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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 3401-3425 out of 3558.

<< < 132 | 133 | 134 | 135 | 136 | 137 | 138 | 139 | 140 | 141 > >>

Public Release: 10-Feb-2014
TGen study uncovers possible genetic markers in breast cancer that spreads to the brain
The Translational Genomics Research Institute has uncovered possible genetic origins of breast cancer that spreads to the brain, according to a first-of-its-kind study published in the scientific journal PLOS ONE.
National Institutes of Health, Flinn Foundation, C.A.R.E.

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Public Release: 10-Feb-2014
Journal of Biological Chemistry
Recycling of 'chauffeur protein' helps regulate fat production
Studying a cycle of protein interactions needed to make fat, Johns Hopkins researchers say they have discovered a biological switch that regulates a protein that causes fatty liver disease in mice. Their findings, they report, may help develop drugs to decrease excessive fat production and its associated conditions in people, including fatty liver disease and diabetes.
Pancreatic Cancer Action Network, NIH/National Heart, Lung and Blood Institute

Contact: Catherine Kolf
Johns Hopkins Medicine

Public Release: 10-Feb-2014
Nature Communications
Chips that listen to bacteria
Researchers led by Ken Shepard (electrical engineering and biomedical engineering professor, Columbia Engineering) and Lars Dietrich, biological sciences assistant professor, Columbia University) have shown integrated circuit technology can be used for a most unusual application -- the study of signaling in bacterial colonies. They have developed a chip based on CMOS technology that enables them to electrochemically image the signaling molecules from these colonies spatially and temporally -- they've developed chips that "listen" to bacteria.
National Institutes of Health, National Science Foundation

Contact: Holly Evarts
Columbia University School of Engineering and Applied Science

Public Release: 10-Feb-2014
American Journal of Respiratory and Critical Care Medicine
Researchers discover immune signature that predicts poor outcome in influenza patients
St. Jude Children's Research Hospital scientists have identified a signature immune response that might help doctors identify which newly diagnosed influenza patients are most likely to develop severe symptoms and suffer poor outcomes. The findings also help explain why infants and toddlers are at elevated risk for flu complications. The research appears in the upcoming issue of the American Journal of Respiratory and Critical Care Medicine.
NIH/National Institute of Allergy and Infectious Diseases, ALSAC

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

Public Release: 10-Feb-2014
Cancer Cell
Normal enzyme aids a mutant 1 to fuel blood cancer's growth
Researchers from Dana-Farber/Boston Children's Cancer and Blood Disorders Center report that a normal enzyme called SYK pairs with FLT3, the most commonly mutated enzyme found in acute myelogenous leukemia (AML), to promote the cancer's growth. This partnership also promotes AML cells' resistance to treatment with FLT3-blocking drugs and could explain the relatively poor showing of FLT3 inhibitors in clinical studies.
NIH/National Cancer Institute, American Cancer Society

Contact: Irene Sege
Dana-Farber Cancer Institute

Public Release: 10-Feb-2014
Proceedings of the National Academy of Sciences
Heart attack research discovers new treatment target
Research led by David Lefer, Ph.D., Professor and Director of the Cardiovascular Center of Excellence at LSU Health Sciences Center New Orleans School of Medicine, demonstrates for the first time cross-talk between two protective signaling molecules during a heart attack. By providing new and important information about the mechanisms involved in heart attacks and organ transplantation, the research identifies a potential new treatment target for heart disease.
NIH/National Heart, Lung, and Blood Institute, Canadian Institutes of Health Research, and others

Contact: Leslie Capo
Louisiana State University Health Sciences Center

Public Release: 10-Feb-2014
Angewandte Chemie International Edition
Nanomotors are controlled, for the first time, inside living cells
Nanomotors have been controlled inside living cells for the first time, report a team of chemists and engineers at Penn State University. The scientists placed tiny rocket-shaped synthetic motors inside live human cells, propelled them with ultrasonic waves and steered them magnetically to spin and to battering against the cell membrane.
National Science Foundaiton, National Institutes of Health, Penn State University

Contact: Barbara K. Kennedy
Penn State

Public Release: 10-Feb-2014
Proceedings of the National Academy of Sciences
New live-cell printing technology works like ancient Chinese woodblocking
With a nod to 3rd century Chinese woodblock printing and children's rubber stamp toys, researchers in Houston have developed a way to print living cells onto any surface, in virtually any shape. Unlike recent, similar work using inkjet printing approaches, almost all cells survive the process, scientists report in this week's Proceedings of the National Academy of Sciences.
National Institutes of Health, US Department of Defense, Alliance for Nanohealth

Contact: David Bricker
Houston Methodist

Public Release: 9-Feb-2014
Nature Methods
Optogenetic toolkit goes multicolor
MIT researchers have found new light-sensitive proteins that allow scientists to study how multiple sets of neurons interact with each other.
National Institutes of Health, Massachusetts Institute of Technology Media Lab, National Science Foundation, Wallace H. Coulter Foundation, Alfred P. Sloan Foundation, NARSAD Young Investigator Grant, Human Frontiers Science Program, and others

Contact: Sarah McDonnell
Massachusetts Institute of Technology

Public Release: 9-Feb-2014
Nature Chemical Biology
Scientists invent advanced approach to identify new drug candidates from genome sequence
In research that could ultimately lead to many new medicines, scientists from the Florida campus of The Scripps Research Institute have developed a potentially general approach to design drugs from genome sequence. As a proof of principle, they identified a highly potent compound that causes cancer cells to attack themselves and die.
National Institutes of Health, Camille and Henry Dreyfus Foundation

Contact: Eric Sauter
Scripps Research Institute

Public Release: 9-Feb-2014
Nature Methods
Genome editing goes hi-fi
Scientists at the Gladstone Institutes have found a way to efficiently edit the human genome one letter at a time -- not only boosting researchers' ability to model human disease, but also paving the way for therapies that cure disease by fixing these so-called "bugs" in a patient's genetic code.
National Institutes of Health, NIH/National Heart, Lung, and Blood Institute, California Institute for Regenerative Medicine, Roddenberry Foundation

Contact: Anne Holden
Gladstone Institutes

Public Release: 7-Feb-2014
UCLA gets $6 million to study new ways to restore hand movement after paralysis
The National Institute of Biomedical Imaging and Bioengineering has awarded UCLA neurosurgeon Dr. Daniel Lu and neuroscientist Reggie Edgerton a $6 million five-year grant to explore new therapies for restoring hand function to patients paralyzed from the neck down. Roughly 273,000 Americans live with spinal-cord injury, and cervical spinal-cord injuries make up more than half of the caseload. Some 12,000 more Americans suffer spinal-cord injuries each year.
NIH/National Institute of Biomedical Imaging and Bioengineering

Contact: Elaine Schmidt
University of California - Los Angeles

Public Release: 7-Feb-2014
European Heart Journal
Researchers use genetic signals affecting lipid levels to probe heart disease risk
New genetic evidence strengthens the case that one well-known type of cholesterol is a likely suspect in causing heart disease, but also casts further doubt on the causal role played by another type. The findings may guide the search for improved treatments for heart disease.
National Institutes of Health, UK Medical Research Council, British Heart Foundation

Contact: John Ascenzi
Children's Hospital of Philadelphia

Public Release: 7-Feb-2014
Study provides surprising new clue to the roots of hunger
Investigators from Beth Israel Deaconess Medical Center make a surprising discovery about the neurons that drive appetite and hunger.
National Institutes of Health, American Diabetes Association

Contact: Bonnie Prescott
Beth Israel Deaconess Medical Center

Public Release: 7-Feb-2014
Women fare worse than men following stroke
The good news: More people survive stroke now than 10 years ago due to improved treatment and prevention. The bad news: Women who survive stroke have a worse quality of life than men, according to a study published in the Feb. 7 online issue of the journal Neurology.
NIH/National Institute of Neurological Disorders and Stroke

Contact: Marguerite Beck
Wake Forest Baptist Medical Center

Public Release: 7-Feb-2014
Stroke trigger more deadly for African-Americans
African-Americans were 39 times more likely to die of a stroke if they were exposed to an infection.
NIH/National Heart, Lung and Blood Institute

Contact: Beata Mostafavi
University of Michigan Health System

Public Release: 7-Feb-2014
Huntington disease prevention trial shows creatine safe, suggests slowing of progression
The first clinical trial of a drug intended to delay the onset of symptoms of Huntington disease reveals that high-dose treatment with the nutritional supplement creatine was safe and well tolerated by most participants. In addition, neuroimaging showed a treatment-associated slowing of regional brain atrophy, evidence that creatine might slow the progression of presymptomatic disease.
National Institutes of Health

Contact: Mike Morrison
Massachusetts General Hospital

Public Release: 7-Feb-2014
Journal of Molecular Diagnostics
Rett syndrome genetic variants now available for advance testing, diagnosis & research
Through collaboration between the Centers for Disease Control and Prevention (CDC) and members of the clinical-laboratory and non-profit-research communities, 35 DNA samples containing many common RS genetic variants have now been characterized and made publicly available, eliminating a major stumbling-block for investigators and opening the possibility of earlier, more accurate diagnosis of Rett syndrome, reports The Journal of Molecular Diagnostics.
NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development

Contact: Eileen Leahy
Elsevier Health Sciences

Public Release: 6-Feb-2014
PLOS Pathogens
Prickly protein
A genetic mechanism that controls the production of a large spike-like protein on the surface of Staphylococcus aureus (staph) bacteria alters the ability of the bacteria to form clumps and to cause disease, according to a new University of Iowa study.
National Institutes of Health

Contact: Jennifer Brown
University of Iowa Health Care

Public Release: 6-Feb-2014
Researchers blend orthopedics, engineering to better repair torn rotator cuffs
Researchers blend orthopedics, engineering to better repair torn rotator cuffs.
National Institutes of Health

Contact: Jim Dryden
Washington University in St. Louis

Public Release: 6-Feb-2014
Nano Letters
Nanoparticle pinpoints blood vessel plaques
A team of researchers, led by scientists at Case Western Reserve University, has developed a multifunctional nanoparticle that enables magnetic resonance imaging to pinpoint blood vessel plaques caused by atherosclerosis. The technology is a step toward creating a non-invasive method of identifying plaques vulnerable to rupture -- the cause of heart attack and stroke -- in time for treatment.
National Institutes of Health, Mt. Sinai Foundation, Natural Sciences and Research Council of Canada

Contact: Kevin Mayhood
Case Western Reserve University

Public Release: 6-Feb-2014
Toxin from brain cells triggers neuron loss in human ALS model
In most cases of amyotrophic lateral sclerosis, or Lou Gehrig's disease, a toxin released by cells that normally nurture neurons in the brain and spinal cord can trigger loss of the nerve cells affected in the disease, Columbia researchers reported today in the online edition of the journal Neuron.
National Institutes of Health, Project ALS, P2ALS, ALS Association,Muscular Dystrophy Association,Parkinson's Disease Foundation

Contact: Karin Eskenazi
Columbia University Medical Center

Public Release: 6-Feb-2014
Brain, Behavior and Immunity
Immune system 'overdrive' in pregnant women puts male child at risk for brain disorders
Johns Hopkins researchers report that fetal mice -- especially males -- show signs of brain damage that lasts into their adulthood when they are exposed in the womb to a maternal immune system kicked into high gear by a serious infection or other malady. The findings suggest that some neurologic diseases in humans could be similarly rooted in prenatal exposure to inflammatory immune responses.
NIH/National Institute of Child Health and Human Development

Contact: Stephanie Desmon
Johns Hopkins Medicine

Public Release: 6-Feb-2014
Cell Reports
A key facilitator of mRNA editing uncovered by IU researchers
Molecular biologists from Indiana University are part of a team that has identified a protein that regulates the information present in a large number of messenger ribonucleic acid molecules that are important for carrying genetic information from DNA to protein synthesis.
National Science Foundation, National Institutes of Health, Sloan Foundation, Showalter Foundation, Indiana University School of Medicine

Contact: Steve Chaplin
Indiana University

Public Release: 6-Feb-2014
Analytical Chemistry
Quick test finds signs of diarrheal disease
Bioengineers at Rice University have developed a simple, highly sensitive and efficient test for the diarrheal disease cryptosporidiosis that could have great impact in developing countries.
NIH/National Institute of Allergy and Infectious Diseases, National Science Foundation

Contact: David Ruth
Rice University

Showing releases 3401-3425 out of 3558.

<< < 132 | 133 | 134 | 135 | 136 | 137 | 138 | 139 | 140 | 141 > >>


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