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Key: Meeting M      Journal J      Funder F

Showing releases 3251-3275 out of 3572.

<< < 126 | 127 | 128 | 129 | 130 | 131 | 132 | 133 | 134 | 135 > >>

Public Release: 3-Mar-2014
Proceedings of the National Academy of Sciences
Big stride in understanding PP1, the ubiquitous enzyme
The enzyme PP1 has a key role in many of the body's healthy functions and diseases. It's so generally important that drug developers dare not target it. In a new study in the Proceedings of the National Academy of Sciences, Brown University scientists report a big leap in understanding how PP1 interacts with other proteins to behave specifically in distinct situations. That could lead to medicines that target it for precise benefits.
NIH/National Institute of General Medical Sciences

Contact: David Orenstein
Brown University

Public Release: 3-Mar-2014
Proceedings of the National Academy of Sciences
Experimental stroke drug also shows promise for people with Lou Gehrig's disease
Keck School of Medicine of University of Southern California neuroscientists have found that early muscle impairment related to Lou Gehrig's disease, also called amyotrophic lateral sclerosis, or ALS, in mice is proportional to the degree of damage to the blood-spinal cord barrier, which protects the central nervous system from toxins. Repairing damage to and restoring the blood-spinal cord barrier's integrity with an experimental neurovascular medicine being studied in human stroke patients appears to delay disease progression.
National Institutes of Health, ALS Association

Contact: Alison Trinidad
University of Southern California - Health Sciences

Public Release: 3-Mar-2014
BPA linked to prostate cancer, study shows
Findings by Cincinnati Cancer Center researchers show that levels of bisphenol A (BPA) in men's urine could be a marker of prostate cancer and that low levels of BPA exposure can cause cellular changes in both non-malignant and malignant prostate cells.
National Institutes of Health, Department of Defense, University of Cincinnati

Contact: Katie Pence
University of Cincinnati Academic Health Center

Public Release: 3-Mar-2014
Journal of Experimental Medicine
Gut microbes spur development of bowel cancer
It is not only genetics that predispose to bowel cancer; microbes living in the gut help drive the development of intestinal tumors, according to new research in mice.
National Institutes of Health

Contact: Rita Sullivan King
Rockefeller University Press

Public Release: 3-Mar-2014
Alcoholism: Clinical & Experimental Research
Binge drinking is harmful to older drinkers, may be hidden by weekly average
Studies examining the potential health benefits of moderate drinking generally focus on average levels of drinking rather than drinking patterns. A new study shows that, among older moderate drinkers, those who binge drink have a significantly greater mortality risk than regular moderate drinkers.
NIH/National Institute on Alcohol Abuse and Alcoholism, Department of Veterans Affairs Health

Contact: Charles J. Holahan, Ph.D.
Alcoholism: Clinical & Experimental Research

Public Release: 3-Mar-2014
Alcoholism: Clinical & Experimental Research
Hangovers do not seem to have much influence on the time to next drink
Many people believe that hangovers can either delay subsequent drinking due to pain and discomfort, or hasten drinking to relieve hangover symptoms. A new study investigates if a hangover that follows a drinking episode can influence the time to next drink. Results indicate that hangovers appear to have a very modest effect on subsequent drinking.
National Institutes of Health

Contact: Thomas M. Piasecki, Ph.D.
Alcoholism: Clinical & Experimental Research

Public Release: 3-Mar-2014
Alcoholism: Clinical & Experimental Research
Blurred Lines? Sexual boundaries are not really all that blurred
Sexual aggression has become a common experience in bars. New findings show that approximately 90 percent of the incidents involve male initiators and female targets. The initiators' level of invasiveness was related to intoxication of the targets but not their own intoxication. This suggests that intoxicated women were being targeted, perhaps perceived as easier or more blameworthy.
NIH/National Institute on Alcohol Abuse and Alcoholism

Contact: Kathryn Graham, Ph.D.
Alcoholism: Clinical & Experimental Research

Public Release: 2-Mar-2014
Nature Methods
Imaging dynamics of small biomolecules inside live cells
Researchers at Columbia University have made a significant step toward visualizing small biomolecules inside living biological systems with minimum disturbance, a longstanding goal in the scientific community. In a study published March 2 in Nature Methods, assistant professor of chemistry Wei Min's research team has developed a general method to image a broad spectrum of small biomolecules, such as small molecular drugs and nucleic acids, amino acids, lipids for determining where they are localized and how they function inside cells.
National Institutes of Health, US Army Research Office, Alfred P. Sloan Foundation

Contact: Beth Kwon
Columbia University

Public Release: 2-Mar-2014
Nature Immunology
In first moments of infection, a division and a decision
Using technologies capable of tracing the destiny of a single cell, researchers at the University of California, San Diego School of Medicine describe for the first time the earliest stages of fate determination among white blood cells called T lymphocytes, providing new insights that may help drug developers create more effective, longer-lasting vaccines against microbial pathogens or cancer.
National Institutes of Health, University of California San Diego Digestive Diseases Research Development Center, California Institute for Regenerative Medicine

Contact: Scott LaFee
University of California - San Diego

Public Release: 28-Feb-2014
Journal of Virology
Light zaps viruses: How photosensitization can stop viruses from infecting cells
Researchers find evidence that photosensitizing a virus's membrane covering can inhibit its ability to enter cells and potentially lead to the development of stronger, cheaper medications to fight a host of tough viruses.
National Institutes of Health, Fundação para a Ciência e a Tecnologia

Contact: Enrique Rivero
University of California - Los Angeles Health Sciences

Public Release: 28-Feb-2014
BMC Developmental Biology
3-D imaging sheds light on Apert syndrome development
Three-dimensional imaging of two different mouse models of Apert Syndrome shows that cranial deformation begins before birth and continues, worsening with time, according to a team of researchers who studied mice to better understand and treat the disorder in humans.
NIH/National Institute of Dental and Craniofacial Research, National Science Foundation

Contact: A'ndrea Elyse Messer
Penn State

Public Release: 28-Feb-2014
New England Journal of Medicine
BNI study reveal unexpected findings
Research on a deadly form of brain cancer co-authored by a physician at Barrow Neurological Institute at St. Joseph's Hospital and Medical Center has been published in the New England Journal of Medicine. The three-year research project led locally by David Brachman, M.D., revealed that a 'promising' drug therapy failed to improve survival among patients with newly diagnosed glioblastoma.
NIH/National Cancer Institute

Contact: Lynne Reaves
St. Joseph's Hospital and Medical Center

Public Release: 28-Feb-2014
Movement Disorders
Shaky hand, stable spoon: U-M study shows device helps essential tremor patients
For people whose hands shake uncontrollably due to a medical condition, just eating can be a frustrating and embarrassing ordeal -- enough to keep them from sharing a meal with others. But a small new study suggests that a new handheld electronic device can help such patients overcome the hand shakes caused by essential tremor, the most common movement disorder.
National Institutes of Health

Contact: Kara Gavin
University of Michigan Health System

Public Release: 28-Feb-2014
Dangerous mistaken identity
Tau proteins, which are responsible for Alzheimer's disease, bind to the folding protein HSP90. The molecular recognition mechanisms that play a role here, have been unveiled by an international team of scientists led by the Technische Universitaet Muenchen and the Helmholtz Zentrum Muenchen. This might open the door for new approaches for the treatment of Alzheimer's disease, as the scientists report in the trade journal Cell.
Austrian Academy of Sciences, German Research Foundation, European Community, Portugese Fundação para a Ciência e a Tecnologia, National Institutes of Health, Dutch Organization for Scientific Research, Bavarian Ministry of Science and Research

Contact: Andreas Battenberg
Technische Universitaet Muenchen

Public Release: 28-Feb-2014
Effects of meth use on brain metabolism, sleep studied
Washington State University sleep scientist Jonathan Wisor has received a grant from the National Institutes of Health to study the effects of chronic methamphetamine use on brain metabolism and sleep. The two-year, $395,577 grant comes from the National Institute on Drug Abuse, which is part of the NIH.
National Institutes of Health

Contact: Jonathan Wisor
Washington State University

Public Release: 28-Feb-2014
Researchers identify brain differences linked to insomnia
Johns Hopkins researchers report that people with chronic insomnia show more plasticity and activity than good sleepers in the part of the brain that controls movement.
NIH/National Institute of Child Health and Human Development

Contact: Stephanie Desmon
Johns Hopkins Medicine

Public Release: 28-Feb-2014
Teachers College Record
Retention leads to discipline problems in other kids
When a student repeats a grade, it can spell trouble for the student's classmates, according to a new Duke-led study of nearly 80,000 middle-schoolers. Higher numbers of repeaters were linked with higher suspension rates in the school as a whole, and more discipline problems such as substance abuse, fighting and classroom disruption.
National Institutes of Health

Contact: Alison Jones
Duke University

Public Release: 27-Feb-2014
Preventive Medicine
Twitter 'big data' can be used to monitor HIV and drug-related behavior, UCLA study shows
Real-time social media like Twitter could be used to track HIV incidence and drug-related behaviors with the aim of detecting and potentially preventing outbreaks.
NIH/National Institutes of Mental Health

Contact: Enrique Rivero
University of California - Los Angeles Health Sciences

Public Release: 27-Feb-2014
Targeting metabolism to develop new prostate cancer treatments
A University of Houston scientist is working to develop the next generation of prostate cancer therapies targeted at metabolism. Daniel Frigo is looking at a cascade of biochemical reactions inside the cell, focusing on an enzyme considered a master regulator of metabolism. Frigo wants to unlock more effective and less harmful treatments. Funded by the Department of Defense and National Institutes of Health, he most recently received another grant last week from Golfers Against Cancer.
Golfers Against Cancer, US Department of Defense, National Institutes of Health, and others

Contact: Lisa Merkl
University of Houston

Public Release: 27-Feb-2014
Cancer Research
Study identifies possible new target for future brain cancer drugs
A molecule in cells that shuts down the expression of genes might be a promising target for new drugs designed to treat glioblastoma, the most frequent and lethal form of brain cancer. The findings suggest that the protein PRMT5 is a possible prognostic factor and therapeutic target for glioblastoma, and they provide a rationale for developing agents that target PRMT5 in this deadly disease.
NIH/National Institute of Neurological Disorders and Stroke, Ohio Cancer Research Associates, V Foundation

Contact: Darrell E. Ward
Ohio State University Wexner Medical Center

Public Release: 27-Feb-2014
Making treatment of rare blood disorder more affordable and effective
A University of Pennsylvania research team has defined a possible new way to fight a disease that is currently treatable only with the most expensive drug available for sale in the United States. In a study published this month in Blood, the Penn team describes the strategy, based on the oldest part of the human immune system -- called 'complement' -- that could turn out to be less costly and more effective for the majority of patients with a rare blood disorder.
NIH/National Institute of Allergy and Infectious Diseases, NIH/National Institute of General Medical Sciences, NIH/National Eye Institute

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 27-Feb-2014
Proceedings of the National Academy of Sciences
Scientists describe deadly immune 'storm' caused by emergent flu infections
Scientists at the Scripps Research Institute have mapped key elements of a severe immune overreaction -- a 'cytokine storm' -- that can both sicken and kill patients who are infected with certain strains of flu virus. Their findings also clarify the workings of a potent new class of anti-inflammatory compounds that prevent this immune overreaction in animal models.
National Institutes of Health, American Heart Association

Contact: Mika Ono
Scripps Research Institute

Public Release: 27-Feb-2014
Study reveals mechanisms cancer cells use to establish metastatic brain tumors
New research from Memorial Sloan Kettering provides fresh insight into the biologic mechanisms that individual cancer cells use to metastasize to the brain.
National Institutes of Health, US Department of Defense Innovator Award, Alan and Sandra Gerry Metastasis Research Initiative

Contact: Caitlin Hool
Memorial Sloan Kettering Cancer Center

Public Release: 27-Feb-2014
Reproductive Toxicology
Bisphenol A (BPA) at very low levels can adversely affect developing organs in primates
Bisphenol A is a chemical that is used in a wide variety of consumer products and exhibits hormone-like properties. Fetuses, infants, children or adults exposed to the chemical have been shown to exhibit numerous abnormalities, including cancer, as well as reproductive, immune and brain-behavior problems. Now, researchers at the University of Missouri have determined that daily exposure to very low concentrations of bisphenol A by pregnant females also can cause fetal abnormalities in primates.
NIH/National Institute of Environmental Health Sciences

Contact: Jeff Sossamon
University of Missouri-Columbia

Public Release: 27-Feb-2014
PLOS Genetics
BUSM Study discovers novel therapeutic targets for Huntington's disease
A study led by researchers at Boston University School of Medicine provides novel insight into the impact that genes may have on Huntington's disease. The study, published online in PLOS Genetics, identified specific small segments of RNA (called micro RNA or miRNA) encoded in DNA in the human genome that are highly expressed in Huntington's disease. Micro RNAs are important because they regulate the expression of genes.
NIH/National Institute of Neurological Disorders and Stroke, Jerry McDonald Huntington's Disease Research Fund

Contact: Gina DiGravio
Boston University Medical Center

Showing releases 3251-3275 out of 3572.

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