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Department of Health and Human Services

News from the National Institutes of Health

Funded News


Key: Meeting M      Journal J      Funder F

Showing releases 3451-3475 out of 3518.

<< < 134 | 135 | 136 | 137 | 138 | 139 | 140 | 141 > >>

Public Release: 7-Nov-2013
Cell
Researchers build muscle in diseased mice; create human muscle cells in a dish
Skeletal muscle has proved to be very difficult to grow in patients with muscular dystrophy and other disorders that degrade and weaken muscle. Researchers at Boston Children's Hospital's Stem Cell Program now report boosting muscle mass and reversing disease in a mouse model of Duchenne muscular dystrophy, using a "cocktail" of three compounds identified through a new rapid culture system. Adding the same compounds to stem cells derived from patients' skin cells, they then successfully grew human muscle cells in a dish.
National Institutes of Health, Harvard Stem Cell Institute, Howard Hughes Medical Institute

Contact: Irene Sege
irene.sege@childrens.harvard.edu
617-919-3110
Boston Children's Hospital

Public Release: 7-Nov-2013
Arteriosclerosis, Thrombosis and Vascular Biology
Clotting protein hardens aging hearts
The Rice lab of bioengineer Jane Grande-Allen found through studies of pigs' heart valves that age plays a critical role in the valves' progressive hardening, and the problem may be due to the infiltration of a protein known as von Willebrand factor. Tissues from pig valves are commonly used to make human heart-valve replacements.
American Heart Association, National Institutes of Health, Mary R. Gibson Foundation, Mabel and Everett Hinkson Memorial Fund

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University

Public Release: 7-Nov-2013
Cell
Human muscle stem cell therapy gets help from zebrafish
Harvard Stem Cell Scientists have discovered that the same chemicals that stimulate muscle development in zebrafish can also be used to differentiate human stem cells into muscle cells in the laboratory, an historically challenging task that, now overcome, makes muscle cell therapy a more realistic clinical possibility.
National Institutes of Health

Contact: B. D. Colen
bd_colen@harvard.edu
617-495-7821
Harvard University

Public Release: 7-Nov-2013
Cell
Breakthrough discoveries on cellular regeneration seek to turn back the body's clock
Two groups of scientists at the Children's Medical Center Research Institute at UT Southwestern have made complementary discoveries that break new ground on efforts to turn back the body's clock on cellular activity, paving the way for a better understanding of stem cells, tissue growth, and regeneration.
National Institutes of Health, Cancer Prevention and Research Institute of Texas

Contact: Lisa Warshaw
lisa.warshaw@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 7-Nov-2013
Cell
Mayo Clinic researchers identify role of Cul4 molecule in genome instability and cancer
Mayo Clinic researchers have shown that a molecule called Cul4 helps to deposit DNA-packaging histone proteins onto DNA, an integral step in cramming yards of genetic code into compact coils that can fit into each cell. When DNA isn't packaged correctly, it can lead to the genomic instability characteristic of many forms of cancer.
National Institutes of Health, Mayo Clinic

Contact: Joe Dangor
newsbureau@mayo.edu
507-284-5005
Mayo Clinic

Public Release: 7-Nov-2013
Current Biology
Tricking algae's biological clock boosts production of drugs, biofuels
Tricking algae's biological clock to remain in its daytime setting can dramatically boost the amount of commercially valuable compounds that these simple marine plants can produce when they are grown in constant light.
NIH/National Institute of General Medical Sciences, US Department of Energy, Japanese Society for the Promotion of Science, Asahi Glass Foundation

Contact: David Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University

Public Release: 7-Nov-2013
Cell Stem Cell
USC study identifies mechanism that makes ordinary stem cells create tumors
A new study from the Ostrow School of Dentistry of USC published in Cell Stem Cell illustrates how changes in cell signaling can cause ordinary stem cells in the jaw to start forming benign but potentially harmful tumors. Principal investigator Songtao Shi, professor at the Ostrow School of Dentistry Center for Craniofacial Molecular Biology, and his collaborators uncovered a cellular signaling pathway that converts healthy mesenchymal stem cells in the jaw into ossifying fibroma mesenchymal stem cells.
NIH/National Institute of Dental and Craniofacial Research, California Institute for Regenerative Medicine

Contact: Beth Newcomb
bethdunh@usc.edu
213-740-4279
University of Southern California

Public Release: 7-Nov-2013
Genome Research
HPV can damage genes and chromosomes directly, whole-genome sequencing study shows
A study has identified a new mechanism by which the human papillomavirus (HPV) may contribute to cancer development. Using whole-genome sequencing, researchers show that strains of HPV that cause cervical, head and neck and other cancers can directly damage genes and chromosomes where they insert their DNA into human DNA.
Ohio Cancer Research Association, Oral Cancer Foundation, NIH/National Cancer Institute

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Wexner Medical Center

Public Release: 7-Nov-2013
Journal of the American Board of Family Medicine
Female doctors twice as likely to screen low-risk women for cervical cancer with HPV test
How likely is it that your doctor orders the HPV test to screen you for cervical cancer?
National Institutes of Health, NIH/National Cancer Institute

Contact: Beata Mostafavi
bmostafa@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 7-Nov-2013
JAMA Ophthalmology
Peripheral prism glasses help hemianopia patients get around
Mass. Eye and Ear led research shows Peripheral prism glasses provide a simple and inexpensive mobility rehabilitation intervention for hemianopia (blindness in one half of the visual field in both eyes).
National Institutes of Health

Contact: Mary Leach
Mary_Leach@meei.harvard.edu
617-573-4170
Massachusetts Eye and Ear Infirmary

Public Release: 6-Nov-2013
Angewandte Chemie
OU natural products discovery group asks for public's help with citizen science program
The University of Oklahoma Natural Products Discovery Group has taken an unconventional approach to finding new compounds with therapeutic relevance by launching a crowdsourcing initiative with citizen scientists from around the country. OU researchers team with the public to sample soils from all across the United States for the purpose of identifying new microorganisms that produce drug-like compounds.
National Institutes of Health

Contact: Jana Smith
jana.smith@ou.edu
405-325-1322
University of Oklahoma

Public Release: 6-Nov-2013
JAMA Pediatrics
Findings announced from landmark study on safety of adolescent bariatric surgery
Initial results of a first and largest of its kind study focusing on the safety of adolescent bariatric surgery were published this week in JAMA Pediatrics. The "Teen Longitudinal Assessment of Bariatric Surgery" study is funded by the National Institutes of Health and is being conducted at five sites in the US, including Nationwide Children's Hospital.
National Institutes of Health

Contact: Gina Bericchia
Gina.Bericchia@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital

Public Release: 6-Nov-2013
Psychopharmacology
Addicts may be seeking relief from emotional lows more than euphoric highs
Rutgers researchers are challenging the commonly held view that drug addiction occurs because users are always going after the high. Based on new animal studies, they say the initial positive feelings of intoxication are short lived -- quickly replaced by negative emotional responses which may be more important in understanding substance abuse.
NIH/National Institute on Drug Abuse

Contact: Robin Lally
732-932-7084 x652
Rutgers University

Public Release: 6-Nov-2013
Journal of Adolescent Research
Mothers' relationships can influence adolescent children's relationships, MU study finds
Gary Glick, doctoral candidate, the MU College of Arts & Science, Department of Psychological Sciences, found that mothers' relationships can influence adolescent children's relationships with their friends, particularly the negative and antagonistic aspects.
NIH/National Institute of Mental Health

Contact: Jeff Sossamon
sossamonj@missouri.edu
873-882-3346
University of Missouri-Columbia

Public Release: 6-Nov-2013
Journal of Consulting and Clinical Psychology
CWRU study finds mending ruptures in client-therapist relationship has positive benefits
In order for prolonged exposure therapy, an evidence-based psychotherapy for post traumatic stress disorder, to reach its full potential, any misperceptions or ruptures in trust and communication between therapist and client need fixing, according to a new Case Western Reserve University study.
NIH/National Institute of Mental Health

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University

Public Release: 6-Nov-2013
Neurology
Hospitals with neurology residency programs more likely to administer life-saving clot-busting drugs
Stroke patients treated at hospitals with neurology residency programs are significantly more likely to get life-saving clot-busting drugs than those seen at other teaching or non-teaching hospitals, new Johns Hopkins-led research suggests.
NIH/National Institute of Neurological Disorders and Stroke, NIH/National Insitute on Aging, and others

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine

Public Release: 6-Nov-2013
Family Relations
In dual-career couples, mothers still do the most child care
Even in couples most likely to believe in sharing parenting responsibilities, mothers still bear significantly more of the child care load, a new study reveals.
National Science Foundation, NIH/National Institute of Child Health and Human Development

Contact: Sarah Schoppe-Sullivan
Schoppe-sullivan.1@osu.edu
614-688-3437
Ohio State University

Public Release: 6-Nov-2013
Nature
Brain may play key role in blood sugar metabolism and development of diabetes
The development of diabetes Type 2, the authors argue, requires a failure of both the islet-cell system in the pancreas and a brain-centered system for regulating blood sugar levels. Boosting insulin levels alone will lower glucose levels, but only addresses half the problem. To restore normal glucose regulation requires addressing the failures of the brain-centered system as well. Approaches that target both systems may not only achieve better blood glucose control, but could actually cause diabetes to go into remission.
National Institutes of Health, Helmholtz Alliance ICEMED

Contact: Michael McCarthy
mxmc@mac.com
206-543-3620
University of Washington

Public Release: 6-Nov-2013
SDSU receives $8.5M for heart research
The National Institutes of Health has awarded a prestigious Program Project Grant totaling more than $8.5 million over five-years to San Diego State University to better understand how the heart heals and ways stem cells can help the heart repair itself.
National Institutes of Health

Contact: Natalia Elko
natalia.vanstralen@mail.sdsu.edu
619-594-2585
San Diego State University

Public Release: 6-Nov-2013
Circulation
'Don't get sick in July'
With almost no experience, newly graduated medical students enter teaching hospitals around the country every July, beginning their careers as interns. At the same time, the last year's interns and junior residents take a step up and assume new responsibilities. More experienced physicians share a joke about this changing of the guard: Don't get sick in July.
National Institutes of Health, NIH/National Institute on Aging

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School

Public Release: 6-Nov-2013
Journal of Biological Chemistry
Research reveals possible cause of diabetic cardiomyopathy
Researchers now know that the leading cause of diabetic cardiomyopathy can be attributed to PKC activation and its downstream effects on gene expression. Knowing how cardiomyopathy manifests, further research can use these results to concentrate on the prevention and treatment of heart failure in diabetics.
American Heart Association, March of Dimes Foundation, National Institutes of Health

Contact: Kristen Hensley
k.hensley@utmb.edu
409-772-8772
University of Texas Medical Branch at Galveston

Public Release: 6-Nov-2013
Journal of Neuroscience
Postoperative pain may increase risk of temporary problems with learning, memory
The pain caused by a surgical incision may contribute to the risk of postoperative cognitive dysfunction, a sometimes transient impairment in learning and memory that affects a small but significant number of patients in the days following a surgical procedure.
National Institutes of Health, Alzheimer's Association, Cure Alzheimer's Fund

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital

Public Release: 6-Nov-2013
Cancer
Prognostic value of baseline HRQOL for survival for 11 types of cancer pointed out by EORTC study
Results of an EORTC study published in Cancer point out the prognostic value of baseline recorded health-related quality of life for survival for eleven types of cancer: brain, breast, colorectal, esophageal, head and neck, lung, melanoma, ovarian, pancreatic, prostate, and testicular cancer. For each cancer site, at least one health-related quality of life parameter provided additional prognostic information over and above the clinical and sociodemographic variables.
Pfizer Foundation, European Organisation for Research and Treatment of Cancer Charitable Trust, NIH/National Cancer Institute

Contact: John Bean
john.bean@eortc.be
European Organisation for Research and Treatment of Cancer

Public Release: 6-Nov-2013
Lancet Oncology
Long term results of EORTC trial for patients with resectable liver metastases from colorectal cancer
Long term results of the randomized phase III EORTC intergroup trial 40983 were recently reported in The Lancet Oncology. The observed 4.1 percent difference in overall survival at five years for patients with initially resectable liver metastases from colorectal cancer was not significant for perioperative chemotherapy with FOLFOX4 (folinic acid, fluorouracil, and oxaliplatin) compared with surgery alone. The authors conclude that perioperative chemotherapy with FOLFOX4 should remain the reference treatment for this population of patients.
Sanofi -Aventis, NIH/National Cancer Institute, Norwegian and Swedish Cancer Societies, Cancer Research UK, Ligue Nationale Contre le Cancer

Contact: John Bean
john.bean@eortc.be
European Organisation for Research and Treatment of Cancer

Public Release: 6-Nov-2013
Nature
RNA controls splicing during gene expression, further evidence of 'RNA world' origin in modern life
RNA is the key functional component of spliceosomes, molecular machines that control how genes are expressed, report scientists from the University of Chicago online, Nov. 6 in Nature. The discovery establishes that RNA, not protein, is responsible for catalyzing this fundamental biological process and enriches the hypothesis that life on earth began in a world based solely on RNA.
National Institutes of Health, Chicago Biomedical Consortium

Contact: Kevin Jiang
kevin.jiang@uchospitals.edu
773-795-5227
University of Chicago Medical Center

Showing releases 3451-3475 out of 3518.

<< < 134 | 135 | 136 | 137 | 138 | 139 | 140 | 141 > >>

     
   

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