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Showing releases 3276-3300 out of 3332.

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Public Release: 1-Jun-2012
Neuroscientists reach major milestone in whole-brain circuit mapping project
Neuroscientists at Cold Spring Harbor Laboratory reached an important milestone today, publicly releasing the first installment out of 500 terabytes of data so far collected in their pathbreaking project to construct the first whole-brain wiring diagram of a vertebrate brain, that of the mouse.
National Institutes of Health, Keck Foundation

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Public Release: 1-Jun-2012
Journal of Clinical Investigation
Improving obesity-induced insulin sensitivity
To identify drug targets that will improve insulin sensitivity, Dr. Jerrold Olefsky and colleagues from the University of California in San Diego investigated the role of a G protein-coupled receptor in insulin resistance and energy homeostasis.
National Institutes of Health, EU Ideas, Swiss National Science Foundation

Contact: Sarah Jackson
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 31-May-2012
Journal of Allergy and Clinical Immunology
Smoking during pregnancy linked to severe asthma in teen years
African-American and Latino children whose mothers smoked during pregnancy are more likely to suffer from acute asthma symptoms in their teens than asthma sufferers whose mothers did not smoke, according to a new study led by a research team at UCSF.
National Institutes of Health, American Asthma Foundation, Ernest S. Bazley Trust, Flight Attendant Medical Research Institute, Fund for Henry Ford Hospital, RWJF Amos Medical Faculty Award, Sandler Foundation

Contact: Kristen Bole
krisen.bole@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 31-May-2012
Cancer Research
Researchers identify promising biomarkers and new therapeutic targets for kidney cancer
Using blood, urine and tissue analysis of a unique mouse model, a team led by UC Davis researchers has identified several proteins as diagnostic biomarkers and potential therapeutic targets for kidney cancer.
National Institutes of Health, US Department of Veterans' Affairs

Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System

Public Release: 31-May-2012
NYUCD receives grant to identify biomarkers for the progression of periodontal disease
New York University College of Dentistry has been selected as one of five institutions that are sharing a $20.7 million grant from the National Institute of Dental and Craniofacial Research to the Forsyth Institute to find new ways to diagnose and fight periodontal disease.
NIH/National Institute of Dental and Craniofacial Research

Contact: Christopher James
christopher.james@nyu.edu
212-998-6876
New York University

Public Release: 31-May-2012
Nature Chemical Biology
New strategy directly activates cellular 'death protein'
Researchers at Dana-Farber/Children's Hospital Cancer Center have devised a strategy to directly activate a natural "death" protein, triggering the self-destruction of cells -- which could lead to new possibilities for designing cancer drugs.
William Lawrence and Blanche Hughes Foundation, National Institutes of Health, Stand Up to Cancer

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute

Public Release: 31-May-2012
American Journal of Physiology - Renal Physiology
Intravenous kidney cell transplant experiments raise hope for future human kidney failure treatments
Indiana University School of Medicine scientists have successfully transplanted primary kidney cells intravenously to treat renal failure in rats, pointing the way to a possible future alternative to kidney transplants and expensive dialysis treatments in humans.
National Institutes of Health, US Veterans Administration

Contact: Eric Schoch
eschoch@iupui.edu
317-274-7722
Indiana University School of Medicine

Public Release: 31-May-2012
American Journal of Human Genetics
Researchers at Boston Children's Hospital identify a genetic cause for CLOVES syndrome
Using advanced technologies for rapidly sequencing and analyzing DNA from clinical and pathologic samples, a multidisciplinary research team consisting of geneticists, pathologists and surgeons at Boston Children's Hospital has identified the genetic basis for CLOVES syndrome, a rare congenital malformation and overgrowth disorder.
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases, Manton Center for Orphan Disease Research, Stuart and Jane Weitzman Family Vascular Anomalies Fund, Howard Hughes Medical Institute

Contact: Erin Tornatore
erin.tornatore@childrens.harvard.edu
617-919-3110
Boston Children's Hospital

Public Release: 31-May-2012
Nature
Researchers identify mechanism that maintains stem cells readiness
An immune-system receptor plays an unexpected but crucially important role in keeping stem cells from differentiating and in helping blood cancer cells grow, researchers at UT Southwestern Medical Center report today in the journal Nature.
National Institutes of Health, American Society of Hematology, March of Dimes, US Department of Defense, Cancer Prevention and Research Institute of Texas, Gabrielle's Angel Foundation

Contact: Deborah Wormser
deborah.wormser@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 31-May-2012
Einstein awarded $6 million grant to develop new TB vaccine against drug-resistant strains
The National Institutes of Health has awarded researchers at Albert Einstein College of Medicine at Yeshiva University a five-year, $5.9 million grant to develop a new vaccine against tuberculosis, including the toughest-to-treat forms of the disease known as multi drug-resistant and extensively drug-resistant.
National Institutes of Health

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine

Public Release: 31-May-2012
Developmental Cell
We need to talk: How cells communicate to activate notch
researchers from UCLA's Jonsson Comprehensive Cancer Center have shown for the first time that the mechanical force produced by cell-cell interactions is critical for programming by the Notch signaling system.
University of California Cancer Research Coordinating Committee, NIH/National Institute of General Medical Sciences, Jonsson Cancer Center Foundation, others

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences

Public Release: 31-May-2012
Current Biology
Restless legs syndrome in fruit flies: Mutation in fly version of a human RLS gene disturbs sleep
Scientists have discovered that mutations in the gene BTBD9, which is linked with restless legs syndrome (RLS) in humans, disturb sleep in fruit flies. The mutant flies wake up more often during sleep periods, which resembles a key feature of human RLS. The same mutations in BTBD9 also reduce levels of the neurotransmitter dopamine in the flies. Some kind of deficiency in dopamine signaling is thought to lie behind RLS in humans.
National Institutes of Health, Sleep Research Society, Restless Legs Foundation

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory Health Sciences

Public Release: 31-May-2012
PLOS ONE
Weather patterns can be used to forecast rotavirus outbreaks
By correlating weather factors like temperature, rain, and snowfall, Elena Naumova, Ph.D., professor of civil and environmental engineering at Tufts School of Engineering, is able to predict the timing and intensity of rotavirus, a disease that causes extreme diarrhea, dehydration and thousands of death annually, particularly among children. Her research focused on one of the hardest-hit regions of the world, South Asia.
NIH/National Institute of Environmental Health Sciences, National Institutes of Health, FIC Global Infectious Disease Research Training, others

Contact: Alex Reid
Alexander.Reid@tufts.edu
617-627-4173
Tufts University

Public Release: 31-May-2012
PLOS ONE
'Safe' levels of arsenic in drinking water found to compromise pregnant/lactating mothers, offspring
Exposure to arsenic in drinking water at the level the US Environmental Protection Agency currently deems as safe in the United States (10 parts per billion) induces adverse health outcomes in pregnant and lactating mice and their offspring, concludes a study led by Joshua Hamilton of the Marine Biological Laboratory and Courtney Kozul-Horvath at Geisel School of Medicine at Dartmouth.
NIH/National Institute of Environmental Health Sciences

Contact: Diana Kenney
dkenney@mbl.edu
508-289-7139
Marine Biological Laboratory

Public Release: 31-May-2012
Science
Alzheimer's protein structure suggests new treatment directions
The molecular structure of a protein involved in Alzheimer's disease -- and the surprising discovery that it binds cholesterol -- could lead to new therapeutics for the disease, Vanderbilt University investigators report in the June 1 issue of the journal Science.
NIH/National Institute of General Medical Sciences, Alzheimer's Association

Contact: Melissa Marino
melissa.marino@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center

Public Release: 30-May-2012
Proceedings of the National Academy of Sciences
Neural protective protein has 2 faces
A protein produced by the central nervous system's support cells seems to play two opposing roles in protecting nerve cells from damage, an animal study by Johns Hopkins researchers suggests: decreasing its activity seems to trigger support cells to gear up their protective powers, but increasing its activity appears to be key to actually use those powers to defend cells from harm.
National Institutes of Health, Alfred P. Sloan Fellowship Award

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medicine

Public Release: 30-May-2012
Nature Chemical Biology
Training cells to perform Boolean functions? It's logical
Johns Hopkins scientists have engineered cells that behave like AND and OR Boolean logic gates, producing an output based on one or more unique inputs. This feat, published in the May issue of Nature Chemical Biology, could eventually help researchers create computers that use cells as tiny circuits.
National Institutes of Health, National Science Foundation, NIH/National Center for Research Resources

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medicine

Public Release: 30-May-2012
Annals of Surgery
Surgical site infections more likely in patients with history of skin infection
People with a past history of just a single skin infection may be three times more likely to develop a painful, costly -- and potentially deadly -- surgical site infection when they have an operation, according to new Johns Hopkins research.
NIH/National Center for Research Resources, NIH/National Center for Advancing Translational Sciences

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine

Public Release: 30-May-2012
2012 American Society of Clinical Oncology Annual Meeting
'Just do it!' not good enough for cancer patients, UR researchers say
Exercise generally helps the nation's 12 million cancer survivors, but researchers are still working toward being able to prove, with scientific certainty, that prescriptions for daily yoga or 20 minutes of walking will likely extend a patient's survival.
NIH/National Cancer Institute

Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
University of Rochester Medical Center

Public Release: 30-May-2012
Cell Host & Microbe
To spread, nervous system viruses sabotage cell, hijack transportation
Princeton University researchers have found that herpes and other viruses that attack the nervous system may thrive by disrupting cell function in order to hijack a neuron's internal transportation network and spread to other cells.
National Institutes of Health, National Science Foundation

Contact: Morgan Kelly
mgnkelly@princeton.edu
609-258-5729
Princeton University

Public Release: 30-May-2012
Cancer Cell
Researchers identify a 'life-and-death' molecule on chronic leukemia cells
A new study has identified a life-and-death signaling role for a molecule on the surface of the immune cells involved in chronic lymphocytic leukemia (CLL), the most common form of chronic leukemia. The study examines how an experimental drug called SMIP-016 kills CLL cells. The finding could lead to more effective therapy for this incurable cancer, which occurs in more than 16,000 Americans annually.
Leukemia and Lymphoma Society, NIH/National Cancer Institute, Mr. and Mrs. Michael Thomas, Harry Mangurian Foundation, D. Warren Brown Foundation

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center

Public Release: 30-May-2012
American Journal of Psychiatry
Genes predict if medication can help you quit smoking
A new study shows the same gene variations that make it difficult to stop smoking also increase the likelihood that heavy smokers will respond to nicotine-replacement therapy and drugs that thwart cravings. The finding suggests it may one day be possible to predict which patients are most likely to benefit from drug treatments for nicotine addiction.
NIH/National Cancer Institute, NIH/National Institute on Drug Abuse, NIH/National Human Genome Research Institute, NIH/National Heart, Lung, and Blood Institute, NIH/National Center for Research Resources

Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine

Public Release: 30-May-2012
Science Translational Medicine
UCSF researchers identify a potential new HIV vaccine/therapy target
The discovery by researchers at UCSF may shed light on the mystery of why some people infected with HIV are better able to control the virus, live longer and have fewer associated health problems than others who have been infected as long, they said. It also provides a potential new target for developing therapies or vaccines.
National Institutes of Health, Bill and Melinda Gates Foundation, California National Primate Research Center, NIH/National Center for Research Resources, Harvey V. Berneking Living Trust

Contact: Jeff Sheehy
jsheehy@ari.ucsf.edu
415-597-8165
University of California - San Francisco

Public Release: 30-May-2012
Biomicrofluidics
Biochip-based device for cell analysis
Inexpensive, portable devices that can rapidly screen cells for leukemia or HIV may soon be possible thanks to a chip that can produce three-dimensional focusing of a stream of cells, according to researchers.
National Institutes of Health, National Science Foundation, US Department of Agriculture

Contact: A'ndrea Elyse Messer
aem1@psu.edu
814-865-9481
Penn State

Public Release: 30-May-2012
Journal of General Internal Medicine
Patient mental health overlooked by physician when a family member is present
New study finds that patients with poor mental health function may experience more communication challenges during physicians visits if accompanied by a loved one.
NIH/National Institute of Mental Health

Contact: Natalie Wood-Wright
nwoodwri@jhsph.edu
410-614-6029
Johns Hopkins University Bloomberg School of Public Health

Showing releases 3276-3300 out of 3332.

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