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Key: Meeting M      Journal J      Funder F

Showing releases 3351-3375 out of 3509.

<< < 130 | 131 | 132 | 133 | 134 | 135 | 136 | 137 | 138 | 139 > >>

Public Release: 10-Nov-2013
Nature Medicine
Hope for transplant patients as study finds key to organ scarring
Patients with damaged organs could be helped by new treatments after scientists have discovered how tissues scar. Researchers say that the finding could pave the way for new drugs and eventually reduce the number of patients on organ transplant waiting lists.
Wellcome Trust, Medical Research Council, National Institutes of Health

Contact: Eleanor Cowie
University of Edinburgh

Public Release: 10-Nov-2013
Nature Medicine
Research by Saint Louis University scientists offers way to disrupt fibrosis
Scientists have identified a pathway that regulates fibrosis, suggesting a possible pharmacologic approach to treat patients with a broad range of fibrotic diseases.
National Institutes of Health

Contact: Nancy Solomon
Saint Louis University

Public Release: 10-Nov-2013
Nature Biotechnology
Single-cell genome sequencing gets better
Researchers led by bioengineers at the University of California, San Diego have generated the most complete genome sequences from single E. coli cells and individual neurons from the human brain. Preliminary data suggest that individual neurons from the same brain have different genetic compositions. The breakthrough, published in Nature Biotechnology, comes from a new single-cell genome sequencing technique that confines genome amplification to fluid-filled wells with a volume of just 12 nanoliters.
National Institutes of Health, US National Science Foundation

Contact: Daniel Kane
University of California - San Diego

Public Release: 9-Nov-2013
Psychological Science
You want fries with that? Don't go there
A new Dartmouth neuroimaging study suggests chronic dieters overeat when the regions of their brain that balance impulsive behavior and self-control become disrupted, decreasing their capacity to resist temptation.
NIH/National Institute on Drug Abuse, NIH/National Heart, Lung, and Blood Institute

Contact: John Cramer
Dartmouth College

Public Release: 9-Nov-2013
ASN Kidney Week 2013
New England Journal of Medicine
Genetic variation increases risk of kidney disease progression in African-Americans
New research provides direct evidence that genetic variations in some African Americans with chronic kidney disease contribute to a more rapid decline in kidney function compared with white Americans. The research, led by investigators from the University of Maryland School of Medicine and Johns Hopkins University, may help explain, in part, why even after accounting for differences in socioeconomic background, end-stage kidney disease is twice as prevalent among blacks as whites.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Contact: Bill Seiler
University of Maryland Medical Center

Public Release: 9-Nov-2013
Neuroscience 2013
Simple dot test may help gauge the progression of dopamine loss in Parkinson's disease
Could figuring out how much dopamine a patient with Parkinson's disease has lost be as simple as completing a dot test? Researchers hope the easy task might lead to ways of improving clinical treatment of Parkinson's patients. "It is very difficult now to assess the extent of dopamine loss...," says lead author Katherine R. Gamble. "Use of this test may provide some help for physicians who treat people with Parkinson's disease..."
National Institutes of Health

Contact: Karen Mallet
Georgetown University Medical Center

Public Release: 8-Nov-2013
Proceedings of the National Academy of Sciences
New therapeutic target identified for ALS and frontotemporal degeneration
A team of scientists led by researchers from the University of California, San Diego School of Medicine and Ludwig Institute for Cancer Research have identified a novel therapeutic approach for the most frequent genetic cause of ALS, a disorder of the regions of the brain and spinal cord that control voluntary muscle movement, and frontal temporal degeneration, the second most frequent dementia.
National Institutes of Health, Target ALS, Amyotrophic Lateral Sclerosis Association

Contact: Debra Kain
University of California - San Diego

Public Release: 8-Nov-2013
Penn study identifies new trigger for breast cancer metastasis
For years, scientists have observed that tumor cells from certain breast cancer patients with aggressive forms of the disease contained low levels of mitochondrial DNA. But, until recently, no one was able to explain how this characteristic influenced disease progression. Now, University of Pennsylvania researchers have revealed how a reduction in mitochondrial DNA content leads human breast cancer cells to take on aggressive, metastatic properties.
National Institutes of Health, Harriet Ellison Woodward Trust

Contact: Katherine Unger Baillie
University of Pennsylvania

Public Release: 8-Nov-2013
Neuroscience 2013
Brain, Behavior and Immunity
In animal study, 'cold turkey' withdrawal from drugs triggers mental decline
Can quitting drugs without treatment trigger a decline in mental health? That appears to be the case in an animal model of morphine addiction. Georgetown University Medical Center researchers say their observations suggest that managing morphine withdrawal could promote a healthier mental state in people. The study will be presented at Neuroscience 2013, the annual meeting of the Society for Neuroscience.
NIH/National Institute on Drug Abuse

Contact: Karen Mallet
Georgetown University Medical Center

Public Release: 8-Nov-2013
Arthritis & Rheumatism
Mother's immunosuppressive medications not likely to put fetus at risk
Women with chronic autoimmune diseases who take immunosuppressive medications during their first trimester of pregnancy are not putting their babies at significantly increased risk of adverse outcomes, according to a Vanderbilt study released online by the journal Arthritis and Rheumatism.
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases, Agency for Healthcare Research and Quality, Food and Drug Administration

Contact: Craig Boerner
Vanderbilt University Medical Center

Public Release: 8-Nov-2013
Journal of Biological Chemistry
TGen-led study reveals TWEAK-Fn14 as key drug target
A cellular pathway interaction known as TWEAK-Fn14, often associated with repair of acute injuries, also is a viable target for drug therapy that could prevent the spread of cancer, especially brain cancer, according to a study led by the Translational Genomics Research Institute.
Ben and Catherine Ivy Foundation, NIH/National Cancer Institute

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Public Release: 8-Nov-2013
Development and Psychopathology
Depression therapy effective for poor, minority moms
Faced with the dual demands of motherhood and poverty, as many as one-fourth of low-income minority mothers struggle with major depression. Now a new study shows that screening for the disorder and providing short-term, relationship-focused therapy through weekly home visits can relieve depression among minority mothers, even in the face of poverty and personal histories of abuse or violence.
NIH/National Institute of Mental Health

Contact: Susan Hagen
University of Rochester

Public Release: 8-Nov-2013
ASN Kidney Week 2013
New England Journal of Medicine
Repurposed drug may be first targeted treatment for serious kidney disease
A team led by Massachusetts General Hospital researchers is reporting that treatment with abatacept appeared to halt the course of focal segmental glomerulosclerosis in five patients, preventing four from losing transplanted kidneys and achieving disease remission in the fifth.
National Institutes of Health, Boston Area Diabetes Endocrinology Research Center, American Society for Nephrology

Contact: Mike Morrison
Massachusetts General Hospital

Public Release: 8-Nov-2013
Nature Communications
Edited RNA + invasive DNA add individuality
A study in Nature Communications finds that an enzyme that edits RNA may loosen the genome's control over invasive snippets of DNA that affect how genes are expressed. In fruit flies, that newly understood mechanism appears to contribute to differences among individuals such as eye color and life span.
NIH/National Institute on Aging, Ellison Medical Foundation

Contact: David Orenstein
Brown University

Public Release: 8-Nov-2013
Journal of Clinical Investigation
Researchers identify a histone demethylase associated with non-small cell lung cancer
In this issue of the Journal of Clinical Investigation, MinGyu Lee and colleagues at MD Anderson Cancer Center evaluated histone methylation modifications in NSCLS cell lines and determined that the histone demethylase KDM2A was upregulated in NSCLC cell lines.
National Institutes of Health, Center for Cancer Epigenetics at the UT MD Anderson Cancer Center

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 8-Nov-2013
Journal of Clinical Investigation
Ion channel inhibition limits injury-induced loss of kidney filtration
In this issue of the Journal of Clinical Investigation, Anna Greka and colleagues at Massachusetts General Hospital determined that mice lacking the ion channel TRPC5 were protected from losing kidney filter function following kidney injury.
National Institutes of Health, Boehringer Ingelheim Fonds, Swedish Research Council, Swedish Governmental Agency

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 8-Nov-2013
Journal of Clinical Investigation
JCI early table of contents for Nov. 8, 2013
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Nov., 8, 2013, in the JCI: Ion channel inhibition limits injury-induced loss of kidney filtration, Researchers identify a histone demethylase associated with non-small cell lung cancer,Antibodies against low-density lipoprotein receptor–related protein 4 induce myasthenia gravis, Inhibition of Coxsackievirus-associated dystrophin cleavage prevents cardiomyopathy, Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma, and more.
National Institutes of Health, Spanish Ministry of Economy, BBVA Foundation, European Research Council, Flight Attendant Medical Research Institute

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 7-Nov-2013
OHSU Vollum Institute research gives new insight into how antidepressants work in the brain
Research from Oregon Health & Science University's Vollum Institute, published in the current issue of Nature, is giving scientists a never-before-seen view of how nerve cells communicate with each other. That new view can give scientists a better understanding of how antidepressants work in the human brain -- and could lead to the development of better antidepressants with few or no side effects.
American Heart Association, NIH/National Institute of Mental Health, and others

Contact: Todd Murphy
Oregon Health & Science University

Public Release: 7-Nov-2013
PLOS Genetics
Dartmouth researcher finds novel genetic patterns that make us rethink biology and individuality
Scott Williams, Ph.D., of the iQBS at Dartmouth, has made two novel discoveries: 1) a person can have several DNA mutations in parts of their body, with their original DNA in the rest -- resulting in several different genotypes in one individual -- and 2) some of the same genetic mutations occur in unrelated people. We think of each person's DNA as unique, but if a person can have more than one genotype, this may have broad implications.
National Institutes of Health

Contact: Derik Hertel
The Geisel School of Medicine at Dartmouth

Public Release: 7-Nov-2013
UT Southwestern researchers identify how body clock affects inflammation
UT Southwestern Medical Center researchers report that disrupting the light-dark cycle of mice increased their susceptibility to inflammatory disease, indicating that the production of a key immune cell is controlled by the body's circadian clock.
National Institutes of Health, Burroughs Wellcome Foundation, Howard Hughes Medical Institute

Contact: Deborah Wormser
UT Southwestern Medical Center

Public Release: 7-Nov-2013
Molecular Cell
Unique change in protein structure guides production of RNA from DNA
One of biology's most fundamental processes is transcription. It is just one step of many required to build proteins -- and without it life would not exist. However, many aspects of transcription remain shrouded in mystery. But now, scientists at the Gladstone Institutes are shedding light on key aspects of transcription, and in so doing are coming even closer to understanding the importance of this process in the growth and development of cells -- as well as what happens when this process goes awry.
National Institutes of Health, NIH/National Institute of Environmental Health Sciences

Contact: Anne Holden
Gladstone Institutes

Public Release: 7-Nov-2013
Nature Biotechnology
Cost-effective method accurately orders DNA sequencing along entire chromosomes
A new computational method has been shown to quickly assign, order and orient DNA sequencing information along entire chromosomes. The method may help overcome a major obstacle that has delayed progress in designing rapid, low-cost -- but still accurate -- ways to assemble genomes from scratch. Data gleaned through this new method can also validate certain types of chromosomal abnormalities in cancer.
National Institutes of Health, NIH/National Human Genome Research Institute, National Science Foundation

Contact: Leila Gray
University of Washington

Public Release: 7-Nov-2013
Journal of Alzheimer's Disease
New method predicts time from Alzheimer's onset to nursing home, death
A Columbia University Medical Center-led research team has clinically validated a new method for predicting time to nursing home residence or death for patients with Alzheimer's. The method uses data from a single patient visit, and is based on a complex model of Alzheimer's progression developed by consecutively following two sets of Alzheimer's patients for 10 years each.
NIH/National Institute on Aging

Contact: Elizabeth Streich
Columbia University Medical Center

Public Release: 7-Nov-2013
Hope builds for a drug that might shut down a variety of cancers
The most frequently mutated gene across all types of cancers is a gene called p53. Unfortunately it has been difficult to directly target this gene with drugs. Now a multi-institutional research team, led by Dr. Lewis Cantley and investigators at Weill Cornell Medical College, has identified a family of enzymes they say is crucial for the growth of cancers that have genetic aberrations in p53.
National Institutes of Health, Stand Up to Cancer Dream Team Translational Research Grant, Program of the Entertainment Industry

Contact: Sarah Smith
Weill Cornell Medical College

Public Release: 7-Nov-2013
NIH funds researchers using light to control and monitor neural activity
Samarendra Mohanty, assistant professor of physics at The University of Texas at Arlington, expects to receive a total of $384,269 over the next two years from the NIH's National Institute of Neurological Disorders and Stroke. His work involves using a near-infrared ultrafast laser beam to deliver genes that allow expression of light-sensitive proteins, called opsins, in specific cells. That proteins' expression allows researchers to influence neural activity through optical or light stimulation -- a technique known as optogenetics.
National Institutes of Health

Contact: Traci Peterson
University of Texas at Arlington

Showing releases 3351-3375 out of 3509.

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