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Department of Health and Human Services

News from the National Institutes of Health

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Key: Meeting M      Journal J      Funder F

Showing releases 3351-3375 out of 3702.

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Public Release: 10-Nov-2014
Thousands of never-before-seen human genome variations uncovered
Thousands of never-before-seen genetic variants in the human genome have been uncovered using a new genome sequencing technology. These discoveries close many human genome mapping gaps that have long resisted sequencing. The technique, called single-molecule, real-time DNA sequencing, may now make it possible for researchers to identify potential genetic mutations behind many conditions whose genetic causes have long eluded scientists.
National Institutes of Health, NIH/National Institute of Neurological Disorders and Stroke, Howard Hughes Medical Institute

Contact: Michael McCarthy
University of Washington Health Sciences/UW Medicine

Public Release: 10-Nov-2014
Cancer Discovery
Mayo Clinic researchers identify first steps in formation of pancreatic cancer
Researchers at Mayo Clinic's campus in Jacksonville say they have identified first steps in the origin of pancreatic cancer and that their findings suggest preventive strategies to explore.
National Institutes of Health

Contact: Kevin Punsky
Mayo Clinic

Public Release: 10-Nov-2014
Nature Genetics
Re-learning how to read a genome
There are roughly 20,000 genes and thousands of other regulatory 'elements' stored within our DNA. Somehow all of this coded information needs to be read and transcribed into messages that can be used by cells. New research has revealed that the initial steps of the reading process are actually remarkably similar at both genes and regulatory elements. The main differences seem to occur after the initial step, in the length and stability of the messages.
National Institutes of Health

Contact: Jaclyn Jansen
Cold Spring Harbor Laboratory

Public Release: 10-Nov-2014
Nature Neuroscience
Some neurons can multitask, raising questions about the importance of specialization
The brain is constantly processing sensory information while supporting a dizzying array of behaviors. For decades, biologists have assumed that specialized classes of neurons process all this information at once. But a team of scientists at CSHL has found a population of neurons in the rat brain that support multiple behaviors at once. These neurons cannot be individually classified by specialization, challenging assumptions about how information is encoded in the brain.
National Institutes of Health, John Merck Fund, McKnight Foundation, Marie Robertson Memorial Fund of Cold Spring Harbor Laboratory, Swartz Foundation Fellowship

Contact: Jaclyn Jansen
Cold Spring Harbor Laboratory

Public Release: 10-Nov-2014
Catalyst-where-you-want-it method expands the possibilities for new drug development
Chemists at The Scripps Research Institute and the Shanghai Institute of Organic Chemistry have described a method for creating and modifying organic compounds that overcomes a major limitation of previous methods.
Chinese Academy of Sciences, NIH/National Institute of General Medical Sciences

Contact: Madeline McCurry-Schmidt
Scripps Research Institute

Public Release: 10-Nov-2014
JAMA Pediatrics
Overall risk of birth defects appears low for women taking antiretrovirals during early pregnancy
Among pregnant women infected with HIV, the use of antiretroviral medications early in pregnancy to treat their HIV or to prevent mother-to-child transmission of HIV does not appear to increase the risk of birth defects in their infants, according to a new study led by Harvard School of Public Health.
NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development,NIH/National Institute on Drug Abuse, NIH/National Institute of Allergy and Infectious Diseases, NIH/National Institute of Mental Health, and others

Contact: Marge Dwyer
Harvard School of Public Health

Public Release: 10-Nov-2014
Journal of Clinical Investigation
Tumor-associated neutrophils boost anti-tumor immune responses
A new study in the Journal of Clinical Investigation suggests that tumor-associated neutraphils help bolster the immune response against lung tumors.
National Institutes of Health, Janssen Pharmaceuticals, Lung Cancer Translation Center of Excellence of the Abramson Cancer Center at the University of Pennsylvania

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 10-Nov-2014
Journal of Clinical Investigation
Cervical component protects against infection and preterm birth in mice
A new study in the Journal of Clinical Investigation demonstrates that the cervical component hyaluronan provides protection against infection-induced preterm birth.
National Institutes of Health

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 10-Nov-2014
Cancer Cell
Classification of gene mutations in a children's cancer may point to improved treatments
Oncology researchers studying gene mutations in the children's cancer neuroblastoma are refining their diagnostic tools to predict which patients are more likely to respond to drugs called ALK inhibitors that target such mutations.
National Institutes of Health, US Army Peer-Reviewed Medical Research Program, National Science Foundation

Contact: Rachel Salis-Silverman
Children's Hospital of Philadelphia

Public Release: 10-Nov-2014
Proceedings of the National Academy of Sciences
How cartilage cells sense forceful injury
Duke scientists are closer to understanding how cartilage senses injury-causing mechanical strain at the cellular level: a pair of channels that work together to cause cartilage cells to die off in droves. Using a substance found in tarantula venom to block these channels, the researchers have prevented cell death caused when cartilage cells detect mechanical strain. The findings could lead to drug targets for protecting joints and preventing the pain associated with cartilage injuries.
National Institutes of Health

Contact: Karl Bates
Duke University

Public Release: 10-Nov-2014
Proceedings of the National Academy of Sciences
Study shows marijuana's long-term effects on the brain
The effects of chronic marijuana use on the brain may depend on age of first use and duration of use, according to researchers at the Center for BrainHealth at The University of Texas at Dallas. In a paper published today in Proceedings of the National Academy of Sciences (PNAS), researchers for the first time comprehensively describe existing abnormalities in brain function and structure of long-term marijuana users with multiple magnetic resonance imaging (MRI) techniques.
NIH/National Institute on Drug Abuse

Contact: Shelly Kirkland
Center for BrainHealth

Public Release: 10-Nov-2014
Cancer Cell
Researchers find new target for kidney cancer therapy
Cincinnati Cancer Center researchers have discovered that a membrane channel, Transient Receptor Potential Melastatin 3, or TRPM3, promotes growth of kidney cancer tumors, and targeting this channel therapeutically could lead to more treatments for a disease that currently has few treatment options.
National Institutes of Health, Veterans Affairs Merit Award, UC Center for Environmental Genetics Award

Contact: Katie Pence
University of Cincinnati Academic Health Center

Public Release: 7-Nov-2014
Journal of the American Board of Family Medicine
Nurse navigators may aid colon cancer screening follow-up
Group Health patients with a positive screening test for colon cancer (a stool test or sigmoidoscopy) tended to be more likely to get the recommended follow-up test, a diagnostic colonoscopy, if nurse navigators contacted them than if they got usual care, according to Beverly B. Green, MD, MPH, a Group Health physician and a Group Health Research Institute associate investigator.
NIH/National Cancer Institute

Contact: Joan DeClaire
Group Health Research Institute

Public Release: 7-Nov-2014
Proceedings of the National Academy of Sciences
CCNY-led discovery may help breast cancer treatment
Researchers led by Dr. Debra Auguste, associate professor, biomedical engineering, in the Grove School of Engineering at The City College of New York, have identified a molecule that could lead to developing treatment for one of the most aggressive forms of breast cancer.
National Institutes of Health

Contact: Jay Mwamba
City College of New York

Public Release: 7-Nov-2014
Researchers take new approach to stop 'most wanted' cancer protein
Researchers have found a way to defeat one of the most tantalizing yet elusive target proteins in cancer cells by turning the protein's own molecular machinations against it. They used a specially crafted compound to disrupt the protein's ability to rev up its own production and that of other proteins involved in tumor cell growth in an aggressive form of neuroblastoma. The resulting shrinkage of tumors caused little or no harm to normal cells.
National Institutes of Health, American Cancer Society, US Department of Defense, Friends for Life Neuroblastoma Foundation

Contact: Irene Sege
Dana-Farber Cancer Institute

Public Release: 7-Nov-2014
The Gerontological Society of America's 67th Annual Scientific Meeting
Research shows easy-to-walk communities can blunt cognitive decline
Amber Watts found walkable communities resulted in better outcomes both for physical health -- such as lower body mass and blood pressure -- and cognition (such as better memory) in the 25 people with mild Alzheimer's disease and 39 older adults without cognitive impairment she tracked.
NIH/National Institute on Aging, KU Alzheimer's Disease Center, KU Strategic Initiative Grant, Frontiers Clinical Translational Science award

Contact: Brendan M Lynch
University of Kansas

Public Release: 7-Nov-2014
Reprogrammed cells grow into new blood vessels
By transforming human scar cells into blood vessel cells, scientists may have discovered a new way to repair damaged tissue. The method, described in an upcoming issue of Circulation (early online), appeared to improve blood flow, oxygenation, and nutrition to areas in need.
National Institutes of Health, American Heart Association

Contact: David Bricker
Houston Methodist

Public Release: 7-Nov-2014
Nature Communications
No junk: Long RNA mimics DNA, restrains hormone responses
Emory researchers have obtained a detailed picture of how the Gas5 RNA interacts with steroid hormone receptors. Their findings show how the Gas5 RNA takes the place of DNA, and give hints as to how it evolved.
American Heart Association, NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Contact: Quinn Eastman
Emory Health Sciences

Public Release: 7-Nov-2014
Sleep starts later as teens age, but school still starts early
By following dozens of younger and older adolescents for more than two years, researchers in a new study were able to determine that the children fell asleep later and their circadian rhythms shifted later as they grew older. But early school start times interfere with their tendency to sleep later, reducing their total sleep. The study bolsters new recommendations for later school start times.
NIH/National Institute of Alcohol Abuse and Alcoholism

Contact: David Orenstein
Brown University

Public Release: 6-Nov-2014
Annals of Neurology
Scripps researchers identify new genetic cause of epilepsy
A research team led by scientists at the Scripps Translational Science Institute has used whole genome sequencing to identify a new genetic cause of a severe, rare and complex form of epilepsy that becomes evident in early childhood and can lead to early death.
Scripps Genomic Medicine, National Institutes of Health, Shaffer Family Foundation, Anne and Henry Zarrow Foundation, National Human Genome Institute

Contact: Keith Darce
Scripps Health

Public Release: 6-Nov-2014
Migration negation
Researchers have now identified a cellular culprit that should help researchers better understand how metastasis begins. Their findings may also inform the design of new treatments to combat it.
National Institutes of Health

Contact: David Cameron
Harvard Medical School

Public Release: 6-Nov-2014
The Gerontological Society of America's 67th Annual Scientific Meeting
Study highlights prevalence of mistreatment between nursing home residents
Inappropriate, disruptive, or hostile behavior between nursing home residents is a sizable and growing problem, according to new research from Weill Cornell Medical College and Cornell University.
NIH/National Institute on Aging, New York State Department of Health, National Institute of Justice

Contact: Ashley Paskalis
Weill Cornell Medical College

Public Release: 6-Nov-2014
Gut bacteria: How genes determine the fit of your jeans
Our genetic makeup influences whether we are fat or thin by shaping which types of microbes thrive in our body, according to a Cornell-led study published today in the journal Cell.
National Institutes of Health, Cornell Center for Comparative Population Genomics, Wellcome Trust, Seventh Framework Programme

Contact: Melissa Osgood
Cornell University

Public Release: 6-Nov-2014
JAMA Pediatrics
Is violent injury a chronic disease? Study suggests so & may aid efforts to stop the cycle
Teens and young adults who get seriously injured in an assault are nearly twice as likely as their peers to end up back in the emergency room for a violent injury within the next two years, a new University of Michigan study finds. The researchers call this repeating pattern of violent injury a reoccurring disease, but their landmark study also suggests potentially powerful opportunities to intervene in ways that could stop the cycle.
NIH/National Institute on Drug Abuse, NIH/National Institute on Alcohol Abuse and Alcoholism, Centers for Disease Control and Prevention

Contact: Kara Gavin
University of Michigan Health System

Public Release: 6-Nov-2014
New research adds spice to curcumin's health-promoting benefits
The health benefits of over-the-counter curcumin supplements might not get past your gut, but new research shows that a modified formulation of the spice releases its anti-inflammatory goodness throughout the body.
NIH/National Cancer Institute, National Center for Advancing Translational Sciences

Contact: Nicholas Young
Ohio State University

Showing releases 3351-3375 out of 3702.

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