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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 3401-3425 out of 3531.

<< < 132 | 133 | 134 | 135 | 136 | 137 | 138 | 139 | 140 | 141 > >>

Public Release: 12-Dec-2013
First step of metastasis halted in mice with breast cancer
Cell biologists at Johns Hopkins have identified a unique class of breast cancer cells that lead the process of invasion into surrounding tissues. Because invasion is the first step in the deadly process of cancer metastasis, the researchers say they may have found a weak link in cancer's armor and a possible new target for therapy.
NIH/National Cancer Institute, NIH/National Institute of Environmental Health Sciences, US Department of Defense CDMRP Breast Cancer Program, Avon Foundation, Mary Kay Foundation, Safeway Foundation, Cindy Rosencrans Fund for Triple Negative Breast Cancer

Contact: Catherine Kolf
Johns Hopkins Medicine

Public Release: 12-Dec-2013
American Journal of Pathology
Enzyme BACE1 may be important in predicting onset of Alzheimer disease
The critical enzyme beta-secretase1 (BACE1) is known to be elevated in brains with sporadic Alzheimer disease (AD). Scientists have now found increased levels of BACE1 in brains with mild cognitive impairment, suggesting that BACE1 activity is important for conversion of mild cognitive impairment to AD and may be an early indicator of AD. The results are published in the January issue of The American Journal of Pathology.
National Institutes of Health, Alzheimer Association, National Natural Science Foundation of China

Contact: Eileen Leahy
Elsevier Health Sciences

Public Release: 12-Dec-2013
Salmonella jams signals from bacteria-fighting mast cells
A protein in Salmonella inactivates mast cells -- critical players in the body's fight against bacteria and other pathogens -- rendering them unable to protect against bacterial spread in the body, according to researchers at Duke Medicine and Duke-National University of Singapore.
National Institutes of Health, Duke-NUS

Contact: Rachel Harrison
Duke University Medical Center

Public Release: 12-Dec-2013
Cell Reports
Temple scientists studying mitochondrial calcium handling yield new disease targets
When things go wrong, cells turn to built-in safety mechanisms for survival. One of those mechanisms involves calcium uptake by mitochondria, the energy-producing powerhouses of cells. Long a mystery, new research by scientists at the Temple University School of Medicine Center for Translational Research shows exactly how mitochondria handle damaging excess calcium from the intracellular environment, and how problems with calcium regulation can lead to vascular damage.
National Institutes of Health

Contact: Jeremy Walter
Temple University Health System

Public Release: 12-Dec-2013
Cell Reports
Combining mutants results in 5-fold lifespan extension in C. elegans
What are the limits to longevity? Scientists at the Buck Institute combined mutations in two pathways well-known for lifespan extension and report a synergistic five-fold lifespan extension in the nematode C. elegans. The worms lived to the human equivalent of 400 to 500 years. The research introduces the possibility of combination therapy for aging and could help explain why scientists are having a difficult time identifying single genes responsible for long lives in human centenarians.
National Institutes of Health, American Federation for Aging Research, Hillblom Foundation

Contact: Kris Rebillot
Buck Institute for Age Research

Public Release: 12-Dec-2013
2013 CTRC-AACR San Antonio Breast Cancer Symposium
Exercise improves drug-associated joint pain in breast cancer survivors
Breast cancer survivors taking aromatase inhibitors such as anastrozole, letrozole, and exemestane experienced a reduction in joint pain if they exercised while on treatment, according to results presented here at the 2013 San Antonio Breast Cancer Symposium, held Dec. 10-14.
NIH/National Cancer Institute

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 11-Dec-2013
Journal of Vision
Trained airport checkpoint screeners miss rare targets
Holiday travelers will be relieved to know that security threats are rarely encountered at airport checkpoints. But according to a new study published in the Journal of Vision, the low frequency at which trained airport screeners find threats reduces the chances targets will be found.
US Deptartment of Homeland Security, Transporation Security Administration, National Institutes of Health

Contact: Katrina Norfleet
Association for Research in Vision and Ophthalmology

Public Release: 11-Dec-2013
Liquid to gel to bone
Rice bioengineers have developed a hydrogel scaffold for craniofacial bone tissue regeneration that starts as a liquid, solidifies into a gel in the body and liquefies again for removal.
National Institutes of Health, Baylor College of Medicine Scientific Training Program for Dental Academic Researchers

Contact: David Ruth
Rice University

Public Release: 11-Dec-2013
Science Translational Medicine
Dietary amino acids improve sleep problems in mice with traumatic brain injury
Scientists have discovered how to fix sleep disturbances in mice with traumatic brain injuries -- a discovery that could lead to help for hundreds of thousands of people who have long-term and debilitating sleep and wakefulness issues after they suffer concussions.
National Institutes of Health

Contact: Todd Murphy
Oregon Health & Science University

Public Release: 11-Dec-2013
Current Biology
Researchers at Penn show optimal framework for heartbeats
There is an optimal amount of strain that a beating heart can generate and still beat at its usual rate, once per second. Researchers at the University of Pennsylvania have now shown that this "sweet spot" depends on the stiffness of the collagen framework that the heart's cells live within.
National Institutes of Health, National Science Foundation

Contact: Evan Lerner
University of Pennsylvania

Public Release: 11-Dec-2013
Aging Cell
Sleep-deprived mice show connections among lack of shut-eye, diabetes, age
For the first time, researchers describe the effect of sleep deprivation on the unfolded protein response in peripheral tissue. Stress in pancreatic cells due to sleep deprivation may contribute to the loss or dysfunction of cells important to maintaining proper blood sugar levels, and that these functions may be exacerbated by normal aging. The combined effect of aging and sleep deprivation resulted in a loss of control of blood sugar, somewhat like pre-diabetes in mice.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases, NIH/National Institute on Aging

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 11-Dec-2013
Proceedings of the National Academy of Sciences
Staying ahead of Huntington's disease
Rohit Pappu, Ph.D., and his colleagues are working to stay ahead of Huntington's disease, a devastating, incurable disorder that results from the death of certain neurons in the brain
National Institutes of Health

Contact: Neil Schoenherr
Washington University in St. Louis

Public Release: 11-Dec-2013
Boston Hospital Trio awarded $25 million NIH grant to study critical limb ischemia
A team of researchers from Brigham and Women's Hospital, Boston Medical Center and Massachusetts General Hospital has been awarded $25 million by the National Institutes of Health to conduct a four-year, randomized clinical trial -- the BEST-CLI Trial (Best Endovascular versus Best Surgical Therapy in Patients with Critical Limb Ischemia).
National Institutes of Health

Contact: Marjorie Montemayor-Quellenberg
Brigham and Women's Hospital

Public Release: 11-Dec-2013
IU-designed probe opens new path for drug development against leading STD
Biochemical sleuthing by an Indiana University graduate student has ended a nearly 50-year-old search to find a megamolecule in bacterial cell walls commonly used as a target for antibiotics, but whose presence had never been identified in the bacterium responsible for the most commonly reported sexually transmitted disease in the United States.
National Institutes of Health

Contact: Stephen Chaplin
Indiana University

Public Release: 11-Dec-2013
Developmental Cell
1 protein, 2 personalities: Penn team identifies new mechanism of cancer spread
A new finding by University of Pennsylvania scientists has identified key steps that trigger the disintegration of cellular regulation that leads to cancer. Their discovery -- that a protein called Exo70 has a split personality, with one form keeping cells under tight control and another contributing to the ability of tumors to invade distant parts of the body -- points to new possibilities for diagnosing cancer metastasis.
National Institutes of Health

Contact: Katherine Unger Baillie
University of Pennsylvania

Public Release: 11-Dec-2013
Psychological Science
Even when test scores go up, some cognitive abilities don't
MIT neuroscientists find even high-performing schools don't influence their students' abstract reasoning.
Bill and Melinda Gates Foundation, National Institutes of Health

Contact: Sarah McDonnell
Massachusetts Institute of Technology

Public Release: 11-Dec-2013
Ethnicity and Disease
Eating burgers from restaurants associated with higher obesity risk in in African-American women
Americans are increasingly eating more of their meals prepared away from home, and this is particularly true among African-Americans, who also have higher rates of obesity than other Americans. Young adults tend to eat out more often at fast-food restaurants and these establishments are more often found in minority neighborhoods.
Aetna Foundation, NIH/National Cancer Institute

Contact: Gina DiGravio
Boston University Medical Center

Public Release: 11-Dec-2013
Mounting challenges undermine parenting
New findings from a long-running study of nearly 1,300 rural children by UNC's Frank Porter Graham Child Development Institute reveal that parenting deteriorates when families face a number of risk factors at once. As a result, children's intellectual, emotional, and social development suffers.
NIH/National Institute of Child Health and Human Development

Contact: Lynne Vernon-Feagans
Frank Porter Graham Child Development Institute

Public Release: 11-Dec-2013
Science Translational Medicine
Johns Hopkins researchers identify a new way to predict the prognosis for heart failure patients
Johns Hopkins researchers have identified a new way to predict which heart failure patients are likely to see their condition get worse and which ones have a better prognosis. Their study is one of the first to show that energy metabolism within the heart, measured using a noninvasive magnetic resonance imaging test, is a significant predictor of clinical outcomes, independent of a patient's symptoms or the strength of the heart's ability to pump blood, known as the ejection fraction.
NIH/National Heart, Lung, and Blood Institute

Contact: Ellen Beth Levitt
Johns Hopkins Medicine

Public Release: 11-Dec-2013
Rare gene variants double risk for Alzheimer's disease
A team of researchers led by Washington University School of Medicine in St. Louis has identified variations in a gene that double a person's risk of developing Alzheimer's disease later in life. The newly identified variations occur rarely in the population, making them hard for researchers to identify. But they're important because individuals who carry them are at substantially increased risk.
National Institutes of Health, Alzheimer's Association, BrightFocus Foundation

Contact: Jim Dryden
Washington University School of Medicine

Public Release: 11-Dec-2013
Cell Host & Microbe
Scientists discover chemical modification in human malaria parasite DNA
University of California, Riverside researchers who are trying to understand the biology of Plasmodium, the human malaria parasite, have discovered a potential weakness--low levels of DNA methylation in Plasmodium's genome that may be critical to the survival of the parasite. Until now, the existence of DNA methylation -- a biochemical process involving the modification of DNA -- in the Plasmodium parasite was disputable.
National Institutes of Health, National Science Foundation

Contact: Iqbal Pittalwala
University of California - Riverside

Public Release: 11-Dec-2013
Brief laser-light treatment may significantly improve effectiveness of influenza vaccines
Pretreating the site of intradermal vaccination with near-infrared laser light may substantially improve vaccine effectiveness without the adverse effects of chemical additives currently used to boost vaccine efficacy.
NIH/National Institutes of Health, Defense Advanced Research Projects Agency, Bill & Melinda Gates Foundation

Contact: Kristen Chadwick
Massachusetts General Hospital

Public Release: 11-Dec-2013
Multi-gene test could help spot breast cancer patients most at risk
A new test may help physicians identify patients with the most lethal forms of triple-negative breast cancer. It was able to distinguish between patients with a good or poor prognosis, even within groups of patients already stratified by existing tests. It also suggests potential targets for new drugs and therapies.
National Institutes of Health

Contact: John Easton
University of Chicago Medical Center

Public Release: 11-Dec-2013
Science Translational Medicine
Dietary amino acids relieve sleep problems after traumatic brain injury in animals
Scientists who fed a cocktail of key amino acids to mice improved sleep disturbances caused by brain injuries in the animals. These new findings suggest a potential dietary treatment for millions of people affected by traumatic brain injury -- a condition that is currently untreatable.
National Institutes of Health

Contact: John Ascenzi
Children's Hospital of Philadelphia

Public Release: 11-Dec-2013
2013 CTRC-AACR San Antonio Breast Cancer Symposium
Exercise protects against aggressive breast cancer in black women
A nearly 20-year observational study involving more than 44,700 black women nationwide found that regular vigorous exercise offers significant protection against development of the most aggressive subtypes of breast cancer. The findings from the Black Women's Health Study are being presented Wednesday, Dec. 11 at the 2013 San Antonio Breast Cancer Symposium.
NIH/National Cancer Institute

Contact: Karen Teber
Georgetown University Medical Center

Showing releases 3401-3425 out of 3531.

<< < 132 | 133 | 134 | 135 | 136 | 137 | 138 | 139 | 140 | 141 > >>


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