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Department of Health and Human Services

News from the National Institutes of Health

Funded News


Key: Meeting M      Journal J      Funder F

Showing releases 3251-3275 out of 3494.

<< < 126 | 127 | 128 | 129 | 130 | 131 | 132 | 133 | 134 | 135 > >>

Public Release: 13-Nov-2013
Diabetes Care
Intranasal insulin improves cognitive function in patients with type 2 diabetes
A research team led by investigators at Beth Israel Deaconess Medical Center finds that a single dose of intranasal insulin can improve cognitive function in patients with diabetes.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases, NIH/National Institute on Aging, Veterans Administration, China Scholarship Council

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center

Public Release: 13-Nov-2013
Critical Care Medicine
BUSM/BMC study shows decrease in sepsis mortality rates
A recent study from Boston University School of Medicine and Boston Medical Center shows a significant decrease in severe sepsis mortality rates over the past 20 years. Looking at data from patients with severe sepsis enrolled in clinical trials, researchers found that in-hospital mortality rates decreased from 47 percent between 1991 and 1995 to 29 percent between 2006 and 2009, a time period when no new pharmacological treatments were developed for severe sepsis.
NIH/National Heart, Lung, and Blood Institute

Contact: Jenny Eriksen
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center

Public Release: 13-Nov-2013
Clinical Cancer Research
Finding antitumor T cells in a patient's own cancer
In a paper recently published in Clinical Cancer Research, investigators in the lab of Daniel Powell, Ph.D., at the Perelman School of Medicine, University of Pennsylvania, demonstrated for the first time that a T cell activation molecule can be used as a biomarker to identify rare antitumor T cells in human cancers. The molecule, CD137, is a protein that is not normally found on the surface of resting T cells but its expression is induced when the T cell is activated.
NIH/Nationcal Cancer Institute, Sandy Rollman Ovarian Cancer Foundation, Ovarian Cancer Research Fund

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 13-Nov-2013
JAMA Internal Medicine
Study finds few patients with newly-diagnosed hyperlipidemia receive recommended thyroid screening
Despite current guidelines that recommend newly diagnosed high-cholesterol patients have a TSH blood test done to make sure they do not have hypothyroidism, researchers from Boston University School of Medicine and Boston Medical Center have found that only about half of these patients were screened for thyroid dysfunction. The findings, which appear online in JAMA Internal Medicine, show the current guidelines may be underutilized.
National Institutes of Health

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center

Public Release: 13-Nov-2013
mBio
Compound stymies polyomaviruses in lab tests
There is no approved medicine to treat polyomaviruses, which afflict those with weakened immune systems, but scientists have found that a chemical compound called Retro-2 is able to significantly reduce the infectivity and spread of the viruses in lab cell cultures. Now they are working to improve it further.
National Institutes of Health, National Science Foundation, Johnson & Johnson

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

Public Release: 13-Nov-2013
Science Translational Medicine
Mystery explained: How a common chemo drug thwarts graft rejection in bone marrow transplants
Results of a Johns Hopkins study may explain why a chemotherapy drug called cyclophosphamide prevents graft-versus-host (GVHD) disease in people who receive bone marrow transplants. The experiments point to an immune system cell that evades the toxic effects of cyclophosphamide and protects patients from a lethal form of GVHD.
National Institutes of Health, NIH/National Cancer Institute, NIH/National Heart, Lung, and Blood Institute

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 13-Nov-2013
Science Translational Medicine
Novel gene therapy works to reverse heart failure
Researchers at the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai have successfully tested a powerful gene therapy, delivered directly into the heart, to reverse heart failure.
National Institutes of Health, NIH/National Heart, Lung, and Blood Institute

Contact: Lauren Woods
lauren.woods@mountsinai.org
212-241-2836
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 13-Nov-2013
PLOS ONE
IU cognitive scientists ID new mechanism at heart of early childhood learning and social behavior
An Indiana University study provides compelling evidence for a new and possibly dominant way for social partners to coordinate joint attention, key for parent-child communication and early language learning. The findings open up new questions about language learning and the teaching of language. They could also have major implications for the treatment of children with early social-communication impairment, such as autism, where joint caregiver-child attention with respect to objects and events is a key issue.
National Science Foundation, National Institutes of Health

Contact: Liz Rosdeitcher
rosdeitc@indiana.edu
812-855-4507
Indiana University

Public Release: 13-Nov-2013
Journal of Hospital Medicine
Study finds widespread use of opioid medications in nonsurgical hospital patients
Amid a growing climate of concern regarding the overuse of opioid pain medications, a comprehensive analysis of more than 1 million hospital admissions has found that over 50 percent of all nonsurgical patients were prescribed opioids during their hospitalization -- often at very high doses -- and that more than half of those exposed were still receiving these medications on the day they were discharged from the hospital.
NIH/National Institute on Aging

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center

Public Release: 13-Nov-2013
Science Translational Medicine
Newly discovered mechanism suggests novel approach to prevent type 1 diabetes
New research led by Harvard School of Public Health demonstrates a disease mechanism in type 1 diabetes that can be targeted using simple, naturally occurring molecules to help prevent the disease. The work highlights a previously unrecognized molecular pathway that contributes to the malfunction of insulin-producing pancreatic beta cells in T1D in humans and mice, and shows that a chemical intervention can help beta cells function properly and survive.
Juvenile Diabetes Research Foundation, National Institutes of Health, European Union, Fonds National de la Recherche Scientifique, Schuylar

Contact: Marge Dwyer
mhdwyer@hsph.harvard.edu
617-432-8416
Harvard School of Public Health

Public Release: 12-Nov-2013
Nucleic Acids Research
Researcher finds potential new use for old drugs
A class of drugs used to treat parasitic infections such as malaria may also be useful in treating cancers and immune-related diseases, a new WSU-led study has found. Researchers discovered that simple modifications to the drug furamidine have a major impact on its ability to affect specific human proteins involved in the on-off switches of certain genes.
National Institutes of Health

Contact: Gregory Poon
gpoon@wsu.edu
509-335-8341
Washington State University

Public Release: 12-Nov-2013
Addiction
Parental monitoring lowers odds of a gambling problem
Keeping an eye on your child can lower their odds for gambling by young adulthood. Adolescents who had poor parental supervision at age 11, and which continued to decline through age 14, were significantly more likely than their peers to be problem gamblers between ages 16-22. This is the first study to examine the relationship between parental monitoring during early adolescence and gambling behaviors in late adolescence and young adulthood.
NIH/National Institute of Child and Human Development

Contact: Stephanie Berger
sb2247@columbia.edu
212-305-4372
Columbia University's Mailman School of Public Health

Public Release: 12-Nov-2013
Lymphology
NYU researchers find a new solution in detecting breast-cancer related lymphedem
Doctors struggle to detect and diagnose breast-cancer related Lymphedema -- a condition affecting the lymphatic system and causing psychosocial distress and physical challenges for patients.
Avon Foundation, National Institutes of Health

Contact: Christopher James
christopher.james@nyu.edu
212-998-6876
New York University

Public Release: 12-Nov-2013
Mayo Clinic: Researchers to study body's defense system to find new treatments for Alzheimer's
Researchers at Mayo Clinic in Florida, the University of Florida in Gainesville, and the Institute for Systems Biology in Seattle have received a $7.5 million grant from the National Institutes of Health to take a new and more expanded approach to identifying drug targets to treat and possibly prevent Alzheimer's disease.
National Institutes of Health

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic

Public Release: 12-Nov-2013
Neuroscience 2013
Using morphine after abdominal surgery may prolong pain, CU-Boulder researchers find
Using morphine to fight the pain associated with abdominal surgery may paradoxically prolong a patient's suffering, doubling or even tripling the amount of time it takes to recover from the surgical pain, according to researchers at the University of Colorado Boulder.
National Institutes of Health

Contact: Peter Grace
Peter.Grace@colorado.edu
University of Colorado at Boulder

Public Release: 12-Nov-2013
EMBO Journal
Wayne State researchers discover specific inhibitor for rheumatoid arthritis treatment
Researchers from Wayne State University and Northwestern University have contributed to an important discovery in the inflammatory stress mechanism and specific inhibitor for the treatment of rheumatoid arthritis.
National Institutes of Health, American Heart Association

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research

Public Release: 12-Nov-2013
Neuropsychology
Johns Hopkins research may improve early detection of dementia
Using scores obtained from cognitive tests, Johns Hopkins researchers think they have developed a model that could help determine whether memory loss in older adults is benign or a stop on the way to Alzheimer's disease.
NIH/National Institute of Mental Health

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine

Public Release: 12-Nov-2013
Molecular Cancer Therapeutics
Controlling the hormonal environment in endometrial cancer sensitizes tumors to PARP inhibitors
Modulating the hormonal environment in which endometrial cancers grow could make tumors significantly more sensitive to a new class of drugs known as PARP inhibitors.
Concern Foundation, NIH/National Cancer Institute, UCLA's Scholars in Translational Medicine Program

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-794-0777
University of California - Los Angeles Health Sciences

Public Release: 12-Nov-2013
Neuroscience 2013
Mindfulness inhibits implicit learning -- the wellspring of bad habits
Being mindful appears to help prevent the formation of bad habits, but perhaps good ones too. Behavioral and neuroimaging studies suggest that mindfulness can undercut the automatic learning processes, such as implicit learning. "Our theory is that one learns habits -- good or bad -- implicitly, without thinking about them," says author Chelsea Stillman. "We wanted to see if mindfulness impeded implicit learning."
National Institutes of Health

Contact: Karen Mallet
km463@georgetown.edu
Georgetown University Medical Center

Public Release: 11-Nov-2013
Proceedings of the National Academy of Sciences
New look identifies crucial clumping of diabetes-causing proteins
Subtle differences in the shape of proteins protect some and endanger others. "All mammals make this same protein called amylin, and it only differs a little bit from species to species," says Martin Zanni, a University of Wisconsin–Madison chemistry professor. "The mammals that get type 2 diabetes, their amylin proteins aggregate in the pancreas into plaque that kills the cells around them. As a result, you can't make insulin."
National Institutes of Health

Contact: Martin Zanni
zanni@chem.wisc.edu
608-262-4783
University of Wisconsin-Madison

Public Release: 11-Nov-2013
Molecular Biology and Evolution
Penn team elucidates evolution of bitter taste sensitivity
People often have strong negative reactions to bitter substances, which, though found in healthful foods like vegetables, can also signify toxicity. For this reason, the ability to sense bitterness likely played an important role in human evolution. A new study by University of Pennsylvania scientists suggests that a genetic mutation that makes certain people sensitive to the taste of a bitter compound appears to have been advantageous for certain human populations in Africa.
National Science Foundation, National Institutes of Health

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania

Public Release: 11-Nov-2013
Clinical Immunology
Putting Lupus in permanent remission
Northwestern Medicine® scientists have successfully tested a nontoxic therapy that suppresses Lupus in blood samples of people with the autoimmune disease.
Alliance for Lupus Research, National Institutes of Health

Contact: Erin White
ewhite@northwestern.edu
847-491-4888
Northwestern University

Public Release: 11-Nov-2013
Journal of Allergy & Clinical Immunology
First genetic mutations linked to atopic dermatitis identified in African-American children
Two specific genetic variations in people of African descent are responsible for persistent atopic dermatitis, an itchy, inflammatory form of the skin disorder eczema. A new report by researchers in the Perelman School of Medicine at the University of Pennsylvania found that loss-of-function mutations to Filaggrin-2, a gene that creates a protein responsible for retaining moisture and protecting the skin from environmental irritants, were associated with atopic dermatitis in African American children.
NIH/National Institute of Arthritis Musculoskeletal and Skin Diseases

Contact: Kim Menard
kim.menard@uphs.upenn.edu
215-662-6183
University of Pennsylvania School of Medicine

Public Release: 11-Nov-2013
New England Journal of Medicine
APOL1 gene speeds kidney disease progression and failure in blacks, regardless of diabetes status
A large study co-authored by Penn Medicine researchers published this week in the New England Journal of Medicine found that African Americans with the APOL1 gene variant experience faster progression of chronic kidney disease and have a significantly increased risk of kidney failure, regardless of their diabetes status.
National Institutes of Health

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine

Public Release: 11-Nov-2013
Nature Neuroscience
Signal found to enhance survival of new brain cells
A specialized type of brain cell that tamps down stem cell activity ironically, perhaps, encourages the survival of the stem cells' progeny, Johns Hopkins researchers report. Understanding how these new brain cells "decide" whether to live or die and how to behave is of special interest because changes in their activity are linked to neurodegenerative diseases such as Alzheimer's, mental illness and aging.
NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute of Environmental Health Sciences, NIH/National Institute of Child Health and Human Development, Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, and others

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine

Showing releases 3251-3275 out of 3494.

<< < 126 | 127 | 128 | 129 | 130 | 131 | 132 | 133 | 134 | 135 > >>

     
   

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