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Department of Health and Human Services

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Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 3326-3350 out of 3690.

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Public Release: 12-Jun-2014
Delinquent youth -- especially girls -- more likely to die violently as adults
Delinquency in youth predicts a significantly higher rate of violent death in adulthood -- nearly twice the rate of combat troops in wartime Iraq and Afghanistan. Delinquent females -- among the most vulnerable -- died violently at nearly five times the rate of those in the general population, while delinquent males died at three times the rate. This is the first large-scale study to look at death rates in delinquent females and adds new data on Hispanics.
National Institutes of Health, Office of Juvenile Justice and Delinquency Prevention

Contact: Marla Paul
Northwestern University

Public Release: 12-Jun-2014
Current Biology
Protein anchors help keep embryonic development 'just right'
It's been known that specific proteins, called histones, must exist within a certain range -- if there are too few, a fruit fly's DNA is damaged; if there are too many, the cell dies. Now research out of the University of Rochester shows that different types of histone proteins also need to exist in specific proportions. The work further shows that cellular storage facilities keep over-produced histones in reserve until they are needed.
National Institutes of Health

Contact: Peter Iglinski
University of Rochester

Public Release: 12-Jun-2014
Journal of Neuroscience
Findings point toward one of first therapies for Lou Gehrig's disease
Researchers have determined that a copper compound known for decades may form the basis for a therapy for amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. In humans, prior to this, no therapy for ALS has ever been discovered that could extend lifespan more than a few additional months.
National Institutes of Health, Linus Pauling Institute, Australian National Health and Medical Research Council

Contact: Joseph Beckman
Oregon State University

Public Release: 12-Jun-2014
Neurogastroenterology & Motility
Heart rate variability may predict risk of disease in premature infants
Measuring variability of heart rate may identify premature infants at risk of developing necrotizing enterocolitis, a serious inflammatory condition that can lead to death, according to Penn State College of Medicine researchers.
National Institutes of Health, Children's Miracle Network, Johnson & Johnson Health Behaviors, Quality of Life

Contact: Matt Solovey
Penn State

Public Release: 12-Jun-2014
When good people do bad things
MIT researchers find that being in a group makes some people lose touch with their personal moral beliefs.
NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development , Air Force Office of Scientific Research, Packard Foundation

Contact: Sarah McDonnell
Massachusetts Institute of Technology

Public Release: 12-Jun-2014
Journal of Immunology
Proliferation cues 'natural killer' cells for job change
Why would already abundant 'natural killer' cells proliferate even further after subduing an infection? It's been a biological mystery for 30 years. But now Brown University scientists have an answer: After proliferation, the cells switch from marshaling the immune response to calming it down. The findings illuminate the functions of a critical immune system cell important for early defense against disease induced by viral infection.
National Institutes of Health, U.S. Department of Education

Contact: David Orenstein
Brown University

Public Release: 12-Jun-2014
Synchronized brain waves enable rapid learning
The human mind can rapidly absorb and analyze new information as it flits from thought to thought. These quickly changing brain states may be encoded by synchronization of brain waves across different brain regions, according to a new study from MIT neuroscientists.
NIH/National Institute of Mental Health

Contact: Sarah McDonnell
Massachusetts Institute of Technology

Public Release: 12-Jun-2014
JAHA: Journal of the American Heart Association
Brain power
Columbia Engineering Professor Elizabeth M. C. Hillman has identified a new component of the biological mechanism that controls blood flow in the brain, demonstrating that the vascular endothelium plays a critical role in the regulation of blood flow in response to stimulation in the living brain. Understanding how and why the brain regulates its blood flow could provide important clues to understanding early brain development, disease, and aging.
NIH/National Institute of Neurological Disorders and Stroke

Contact: Holly Evarts
Columbia University School of Engineering and Applied Science

Public Release: 12-Jun-2014
Cancer Epidemiology, Biomarkers & Prevention
Childhood cancer survivors hospitalized frequently years after cancer treatment
Survivors of childhood cancers were hospitalized more often and for longer durations because of blood disorders and other problems, many years after cancer treatment was completed, compared with the general population, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
National Institutes of Health, Huntsman Cancer Foundation, Utah Cancer Registry, Primary Children's Medical Foundation Award

Contact: Lauren Riley
American Association for Cancer Research

Public Release: 12-Jun-2014
Viral infections, including flu, could be inhibited by naturally occurring protein
By boosting a protein that naturally exists in our cells, an international team of researchers led by the University of Pittsburgh Cancer Institute, partner with UPMC CancerCenter, has found a potential way to enhance our ability to sense and inhibit viral infections. The laboratory-based discovery, which could lead to more effective treatments for viruses ranging from hepatitis C to the flu, appears in the June 19 issue of the journal Immunity.
NIH/National Institute of Allergy and Infectious Diseases

Contact: Allison Hydzik
University of Pittsburgh Schools of the Health Sciences

Public Release: 12-Jun-2014
Cell Reports
Penn study describes new models for testing Parkinson's disease immune-based drugs
Using powerful, newly developed cell culture and mouse models of sporadic Parkinson's disease (PD), a team of researchers from the Perelman School of Medicine at the University of Pennsylvania, has demonstrated that immunotherapy with specifically targeted antibodies may block the development and spread of PD pathology in the brain.
NIH/National Institute on Aging, NIH/National Institute of Neurological Disorders and Stroke, Michael J. Fox Foundation, Keefer Family, Parkinson Council

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 12-Jun-2014
Broad Institute, MGH researchers chart cellular complexity of brain tumors
Scientists from the Broad Institute and Massachusetts General Hospital have conducted a first-of-its-kind study that characterizes the cellular diversity within glioblastoma tumors from patients. The study, which looked at the expression of thousands of genes in individual cells from patient tumors, revealed that the cellular makeup of each tumor is more heterogeneous than previously suspected. The findings, which appear online in Science Express, will help guide future investigations into potential treatments for this devastating disease.
Klarman Family Foundation, National Institutes of Health, Howard Hughes Medical Institute, and others

Contact: Haley Bridger
Broad Institute of MIT and Harvard

Public Release: 12-Jun-2014
Cancer drug boosts levels of vascular-protective gene, KLF2
Case Western Reserve University researchers have discovered that an existing, drug, bortezomib, Velcade, used to help cancer patients has the potential to protect thousands of others from the often-deadly impact of vascular clots. As hematologist Lalitha Nayak, M.D., an assistant professor of medicine, reports in the June 12 edition of the journal Blood, the anti-thrombotic effects of bortezomib are determined by KLF2, part of a family of Kruppel-like factors -- master regulators of vascular health.
National Institutes of Health

Contact: Jeannette Spalding
Case Western Reserve University

Public Release: 12-Jun-2014
Child Development
Toddlers whose parents use subsidies to buy center-based care more likely to enroll in Head Start
Using nationally representative data on approximately 2,100 children, a study by researchers from Georgetown University and Columbia University has found that children of parents who use subsidies to purchase center-based care in the toddler years are more likely to be enrolled in Head Start or public prekindergarten in their preschool years. The study highlights one previously unconsidered benefit of a federally funded subsidy program that serves nearly 2 million American children each month.
NIH/National Institute of Child Health and Human Development

Contact: Hannah Klein
Society for Research in Child Development

Public Release: 12-Jun-2014
Child Development
New study sheds light on what happens to 'cool' kids
A new study has found that teens who tried to act cool in early adolescence were more likely to experience a range of problems in early adulthood. Teens needed more and more extreme behaviors to appear cool, eventually engaging in serious criminal behaviors in addition to alcohol and drug use. By young adulthood, they were found to be less competent overall than their less 'cool' peers. Teens were followed from age 13 to age 23.
NIH/National Institute of Child Health and Human Development, NIH/National Institute of Mental Health

Contact: Hannah Klein
Society for Research in Child Development

Public Release: 11-Jun-2014
Fungal protein found to cross blood-brain barrier
In a remarkable series of experiments on a fungus that causes cryptococcal meningitis, a deadly infection of the membranes that cover the spinal cord and brain, investigators at UC Davis have isolated a protein that appears to be responsible for the fungus' ability to cross from the bloodstream into the brain.
National Institutes of Health

Contact: Carole Gan
University of California - Davis Health System

Public Release: 11-Jun-2014
Journal of Immunology
Infant immune systems learn fast, but have short memories
Forgetful immune systems leave infants particularly prone to infections, according to a new Cornell University study. Upending the common theory that weak immune cells are to blame, the study has found that infants' immune systems actually respond to infection with more speed and strength than adults, but the immunities they create fail to last.
National Institutes of Health, National Science Foundation

Contact: Melissa Osgood
Cornell University

Public Release: 11-Jun-2014
Cell Host & Microbe
A key step toward a safer strep vaccine
An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, have identified the genes encoding a molecule that famously defines Group A Streptococcus (strep), a pathogenic bacterial species responsible for more than 700 million infections worldwide each year.
National Institutes of Health

Contact: Scott LaFee
University of California - San Diego

Public Release: 11-Jun-2014
Breakthrough study sheds new light on best medication for children with seizures
A recently published clinical study in the Journal of the American Medical Association has answered an urgent question that long puzzled ER pediatricians: Is the drug lorazepam really safer and more effective than diazepam -- the US Food and Drug Administration-approved medication as first line therapy most often used by emergency room doctors to control major epileptic seizures in children?
NIH/National Institute of Child Health and Human Development

Contact: Julie O'Connor
Wayne State University - Office of the Vice President for Research

Public Release: 11-Jun-2014
Does dad matter? New study looks at his environmental exposure in reproductive success
Phthalates are compounds found in plastics and personal care products that are estimated to be detectable in nearly 100 percent of the U.S. population. The study will examine the possible influence of paternal phthalate exposure on sperm quality and embryo development and whether DNA methylation in sperm cells may be a pathway by which a father's exposure influences these endpoints.
National Institutes of Health

Contact: Janet Lathrop
University of Massachusetts at Amherst

Public Release: 11-Jun-2014
Migrating north may trigger immediate health declines among Mexicans
Mexican immigrants who relocate to the United States are more likely to experience declines in health within a short time period compared with other Mexicans, according to a study led by Princeton University's Woodrow Wilson School of Public and International Affairs. Barriers faced by immigrants -- like poorly paying jobs, crowded housing and family separation, as well as the migration process itself -- may be cause of such health declines.
NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development, Sector Research Fund

Contact: B. Rose Huber
Princeton University, Woodrow Wilson School of Public and International Affairs

Public Release: 11-Jun-2014
Journal of Health and Social Behavior
Peer pressure is weaker for kids to quit smoking
Adolescents tend to be more powerful in influencing their friends to start smoking than in helping them to quit, according to sociologists.
NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development

Contact: Matt Swayne
Penn State

Public Release: 11-Jun-2014
Science Signaling
Researchers identify regulation process of protein linked to bipolar disorder
Researchers from Tufts have gained new insight into a protein associated with bipolar disorder. The study, published in the June 3 issue of Science Signaling, reveals that calcium channels in resting neurons activate the breakdown of Sp4, which belongs to a class of proteins called transcription factors that regulate gene expression.
NIH/National Institute of Child Health and Human Development, Canadian Institutes of Health Research, NIH/National Institute of Neurological Disorders and Stroke

Contact: Siobhan Gallagher
Tufts University, Health Sciences Campus

Public Release: 11-Jun-2014
Cell Host & Microbe
MGH/Ragon Institute study finds how protein blocks HIV life cycle in elite controllers
A research team has learned more about one way the immune systems of elite controllers - those rare individuals able to control HIV infection without drug treatment - block a key step in the virus's life cycle. They report finding that p21, a protein best known as a tumor suppressor, inhibits reverse transcription by blocking a human enzyme essential to the process.
National Institutes of Health, American Foundation for AIDS Research, Doris Duke Charitable Foundation

Contact: Sarah Dionne Sullivan
Massachusetts General Hospital

Public Release: 11-Jun-2014
Frontiers in Neurology
Study finds cognitive performance can be improved in teens months, years after traumatic brain injury
Traumatic brain injuries from sports, recreational activities, falls or car accidents are the leading cause of death and disability in children and adolescents. While previously it was believed that the window for brain recovery was at most one year after injury, new research from the Center for BrainHealth at The University of Texas at Dallas published online today in the open-access journal Frontiers in Neurology shows cognitive performance can be improved to significant degrees months, and even years, after injury, given targeted brain training.
NIH/National Institute of Child Health and Human Development, Crystal Charity Ball Foundation

Contact: Shelly Kirkland
Center for BrainHealth

Showing releases 3326-3350 out of 3690.

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