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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 3376-3400 out of 3499.

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Public Release: 7-Nov-2013
Journal of Alzheimer's Disease
New method predicts time from Alzheimer's onset to nursing home, death
A Columbia University Medical Center-led research team has clinically validated a new method for predicting time to nursing home residence or death for patients with Alzheimer's. The method uses data from a single patient visit, and is based on a complex model of Alzheimer's progression developed by consecutively following two sets of Alzheimer's patients for 10 years each.
NIH/National Institute on Aging

Contact: Elizabeth Streich
Columbia University Medical Center

Public Release: 7-Nov-2013
Hope builds for a drug that might shut down a variety of cancers
The most frequently mutated gene across all types of cancers is a gene called p53. Unfortunately it has been difficult to directly target this gene with drugs. Now a multi-institutional research team, led by Dr. Lewis Cantley and investigators at Weill Cornell Medical College, has identified a family of enzymes they say is crucial for the growth of cancers that have genetic aberrations in p53.
National Institutes of Health, Stand Up to Cancer Dream Team Translational Research Grant, Program of the Entertainment Industry

Contact: Sarah Smith
Weill Cornell Medical College

Public Release: 7-Nov-2013
NIH funds researchers using light to control and monitor neural activity
Samarendra Mohanty, assistant professor of physics at The University of Texas at Arlington, expects to receive a total of $384,269 over the next two years from the NIH's National Institute of Neurological Disorders and Stroke. His work involves using a near-infrared ultrafast laser beam to deliver genes that allow expression of light-sensitive proteins, called opsins, in specific cells. That proteins' expression allows researchers to influence neural activity through optical or light stimulation -- a technique known as optogenetics.
National Institutes of Health

Contact: Traci Peterson
University of Texas at Arlington

Public Release: 7-Nov-2013
Researchers build muscle in diseased mice; create human muscle cells in a dish
Skeletal muscle has proved to be very difficult to grow in patients with muscular dystrophy and other disorders that degrade and weaken muscle. Researchers at Boston Children's Hospital's Stem Cell Program now report boosting muscle mass and reversing disease in a mouse model of Duchenne muscular dystrophy, using a "cocktail" of three compounds identified through a new rapid culture system. Adding the same compounds to stem cells derived from patients' skin cells, they then successfully grew human muscle cells in a dish.
National Institutes of Health, Harvard Stem Cell Institute, Howard Hughes Medical Institute

Contact: Irene Sege
Boston Children's Hospital

Public Release: 7-Nov-2013
Arteriosclerosis, Thrombosis and Vascular Biology
Clotting protein hardens aging hearts
The Rice lab of bioengineer Jane Grande-Allen found through studies of pigs' heart valves that age plays a critical role in the valves' progressive hardening, and the problem may be due to the infiltration of a protein known as von Willebrand factor. Tissues from pig valves are commonly used to make human heart-valve replacements.
American Heart Association, National Institutes of Health, Mary R. Gibson Foundation, Mabel and Everett Hinkson Memorial Fund

Contact: David Ruth
Rice University

Public Release: 7-Nov-2013
Human muscle stem cell therapy gets help from zebrafish
Harvard Stem Cell Scientists have discovered that the same chemicals that stimulate muscle development in zebrafish can also be used to differentiate human stem cells into muscle cells in the laboratory, an historically challenging task that, now overcome, makes muscle cell therapy a more realistic clinical possibility.
National Institutes of Health

Contact: B. D. Colen
Harvard University

Public Release: 7-Nov-2013
Breakthrough discoveries on cellular regeneration seek to turn back the body's clock
Two groups of scientists at the Children's Medical Center Research Institute at UT Southwestern have made complementary discoveries that break new ground on efforts to turn back the body's clock on cellular activity, paving the way for a better understanding of stem cells, tissue growth, and regeneration.
National Institutes of Health, Cancer Prevention and Research Institute of Texas

Contact: Lisa Warshaw
UT Southwestern Medical Center

Public Release: 7-Nov-2013
Mayo Clinic researchers identify role of Cul4 molecule in genome instability and cancer
Mayo Clinic researchers have shown that a molecule called Cul4 helps to deposit DNA-packaging histone proteins onto DNA, an integral step in cramming yards of genetic code into compact coils that can fit into each cell. When DNA isn't packaged correctly, it can lead to the genomic instability characteristic of many forms of cancer.
National Institutes of Health, Mayo Clinic

Contact: Joe Dangor
Mayo Clinic

Public Release: 7-Nov-2013
Current Biology
Tricking algae's biological clock boosts production of drugs, biofuels
Tricking algae's biological clock to remain in its daytime setting can dramatically boost the amount of commercially valuable compounds that these simple marine plants can produce when they are grown in constant light.
NIH/National Institute of General Medical Sciences, US Department of Energy, Japanese Society for the Promotion of Science, Asahi Glass Foundation

Contact: David Salisbury
Vanderbilt University

Public Release: 7-Nov-2013
Cell Stem Cell
USC study identifies mechanism that makes ordinary stem cells create tumors
A new study from the Ostrow School of Dentistry of USC published in Cell Stem Cell illustrates how changes in cell signaling can cause ordinary stem cells in the jaw to start forming benign but potentially harmful tumors. Principal investigator Songtao Shi, professor at the Ostrow School of Dentistry Center for Craniofacial Molecular Biology, and his collaborators uncovered a cellular signaling pathway that converts healthy mesenchymal stem cells in the jaw into ossifying fibroma mesenchymal stem cells.
NIH/National Institute of Dental and Craniofacial Research, California Institute for Regenerative Medicine

Contact: Beth Newcomb
University of Southern California

Public Release: 7-Nov-2013
Genome Research
HPV can damage genes and chromosomes directly, whole-genome sequencing study shows
A study has identified a new mechanism by which the human papillomavirus (HPV) may contribute to cancer development. Using whole-genome sequencing, researchers show that strains of HPV that cause cervical, head and neck and other cancers can directly damage genes and chromosomes where they insert their DNA into human DNA.
Ohio Cancer Research Association, Oral Cancer Foundation, NIH/National Cancer Institute

Contact: Darrell E. Ward
Ohio State University Wexner Medical Center

Public Release: 7-Nov-2013
Journal of the American Board of Family Medicine
Female doctors twice as likely to screen low-risk women for cervical cancer with HPV test
How likely is it that your doctor orders the HPV test to screen you for cervical cancer?
National Institutes of Health, NIH/National Cancer Institute

Contact: Beata Mostafavi
University of Michigan Health System

Public Release: 7-Nov-2013
JAMA Ophthalmology
Peripheral prism glasses help hemianopia patients get around
Mass. Eye and Ear led research shows Peripheral prism glasses provide a simple and inexpensive mobility rehabilitation intervention for hemianopia (blindness in one half of the visual field in both eyes).
National Institutes of Health

Contact: Mary Leach
Massachusetts Eye and Ear Infirmary

Public Release: 6-Nov-2013
Angewandte Chemie
OU natural products discovery group asks for public's help with citizen science program
The University of Oklahoma Natural Products Discovery Group has taken an unconventional approach to finding new compounds with therapeutic relevance by launching a crowdsourcing initiative with citizen scientists from around the country. OU researchers team with the public to sample soils from all across the United States for the purpose of identifying new microorganisms that produce drug-like compounds.
National Institutes of Health

Contact: Jana Smith
University of Oklahoma

Public Release: 6-Nov-2013
JAMA Pediatrics
Findings announced from landmark study on safety of adolescent bariatric surgery
Initial results of a first and largest of its kind study focusing on the safety of adolescent bariatric surgery were published this week in JAMA Pediatrics. The "Teen Longitudinal Assessment of Bariatric Surgery" study is funded by the National Institutes of Health and is being conducted at five sites in the US, including Nationwide Children's Hospital.
National Institutes of Health

Contact: Gina Bericchia
Nationwide Children's Hospital

Public Release: 6-Nov-2013
Addicts may be seeking relief from emotional lows more than euphoric highs
Rutgers researchers are challenging the commonly held view that drug addiction occurs because users are always going after the high. Based on new animal studies, they say the initial positive feelings of intoxication are short lived -- quickly replaced by negative emotional responses which may be more important in understanding substance abuse.
NIH/National Institute on Drug Abuse

Contact: Robin Lally
732-932-7084 x652
Rutgers University

Public Release: 6-Nov-2013
Journal of Adolescent Research
Mothers' relationships can influence adolescent children's relationships, MU study finds
Gary Glick, doctoral candidate, the MU College of Arts & Science, Department of Psychological Sciences, found that mothers' relationships can influence adolescent children's relationships with their friends, particularly the negative and antagonistic aspects.
NIH/National Institute of Mental Health

Contact: Jeff Sossamon
University of Missouri-Columbia

Public Release: 6-Nov-2013
Journal of Consulting and Clinical Psychology
CWRU study finds mending ruptures in client-therapist relationship has positive benefits
In order for prolonged exposure therapy, an evidence-based psychotherapy for post traumatic stress disorder, to reach its full potential, any misperceptions or ruptures in trust and communication between therapist and client need fixing, according to a new Case Western Reserve University study.
NIH/National Institute of Mental Health

Contact: Susan Griffith
Case Western Reserve University

Public Release: 6-Nov-2013
Hospitals with neurology residency programs more likely to administer life-saving clot-busting drugs
Stroke patients treated at hospitals with neurology residency programs are significantly more likely to get life-saving clot-busting drugs than those seen at other teaching or non-teaching hospitals, new Johns Hopkins-led research suggests.
NIH/National Institute of Neurological Disorders and Stroke, NIH/National Insitute on Aging, and others

Contact: Stephanie Desmon
Johns Hopkins Medicine

Public Release: 6-Nov-2013
Family Relations
In dual-career couples, mothers still do the most child care
Even in couples most likely to believe in sharing parenting responsibilities, mothers still bear significantly more of the child care load, a new study reveals.
National Science Foundation, NIH/National Institute of Child Health and Human Development

Contact: Sarah Schoppe-Sullivan
Ohio State University

Public Release: 6-Nov-2013
Brain may play key role in blood sugar metabolism and development of diabetes
The development of diabetes Type 2, the authors argue, requires a failure of both the islet-cell system in the pancreas and a brain-centered system for regulating blood sugar levels. Boosting insulin levels alone will lower glucose levels, but only addresses half the problem. To restore normal glucose regulation requires addressing the failures of the brain-centered system as well. Approaches that target both systems may not only achieve better blood glucose control, but could actually cause diabetes to go into remission.
National Institutes of Health, Helmholtz Alliance ICEMED

Contact: Michael McCarthy
University of Washington

Public Release: 6-Nov-2013
SDSU receives $8.5M for heart research
The National Institutes of Health has awarded a prestigious Program Project Grant totaling more than $8.5 million over five-years to San Diego State University to better understand how the heart heals and ways stem cells can help the heart repair itself.
National Institutes of Health

Contact: Natalia Elko
San Diego State University

Public Release: 6-Nov-2013
'Don't get sick in July'
With almost no experience, newly graduated medical students enter teaching hospitals around the country every July, beginning their careers as interns. At the same time, the last year's interns and junior residents take a step up and assume new responsibilities. More experienced physicians share a joke about this changing of the guard: Don't get sick in July.
National Institutes of Health, NIH/National Institute on Aging

Contact: David Cameron
Harvard Medical School

Public Release: 6-Nov-2013
Journal of Biological Chemistry
Research reveals possible cause of diabetic cardiomyopathy
Researchers now know that the leading cause of diabetic cardiomyopathy can be attributed to PKC activation and its downstream effects on gene expression. Knowing how cardiomyopathy manifests, further research can use these results to concentrate on the prevention and treatment of heart failure in diabetics.
American Heart Association, March of Dimes Foundation, National Institutes of Health

Contact: Kristen Hensley
University of Texas Medical Branch at Galveston

Public Release: 6-Nov-2013
Journal of Neuroscience
Postoperative pain may increase risk of temporary problems with learning, memory
The pain caused by a surgical incision may contribute to the risk of postoperative cognitive dysfunction, a sometimes transient impairment in learning and memory that affects a small but significant number of patients in the days following a surgical procedure.
National Institutes of Health, Alzheimer's Association, Cure Alzheimer's Fund

Contact: Sue McGreevey
Massachusetts General Hospital

Showing releases 3376-3400 out of 3499.

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