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Department of Health and Human Services

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Key: Meeting M      Journal J      Funder F

Showing releases 3251-3275 out of 3555.

<< < 126 | 127 | 128 | 129 | 130 | 131 | 132 | 133 | 134 | 135 > >>

Public Release: 30-Jan-2014
Science
Scientists discover new genetic forms of neurodegeneration
In a study published in the Jan. 31, 2014, issue of Science, an international team led by scientists at the University of California, San Diego, School of Medicine report doubling the number of known causes for the neurodegenerative disorder known as hereditary spastic paraplegia. The disorder is characterized by progressive stiffness and contraction of the lower limbs and is associated with epilepsy, cognitive impairment, blindness and other neurological features.
Deutsche Forschungsgemeinschaft, Brain & Behavior Research Foundation, and National Institutes of Health

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 29-Jan-2014
Proceedings of the National Academy of Sciences
Findings point to potential treatment for virus causing childhood illnesses
Researchers have discovered a potential treatment for a viral infection that causes potentially fatal brain swelling and paralysis in children. The findings also point to possible treatments for related viruses including those that cause "common cold" symptoms.
National Institutes of Health

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University

Public Release: 29-Jan-2014
Nature
Puzzling question in bacterial immune system answered
Berkeley researchers have answered a central question about Cas9, an enzyme that plays an essential role in the bacterial immune system and is fast becoming a valuable tool for genetic engineering: How is Cas9 able to precisely discriminate between non-self DNA that must be degraded and self DNA that may be almost identical within genomes that are millions to billions of base pairs long.
National Science Foundation, National Institutes of Health

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory

Public Release: 29-Jan-2014
Progress in Community Health Partnerships: Research, Education and Action
U of Maryland study: Partnership may help address cancer, health disparities
Robust partnerships between rural community health education centers and academic health care institutions can make substantial strides toward addressing race-, income- and geographically based health disparities in underserved communities by empowering both the community and leading University institutions, according to newly published research from the University of Maryland School of Medicine.
NIH/National Cancer Institute, NIH/National Institute on Minority Health and Health Disparities

Contact: Christopher Hardwick
chardwick@som.umaryland.edu
410-706-5260
University of Maryland Medical Center

Public Release: 29-Jan-2014
Molecular Pharmacology
Obesity-induced fatty liver disease reversed in mice
Johns Hopkins researchers have discovered that valproic acid, a widely prescribed drug for treating epilepsy, has the additional benefits of reducing fat accumulation in the liver and lowering blood sugar levels in the blood of obese mice.
NIH/National Institute of General Medical Sciences

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine

Public Release: 29-Jan-2014
PLOS ONE
Lung and bladder cancers have common cell-cycle biomarkers
University of Colorado Cancer Center study shows bladder and lung cancers are marked by shared differences in the genetics that control the cell cycle. Measuring these genetic signatures could allow doctors to refine a patient's prognosis, choose appropriate treatments, and perhaps offer new treatments that target these shared genetic abnormalities.
NIH/National Cancer Institute, National Institutes of Health

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

Public Release: 29-Jan-2014
Endocrine-Related Cancer
Prostate cancer signal reawakens 'sleeper agent' cells in bones
Dormant prostate cancer cells in bone tissue can be reawakened to cause secondary tumors, according to new research published in Endocrine-Related Cancer. Targeting the wake-up call could prevent metastasis and improve prostate cancer survival rates.
NIH/National Cancer Institute, Prostate Cancer Foundation, and others

Contact: Omar Jamshed
omar.jamshed@bioscientifica.com
44-014-546-42206
BioScientifica Limited

Public Release: 29-Jan-2014
Menopause
Testosterone isn't the help some hoped for when women go through menopause early
With plummeting hormone levels, natural menopause before age 40 can put a damper on women's mental well being and quality of life. But bringing testosterone back up to normal may not bring them the boost some hoped for, found a new study published online today in Menopause, the journal of The North American Menopause Society.
NIH/Eunice Kennedy Shriver National Institute of Child Health, National Institutes of Health, Procter & Gamble

Contact: Eileen Petridis
epetridis@fallscommunications.com
216-696-0229
The North American Menopause Society (NAMS)

Public Release: 29-Jan-2014
Journal of the Acoustical Society of America
Decibels and democracy
Voice votes, common in civic and political decision making at all levels, can be skewed by a single, loud voice, according to a study led by the University of Iowa. The researchers propose locating everyone within equal distance from the vote recorder or controlling for sound on voters' microphones. Results appear in the Journal of the Acoustical Society of America.
National Institutes of Health

Contact: Richard Lewis
richard-c-lewis@uiowa.edu
319-384-0012
University of Iowa

Public Release: 29-Jan-2014
Science Translational Medicine
Vaccine used to treat cervical precancers triggers immune cell response
Preliminary results of a small clinical trial show that a vaccine used to treat women with high-grade precancerous cervical lesions triggers an immune cell response within the damaged tissue itself. The Johns Hopkins scientists who conducted the trial said the finding is significant because measuring immune system responses directly in the lesions may be a more accurate way to evaluate so-called "therapeutic" vaccines than by the conventional means of blood analysis.
NIH/National Cancer Institute

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 29-Jan-2014
Nature
Neanderthals' genetic legacy
Remnants of Neanderthal DNA in modern humans are associated with genes affecting type 2 diabetes, Crohn's disease, lupus, biliary cirrhosis and smoking behavior. They also concentrate in genes that influence skin and hair characteristics. At the same time, Neanderthal DNA is conspicuously low in regions of the X chromosome and testes-specific genes.
National Science Foundation, National Institutes of Health

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School

Public Release: 29-Jan-2014
JAMA Psychiatry
Less than half of children treated for anxiety achieve long-term relief
Fewer than one in two children and young adults treated for anxiety achieve long-term relief from symptoms, according to the findings of a study by investigators from the Johns Hopkins Children's Center and five other institutions.
NIH/National Institute of Mental Health

Contact: Ekaterina Pesheva
epeshev1@jhmi.edu
410-502-9433
Johns Hopkins Medicine

Public Release: 28-Jan-2014
International Journal of Cancer
Berkeley Lab research finds running may be better than walking for breast cancer survival
Previous studies have shown that breast cancer survivors who meet the current exercise recommendations (2.5 hours of moderate intensity physical activity per week) are at 25 percent lower risk for dying from breast cancer. New research from Berkeley Lab, and reported in the International Journal of Cancer, suggests that exceeding the recommendations may provide greater protection, and that running may be better than walking.
NIH/National Heart, Lung, and Blood Institute, National Institutes of Health

Contact: Jon Weiner
jrweiner@lbl.gov
510-486-4014
DOE/Lawrence Berkeley National Laboratory

Public Release: 28-Jan-2014
International Journal of Radiation Oncology • Biology • Physics
'Weeding the garden' lets ALK+ lung cancer patients continue crizotinib
Patients taking crizotinib for ALK+ non-small cell lung cancer may safely and durably use up to three courses of targeted radiation therapy to eradicate pockets of drug-resistant disease.
NIH/National Cancer Institute

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

Public Release: 28-Jan-2014
Journal of Neuroscience
Low levels of pro-inflammatory agent help cognition in rats
Although inflammation is frequently a cause of disease in the body, research from the University of Texas Health Science Center at San Antonio indicates that low levels of a pro-inflammatory cytokine in the brain are important for cognition. Cytokines are proteins produced by the immune system.
NIH/National Institute of Mental Health, Brain and Behavior Research Foundation

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio

Public Release: 28-Jan-2014
Diabetes Care
Future directions for landmark diabetes study in journal Diabetes Care
The journal Diabetes Care, published by the American Association of Diabetes, features a series of articles commemorating the 30th anniversary of two groundbreaking diabetes studies. Rose A. Gubitosi-Klug, M.D., Ph.D., of University Hospitals Rainbow Babies & Children's Hospital and Case Western Reserve School of Medicine, penned the series' summary and mapped out future directions for the research in the issue.
National Institutes of Health

Contact: George Stamatis
george.stamatis@uhhospitals.org
216-844-3667
University Hospitals Case Medical Center

Public Release: 28-Jan-2014
eLife
Researchers open door to new HIV therapy
UC Berkeley structural biologist James Hurley and NIH cell biologist Juan Bonifacino have identified a new target for possible anti-AIDS drugs that would complement the current cocktail of drugs used to keep HIV in check. The target is a protein that interacts with an HIV protein, Nef, that slams the door to other viruses once a cell is infected.
National Institutes of Health

Contact: Robert Sanders
rlsanders@berkeley.edu
510-643-6998
University of California - Berkeley

Public Release: 28-Jan-2014
Journal of General Physiology
UA researchers find culprit behind skeletal muscle disease
Genetic mutations in titin, a protein that is vital for proper muscular function, can cause skeletal muscle disease, according to a new study by UA doctoral candidate Danielle Buck and her mentor, Henk Granzier, published Monday in the Journal of General Physiology. The work answers a question that remained after previous studies, which couldn't say if the deviations caused myopathies, or merely resulted from them.
National Institutes of Health, Bellows, ARCS Foundation, American Heart Association

Contact: Shelley Littin
littin@email.arizona.edu
319-541-1482
University of Arizona

Public Release: 28-Jan-2014
Nature Communications
Converting adult human cells to hair-follicle-generating stem cells
Researchers have come up with a method to convert adult cells into epithelial stem cells, the first time anyone has achieved this in either humans or mice. The epithelial stem cells, when implanted into immunocompromised mice, regenerated the different cell types of human skin and hair follicles, and even produced structurally recognizable hair shaft, raising the possibility that they may eventually enable hair regeneration in people.
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 28-Jan-2014
EMBO Molecular Medicine
Finding points to possible new Parkinson's therapy
A new study shows that, when properly manipulated, a population of support cells found in the brain called astrocytes could provide a new and promising approach to treat Parkinson's disease. These findings, which were made using an animal model of the disease, demonstrate that a single therapy could simultaneously repair the multiple types of neurological damage caused by Parkinson's, providing an overall benefit that has not been achieved in other approaches.
Catherine Carlson Fund, Spitzer Foundation, New York State Stem Cell Science, and NIH/National Institute of Allergy and Infectious Diseases

Contact: Mark Michaud
mark_michaud@urmc.rochester.edu
585-273-4790
University of Rochester Medical Center

Public Release: 27-Jan-2014
Proceedings of the National Academy of Sciences
Critical protein discovered for healthy cell growth in mammals
A protein that is required for the growth of tiny, but critical, hair-like structures called cilia on cell surfaces has been discovered. The research has important implications for human health because lack of cilia can lead to serious diseases such as polycystic kidney disease, blindness and neurological disorders. A paper describing the research will be published sometime this week in the online early edition of the Proceedings of the National Academy of Sciences.
National Institutes of Health, Burroughs Wellcome Fund, Packard Foundation, Penn State University, Program for Breakthrough Biomedical Research, American Heart Association

Contact: Barbara K. Kennedy
sciencew@psu.edu
814-863-4682
Penn State

Public Release: 27-Jan-2014
Nature Medicine
Promising class of antibiotics discovered for treatment of drug-resistant tuberculosis
St. Jude Children's Research Hospital scientists have discovered a promising new class of antibiotics that could aid efforts to overcome drug-resistance in tuberculosis (TB), a global killer. The drugs increased survival of mice infected with TB and were effective against drug-resistant strains of TB.
National Institutes of Health, NIH/National Institute for Allergy and Infectious Diseases, Government of Spain, American Lebanese Syrian Associated Charities

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital

Public Release: 27-Jan-2014
Epidemiology
Low vitamin D levels during pregnancy may increase risk of severe preeclampsia
Women who are deficient in vitamin D in the first 26 weeks of their pregnancy may be at risk of developing severe preeclampsia, a potentially life-threatening disorder diagnosed by an increase in blood pressure and protein in the urine, according to research by the University of Pittsburgh Graduate School of Public Health.
National Institutes of Health

Contact: Allison Hydzik
hydzikam@upmc.edu
412-647-9975
University of Pittsburgh Schools of the Health Sciences

Public Release: 27-Jan-2014
Nature Neuroscience
Permanent changes in brain genes may not be so permanent after all
In normal development, all cells turn off genes they don't need, often by attaching a chemical methyl group to the DNA, a process called methylation. Historically, scientists believed methyl groups could only stick to a particular DNA sequence: a cytosine followed by a guanine, called CpG. But in recent years, they have been found on other sequences, and so-called non-CpG methylation has been found in stem cells, and in neurons in the brain.
NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute of Environmental Health Sciences, NIH/National Institute of Mental Health, NIH/National Institute of Child Health and Human Development

Contact: Vanessa McMains
vmcmain1@jhmi.edu
410-502-9410
Johns Hopkins Medicine

Public Release: 27-Jan-2014
New England Journal of Medicine
Choosing Wisely -- the politics and economics of labeling low-value services
The Choosing Wisely campaign, lists of services developed by physicians' specialty societies, is a good start to spark discussion between physicians their patients about treatments and tests that may not be warranted. But researchers, led by Dr. Nancy Morden of the Dartmouth Institute for Health Policy & Clinical Practice, writing in a New England Journal of Medicine perspective say the list could be improved to include more common services and higher cost services.
NIH/National Institute on Aging, Robert Wood Johnson Foundation, Commonwealth Fund

Contact: Annmarie Christensen
Annmarie.Christensen@Dartmouth.edu
603-653-0897
The Geisel School of Medicine at Dartmouth

Showing releases 3251-3275 out of 3555.

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