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Department of Health and Human Services

News from the National Institutes of Health

Funded News


Key: Meeting M      Journal J      Funder F

Showing releases 3276-3300 out of 3555.

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Public Release: 27-Jan-2014
Nature Neuroscience
Permanent changes in brain genes may not be so permanent after all
In normal development, all cells turn off genes they don't need, often by attaching a chemical methyl group to the DNA, a process called methylation. Historically, scientists believed methyl groups could only stick to a particular DNA sequence: a cytosine followed by a guanine, called CpG. But in recent years, they have been found on other sequences, and so-called non-CpG methylation has been found in stem cells, and in neurons in the brain.
NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute of Environmental Health Sciences, NIH/National Institute of Mental Health, NIH/National Institute of Child Health and Human Development

Contact: Vanessa McMains
vmcmain1@jhmi.edu
410-502-9410
Johns Hopkins Medicine

Public Release: 27-Jan-2014
New England Journal of Medicine
Choosing Wisely -- the politics and economics of labeling low-value services
The Choosing Wisely campaign, lists of services developed by physicians' specialty societies, is a good start to spark discussion between physicians their patients about treatments and tests that may not be warranted. But researchers, led by Dr. Nancy Morden of the Dartmouth Institute for Health Policy & Clinical Practice, writing in a New England Journal of Medicine perspective say the list could be improved to include more common services and higher cost services.
NIH/National Institute on Aging, Robert Wood Johnson Foundation, Commonwealth Fund

Contact: Annmarie Christensen
Annmarie.Christensen@Dartmouth.edu
603-653-0897
The Geisel School of Medicine at Dartmouth

Public Release: 27-Jan-2014
Cell Metabolism
Scientists find genetic mechanism linking aging to specific diets
In new research published this month in Cell Metabolism, USC scientists Sean Curran and Shanshan Pang identify a collection of genes that allow an organism to adapt to different diets and show that without them, even minor tweaks to diet can cause premature aging and death.
National Institutes of Health, Ellison Medical Foundation, American Federation of Aging

Contact: Robert Perkins
perkinsr@usc.edu
213-740-9226
University of Southern California

Public Release: 27-Jan-2014
PLOS ONE
New, unusually large virus kills anthrax agent
From a zebra carcass on the plains of Namibia in Southern Africa, an international team of researchers has discovered a new, unusually large virus (or bacteriophage) that infects the bacterium that causes anthrax. The novel bacteriophage could eventually open up new ways to detect, treat or decontaminate the anthrax bacillus and its relatives that cause food poisoning.
National Institutes of Health

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis

Public Release: 27-Jan-2014
AIDS and Behavior
HIV medications dialogue differs by race, ethnicity
Researchers found specific racial and ethnic differences in discussions of HIV medicine adherence in a newly published analysis of recorded office visits between 45 doctors and nurse practitioners and more than 400 patients.
NIH/ National Institute of Mental Health, Agency for Healthcare Research and Quality

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

Public Release: 27-Jan-2014
Mayo Clinic study finds standardized protocol and surgery improve mortality outcomes
For patients who have experienced a large stroke that cuts off blood supply to a large part of the brain, the use of standardized medical management protocol and surgery to decompress swelling can improve life expectancy, Mayo Clinic researchers found in a recent study.
NIH/National Institute of Neurological Disorders and Stroke

Contact: Micah Dorfner
dorfner.micah@mayo.edu
507-304-7178
Mayo Clinic

Public Release: 27-Jan-2014
Nature Neuroscience
Expanding our view of vision
New brain-scanning technique from Massachusetts Institute of Technology researchers allows scientists to see when and where the brain processes visual information.
NIH/National Eye Institute, National Science Foundation, Alexander von Humboldt Foundation

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology

Public Release: 27-Jan-2014
JAX Genomic Medicine's Jeffrey Chuang, Ph.D., receives $519,750 grant for RNA studies
Jackson Laboratory Associate Professor Jeffrey Chuang, Ph.D., has been awarded a two-year grant totaling $519,750 from the National Human Genome Research Institute for his studies of how RNA (molecules vital to protein formation in cells) interacts with proteins to change how genes are expressed.
NIH/National Human Genome Research Institute

Contact: Joyce Peterson
joyce.peterson@jax.org
207-288-6058
Jackson Laboratory

Public Release: 27-Jan-2014
Physical Medicine & Rehabilitation
Severity of spatial neglect after stroke predicts long-term mobility recovery in community
Stroke rehabilitation researchers at Kessler Foundation report an association between acute, severe spatial neglect post stroke and long-term recovery of mobility. This new study indicates that severity of spatial neglect during the acute inpatient rehabilitation for right brain stroke may predict functional mobility in the community after discharge. "Severity of spatial neglect during acute inpatient rehabilitation predicts community mobility post stroke," was epublished ahead of print in Physical Medicine & Rehabilitation on January 9, 2014.
NIH/National Institute of Neurological Disorders and Stroke, National Institute on Disability and Rehabilitation Research

Contact: Carolann Murphy
cmurphy@kesslerrfoundation.org
973-324-8382
Kessler Foundation

Public Release: 27-Jan-2014
Proceedings of the National Academy of Sciences
Visual system can retain considerable plasticity after extended blindness
Deprivation of vision during critical periods of childhood development has long been thought to result in irreversible vision loss. Now, researchers have challenged that theory by studying a unique population of pediatric patients who were blind during these critical periods before removal of bilateral cataracts.
National Institutes of Health

Contact: Mary_Leach@meei.harvard.edu
Mary_Leach@meei.harvard.edu
Massachusetts Eye and Ear Infirmary

Public Release: 27-Jan-2014
Journal of Cardiovascular Translational Research
Brain biomarker shows promise in heart
A biomarker widely used to diagnose brain injury has shown early promise for assessing the severity of heart inflammation, or myocarditis, find researchers at Columbia University's Mailman School of Public Health, Johns Hopkins, and the Mayo Clinic. The study is published online in the January issue of the Journal of Cardiovascular Translational Research.
NIH/National Heart, Lung, and Blood Institute, NIH/National Institute of Environmental Health Sciences, American Heart Association

Contact: Timothy S. Paul
tp2111@columbia.edu
212-305-2676
Columbia University's Mailman School of Public Health

Public Release: 27-Jan-2014
Cancer Research
Fragmented sleep accelerates cancer growth
Poor-quality sleep marked by frequent awakenings can speed cancer growth, increase tumor aggressiveness and dampen the immune system's ability to control or eradicate early cancers. This study is the first to demonstrate the direct effects of fragmented sleep on tumor growth and invasiveness. It points to a biological mechanism that could serve as a target for therapy.
National Institutes of Health

Contact: John Easton
john.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center

Public Release: 27-Jan-2014
Lancet Respiratory Medicine
Rare genetic variations may account for severe reaction to LABA drugs in some people
More than 25 million people in the United States have asthma, a chronic lung disease that inflames and narrows the airways causing recurring periods of wheezing, chest tightness, shortness of breath and coughing.
National Institutes of Health

Contact: Marguerite Beck
marbeck@wakehealth.edu
336-716-2415
Wake Forest Baptist Medical Center

Public Release: 27-Jan-2014
Journal of the American Academy of Child and Adolescent Psychiatry
Study on DSM-5 shows effects on autism diagnosis and prevalence
A new study finds that the estimated prevalence of autism under the new DSM-5 criteria would decrease only to the extent that some children would receive the new diagnosis of social communication disorder. The study, funded in part by a research grant from Autism Speaks, the world's leading autism science and advocacy organization, appears online in the Journal of the American Academy of Child and Adolescent Psychiatry.
Autism Speaks, Brian Research Foundation, Simons Foundation, National Institutes of Health

Contact: Steffanie Marchese
steffanie.marchese@autismspeaks.org
646-385-8537
Autism Speaks

Public Release: 27-Jan-2014
JAMA Neurology
Environmental risk factor for Alzheimer's: DDT exposure
Patients with Alzheimer's disease have significantly higher levels of DDE, the long-lasting metabolite of the pesticide DDT, in their blood than healthy people, a team of researchers from Rutgers, Emory and UT Southwestern has found.
NIH/National Institute of Environmental Health Sciences, NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute on Aging

Contact: Quinn Eastman
qeastma@emory.edu
404-727-7829
Emory Health Sciences

Public Release: 27-Jan-2014
JAMA Internal Medicine
Health care savings: Reducing inappropriate antibiotic prescriptions
Despite widely accepted prescription guidelines, physicians continue to prescribe antibiotics for colds even when they won't help. A new study in JAMA Internal Medicine offers an inexpensive and seemingly simple "nudge" that reduced inappropriate antibiotic prescribing by nearly 20 percent.
NIH/National Institute on Aging

Contact: Suzanne Wu
suzanne.wu@usc.edu
213-740-0252
University of Southern California

Public Release: 27-Jan-2014
JAMA Neurology
Pesticide exposure linked to Alzheimer's disease
Researchers at Rutgers University say exposure to DDT -- banned in the United States since 1972 but still used as a pesticide in other countries -- may increase the risk and severity of Alzheimer's disease in some people, particularly those over the age of 60.
National Institutes of Health

Contact: Robin Lally
rlally@ucm.rutgers.edu
848-932-0557
Rutgers University

Public Release: 27-Jan-2014
Journal of Clinical Oncology
Yoga can lower fatigue, inflammation in breast cancer survivors
Practicing yoga for as little as three months can reduce fatigue and lower inflammation in breast cancer survivors, according to new research. The more the women in the study practiced yoga, the better their results.
NIH/National Cancer Institute

Contact: Emily Caldwell
caldwell.151@osu.edu
614-292-8310
Ohio State University

Public Release: 27-Jan-2014
Lancet Infectious Diseases
Scientists reveal cause of one of the most devastating pandemics in human history
An international team of scientists has discovered that two of the world's most devastating plagues -- the plague of Justinian and the Black Death, each responsible for killing as many as half the people in Europe -- were caused by distinct strains of the same pathogen, one that faded out on its own, the other leading to worldwide spread and re-emergence in the late 1800s. These findings suggest a new strain of plague could emerge again in humans in the future.
Social Sciences and Humanities Research Council of Canada, Canada Research Chairs Program, US Department of Homeland Security, National Institutes of Health, and Australian National Health and Medical Research Council

Contact: Michelle Donovan
donovam@mcmaster.ca
905-525-9140
McMaster University

Public Release: 27-Jan-2014
EMBO Journal
Cannabis during pregnancy endangers fetal brain development
A current study by an international consortium of researchers, including researchers from Karolinska Institutet in Sweden, shows that the consumption of Cannabis during pregnancy can impair the development of the fetus' brain with long-lasting effects after birth. Cannabis is particularly powerful to derail how nerve cells form connections, potentially limiting the amount of information the affected brain can process.
Swedish Research Council, Wellcome Trust, National Institutes of Health, and others

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet

Public Release: 27-Jan-2014
Proceedings of the National Academy of Sciences
Persistent HIV replication associated with lower drug concentrations in lymphatic tissues
Drugs used to treat HIV penetrate poorly into lymphatic tissues where most HIV replication takes place and there is persistent low-level virus replication in these tissues according to research from the University of Minnesota and University of Nebraska Medical Center.
National Institutes of Health

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center

Public Release: 27-Jan-2014
Journal of General Physiology
Protecting the skin from sun exposure
The ultraviolet radiation (UVR) present in sunlight is the most common environmental carcinogen. To develop better methods of protection from the sun, we need to understand how the human skin detects and responds to UVR. Researchers provide new insight into the molecular pathway underlying this process.
National Institutes of Health, National Science Foundation, Brown University

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

Public Release: 27-Jan-2014
Journal of General Physiology
A trigger for muscular diseases
Various muscular diseases are associated with changes in the elasticity of the protein titin, but whether these changes are a cause or an effect of disease has been unclear. Researchers help solve this "chicken or the egg" conundrum and identify a key player in determining titin's size and stiffness.
Bellows Foundation, Achievement Rewards for College Scientists Foundation, American Heart Association, National Institutes of Health

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

Public Release: 26-Jan-2014
Nature Biotechnology
Shortening guide RNA markedly improves specificity of CRISPR-Cas nucleases
A simple adjustment to a powerful gene-editing tool may be able to improve its specificity. Massachusetts General Hospital investigators have found that adjusting the length of the the guide RNA component of the synthetic enzymes called CRISPR-Cas RNA-guided nucleases can substantially reduce the occurrence of off-target DNA mutations.
National Institutes of Health

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital

Public Release: 26-Jan-2014
Nature Medicine
Cleveland Clinic researchers discover process that turns 'good cholesterol' bad
Cleveland Clinic researchers have discovered the process by which high-density lipoprotein -- the so-called "good cholesterol" -- becomes dysfunctional, loses its cardio-protective properties, and instead promotes inflammation and atherosclerosis, or the clogging and hardening of the arteries. Their research was published online today in the journal Nature Medicine.
National Institutes of Health

Contact: Laura Ambro
ambrol@ccf.org
216-636-5876
Cleveland Clinic

Showing releases 3276-3300 out of 3555.

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