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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 3301-3325 out of 3799.

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Public Release: 19-Sep-2014
Mayo researchers reveal pathway that contributes to Alzheimer's disease
Researchers at Jacksonville's campus of Mayo Clinic have discovered a defect in a key cell-signaling pathway they say contributes to both overproduction of toxic protein in the brains of Alzheimer's disease patients as well as loss of communication between neurons -- both significant contributors to this type of dementia.
National Institutes of Health, Alzheimer's Association, Mayo Clinic

Contact: Kevin Punsky
Mayo Clinic

Public Release: 19-Sep-2014
Acta Crystallographica Section D
A refined approach to proteins at low resolution
Crystals of membrane proteins and protein complexes often diffract to low resolution owing to their intrinsic molecular flexibility, heterogeneity or the mosaic spread of micro-domains. At low resolution, the building and refinement of atomic models is a more challenging task. The deformable elastic network refinement method developed previously has been instrumental in the determination of several structures at low resolution. Here, DEN refinement is reviewed.
National Institutes of Health

Contact: IUCR Press Office
International Union of Crystallography

Public Release: 18-Sep-2014
American Journal of Physiology
Exercise boosts tumor-fighting ability of chemotherapy, Penn team finds
Study after study has proven it true: exercise is good for you. But new research from University of Pennsylvania scientists suggests that exercise may have an added benefit for cancer patients undergoing chemotherapy. Their work, performed in a mouse model of melanoma, found that combining exercise with chemotherapy shrunk tumors more than chemotherapy alone.
National Institutes of Health

Contact: Katherine Unger Baillie
University of Pennsylvania

Public Release: 18-Sep-2014
Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies
A novel robot that can operate inside the bore of an MRI scanner is currently being tested as part of a biomedical research partnership program at Brigham and Women's Hospital in Boston with the aim of determining if the robot, in conjunction with real-time MRI images, can make prostate cancer biopsies faster, more accurate, less costly, and less discomforting. The system also has the potential to deliver prostate cancer therapies with greater precision.
National Institutes of Health

Contact: Michael Cohen
Worcester Polytechnic Institute

Public Release: 18-Sep-2014
Nature Neuroscience
No sedative necessary: Scientists discover new 'sleep node' in the brain
A sleep-promoting circuit located deep in the primitive brainstem has revealed how we fall into deep sleep. Discovered by researchers at Harvard School of Medicine and the University at Buffalo School of Medicine and Biomedical Sciences, this is only the second 'sleep node' identified in the mammalian brain whose activity appears to be both necessary and sufficient to produce deep sleep.
National Institutes of Health

Contact: Ellen Goldbaum
University at Buffalo

Public Release: 18-Sep-2014
Nature Communications
Sensing neuronal activity with light
For years, neuroscientists have been trying to develop tools that would allow them to clearly view the brain's circuitry in action -- from the first moment a neuron fires to the resulting behavior in an organism. To get this complete picture, neuroscientists are working to develop a range of new tools to study the brain. Researchers at Caltech have developed one such tool that provides a new way of mapping neural networks in a living organism.
National Institutes of Health, NIH/National Institute of Neurological Disorders, Beckman Institute, Gordon and Betty Moore Foundation, US Army Research Office, Shurl and Kay Curci Foundation, Life Sciences Research Foundation

Contact: Deborah Williams-Hedges
California Institute of Technology

Public Release: 18-Sep-2014
New insights on an ancient plague could improve treatments for infections
Dangerous new pathogens such as the Ebola virus invoke scary scenarios of deadly epidemics, but even ancient scourges such as the bubonic plague are still providing researchers with new insights on how the body responds to infections. In a study published online Sept. 18, 2014, in the journal Immunity, researchers at Duke Medicine and Duke-NUS Graduate Medical School Singapore detail how the bacteria that cause bubonic plague hitchhike on immune cells in the lymph nodes and ride into the lungs and the blood stream
National Institutes of Health

Contact: Sarah Avery
Duke University Medical Center

Public Release: 18-Sep-2014
LA BioMed receives NIH grant to study vaccine for hospital-acquired infections
NIH awarded grant to LA BioMed to aid in the research and development of a vaccine to protect patients from the healthcare-related infections, Candida and MRSA.
NIH/National Institute of Allergy and Infectious Diseases

Contact: Laura Mecoy
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)

Public Release: 18-Sep-2014
Down syndrome helps researchers understand Alzheimer's disease
The link between a protein typically associated with Alzheimer's disease and its impact on memory and cognition may not be as clear as once thought, according to a new study from the University of Wisconsin-Madison's Waisman Center. The researchers looked at the role of the brain protein amyloid-β in adults living with Down syndrome, a genetic condition that leaves people more susceptible to developing Alzheimer's.
NIH/National Institute of Aging

Contact: Sigan Hartley
University of Wisconsin-Madison

Public Release: 18-Sep-2014
LSU Health research discovers means to free immune system to destroy cancer
LSU Health New Orleans research has identified the crucial role an inflammatory protein known as Chop plays in the body's ability to fight cancer. Results demonstrate, for the first time, that Chop regulates the activity and accumulation of cells that suppress immune response against tumors. With Chop removed, the T-cells of the immune system mounted an effective attack on the cancer cells, revealing a new target for the development of immunotherapies to treat cancer.
National Institutes of Health

Contact: Leslie Capo
Louisiana State University Health Sciences Center

Public Release: 18-Sep-2014
Clinical Cancer Research
Curcumin, special peptides boost cancer-blocking PIAS3 to neutralize STAT3 in mesothelioma
A common Asian spice and cancer-hampering molecules show promise in slowing the progression of mesothelioma, a cancer of the lung's lining often linked to asbestos. Scientists from Case Western Reserve University and the Georg-Speyer-Haus in Frankfurt, Germany, demonstrate that application of curcumin, a derivative of the spice turmeric, and cancer-inhibiting peptides increase levels of a protein inhibitor known to combat the progression of this cancer. Their findings appear in Clinical Cancer Research.
Centers for Disease Control and Prevention, National Institutes of Health

Contact: Jeannette Spalding
Case Western Reserve University

Public Release: 18-Sep-2014
Journal of the National Cancer Institute
Melanoma risk found to have genetic determinant
A leading Dartmouth researcher, working with The Melanoma Genetics Consortium, GenoMEL, co-authored a paper published today in the Journal of the National Cancer Institute that proves longer telomeres increase the risk of melanoma.
Cancer Research UK, National Institutes of Health

Contact: Robin Dutcher
The Geisel School of Medicine at Dartmouth

Public Release: 18-Sep-2014
Living in a disadvantaged neighborhood worsens musculoskeletal pain outcomes after trauma
People living in lower-income neighborhoods have worse musculoskeletal pain outcomes over time after stressful events such as motor vehicle collisions than people from higher-income neighborhoods, a new study finds.
National Institutes of Health

Contact: Tom Hughes
University of North Carolina Health Care

Public Release: 18-Sep-2014
World breakthrough: A new molecule allows for an increase in stem cell transplants
Investigators from the Institute for Research in Immunology and Cancer at the Universite de Montreal have just published, in the prestigious magazine Science, the announcement of the discovery of a new molecule, the first of its kind, which allows for the multiplication of stem cells in a unit of cord blood.
Canada's Stem Cell Network, IRICor, Reseau de therapie cellulaire et tissulaire, Fonds de recherche du Quebec -- Sante, National Institutes of Health

Contact: Manon Pepin
University of Montreal

Public Release: 18-Sep-2014
Stem Cell Reports
NYU Langone scientists report reliable and highly efficient method for making stem cells
Scientists have found a way to boost dramatically the efficiency of the process for turning adult cells into so-called pluripotent stem cells by combining three well-known compounds, including vitamin C. Using the new technique in mice, the researchers increased the number of stem cells obtained from adult skin cells by more than 20-fold compared with the standard method.
Helen Kimmel Foundation, March of Dimes, NIH/National Institute of Child Health and Human Development, NIH/National Institute of General Medical Sciences

Contact: Jim Mandler
NYU Langone Medical Center / New York University School of Medicine

Public Release: 18-Sep-2014
Study shows how epigenetic memory is passed across generations
A growing body of evidence suggests that environmental stresses can cause changes in gene expression that are transmitted from parents to their offspring, making 'epigenetics' a hot topic. Epigenetic modifications do not affect the DNA sequence of genes, but change how the DNA is packaged and how genes are expressed. Now, scientists have shown how epigenetic memory can be passed across generations and from cell to cell during development.
National Institutes of Health, ARCS Foundation

Contact: Tim Stephens
University of California - Santa Cruz

Public Release: 18-Sep-2014
Scientists discover 'dimmer switch' for mood disorders
Researchers at University of California, San Diego School of Medicine have identified a control mechanism for an area of the brain that processes sensory and emotive information that humans experience as 'disappointment.'
National Institutes of Health

Contact: Scott LaFee
University of California - San Diego

Public Release: 18-Sep-2014
World population to keep growing this century, hit 11 billion by 2100
The chance that world population in 2100 will be between 9.6 billion and 12.3 billion people is 80 percent, according to the first such United Nations forecast to incorporate modern statistical tools.
National Institutes of Health

Contact: Hannah Hickey
University of Washington

Public Release: 18-Sep-2014
Gambling with confidence: Are you sure about that?
Confidence determines much of our path through life, but what is it? Most people would describe it as an emotion or a feeling. In contrast, scientists at CSHL have found that confidence is actually a measurable quantity, and not reserved just for humans. The team, led by CSHL Associate Professor Adam Kepecs, has identified a brain region in rats whose function is required to for the animals to express confidence in their decisions.
Klingenstein, Alfred P. Sloan Foundation, Whitehall Foundation, National Institutes of Health, Fundação para a Ciência e a Tecnologia

Contact: Jaclyn Jansen
Cold Spring Harbor Laboratory

Public Release: 17-Sep-2014
Cancer Research
New non-invasive technique could revolutionize the imaging of metastatic cancer
In preclinical animal models of metastatic prostate cancer, scientists at Virginia Commonwealth University Massey Cancer Center, VCU Institute of Molecular Medicine and Johns Hopkins Medical Institutions have provided proof-of-principle of a new molecular imaging approach that could revolutionize doctors' ability to see tumors that have metastasized to other sites in the body, including the bones.
NIH/National Cancer Institute, Prostate Cancer Foundation, Patrick C. Walsh Foundation, National Foundation for Cancer Research

Contact: John Wallace
Virginia Commonwealth University

Public Release: 17-Sep-2014
Journal of the Americal Chemical Society
Scripps Research Institute chemists modify antibiotic to vanquish resistant bacteria
Scientists at The Scripps Research Institute have devised a new antibiotic based on vancomycin that is powerfully effective against vancomycin-resistant strains of MRSA and other disease-causing bacteria.
National Institutes of Health

Contact: Madeline McCurry Schmidt
Scripps Research Institute

Public Release: 17-Sep-2014
Development and Psychopathology
Fighting parents hurt children's ability to recognize and regulate emotions
Exposure to verbal and physical aggression between parents may hurt a child's ability to identify and control emotions, according to a longitudinal study led by NYU's Steinhardt School of Culture, Education, and Human Development.
NIH/National Institute of Child Health and Human Development, NIH/National Institute on Drug Abuse

Contact: Rachel Harrison
New York University

Public Release: 17-Sep-2014
Nature Genetics
Large study reveals new genetic variants that raise risk for prostate cancer
In an analysis of genetic information among more than 87,000 men, a global team of scientists says it has found 23 new genetic variants -- common differences in the genetic code -- that increase a man's risk for prostate cancer. The so-called 'meta-analysis,' believed to be the largest of its kind, has revealed once hidden mutations among men in a broad array of ethnic groups comprising men of European, African, Japanese and Latino ancestry.
US Department of Defense, NIH/National Cancer Institute, Cancer Research UK, Prostate Cancer UK, EU, Patrick Henry, P. Kevin Jaffe, and Peter Jay Sharpe Foundation

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 17-Sep-2014
Proceedings of the National Academy of Sciences
Math model designed to replace invasive kidney biopsy for lupus patients
Mathematics might be able to reduce the need for invasive biopsies in patients suffering kidney damage related to the autoimmune disease lupus.
National Science Foundation, NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Contact: Avner Friedman
Ohio State University

Public Release: 17-Sep-2014
Basic and Applied Social Psychology
Lack of facial expression leads to perceptions of unhappiness, new OSU research shows
People with facial paralysis are perceived as being less happy simply because they can't communicate in the universal language of facial expression, a new study from an Oregon State University psychology professor shows.
National Institutes of Health

Contact: Kathleen Bogart
Oregon State University

Showing releases 3301-3325 out of 3799.

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