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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 3401-3425 out of 3441.

<< < 132 | 133 | 134 | 135 | 136 | 137 | 138 > >>

Public Release: 1-Aug-2013
Study reveals target for drug development for chronic jaw pain disorder
In a study in mice, researchers at Duke Medicine identified a protein that is critical to temporomandibular joint disorder pain, and could be a promising target for developing treatments for the disorder.
National Institutes of Health, Duke, Keimyung University School of Medicine

Contact: Rachel Harrison
Duke University Medical Center

Public Release: 1-Aug-2013
The when and where of the Y: Research on Y chromosomes finds new clues about human ancestry
Using advanced analysis of DNA from Y chromosomes from men all over the world, scientists have shed new light on the mystery of when and how a few early human ancestors started to give rise to the incredible diversity of today's population.
National Science Foundation, National Institutes of Health

Contact: Kara Gavin
University of Michigan Health System

Public Release: 1-Aug-2013
Journal of Biological Chemistry
Study highlights possible new approach to prostate cancer treatment
A study in the Journal of Biological Chemistry identifies a new therapeutic approach to treat prostate cancer. The research shows that expression of the FoxM1 protein is essential for prostate cancer to develop in mouse models. The study also shows that depletion of FoxM1 in prostate epithelial cells inhibits tumor cell proliferation, the process by which new blood vessels are formed, and metastasis -- the spread of cancer to other organs of the body.
Department of Defense, National Institutes of Health

Contact: Nick Miller
Cincinnati Children's Hospital Medical Center

Public Release: 1-Aug-2013
Targeted therapy identified for protein that protects and nourishes cancer
UT MD Anderson scientists identify the first targeted therapy to block Skp2, which suppresses a cellular defense against cancer and activates glycolysis to feed tumors. The drug restores the senescence program and stifles glycolysis to thwart tumor progression.
NIH/National Cancer Institute, American Cancer Society, Susan G. Komen for the Cure

Contact: Scott Merville
University of Texas M. D. Anderson Cancer Center

Public Release: 1-Aug-2013
Molecular Cell
Sanford-Burnham researchers map a new metabolic pathway involved in cell growth
Deciphering the body's complex molecular pathways that lead to disease when they malfunction is highly challenging. Researchers at Sanford-Burnham Medical Research Institute now have a more complete picture of one particular pathway that can lead to cancer and diabetes. In the study published by Molecular Cell, the scientists uncovered how a protein called p62 has a cascade affect in regulating cell growth in response to the presence of nutrients such as amino acids and glucose.
National Institutes of Health

Contact: Deborah Robison
Sanford-Burnham Medical Research Institute

Public Release: 1-Aug-2013
New insight into how brain 'learns' cocaine addiction
A team of researchers says it has solved the longstanding puzzle of why a key protein linked to learning is also needed to become addicted to cocaine. Results of the study, published in the Aug. 1 issue of the journal Cell, describe how the learning-related protein works with other proteins to forge new pathways in the brain in response to a drug-induced rush of the "pleasure" molecule dopamine.
NIH/National Institute on Drug Abuse, NIH/National Institute of Mental Health, NIH/National Institute of Neurological Disorders and Stroke, NIH/National Cancer Institute, Howard Hughes Medical Institute, US Department of Energy

Contact: Shawna Williams
Johns Hopkins Medicine

Public Release: 1-Aug-2013
BMC Infectious Diseases
The 4-point test to predict death risk from C. difficile
A research paper published today, 2nd August 2013, in BMC Infectious Diseases has for the first time identified a unique four-point test using easily measurable clinical variables which can be used to accurately predict the death risk to patients from C. diff. Accurate prediction means that those patients at risk can be managed accordingly by the clinical team.
NIH/National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care in the South West Peninsula

Contact: Louise Vennells
University of Exeter

Public Release: 1-Aug-2013
Potential nutritional therapy for childhood neurodegenerative disease
Researchers at the University of California, San Diego School of Medicine have identified the gene mutation responsible for a particularly severe form of pontocerebellar hypoplasia, a currently incurable neurodegenerative disease affecting children. Based on results in cultured cells, they are hopeful that a nutritional supplement may one day be able to prevent or reverse the condition.
National Institutes of Health, Howard Hughes Medical Institute, California Institute for Regenerative Medicine

Contact: Scott LaFee
University of California - San Diego

Public Release: 1-Aug-2013
New designer compound treats heart failure by targeting cell nucleus
Researchers from Case Western Reserve University School of Medicine and the Dana-Farber Cancer Institute have made a fundamental discovery relevant to the understanding and treatment of heart failure -- a leading cause of death worldwide. The team discovered a new molecular pathway responsible for causing heart failure and showed that a first-in-class prototype drug, JQ1, blocks this pathway to protect the heart from damage.
National Institutes of Health

Contact: Jessica Studeny
Case Western Reserve University

Public Release: 1-Aug-2013
Cell Stem Cell
UC San Diego researchers develop efficient model for generating human iPSCs
Researchers at the University of California, San Diego School of Medicine report a simple, easily reproducible RNA-based method of generating human induced pluripotent stem cells (iPSCs) in the Aug. 1 edition of Cell Stem Cell. Their approach has broad applicability for the successful production of iPSCs for use in human stem cell studies and eventual cell therapies.
California Institute for Regenerative Medicine, National Institutes of Health, US Department of Defense, Howard Hughes Medical Institute

Contact: Debra Kain
University of California - San Diego

Public Release: 1-Aug-2013
Cell Reports
Neuroscientists find protein linked to cognitive deficits in Angelman syndrome
A team of neuroscientists has identified a protein in laboratory mice linked to impairments similar to those afflicted with Angelman syndrome -- a condition associated with symptoms that include autism, intellectual disability, and motor abnormalities.
National Institutes of Health, Angelman Syndrome Foundation

Contact: James Devitt
New York University

Public Release: 1-Aug-2013
Journal of American Society of Nephrology
Simple ultrasound treatment may help protect the kidneys
Ultrasound treatment can help prevent acute kidney injury in animals. Anti-inflammatory effects of the treatment appear to give it its kidney-protective properties.
National Institutes of Health

Contact: Tracy Hampton
American Society of Nephrology

Public Release: 1-Aug-2013
Journal of Clinical Investigation
Defense against bacterial infection in chronic granulomatous disease
Patients suffering from chronic granulomatous disease (CGD) are prone to recurrent and potentially life threatening bouts of infection due to the inability of phagocytic cells to kill invading microorganisms. In the current issue of the Journal of Clinical Investigation, Griffin Rodgers and colleagues at the National Institutes of Health identify a neutrophil granule protein, OLFM4 as a potential therapeutic target for CGD patients.
National Institutes of Health

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 1-Aug-2013
Journal of Clinical Investigation
Identification of a molecule linking bone loss and bone formation
In this issue of the Journal of Clinical Investigation, Sunao Takeshita and colleagues at the National Center for Geriatrics and Gerontology identify a protein, CTHRC1 that is secreted by bone adsorbing cells and helps initiate bone formation.
Japan/Ministry of Education, NIH/Promotion of Fundamental Studies in Health Sciences

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 31-Jul-2013
Journal of Allergy and Clinical Immunology
New target identified for food allergy therapy
Researchers at National Jewish Health have identified an enzyme that is essential to the allergic reaction to peanuts. Blocking the enzyme's activity in sensitized mice prevented diarrhea and inflammation, and reduced levels of several proteins associated with allergies. The findings, published online in the Journal of Allergy and Clinical Immunology, identify the enzyme, known as Cyp11a1, as a potential target for treatment of increasingly common and potentially deadly food allergy.
National Institutes of Health

Contact: William Allstetter
National Jewish Health

Public Release: 31-Jul-2013
Breath analysis reliably indicates presence, level of infection in mice, UCI study finds
Breath analysis may prove to be an accurate, noninvasive way to quickly determine the severity of bacterial and other infections, according to a UC Irvine study appearing online today in the open-access journal PLOS ONE.
NIH/National Institute of Allergy & Infectious Diseases

Contact: Tom Vasich
University of California - Irvine

Public Release: 31-Jul-2013
Reproductive Health
Obesity doesn't reduce chance of getting pregnant with donor eggs
In women who use donor eggs to become pregnant through in vitro fertilization, those who are obese are just as likely to become pregnant as normal weight women, according to a new report.
NIH/Women's Reproductive Health Research Program

Contact: Diane Duke Williams
Washington University School of Medicine

Public Release: 31-Jul-2013
$1.8 million grant to support research on impact of social stress
Dr. Kim Huhman, a researcher in the Center for Behavioral Neuroscience at Georgia State University, has received a federal five-year, $1.8 million grant for research that may lead to improved strategies for treating and preventing mental health problems associated with exposure to social stress.
NIH/National Institute of Mental Health

Contact: Natasha De Veauuse Brown
Georgia State University

Public Release: 31-Jul-2013
BIDMC's George Tsokos, M.D., receives NIH MERIT award
Beth Israel Deaconess Medical Center Chief of Rheumatology George Tsokos, M.D., is the recipient of a MERIT Award from the National Institutes of Health.
National Institutes of Health

Contact: Bonnie Prescott
Beth Israel Deaconess Medical Center

Public Release: 31-Jul-2013
Nature Communications
Understanding the effects of genes on human traits
Recent technological developments in genomics have revealed a large number of genetic influences on common complex diseases, such as diabetes, asthma, cancer or schizophrenia. However, discovering a genetic variant predisposing to a disease is only a first step. In a study published today in Nature Communications, Montreal researchers with colleagues from Texas, propose a novel approach for scanning the entire genome that will help us understand the effect of genes on human traits.
Genome Canada, Genome Quebec, National Institutes of Health

Contact: Julie Robert
514-934-1934 x71381
McGill University Health Centre

Public Release: 31-Jul-2013
American Journal of Human Genetics
Penn: New variants at gene linked to kidney disease, sleeping sickness resistance
A new study led by University of Pennsylvania researchers involves a classic case of evolution's fickle nature: a genetic mutation that protects against a potentially fatal infectious disease also appears to increase the risk of developing a chronic, debilitating condition.
National Science Foundation, National Institutes of Health

Contact: Katherine Unger Baillie
University of Pennsylvania

Public Release: 31-Jul-2013
Genetic link to gestational diabetes
New Northwestern Medicine® research on the genetics of diabetes could one day help women know their risk for developing gestational diabetes before they become pregnant -- and lead to preventive measures to protect the health of offspring.
National Institutes of Health, American Diabetes Association

Contact: Erin White
Northwestern University

Public Release: 31-Jul-2013
Mount Sinai launches first-ever genetic testing program in the primary care setting
Primary-care providers will use patients' genomic information at the point-of-care to individualize treatment, testing and monitoring with Mount Sinai's Clinical Implementation of Personalized Medicine through Electronic Health Records and Genomic Program, or CLIPMERGE, a novel clinical-decision support engine for delivering guidelines with genetic variants of clinical significance to enhance treatment.
National Institutes of Health

Contact: Mount Sinai Press Office
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 31-Jul-2013
Proceedings of the National Academy of Sciences
Study offers promising new direction for organ regeneration and tissue repair
Researchers have identified an entirely new approach to enhance tissue growth, findings that could lead to advances in organ regeneration and tissue repair, with widespread therapeutic applications.
National Institutes of Health, NIH/National Institute of Environmental Health Sciences, NIH/National Cancer Institute, Robert A. Welch Foundation

Contact: Bonnie Prescott
Beth Israel Deaconess Medical Center

Public Release: 31-Jul-2013
New protein discovered with vast potential for treatment of cancer and other diseases
In cancer research, discovering a new protein that plays a role in cancer is like finding a key and a treasure map: follow the clues and eventually there could be a big reward. At least that's the hope from a new study published in the journal Nature that discovered a novel protein called ceramide-1 phosphate transport protein.
NIH/National Cancer Institute, Veterans Administration

Contact: John Wallace
Virginia Commonwealth University

Showing releases 3401-3425 out of 3441.

<< < 132 | 133 | 134 | 135 | 136 | 137 | 138 > >>


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