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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 3276-3300 out of 3497.

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Public Release: 14-Nov-2013
NIH grant funds multi-center study of mysterious trauma-induced hemorrhaging
The Trans-Agency Consortium for Trauma-Induced Coagulopathy study is a cooperative effort funded by the National Heart, Lung and Blood Institute that establishes a unique collaboration between the NIH and the Department of Defense to study a deadly bleeding syndrome -- called coagulopathy -- that occurs without warning in some trauma patients.
National Institutes of Health

Contact: Jennifer Nachbur
University of Vermont

Public Release: 14-Nov-2013
Canadian Journal of Emergency Medicine
Where someone drowns determines their chance of survival, according to new research
Two new research studies show that location is the most important factor in determining drowning survival.
Heart and Stoke Canada, Canadian Institutes of Health Research, US National Institutes of Health, Lifesaving Society of Ontario

Contact: Geoff Koehler
416-864-6060 x6537
St. Michael's Hospital

Public Release: 14-Nov-2013
Molecule common in some cancers, rheumatoid arthritis leads to potential therapy for both
A molecule that helps cells stick together is significantly over-produced in two very different diseases -- rheumatoid arthritis and a variety of cancers, including breast and brain tumors, concludes a new study. The scientists who made the discovery also found candidate drugs to inhibit the molecule, cadherin-11, one of which is already in a clinical trial.
NIH/National Cancer Institute, US Department of Defense/Breast Cancer Research Program

Contact: Karen Mallet
Georgetown University Medical Center

Public Release: 14-Nov-2013
PLOS Genetics
Deciphering genetic echoes from the past: Illuminating human history
Historical records are often used to learn about ancestry but a new approach, using genetics, is currently being applied. In a recent study, published in PLOS Genetics, scientists from the Stanford University School of Medicine and the University of Miami Miller School of Medicine compared patterns of genetic variation found in populations in and around the Caribbean.
National Institutes of Health

Contact: Eden Martin

Public Release: 13-Nov-2013
Proceedings of the National Academy of Sciences
USC study reveals a protein that keeps people -- and their skeletons -- organized
Most people think that their planners or their iPhones keep them organized, when proteins such as liver kinase b1 actually have a lot more to do with it. New research from postdoctoral fellow Lick Lai in the lab of USC scientist Andy McMahon published in Proceedings of the National Academy of Sciences sheds light on how this important protein keeps people organized on a basic level by promoting orderly skeletal growth and preventing skeletal tumors.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Contact: Cristy Lytal
University of Southern California - Health Sciences

Public Release: 13-Nov-2013
Molecular Cell
Deletion of any single gene provokes mutations elsewhere in the genome
Johns Hopkins researchers report that the deletion of any single gene in yeast cells puts pressure on the organism's genome to compensate, leading to a mutation in another gene. Their discovery, which is likely applicable to human genetics because of the way DNA is conserved across species, could have significant consequences for the way genetic analysis is done in cancer and other areas of research, they say.
NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute of General Medical Sciences

Contact: Catherine Kolf
Johns Hopkins Medicine

Public Release: 13-Nov-2013
Experimental Biology and Medicine
Geranylgeraniol suppresses the viability of human prostate cancer cells and HMG CoA reductase
Geranylgeraniol may be a new weapon in the arsenal of mevalonate-suppressive isoprenoids with potential synergism in the fight against prostate cancer.
National Institutes of Health, Texas Woman's University/Research Enhancement Program

Contact: Huanbiao Mo
Society for Experimental Biology and Medicine

Public Release: 13-Nov-2013
Northeastern researchers have discovered a new treatment to cure MRSA infection
Recent work from Northeastern University Distinguished Professor of Biology Kim Lewis promises to overcome one of the leading public health threats of our time. In a groundbreaking study published Wednesday in the journal Nature, Lewis' team presents a novel approach to treat and eliminate methicillin resistant Staphylococcus aureus, or MRSA, a potent bacterium whose resistance to antibiotics has kept it one step ahead of researchers. That is, until now.
NIH/National Institute of Allergy and Infectious Diseases IAA, EMSL, US Department of Energy/BER

Contact: Kara Shemin
Northeastern University

Public Release: 13-Nov-2013
Diabetes Care
Intranasal insulin improves cognitive function in patients with type 2 diabetes
A research team led by investigators at Beth Israel Deaconess Medical Center finds that a single dose of intranasal insulin can improve cognitive function in patients with diabetes.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases, NIH/National Institute on Aging, Veterans Administration, China Scholarship Council

Contact: Bonnie Prescott
Beth Israel Deaconess Medical Center

Public Release: 13-Nov-2013
Critical Care Medicine
BUSM/BMC study shows decrease in sepsis mortality rates
A recent study from Boston University School of Medicine and Boston Medical Center shows a significant decrease in severe sepsis mortality rates over the past 20 years. Looking at data from patients with severe sepsis enrolled in clinical trials, researchers found that in-hospital mortality rates decreased from 47 percent between 1991 and 1995 to 29 percent between 2006 and 2009, a time period when no new pharmacological treatments were developed for severe sepsis.
NIH/National Heart, Lung, and Blood Institute

Contact: Jenny Eriksen
Boston University Medical Center

Public Release: 13-Nov-2013
Clinical Cancer Research
Finding antitumor T cells in a patient's own cancer
In a paper recently published in Clinical Cancer Research, investigators in the lab of Daniel Powell, Ph.D., at the Perelman School of Medicine, University of Pennsylvania, demonstrated for the first time that a T cell activation molecule can be used as a biomarker to identify rare antitumor T cells in human cancers. The molecule, CD137, is a protein that is not normally found on the surface of resting T cells but its expression is induced when the T cell is activated.
NIH/Nationcal Cancer Institute, Sandy Rollman Ovarian Cancer Foundation, Ovarian Cancer Research Fund

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 13-Nov-2013
JAMA Internal Medicine
Study finds few patients with newly-diagnosed hyperlipidemia receive recommended thyroid screening
Despite current guidelines that recommend newly diagnosed high-cholesterol patients have a TSH blood test done to make sure they do not have hypothyroidism, researchers from Boston University School of Medicine and Boston Medical Center have found that only about half of these patients were screened for thyroid dysfunction. The findings, which appear online in JAMA Internal Medicine, show the current guidelines may be underutilized.
National Institutes of Health

Contact: Gina DiGravio
Boston University Medical Center

Public Release: 13-Nov-2013
Compound stymies polyomaviruses in lab tests
There is no approved medicine to treat polyomaviruses, which afflict those with weakened immune systems, but scientists have found that a chemical compound called Retro-2 is able to significantly reduce the infectivity and spread of the viruses in lab cell cultures. Now they are working to improve it further.
National Institutes of Health, National Science Foundation, Johnson & Johnson

Contact: David Orenstein
Brown University

Public Release: 13-Nov-2013
Science Translational Medicine
Mystery explained: How a common chemo drug thwarts graft rejection in bone marrow transplants
Results of a Johns Hopkins study may explain why a chemotherapy drug called cyclophosphamide prevents graft-versus-host (GVHD) disease in people who receive bone marrow transplants. The experiments point to an immune system cell that evades the toxic effects of cyclophosphamide and protects patients from a lethal form of GVHD.
National Institutes of Health, NIH/National Cancer Institute, NIH/National Heart, Lung, and Blood Institute

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 13-Nov-2013
Science Translational Medicine
Novel gene therapy works to reverse heart failure
Researchers at the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai have successfully tested a powerful gene therapy, delivered directly into the heart, to reverse heart failure.
National Institutes of Health, NIH/National Heart, Lung, and Blood Institute

Contact: Lauren Woods
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 13-Nov-2013
IU cognitive scientists ID new mechanism at heart of early childhood learning and social behavior
An Indiana University study provides compelling evidence for a new and possibly dominant way for social partners to coordinate joint attention, key for parent-child communication and early language learning. The findings open up new questions about language learning and the teaching of language. They could also have major implications for the treatment of children with early social-communication impairment, such as autism, where joint caregiver-child attention with respect to objects and events is a key issue.
National Science Foundation, National Institutes of Health

Contact: Liz Rosdeitcher
Indiana University

Public Release: 13-Nov-2013
Journal of Hospital Medicine
Study finds widespread use of opioid medications in nonsurgical hospital patients
Amid a growing climate of concern regarding the overuse of opioid pain medications, a comprehensive analysis of more than 1 million hospital admissions has found that over 50 percent of all nonsurgical patients were prescribed opioids during their hospitalization -- often at very high doses -- and that more than half of those exposed were still receiving these medications on the day they were discharged from the hospital.
NIH/National Institute on Aging

Contact: Bonnie Prescott
Beth Israel Deaconess Medical Center

Public Release: 13-Nov-2013
Science Translational Medicine
Newly discovered mechanism suggests novel approach to prevent type 1 diabetes
New research led by Harvard School of Public Health demonstrates a disease mechanism in type 1 diabetes that can be targeted using simple, naturally occurring molecules to help prevent the disease. The work highlights a previously unrecognized molecular pathway that contributes to the malfunction of insulin-producing pancreatic beta cells in T1D in humans and mice, and shows that a chemical intervention can help beta cells function properly and survive.
Juvenile Diabetes Research Foundation, National Institutes of Health, European Union, Fonds National de la Recherche Scientifique, Schuylar

Contact: Marge Dwyer
Harvard School of Public Health

Public Release: 12-Nov-2013
Nucleic Acids Research
Researcher finds potential new use for old drugs
A class of drugs used to treat parasitic infections such as malaria may also be useful in treating cancers and immune-related diseases, a new WSU-led study has found. Researchers discovered that simple modifications to the drug furamidine have a major impact on its ability to affect specific human proteins involved in the on-off switches of certain genes.
National Institutes of Health

Contact: Gregory Poon
Washington State University

Public Release: 12-Nov-2013
Parental monitoring lowers odds of a gambling problem
Keeping an eye on your child can lower their odds for gambling by young adulthood. Adolescents who had poor parental supervision at age 11, and which continued to decline through age 14, were significantly more likely than their peers to be problem gamblers between ages 16-22. This is the first study to examine the relationship between parental monitoring during early adolescence and gambling behaviors in late adolescence and young adulthood.
NIH/National Institute of Child and Human Development

Contact: Stephanie Berger
Columbia University's Mailman School of Public Health

Public Release: 12-Nov-2013
NYU researchers find a new solution in detecting breast-cancer related lymphedem
Doctors struggle to detect and diagnose breast-cancer related Lymphedema -- a condition affecting the lymphatic system and causing psychosocial distress and physical challenges for patients.
Avon Foundation, National Institutes of Health

Contact: Christopher James
New York University

Public Release: 12-Nov-2013
Mayo Clinic: Researchers to study body's defense system to find new treatments for Alzheimer's
Researchers at Mayo Clinic in Florida, the University of Florida in Gainesville, and the Institute for Systems Biology in Seattle have received a $7.5 million grant from the National Institutes of Health to take a new and more expanded approach to identifying drug targets to treat and possibly prevent Alzheimer's disease.
National Institutes of Health

Contact: Kevin Punsky
Mayo Clinic

Public Release: 12-Nov-2013
Neuroscience 2013
Using morphine after abdominal surgery may prolong pain, CU-Boulder researchers find
Using morphine to fight the pain associated with abdominal surgery may paradoxically prolong a patient's suffering, doubling or even tripling the amount of time it takes to recover from the surgical pain, according to researchers at the University of Colorado Boulder.
National Institutes of Health

Contact: Peter Grace
University of Colorado at Boulder

Public Release: 12-Nov-2013
EMBO Journal
Wayne State researchers discover specific inhibitor for rheumatoid arthritis treatment
Researchers from Wayne State University and Northwestern University have contributed to an important discovery in the inflammatory stress mechanism and specific inhibitor for the treatment of rheumatoid arthritis.
National Institutes of Health, American Heart Association

Contact: Julie O'Connor
Wayne State University - Office of the Vice President for Research

Public Release: 12-Nov-2013
Johns Hopkins research may improve early detection of dementia
Using scores obtained from cognitive tests, Johns Hopkins researchers think they have developed a model that could help determine whether memory loss in older adults is benign or a stop on the way to Alzheimer's disease.
NIH/National Institute of Mental Health

Contact: Stephanie Desmon
Johns Hopkins Medicine

Showing releases 3276-3300 out of 3497.

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