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Department of Health and Human Services

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Key: Meeting M      Journal J      Funder F

Showing releases 3301-3325 out of 3425.

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Public Release: 15-Aug-2013
Cell
Scripps Research Institute scientists reveal how deadly Ebola virus assembles
Scientists at The Scripps Research Institute have discovered the molecular mechanism by which the deadly Ebola virus assembles, providing potential new drug targets. Surprisingly, the study showed that the same molecule that assembles and releases new viruses also rearranges itself into different shapes, with each shape controlling a different step of the virus's life cycle.
Burroughs Welcome Fund, Skaggs Institute of Chemical Biology, NIH/National Institute of Allergy and Infectious Diseases, and others

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute

Public Release: 15-Aug-2013
Science
The pathway to asthma winds through toll-like receptor 4
In a report that appears online in the journal Science, Dr. David Corry of Baylor College of Medicine and colleagues describe a molecule called toll-like receptor 4 that plays a key role in prompting the innate or immediate response that drives allergic disease and asthma.
National Institutes of Health, C.N. and Mary V. Papadopoulos Charitable Fund

Contact: Dipali Pathak
pathak@bcm.edu
713-798-6826
Baylor College of Medicine

Public Release: 15-Aug-2013
Disease Models & Mechanisms
The first animal model for sexual transmission of HIV
Despite the availability of many animal models of HIV infection, none reproduce the physiological conditions of vaginal intercourse, which is the most common route of HIV transmission. Led by Mary Jane Potash from St. Luke's-Roosevelt Hospital Center and Columbia University Medical Center, a team of researchers describes an approach for transmission of HIV during mouse mating. Their system provides a platform for investigating how the physiological environment during intercourse influences the rate of HIV transmission, and for testing potential therapies.
National INstitutes of Health, CONRAD, Eastern Virginia Medical School/Cooperative Agreement

Contact: Paraminder Dhillon
paraminder.dhillon@biologists.com
The Company of Biologists

Public Release: 15-Aug-2013
Journal of Clinical Investigation
A molecule involved in development of chronic obstructive pulmonary disease
In the current issue of the Journal of Clinical Investigation, Michael Holtzman and colleagues at the Washington University School of Medicine report that expression of an inflammatory molecule, interleukin-33, is increased in the airways of both a mouse model of viral-induced COPD and humans with COPD.
National Institutes of Health, ATS/COPD Foundation, Children's Discovery Institute, Martin Schaeffer Fund

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 15-Aug-2013
Journal of Clinical Investigation
Biomarkers predict time to ovarian cancer recurrence
In this issue of the Journal of Clinical Investigation, Roel Verchaak and colleagues at the MD Anderson Cancer Center identify protein biomarkers that are predictive for time of ovarian cancer recurrence and develop a PRotein-driven index of OVARian cancer.
NIH/National Cancer Institue, National Institutes of Health

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 14-Aug-2013
Preterm babies at risk for later cognitive difficulties
Researchers at the University of California, San Diego have received a five-year, $3 million grant from the Eunice Kennedy Shriver Institute of Child Health and Human Development, part of the National Institutes of Health. The grant will fund a longitudinal study designed to track the developmental trajectory in cognitive, academic and brain measures as very preterm children transition from preschool to grade school. Results will provide the foundation for designing appropriate learning interventions.
National Institutes of Health

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 14-Aug-2013
UCLA Dentistry receives $5 million to study extracellular RNA in saliva
UCLA School of Dentistry receives $5 million from the National Institutes for Health to study biological markers in saliva to attempt to develop a tool for detecting stomach cancer. The study has the potential to create a new paradigm in the field of salivary diagnostics, and it could yield a new method in the detection of life-threatening diseases, including diabetes and cancers of the pancreas, breasts, ovaries and stomach.
National Institutes of Health

Contact: Brianna Deane
bdeane@dentistry.ucla.edu
310-206-0835
University of California - Los Angeles

Public Release: 14-Aug-2013
Proceedings of the National Academy of Sciences
How neurons get wired
University of Arizona scientists have discovered an unknown mechanism that establishes polarity in developing nerve cells. Understanding how nerve cells make connections is an important step in developing cures for nerve damage resulting from spinal cord injuries or neurodegenerative diseases such as Alzheimer's.
National Institutes of Health, Achievement Rewards for College Scientists Foundation, Inc.

Contact: Daniel Stolte
stolte@email.arizona.edu
520-626-4402
University of Arizona

Public Release: 14-Aug-2013
ACS Nano
UGA researchers use nanoparticles to fight cancer
Researchers at the University of Georgia are developing a new treatment technique that uses nanoparticles to reprogram immune cells so they are able to recognize and attack cancer. The findings were published recently in the early online edition of ACS Nano.
National Institutes of Health

Contact: Shanta Dhar
shanta@uga.edu
706-542-1012
University of Georgia

Public Release: 14-Aug-2013
$3.5m NIH grants awarded to SDSU researchers to study fruit flies, gain insight into human health
Sanford Bernstein spends most of his time in the company of fruit flies, but not without good reason. The San Diego State University distinguished professor of biology has been studying fruit flies for more than 30 years, using the tiny insects as test models to uncover new treatments for human muscle and cardiac diseases.
National Institutes of Health, Muscular Dystrophy Association, American Heart Association

Contact: Natalia Van Stralen
Natalia.vanstralen@mail.sdsu.edu
619-594-2585
San Diego State University

Public Release: 14-Aug-2013
Proceedings of the National Academy of Sciences
Rice U. biophysicists zoom in on pore-forming toxin
A new study by Rice University biophysicists offers the most comprehensive picture yet of the molecular-level action of melittin, the major toxin in bee venom. The research could aid in the development of new drugs that use a similar mechanism as melittin's to attack cancer and bacteria. The study appears this week in the Proceedings of the National Academy of Sciences.
National Institutes of Health, Welch Foundation, Taiwan National Science Council

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University

Public Release: 14-Aug-2013
Journal for Medicinal Chemistry
Neutron studies of HIV inhibitors reveal new areas for improvement
The first study of interactions between a common clinical inhibitor and the HIV-1 protease enzyme has been carried out by an international team with members from the US, Britain and France using neutrons at the Institut Laue-Langevin in Grenoble, France.
National Institutes of Health

Contact: Jenny Chapman
jenny@proofcommunication.com
Georgia State University

Public Release: 14-Aug-2013
Journal of Parenteral and Enteral Nutrition
6 months of fish oil reverses liver disease in children with intestinal failure, study shows
A clinical trial conducted at the Children's Discovery and Innovation Institute at Mattel Children's Hospital UCLA has found that, compared with soybean oil, a limited duration (24 weeks) of fish oil is safe and effective in reversing liver disease in children with intestinal failure who require intravenous nutrition. The researchers believe that fish oil may also decrease the need for liver and/or intestinal transplants -- and mortality -- associated with this disease.
National Institutes of Health

Contact: Amy Albin
aalbin@mednet.ucla.edu
310-794-8672
University of California - Los Angeles Health Sciences

Public Release: 14-Aug-2013
Nature
Targeting aggressive prostate cancer
A team of researchers from UC Davis, UC San Diego and other institutions has identified a key mechanism behind aggressive prostate cancer.
National Institutes of Health, US Department of Defense

Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System

Public Release: 14-Aug-2013
Breast Cancer Research and Treatment
Growing use of MRIs leading to more invasive breast cancer surgery
Heavy use of magnetic resonance imaging may be leading to unnecessary breast removal in older women with breast cancer, according to a study by Yale School of Medicine researchers in the current issue of Breast Cancer Research and Treatment.
NIH/National Cancer Institute, Yale Comprehensive Cancer Center

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University

Public Release: 14-Aug-2013
New England Journal of Medicine
Finasteride saves men from prostate cancer, doesn't increase risk of death
A long-term follow-up to a groundbreaking study led by the director of the Cancer Therapy & Research Center confirms that a drug shown to reduce risk of prostate cancer by more than a third has no impact on lifespan but further reduces the risk of prostate cancer.
NIH/National Cancer Institute

Contact: Elizabeth Allen
allenea@uthscsa.edu
210-450-2020
University of Texas Health Science Center at San Antonio

Public Release: 14-Aug-2013
Cell Host & Microbe
CWRU dental researchers discover how an oral bacterium can trigger colorectal cancer
Researchers from Case Western Reserve University School of Dental Medicine have discovered how a common oral bacterium can contribute to colorectal cancer, a finding that opens promising new research avenues for the development of approaches to prevent and treat the disease.
NIH/National Institute of Dental and Craniofacial Research

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University

Public Release: 13-Aug-2013
American Journal of Hypertension
'Hyper-vigilance' about race linked to elevated blood pressure in black patients
Black patients preoccupied with racial concerns have higher blood pressure than those who aren't, according to results of new Johns Hopkins-led research. The findings suggest that heightened race consciousness could at least in part account for the disproportionately high rate of hypertension in black Americans -- the highest prevalence of any group in the United States and one of the highest rates in the world.
NIH/National Heart, Lung and Blood Institute

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine

Public Release: 13-Aug-2013
Urgent! How genes tell cellular construction crews, 'Read me now!'
When egg and sperm combine, the new embryo bustles with activity. Its cells multiply so rapidly they largely ignore their DNA, other than to copy it and to read just a few essential genes. The embryonic cells mainly rely on molecular instructions placed in the egg by its mother in the form of RNA.
Stowers Institute for Medical Research, Pew Charitable Trust, NIH/New Innovator Award

Contact: Gina Kirchweger
gxk@stowers.org
816-806-1036
Stowers Institute for Medical Research

Public Release: 13-Aug-2013
University of Louisville Diabetes & Obesity Center wins second multimillion-dollar COBRE grant
A center created with a five-year National Institutes of Health grant at the University of Louisville in 2008 has won its second five-year grant. The NIH's National Institute of General Medical Sciences has awarded an $11.25 million "Center of Biomedical Research Excellence" grant to UofL's Diabetes and Obesity Center.
NIH/National Institute of General Medical Sciences

Contact: Jill Scoggins
jill.scoggins@louisville.edu
502-852-7461
University of Louisville

Public Release: 13-Aug-2013
Journal of Neuroscience
Newly discovered 'switch' plays dual role in memory formation
Researchers at Johns Hopkins have uncovered a protein switch that can either increase or decrease memory-building activity in brain cells, depending on the signals it detects. Its dual role means the protein is key to understanding the complex network of signals that shapes our brain's circuitry, the researchers say. A description of their discovery appears in the July 31 issue of the Journal of Neuroscience.
Howard Hughes Medical Institute, NIH/National Institute of Neurological Disorders and Stroke

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine

Public Release: 13-Aug-2013
Journal of Neuroscience
Brain scans may help diagnose dyslexia
MIT study shows that differences in a key language structure can be seen even before children start learning to read.
National Institutes of Health, Poitras Center for Affective Disorders Research, Ellison Medical Foundation & Halis Family Foundation

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology

Public Release: 13-Aug-2013
American Journal of Clinical Nutrition
DHA-enriched formula in infancy linked to positive cognitive outcomes in childhood
While the effect of long-chain polyunsaturated fatty acids in infant formula on children's cognitive development may not always be evident on standardized developmental tasks at 18 months, significant effects may emerge later on more specific or fine-grained tasks.
National Institutes of Health, Mead Johnson Nutrition

Contact: Karen Salisbury Henry
kahenry@ku.edu
785-864-0756
University of Kansas

Public Release: 13-Aug-2013
Nature Communications
Sugar is toxic to mice in 'safe' doses
When mice ate a diet of 25 percent extra sugar -- the mouse equivalent of a healthy human diet plus three cans of soda daily -- females died at twice the normal rate and males were a quarter less likely to hold territory and reproduce, according to a toxicity test developed at the University of Utah.
National Institutes of Health, National Science Foundation

Contact: Annalisa Purser
annalisa.purser@utah.edu
801-581-7295
University of Utah

Public Release: 13-Aug-2013
2013 American Sociological Association Annual Meeting
More siblings means less chance of divorce as adult
Growing up with siblings may provide some protection against divorce as an adult, a new nationwide study reveals.
NIH/National Institute of Child Health and Human Development

Contact: Jeff Grabmeier
grabmeier.1@osu.edu
614-292-8457
Ohio State University

Showing releases 3301-3325 out of 3425.

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