why obese patients choose one type of weight loss operation over another reveals that the main factors influencing decision making are whether patients have type 2 diabetes, how much weight they want to lose, and their tolerance for surgical risk to achieve their ideal weight.
National Institutes of Health, NIH/Midcareer Mentorship Award

Contact: Sally Garneski
American College of Surgeons

Public Release: 22-Nov-2013
UT Dallas professor wins $2.3 million NIH award
Dr. Robert Gregg, an assistant professor of mechanical engineering and bioengineering at UT Dallas, received the award based on his creative, innovative and potentially impactful work to improve prosthetic limbs and orthotic devices.
National Institutes of Health

Contact: LaKisha Ladson
University of Texas at Dallas

Public Release: 22-Nov-2013
Genome Biology
Epigenetic changes may explain chronic kidney disease
Researchers found, in a genome-wide survey, significant differences in the pattern of chemical modifications on DNA that affect gene expression in kidney cells from patients with chronic kidney disease versus healthy controls. This is the first study to show that changes in these modifications -- the cornerstone of the field of epigenetics -- might explain chronic kidney disease.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 22-Nov-2013
Cancer Epidemiology, Biomarkers & Prevention
Sugar-sweetened beverage consumption increases endometrial cancer risk
Postmenopausal women who consumed sugar-sweetened beverages were more likely to develop the most common type of endometrial cancer compared with women who did not drink sugar-sweetened beverages, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
NIH/National Cancer Institute

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 21-Nov-2013
UCSF scientist wins $89 million grant to study anal cancer in HIV-infected people
A UC San Francisco investigator has won an eight-year grant from the National Cancer Institute for a major investigation into anal cancer, a debilitating and sometimes fatal disease largely concentrated among people with HIV.
NIH/National Cancer Institute

Contact: Elizabeth Fernandez
University of California - San Francisco

Public Release: 21-Nov-2013
Psychology of Addictive Behaviors
Heavy drinking is bad for marriage if 1 spouse drinks, but not both
Do drinking and marriage mix? That depends on who's doing the drinking -- and how much -- according to a recent study by the University at Buffalo Research Institute on Addictions.
NIH/National Institute on Alcohol Abuse and Alcoholism

Contact: Cathy Wilde
University at Buffalo

Public Release: 21-Nov-2013
Kessler Foundation study provides first Class 1 evidence for cognitive rehabilitation in MS
Kessler Foundation researchers published the results of the MEMREHAB Trial in Neurology, providing the first Class I evidence for the efficacy of cognitive rehabilitation in multiple sclerosis. The article, "An RCT to treat learning impairment in MS," was released as an e-pub ahead of print on Nov. 8. It was accompanied by an editorial, "Let's rehabilitate cognitive rehabilitation for MS."
National Institutes of Health, NIH/National Institute on Disability and Rehabilitation Research

Contact: Carolann Murphy
Kessler Foundation

Public Release: 21-Nov-2013
American Journal of Human Genetics
Study finds gene network associated with alcohol dependence
Using a new approach that combines genome-wide association studies with information about which human proteins interact with one another, researchers from the University of Iowa and Yale University Medical School have identified a group of 39 genes that together are strongly associated with alcoholism.
National Institutes of Health, Alcoholic Beverage Medical Research Foundation, Veterans Administration

Contact: Jennifer Brown
University of Iowa Health Care

Public Release: 21-Nov-2013
MU research sheds light on nerve regeneration following spinal cord injury
University of Missouri researchers have discovered how the sea lamprey, an eel-like fish, regrows the neurons that comprise the long nerve "highways" that link the brain to the spinal cord. Findings may guide future efforts to promote recovery in humans who have suffered spinal cord injuries.
National Institutes of Health

Contact: Jeff Sossamon
University of Missouri-Columbia

Public Release: 21-Nov-2013
Cincinnati Children's researchers develop first molecular test to diagnose eosinophilic esophagitis
Researchers at Cincinnati Children's Hospital Medical Center have developed the first molecular test to diagnose eosinophilic esophagitis (EoE), a chronic upper gastrointestinal disorder. The incidence of EoE has skyrocketed since it was first characterized two decades ago.
National Institutes of Health

Contact: Jim Feuer
Cincinnati Children's Hospital Medical Center

Public Release: 21-Nov-2013
AIDS Patient Care and STDs
High HIV knowledge and risky sexual behavior not associated with HIV testing in young adolescents
New research from Montefiore Medical Center and Albert Einstein College of Medicine has found that teens most likely to be tested for HIV had strong partner communication about HIV and were in committed relationships. Having high knowledge about HIV and engaging in risky sexual activity did not increase testing. The study of nearly 1,000 Bronx, NY teens was published in the November issue of AIDS Patient Care and STDs.
NIH/National Institute of Mental Health, NIH/National Institute on Drug Abuse

Contact: Deirdre Branley
Albert Einstein College of Medicine

Public Release: 21-Nov-2013
Stress and isolation take toll on those under 50 with HIV; older people fare better
Case Western Reserve University researchers were surprised to learn that people younger than 50 years old with HIV feel more isolated and stressed than older people with the disease. They expected their study to reveal just the opposite.
NIH/National Institute for Allergy and Infectious Disease

Contact: Susan Griffith
Case Western Reserve University

Public Release: 21-Nov-2013
Advanced Healthcare Materials
Ultrasound, nanoparticles may help diabetics avoid the needle
A new nanotechnology-based technique for regulating blood sugar in diabetics may give patients the ability to release insulin painlessly using a small ultrasound device, allowing them to go days between injections -- rather than using needles to give themselves multiple insulin injections each day.
National Institutes of Health

Contact: Matt Shipman
North Carolina State University

Public Release: 21-Nov-2013
2 human proteins found to affect how 'jumping gene' gets around
Using a new method to catch elusive "jumping genes" in the act, researchers have found two human proteins that are used by one type of DNA to replicate itself and move from place to place. The discovery, described in the Nov. 21 issue of Cell, breaks new ground in understanding the arms race between a jumping gene and cells working to limit the risk posed by such volatile bits of DNA.
NIH/National Institute of General Medical Sciences

Contact: Shawna Williams
Johns Hopkins Medicine

Public Release: 21-Nov-2013
Molecular Cell
Targets of anticancer drugs have broader functions than what their name suggests
Drugs that inhibit the activity of enzymes called histone deacetylases (HDACs) are being widely developed for treating cancer and other diseases, with two already on the market. Researchers show that a major HDAC still functions in mice even when its enzyme activity is abolished, suggesting that the beneficial effects of HDAC inhibitors may not actually be through inhibiting HDAC activity, and thus warranting the reassessment of the molecular targets of this class of drugs.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 21-Nov-2013
Cell Metabolism
New link between obesity and diabetes found
A single overactive enzyme worsens the two core defects of diabetes -- impaired insulin sensitivity and overproduction of glucose -- suggesting that a drug targeting the enzyme could help correct both at once, according to mouse studies done by researchers at Columbia University Medical Center. The findings were published today in the online edition of Cell Metabolism.
National Institutes of Health, American Heart Association, New York Obesity Research Center, Foundation for Research Support of the State of São Paulo, German Center for Cardiovascular Research, German Ministry of Education

Contact: Karin Eskenazi
Columbia University Medical Center

Public Release: 21-Nov-2013
UCLA first to map autism-risk genes by function
UCLA neuroscientists are the first to map groups of autism-risk genes by function, and uncover how mutations disrupt fetal brain development. Their findings prioritize genetic targets for future research and shed light on autism's molecular origins.
Simons Foundation, NIH/National Institute of Mental Health

Contact: Elaine Schmidt
University of California - Los Angeles Health Sciences

Public Release: 21-Nov-2013
Genetic defect keeps verbal cues from hitting the mark
A genetic defect that profoundly affects speech in humans also disrupts the ability of songbirds to sing effective courtship tunes. This defect in a gene called FoxP2 renders the brain circuitry insensitive to feel-good chemicals that serve as a reward for speaking the correct syllable or hitting the right note, a recent study shows.
National Institutes of Health

Contact: Karl Leif Bates
Duke University

Public Release: 21-Nov-2013
Study of fluke parasites identifies drug resistance mutations; raises hope for new therapies
An international group of scientists lead by Tim Anderson Ph.D., at the Texas Biomedical Research Institute and Philip LoVerde Ph.D., at the University of Texas Health Science Center at San Antonio has identified the mutations that result in drug resistance in a parasite infecting 187 million people in South America, Africa and Asia. The new finding allows detailed understanding of the drugs' mechanism of action and raises prospects of improved therapies.
National Institutes of Health, World Health Organization, Wellcome Trust

Contact: Tim Anderson
Texas Biomedical Research Institute

Public Release: 21-Nov-2013
2 Y genes can replace the entire Y chromosome for assisted reproduction in mice
Live mouse offspring can be generated with assisted reproduction using germ cells from males with the Y chromosome contribution limited to only two genes: the testis determinant factor Sry and the spermatogonial proliferation factor Eif2s3y.
National Institutes of Health, Hawaii Community Foundation

Contact: Monika A. Ward
University of Hawaii at Manoa

Public Release: 20-Nov-2013
Proceedings of the National Academy of Sciences
Scripps oceanography researchers engineer breakthrough for biofuel production
Researchers at Scripps Institution of Oceanography at UC San Diego have developed a method for greatly enhancing biofuel production in tiny marine algae. As reported in this week's online edition of the Proceedings of the National Academy of Sciences, Scripps graduate student Emily Trentacoste led the development of a method to genetically engineer a key growth component in biofuel production.
National Institutes of Health, California Energy Commission, Air Force, Department of Energy, National Science Foundation

Contact: Mario Aguilera
University of California - San Diego

Showing releases 3201-3225 out of 3512.

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