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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 3376-3400 out of 3476.

<< < 131 | 132 | 133 | 134 | 135 | 136 | 137 | 138 | 139 | 140 > >>

Public Release: 11-Sep-2013
Molecular & Cellular Proteomics
First proteomic analysis of birth defect demonstrates power of a new technique
The first proteomic analysis of an animal model of a rare, sometimes deadly birth defect, Smith-Lemli-Opitz syndrome, has revealed that the molecular mechanisms that cause it are more complex than previously understood.
National Institutes of Health, Research to Prevent Blindness, American Heart Association

Contact: Ellen Goldbaum
University at Buffalo

Public Release: 11-Sep-2013
Annals of Surgery
Trauma centers serving mostly white patients have lower death rates for patients of all races
Nearly 80 percent of trauma centers in the United States that serve predominantly minority patients have higher-than-expected death rates, according to new Johns Hopkins research. Moreover, the research shows, trauma patients of all races are 40 percent less likely to die -- regardless of the severity of their injuries -- if they are treated at hospitals with lower-than-expected mortality rates, the vast majority of which serve predominantly white patients.
NIH/National Institute of General Medical Services, NIH/National Heart, Lung, and Blood Institute

Contact: Stephanie Desmon
Johns Hopkins Medicine

Public Release: 11-Sep-2013
Molecular Psychiatry
International study provides new genetic clue to anorexia
The largest DNA-sequencing study of anorexia nervosa has linked the eating disorder to variants in a gene coding for an enzyme that regulates cholesterol metabolism. The finding suggests that anorexia could be caused in part by a disruption in the normal processing of cholesterol, which may disrupt mood and eating behavior.
Price Foundation of Switzerland, National Institutes of Health

Contact: Mika Ono
Scripps Research Institute

Public Release: 11-Sep-2013
'Merlin' is a matchmaker, not a magician
Johns Hopkins researchers have figured out the specific job of a protein long implicated in tumors of the nervous system. Reporting on a new study described in the Sept. 12 issue of the journal Cell, they detail what they call the "matchmaking" activities of a fruit fly protein called Merlin, whose human counterpart, NF2, is a tumor suppressor protein known to cause neurofibromatosis type II when mutated.
NIH/National Eye Institute, US Department of Defense, Howard Hughes Medical Institute

Contact: Catherine Kolf
Johns Hopkins Medicine

Public Release: 11-Sep-2013
Drug treatment means better, less costly care for children with sickle cell disease
The benefits of hydroxyurea treatment in people with sickle cell disease are well known -- fewer painful episodes, fewer blood transfusions and fewer hospitalizations. Now new research from the Johns Hopkins Children's Center and other institutions reveals that by preventing such complications, the drug can also considerably lower the overall cost of medical care in children with this condition.
National Institutes of Health

Contact: Ekaterina Pesheva
Johns Hopkins Medicine

Public Release: 11-Sep-2013
Molecular Genetics and Metabolism
Transplanting fat may be effective treatment for metabolic disease
Transplanting fat may treat such inherited metabolic diseases as maple syrup urine disease by helping the body process the essential amino acids that these patients cannot, according to Penn State College of Medicine researchers.
National Institutes of Health

Contact: Matthew Solovey
Penn State

Public Release: 11-Sep-2013
Lancet Oncology
Gene-expression-based biomarker predicts long-term risk of breast cancer recurrence
A comparison of three methods of predicting the risk of recurrence in women treated for estrogen-receptor-positive breast cancer finds that only the breast cancer index -- a biomarker based on the expression levels of seven tumor-specific genes -- accurately identifies patients who continue to be at risk after five years of treatment with either tamoxifen or the aromatase inhibitor anastrozole.
Avon Foundation, National Institutes of Health, Breast Cancer Foundation, US Department of Defense Breast Cancer Research Program

Contact: Katie Marquedant
Massachusetts General Hospital

Public Release: 11-Sep-2013
Research in Autism Spectrum Disorders
Autistic children with better motor skills more adept at socializing
In a new study looking at toddlers and preschoolers with autism, researchers found that children with better motor skills were more adept at socializing and communicating.
National Institutes of Health, Simons Foundation, First Words, Blue Cross Blue Shield Foundation

Contact: Megan MacDonald
Oregon State University

Public Release: 11-Sep-2013
Cell Host & Microbe
Biologists uncover mechanisms for cholera toxin's deadly effects
Biologists at the University of California, San Diego have identified an underlying biochemical mechanism that helps make cholera toxin so deadly, often resulting in life-threating diarrhea that causes people to lose as much as half of their body fluids in a single day.
NIH/National Institute of Allergy and Infectious Diseases

Contact: Kim McDonald
University of California - San Diego

Public Release: 11-Sep-2013
'Desperation DNA' synthesis could explain genetic mutations
Researchers have discovered the details of how cells repair breaks in both strands of their DNA, a potentially devastating kind of DNA damage. The latest research reveals a mode of replication that can operate in non-dividing cells -- the state of most of the body's cells -- making this kind of replication a potential route for cancer formation.
National Institutes of Health, National Science Foundation

Contact: David Hosick
Indiana University-Purdue University Indianapolis School of Science

Public Release: 11-Sep-2013
Unusual mechanism of DNA synthesis could explain genetic mutations
Researchers have discovered the details of how cells repair breaks in both strands of DNA, a potentially devastating kind of DNA damage.
National Institutes of Health, National Science Foundation

Contact: Brett Israel
Georgia Institute of Technology

Public Release: 11-Sep-2013
Fat marker predicts cognitive decline in people with HIV
Johns Hopkins scientists have found that levels of certain fats found in cerebral spinal fluid can predict which patients with HIV are more likely to become intellectually impaired.
NIH/National Institute on Alcohol Abuse and Alcoholism, NIH/National Institute of Mental Health

Contact: Stephanie Desmon
Johns Hopkins Medicine

Public Release: 11-Sep-2013
Science Translational Medicine
Test could identify which prostate cancers require treatment
The level of expression of three genes associated with aging can be used to predict whether seemingly low-risk prostate cancer will remain slow-growing, according to researchers. Use of this three-gene biomarker, in conjunction with existing cancer-staging tests, could help physicians better determine which men with early prostate cancer can be safely followed with "active surveillance" and spared the risks of prostate removal or other invasive treatment. The findings were published today in the online edition of Science Translational Medicine.
National Institutes of Health, NIH/National Cancer Institute, T.J. Martell Foundation for Leukemia, Cancer & AIDS Research, American Cancer Society

Contact: Karin Eskenazi
Columbia University Medical Center

Public Release: 11-Sep-2013
American Journal of Clinical Nutrition
Variation in bitter receptor mRNA expression affects taste perception
New findings from the Monell Center reveal that a person's sensitivity to bitter taste is shaped not only by which taste genes that person has, but also by how much messenger RNA -- the gene's instruction guide that tells a taste cell to build a specific receptor -- their taste cells make.
NIH/National Institute on Deafness and Other Communication Disorder

Contact: Leslie Stein
Monell Chemical Senses Center

Public Release: 11-Sep-2013
New England Journal of Medicine
Testosterone deficiency not the only cause of age-associated changes in men
Just as the symptoms of menopause in women are attributed to a sharp drop in estrogen production, symptoms often seen in middle-aged men -- changes in body composition, energy, strength and sexual function -- are usually attributed to the less drastic decrease in testosterone production that typically occurs in the middle years. However, a study by Massachusetts General Hospital researchers finds that insufficient estrogen could be at least partially responsible for some of these symptoms.
National Institutes of Health, Abbott Laboratories

Contact: Mike Morrison
Massachusetts General Hospital

Public Release: 10-Sep-2013
Multiple sclerosis appears to originate in different part of brain than long believed
A physician and scientist at Rutgers New Jersey Medical School has found an important clue why the search for the cause of multiple sclerosis has been slow -- it appears that most research on the origins of MS has focused on the wrong part of the brain. Look more to the gray matter and less to the white.
National Institutes of Health

Contact: Rob Forman
Rutgers University

Public Release: 10-Sep-2013
Proceedings of the National Academy of Sciences
Alzheimer's: Newly identified protein pathology impairs RNA splicing
Researchers have identified a previously unrecognized type of pathology in the brains of patients with Alzheimer's disease. These tangle-like structures appear at early stages of Alzheimer's and are not found in other neurodegenerative diseases such as Parkinson's disease. The appearance of these tangles, which sequester proteins involved in RNA splicing, is linked to widespread changes in Alzheimer's brains compared to healthy brains.
NIH/National Institute on Aging, NIH/National Institute of Neurological Disorders and Stroke

Contact: Holly Korschun
Emory Health Sciences

Public Release: 10-Sep-2013
Innovative 'pay for performance' program improves patient outcomes
Paying doctors for how they perform specific medical procedures and examinations yields better health outcomes than the traditional "fee for service" model, where everyone gets paid a set amount regardless of quality or patient outcomes, according to new research conducted by UC San Francisco and the New York City Department of Health and Mental Hygiene.
Robin Hood Foundation, Agency for Healthcare Research and Quality, National Institutes of Health

Contact: Leland Kim
University of California - San Francisco

Public Release: 10-Sep-2013
Nature Medicine
2 common drugs may help treat deadly Middle East Respiratory Syndrome
Treatment with two common drugs reduced viral replication and lung damage when given to monkeys infected with the virus that causes Middle East Respiratory Syndrome. The condition is a deadly pneumonia that has killed more than 100 people, primarily in the Middle East. The new findings show that a combination of interferon-alpha 2b and ribavirin, drugs routinely used to treat hepatitis C, may be effective against this emerging disease.
NIH/National Institute of Allergy and Infectious Diseases

Contact: Leila Gray
University of Washington

Public Release: 10-Sep-2013
Proceedings of the National Academy of Sciences
Shingles symptoms may be caused by neuronal short circuit
The pain and itching associated with shingles and herpes may be due to the virus causing a "short circuit" in the nerve cells that reach the skin.
National Institutes of Health

Contact: Catherine Zandonella
Princeton University

Public Release: 10-Sep-2013
Binghamton University researcher awarded funding to help heart attack risk
Binghamton University researcher Amber Doiron, hopes to give doctors a more accurate way of determining a patient's risk of heart attack or stroke.
NIH/National Institute of Biomedical Imaging and Bioengineering

Contact: Ryan Yarosh
Binghamton University

Public Release: 10-Sep-2013
Discovery about DNA repair could lead to improved cancer treatments
Medical researchers at the University of Alberta have made a basic science discovery that advances the understanding of how DNA repairs itself. When DNA becomes too damaged it ultimately leads to cancer.
Canadian Cancer Society, National Institutes of Health

Contact: Raquel Maurier
University of Alberta Faculty of Medicine & Dentistry

Public Release: 10-Sep-2013
UCI-led study creates new memories by directly changing the brain
By studying how memories are made, UC Irvine neurobiologists created new, specific memories by direct manipulation of the brain, which could prove key to understanding and potentially resolving learning and memory disorders.
NIH/National Institute on Deafness and Other Communication Disorders

Contact: Andrea Burgess
University of California - Irvine

Public Release: 10-Sep-2013
Journal of Reproductive Immunology
Study details paired risk factors in preeclampsia
Preeclampsia is a life-threatening complication of pregnancy. A study of how two immune system-related factors -- one genetic and one sexual -- combine to affect risk could yield strategies for planning pregnancies with improved awareness and management of the odds for being affected by that complication.
NIH/Eunice Kennedy Shriver National Institute of Child Health and Development

Contact: David Orenstein
Brown University

Public Release: 10-Sep-2013
Biological Psychiatry
Study suggests possibility of selectively erasing unwanted memories
Scientists from the Florida campus of The Scripps Research Institute have been able to erase dangerous drug-associated memories in mice and rats without affecting other more benign memories. The surprising discovery points to a clear and workable method to disrupt unwanted memories while leaving the rest intact.
NIH/National Institute for Neurological Disorders and Stroke

Contact: Eric Sauter
Scripps Research Institute

Showing releases 3376-3400 out of 3476.

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