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Showing releases 351-375 out of 611 releases.
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Public Release: 19-Aug-2009
Nature
Study reveals new metabolic safeguards against tumor cells
Researchers have found a new mechanism by which the body kills potential tumor cells. When cells separate from their normal environment -- a common event during tumor formation -- they develop certain metabolic disabilities that prevent them from becoming cancerous. While some tumor genes can help these cells escape such defects, the researchers also found that antioxidant treatment can restore normal metabolic activity in these detached, homeless cells, giving them a second chance to survive and potentially become cancerous.
NIH/National Cancer Institute, National Institutes of Health

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School

Public Release: 18-Aug-2009
JAMA
Palliative care intervention for patients with advanced cancer provides quality of life benefits
Patients with advanced cancer who received a palliative care intervention focused on addressing physical and psychosocial issues and care coordination that was provided at the same time as cancer treatment reported improved quality of life and mood but did not experience a significant change in the number of days in the hospital or the severity of their symptoms compared to patients who received usual care, according to a study in the Aug. 19 issue of JAMA.
NIH/National Cancer Institute

Contact: Mary Hawkins
Mary.S.Hawkins@Dartmouth.edu
603-653-3615
Dartmouth-Hitchcock Medical Center

Public Release: 18-Aug-2009
Journal of Research in Personality
Study: Personality traits associated with stress and worry can be hazardous to your health
Personality traits associated with chronic worrying can lead to earlier death, at least in part because these people are more likely to engage in unhealthy behaviors, such as smoking, according to research from Purdue University.
NIH/National Institute on Aging, US Department of Veterans Affairs

Contact: Amy Patterson Neubert
apatterson@purdue.edu
765-494-9723
Purdue University

Public Release: 18-Aug-2009
JAMA
Low-dose estrogen shown safe and effective for metastatic breast cancer
When estrogen-lowering drugs no longer control metastatic breast cancer, the opposite strategy might work. Raising estrogen levels benefited 30 percent of women whose metastatic breast cancer no longer responded to standard antiestrogen treatment, according to research conducted at Washington University School of Medicine in St. Louis and collaborating institutions.
Avon Foundation, NIH/National Cancer Institute

Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine

Public Release: 17-Aug-2009
Archives of Suicide Research
US-born Asian-American women more likely to think about, attempt suicide
Although Asian-Americans as a group have lower rates of thinking about and attempting suicide than the national average, US-born Asian-American women seem to be particularly at risk for suicidal behavior.
NIH/National Institute of Mental Health, Substance Abuse and Mental Health Services Administration

Contact: Joel Schwarz
joels@u.washington.edu
206-543-2580
University of Washington

Public Release: 17-Aug-2009
Developmental Cell
How to make a lung
A tissue-repair-and-regeneration pathway in the human body, including wound healing, is essential for the early lung to develop properly. Genetically engineered mice fail to develop lungs when two molecules in this pathway, Wnt2 and Wnt2b, are knocked out.
NIH/National Cancer Institute, American Heart Association, NIH/National Heart, Lung and Blood Institute

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 17-Aug-2009
Developmental Cell
Newly discovered mechanism in cell division has implications for chromosome's role in cancer
Errors in cell division can cause mutations that lead to cancer, and a new study could shed light on the role of chromosome abnormalities in uncontrolled cell replication. They uncovered the molecular players and mechanism underlying a little-studied stage of cellular division called Anaphase B.
NIH/National Institutes of General Medical Sciences, American Cancer Society, American Red Cross, Human Frontier Science Program, LaLigue, BioMS, Volkswagen-Stiftung, et al.

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 17-Aug-2009
Nature
Faster, cheaper way to find disease genes in human genome passes initial test
Researchers have successfully developed a novel genomic analysis strategy for faster, cheaper discovery of gene-disease links. The strategy was tested on the genomes of unrelated individuals with the same inherited disorder. The method might be extended to common medical conditions with complex genetics by making it possible to study the genomes of large groups of people.
National Insitutes of Health, NIH/National Heart, Lung and Blood Institute, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Washington Research Foundation, Singapore Agency for Science, Technology and Research

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington

Public Release: 17-Aug-2009
American Association for Cancer Research 97th Annual Meeting
Genome Research
New DNA test uses nanotechnology to find early signs of cancer
Using tiny crystals called quantum dots, Johns Hopkins researchers have developed a highly sensitive test to look for DNA attachments that often are early warning signs of cancer.
NIH/National Cancer Institute, National Science Foundation, Hodson Foundation, Flight Attendant Medical Research Institute

Contact: Phil Sneiderman
prs@jhu.edu
443-287-9960
Johns Hopkins University

Public Release: 17-Aug-2009
Journal of Clinical Investigation
Research points to new target for stopping colon cancer
New research led by scientists at the University of North Carolina at Chapel Hill School of Medicine have found a drug target that suggests a potent way to kill colon cancers that resist current drugs aimed at blocking a molecule found on the surface of cells.
NIH/National Cancer Institute, National Science Foundation, Korea Science and Engineering Foundation

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine

Public Release: 16-Aug-2009
Nature Genetics
Inherited risk factors increase odds of developing childhood acute lymphoblastic leukemia
Scientists at St. Jude Children's Research Hospital have identified inherited variations in two genes that account for 37 percent of childhood acute lymphoblastic leukemia, including a gene that may help predict drug response.
NIH/National Cancer Institute, NIH/National Institutes of General Medical Sciences, American Lebanese Syrian Associated Charities

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Public Release: 14-Aug-2009
PLoS Genetics
USC researchers identify 'regulatory' genetic sequences that may predict risk for prostate cancer
Researchers at the Keck School of Medicine of the University of Southern California have identified a novel genetic mechanism that may govern an individual's risk of developing prostate cancer.
NIH/National Cancer Institute, L.K.Whittier Foundation

Contact: Leslie Ridgeway
leslie.ridgeway@usc.edu
323-442-2823
University of Southern California

Public Release: 13-Aug-2009
Cancer Research
Cancer mortality rates experience steady decline
The number of cancer deaths has declined steadily in the last three decades. Although younger people have experienced the steepest declines, all age groups have shown some improvement, according to a recent report in Cancer Research, a journal of the American Association for Cancer Research.
NIH/National Institute of Child Health and Human Development, Van Andel Institute

Contact: Tim Hawkins
tim.hawkins@vai.org
616-234-5519
Van Andel Research Institute

Public Release: 13-Aug-2009
Grant will expand former smoker-led intervention program
Researchers are helping women who live in public housing in Georgia and South Carolina stop smoking through a proven former smoker-led intervention program.
NIH/National Heart, Lung and Blood Institute

Contact: Jennifer Hilliard
jhilliard@mcg.edu
706-721-8604
Medical College of Georgia

Public Release: 13-Aug-2009
Science
Scientists find a common link of bird flocks, breast milk and trust
What do flocks of birds have in common with trust, monogamy and even breast milk? According to a new report in the journal Science, they are regulated by virtually identical neurochemicals in the brain, known as oxytocin in mammals and mesotocin in birds.
NIH/National Institute of Mental Health

Contact: James Goodson
jlgoodso@indiana.edu
812-856-4756
Indiana University

Public Release: 13-Aug-2009
Cell
New method takes aim at aggressive cancer cells
A multi-institutional team has discovered a chemical that works in mice to kill the rare, aggressive cells within breast cancers that can seed new tumors. These cells, known as cancer stem cells, are thought to enable cancers to spread -- and to reemerge after seemingly successful treatment. Although work is needed to determine whether this chemical holds promise for humans, the study shows that it is possible to find chemicals that selectively kill cancer stem cells.
NIH/National Cancer Institute, Initiative for Chemical Genetics

Contact: Matt Fearer
fearer@wi.mit.edu
617-452-4630
Whitehead Institute for Biomedical Research

Public Release: 12-Aug-2009
PLoS ONE
Worth the effort? Not if you're depressed
New research indicates that decreased cravings for pleasure may be at the root of a core symptom of major depressive disorder. The research is in contrast to the long-held notion that those suffering from depression lack the ability to enjoy rewards, rather than the desire to seek them.
NIH/Nationa Institute on Drug Abuse

Contact: Melanie Moran
melanie.moran@vanderbilt.edu
615-322-2706
Vanderbilt University

Public Release: 12-Aug-2009
New England Journal of Medicine
Vision improvement after gene therapy maintained at 1 year for inherited retinal blindness
One year after a trio of young adults received gene therapy for an inherited form of blindness, researchers have documented that the patients are still experiencing the same level of remarkable vision improvements previously measured within weeks. This is the first study to report one-year gene therapy safety and efficacy results in treating young adults with Leber Congenital Amaurosis, a hereditary condition that causes severe vision impairment in infants and children.
NIH/National Eye Institute

Contact: Kim Guenther
kim.guenther@uphs.upenn.edu
215-200-2312
University of Pennsylvania School of Medicine

Public Release: 12-Aug-2009
National Cancer Institute names Emory to nationwide NCI chemical biology consortium
Emory University's Chemical Biology Discovery Center has been selected by SAIC-Frederick Inc. to be part of an 11-member national consortium aimed at accelerating the discovery and development of new and innovative, targeted cancer therapies. The national Chemical Biology Consortium will bridge the gap between basic scientific investigation and clinical research supported by the NCI.
SAIC-Frederick, NIH/National Cancer Institute

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University

Public Release: 12-Aug-2009
New England Journal of Medicine
Vision researchers see unexpected gain a year into blindness trial
Scientists have discovered that even in adults born with extremely impaired sight, the brain can rewire itself to recognize sections of the retina that have been restored by gene therapy. The report in the New England Journal of Medicine talks about the brain's surprising adaptability a year after three blind volunteers received doses of corrective genes to selected areas of their retinas at Shands at the University of Florida medical center.
NIH/National Eye Institute

Contact: John Pastor
jdpastor@ufl.edu
352-273-5815
University of Florida

Public Release: 12-Aug-2009
Neuron
The mind's eye scans like a spotlight
Researchers at MIT's Picower Institute for Learning and Memory say you are more likely to scan the room, jumping from face to face as you search for your friend. In addition, the timing of these jumps appears to be determined by waves of activity in the brain that act as a clock.
National Science Foundation, NIH/National Institute of Neurological Disorders and Stroke.

Contact: Jen Hirsch
jfhirsch@mit.edu
617-253-1682
Massachusetts Institute of Technology

Public Release: 11-Aug-2009
PLoS ONE
Discovery may lead to powerful new therapy for asthma
University of Texas Medical Branch at Galveston researchers have found that a single enzyme is apparently critical to most allergen-provoked asthma attacks -- and that activity of the enzyme, known as aldose reductase, can be significantly reduced by compounds that have already undergone clinical trials as treatments for complications of diabetes.
American Asthma Foundation, NIH/National Institute of Environmental Health Sciences

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston

Public Release: 11-Aug-2009
NeuroReport
Oxygen treatment hastens memory loss in Alzheimer's mice
Researchers at the University of South Florida and Vanderbilt University suspect the culprit precipitating Alzheimer's disease in some elderly patients may be high concentrations of oxygen administered during or after major surgery -- a hypothesis borne out in a recent animal model study. The findings are published online this month in NeuroReport.
Florida Alzheimer's Disease Research Center, NIH/National Institute on Aging, National Institutes of Health Merit Award

Contact: Gary Arendash, PhD
arendash@cas.usf.edu
813-732-9040
University of South Florida Health

Public Release: 11-Aug-2009
Multi-laboratory study sizes up nanoparticle sizing
As a result of a major inter-laboratory study co-managed by NIST and the National Cancer Institute, the standards body ASTM International has been able to update its guidelines for a commonly used technique for measuring the size of nanoparticles in solutions.
ASTM International, NIH/National Cancer Institute

Contact: Michael Baum
michael.baum@nist.gov
301-975-2763
National Institute of Standards and Technology (NIST)

Public Release: 11-Aug-2009
Journal of American Geriatrics Society
Aging with GRACE: New health care delivery model improves outcomes, saves money
A team approach to preventive health care delivery for older adults developed by researchers from Indiana University and the Regenstrief Institute improves health and quality of life, decreased emergency department visits and lowered hospital admission rates. By the second year the new model saved money for the sickest (those with three to four chronic diseases), and in the third year, a year after the home-based intervention ended, it saved even more.
NIH/National Institute on Aging, Nina Mason Pulliam Charitable Trust, Wishard Health Services

Contact: Cindy Fox Aisen
caisen@iupui.edu
317-274-7722
Indiana University School of Medicine

Showing releases 351-375 out of 611 releases.
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