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News from the National Institutes of Health

Funded News


Key: Meeting M      Journal J      Funder F

Showing releases 3426-3436 out of 3436.

<< < 133 | 134 | 135 | 136 | 137 | 138

Public Release: 1-Aug-2013
Cell
Targeted therapy identified for protein that protects and nourishes cancer
UT MD Anderson scientists identify the first targeted therapy to block Skp2, which suppresses a cellular defense against cancer and activates glycolysis to feed tumors. The drug restores the senescence program and stifles glycolysis to thwart tumor progression.
NIH/National Cancer Institute, American Cancer Society, Susan G. Komen for the Cure

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center

Public Release: 1-Aug-2013
Molecular Cell
Sanford-Burnham researchers map a new metabolic pathway involved in cell growth
Deciphering the body's complex molecular pathways that lead to disease when they malfunction is highly challenging. Researchers at Sanford-Burnham Medical Research Institute now have a more complete picture of one particular pathway that can lead to cancer and diabetes. In the study published by Molecular Cell, the scientists uncovered how a protein called p62 has a cascade affect in regulating cell growth in response to the presence of nutrients such as amino acids and glucose.
National Institutes of Health

Contact: Deborah Robison
drobison@sanfordburnham.org
407-615-0072
Sanford-Burnham Medical Research Institute

Public Release: 1-Aug-2013
Cell
New insight into how brain 'learns' cocaine addiction
A team of researchers says it has solved the longstanding puzzle of why a key protein linked to learning is also needed to become addicted to cocaine. Results of the study, published in the Aug. 1 issue of the journal Cell, describe how the learning-related protein works with other proteins to forge new pathways in the brain in response to a drug-induced rush of the "pleasure" molecule dopamine.
NIH/National Institute on Drug Abuse, NIH/National Institute of Mental Health, NIH/National Institute of Neurological Disorders and Stroke, NIH/National Cancer Institute, Howard Hughes Medical Institute, US Department of Energy

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine

Public Release: 1-Aug-2013
BMC Infectious Diseases
The 4-point test to predict death risk from C. difficile
A research paper published today, 2nd August 2013, in BMC Infectious Diseases has for the first time identified a unique four-point test using easily measurable clinical variables which can be used to accurately predict the death risk to patients from C. diff. Accurate prediction means that those patients at risk can be managed accordingly by the clinical team.
NIH/National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care in the South West Peninsula

Contact: Louise Vennells
l.vennells@exeter.ac.uk
44-013-927-24927
University of Exeter

Public Release: 1-Aug-2013
Cell
Potential nutritional therapy for childhood neurodegenerative disease
Researchers at the University of California, San Diego School of Medicine have identified the gene mutation responsible for a particularly severe form of pontocerebellar hypoplasia, a currently incurable neurodegenerative disease affecting children. Based on results in cultured cells, they are hopeful that a nutritional supplement may one day be able to prevent or reverse the condition.
National Institutes of Health, Howard Hughes Medical Institute, California Institute for Regenerative Medicine

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 1-Aug-2013
Cell
New designer compound treats heart failure by targeting cell nucleus
Researchers from Case Western Reserve University School of Medicine and the Dana-Farber Cancer Institute have made a fundamental discovery relevant to the understanding and treatment of heart failure -- a leading cause of death worldwide. The team discovered a new molecular pathway responsible for causing heart failure and showed that a first-in-class prototype drug, JQ1, blocks this pathway to protect the heart from damage.
National Institutes of Health

Contact: Jessica Studeny
Jessica.studeny@case.edu
216-368-4692
Case Western Reserve University

Public Release: 1-Aug-2013
Cell Stem Cell
UC San Diego researchers develop efficient model for generating human iPSCs
Researchers at the University of California, San Diego School of Medicine report a simple, easily reproducible RNA-based method of generating human induced pluripotent stem cells (iPSCs) in the Aug. 1 edition of Cell Stem Cell. Their approach has broad applicability for the successful production of iPSCs for use in human stem cell studies and eventual cell therapies.
California Institute for Regenerative Medicine, National Institutes of Health, US Department of Defense, Howard Hughes Medical Institute

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 1-Aug-2013
Cell Reports
Neuroscientists find protein linked to cognitive deficits in Angelman syndrome
A team of neuroscientists has identified a protein in laboratory mice linked to impairments similar to those afflicted with Angelman syndrome -- a condition associated with symptoms that include autism, intellectual disability, and motor abnormalities.
National Institutes of Health, Angelman Syndrome Foundation

Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University

Public Release: 1-Aug-2013
Journal of American Society of Nephrology
Simple ultrasound treatment may help protect the kidneys
Ultrasound treatment can help prevent acute kidney injury in animals. Anti-inflammatory effects of the treatment appear to give it its kidney-protective properties.
National Institutes of Health

Contact: Tracy Hampton
thampton@nasw.org
American Society of Nephrology

Public Release: 1-Aug-2013
Journal of Clinical Investigation
Defense against bacterial infection in chronic granulomatous disease
Patients suffering from chronic granulomatous disease (CGD) are prone to recurrent and potentially life threatening bouts of infection due to the inability of phagocytic cells to kill invading microorganisms. In the current issue of the Journal of Clinical Investigation, Griffin Rodgers and colleagues at the National Institutes of Health identify a neutrophil granule protein, OLFM4 as a potential therapeutic target for CGD patients.
National Institutes of Health

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 1-Aug-2013
Journal of Clinical Investigation
Identification of a molecule linking bone loss and bone formation
In this issue of the Journal of Clinical Investigation, Sunao Takeshita and colleagues at the National Center for Geriatrics and Gerontology identify a protein, CTHRC1 that is secreted by bone adsorbing cells and helps initiate bone formation.
Japan/Ministry of Education, NIH/Promotion of Fundamental Studies in Health Sciences

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Showing releases 3426-3436 out of 3436.

<< < 133 | 134 | 135 | 136 | 137 | 138

     
   

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