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Showing releases 426-450 out of 619 releases.
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Public Release: 28-Jul-2009
Therapeutic Drug Monitoring
Common household pesticides linked to childhood cancer cases in Washington area
A study by Georgetown's Lombardi Comprehensive Cancer Center researchers finds a higher level of common household pesticides in the urine of children with acute lymphoblastic leukemia (ALL), a cancer that develops most commonly between 3 and 7 years of age. The findings, published in the August issue of the journal Therapeutic Drug Monitoring, should not be seen as cause-and-effect, but suggests an association between pesticide exposure and development of childhood ALL.
NIH/National Cancer Institute

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center

Public Release: 27-Jul-2009
Proceedings of the National Academy of Sciences
Comprehensive look at rare leukemia finds relatively few genetic changes launch disease
The most comprehensive analysis yet of the genome of childhood acute myeloid leukemia found only a few mistakes in the genetic blueprint, suggesting the cancer arises from just a handful of missteps, according to new findings from St. Jude Children's Research Hospital.
NIH/National Cancer Institute, Leukemia and Lymphoma Society, National Health and Medical Research Council of Australia, American-Lebanese-Syrian Associated Charities

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital

Public Release: 27-Jul-2009
Proceedings of the National Academy of Sciences Early Edition
Molecule plays early role in nonsmoking lung cancer
A study led by Ohio State University Comprehensive Cancer Center and National Cancer Institute researchers suggests that a molecule called miR-21 is important in the development of lung cancer in never-smokers and in smokers. Lung tumors from never-smokers with mutations in a gene called EGFR had particularly high levels of the molecule. The findings may lead to improve targeted therapy for lung cancer, including tumors resistant to targeted drugs such as gefitinib.
National Institutes of Health Intramural Research Program, NIH/National Cancer Institute, Center for Cancer Research

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center

Public Release: 27-Jul-2009
Journal of Clinical Oncology
In the modern post-PSA era, prostate cancer surgery may not be necessary for some patients
Investigators at Memorial Sloan-Kettering Cancer Center, along with collaborating teams at the Cleveland Clinic and the University of Michigan, have completed the first large-scale, multi-institutional study of prostate cancer death after standard treatment to remove the prostate since PSA screening has become widely used as a method to screen for the disease.
NIH/National Cancer Institute, David Koch Foundation, Prostate Cancer Foundation

Contact: Jeanne D'Agostino
dagostij@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center

Public Release: 27-Jul-2009
PLoS Biology
Why retroviruses such as HIV love their neighbors
Retroviruses such as HIV that are already within cells are much more easily transmitted when they are next to uninfected cells than if they are floating free in the bloodstream. Now, Yale University researchers led by Walther Mothes and Jing Jin, a postdoctoral associate in Mothes' lab, have made movies of viral activity within cells that help explain why cell-to-cell transmission is so efficient and provide potential targets for a new generation of AIDS drugs.
NIH/National Cancer Institute, amfAR: The Foundation for AIDS Research

Contact: Bill Hathaway
william.hathaway@yale.edu
203-432-1322
Yale University

Public Release: 27-Jul-2009
Journal of Health and Social Behavior
Divorce undermines health in ways remarriage doesn't heal
Divorce and widowhood have a lingering, detrimental impact on health, even after a person remarries, research at the University of Chicago and Johns Hopkins University shows. "Among the currently married, those who have ever been divorced show worse health on all dimensions. Both the divorced and widowed who do not remarry show worse health on all dimensions," said University of Chicago sociologist Linda Waite and co-author of a new study on marriage and health.
Office of the Demography of Aging, Behavioral and Social Research Program, NIH/National Institute on Aging

Contact: William Harms
w-harms@uchicago.edu
773-702-8356
University of Chicago

Public Release: 24-Jul-2009
Obstetrics and Gynecology
UTMB study identifies women at risk of gaining excessive weight with injectable birth control
A study by the University of Texas Medical Branch at Galveston has identified women who are likely to gain weight while using depot medroxyprogesterone acetate, more commonly known as Depo-Provera or the birth control shot. These findings dispel the myth that all women who use DMPA will gain weight and will help physicians to counsel patients appropriately.
NIH/National Institute of Child Health and Human Development

Contact: Kristen Hensley
k.hensley@utmb.edu
409-772-8772
University of Texas Medical Branch at Galveston

Public Release: 24-Jul-2009
Grant supports LSUHSC research on how like cell receptor systems determine very different functions
Andy Catling, Ph.D., associate professor in the department of pharmacology and the Stanley S. Scott Cancer Center at LSU Health Sciences Center New Orleans, has been awarded a $177, 500 supplement to his RO1 grant by the National Institute of General Medical Sciences to support his research on the mechanism by which seemingly similar cell receptor systems determine quite different functions influenced by hormones and drugs.
NIH/National Institute of General Medical Sciences

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center

Public Release: 23-Jul-2009
Archives of Internal Medicine
Some blood pressure drugs may help protect against dementia, study shows
A particular class of medication used to treat high blood pressure could protect older adults against memory decline and other impairments in cognitive function, according to a newly published study from Wake Forest University School of Medicine.
NIH/National Heart, Lung and Blood Institute, Hartford Geriatrics Health Outcomes Research Scholars Program, NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute on Aging

Contact: Jessica Guenzel
jguenzel@wfubmc.edu
336-716-3487
Wake Forest University Baptist Medical Center

Public Release: 23-Jul-2009
Alcoholism: Clinical & Experimental Research
HIV infection and chronic drinking have a synergistic, damaging effect on the brain
At least half of clinic patients with the human immunodeficiency virus report they also drink heavily. Findings show that co-existing HIV infection and chronic alcoholism synergistically damage brain function. Specifically, immediate episodic memory was impaired, while working memory remained intact.
NIH/National Institute on Alcohol Abuse and Alcoholism

Contact: Edith V. Sullivan, Ph.D.
edie@stanford.edu
650-498-7328
Alcoholism: Clinical & Experimental Research

Public Release: 23-Jul-2009
Cell
Scientists discover key event in prostate cancer progression
Researchers at the Ohio State University Comprehensive Cancer Center and Dana-Farber Cancer Institute have discovered how hormone-dependent prostate cancer advances to the incurable hormone-independent disease state. The study shows that in androgen-independent prostate cancer, androgen receptors are reprogrammed to regulate genes involved in a later phase of cell division. A small epigenetic change in a gene called UBE2C is responsible for this reprogramming. Increased expression of that gene correlated with progression to the hormone-independent phase.
NIH/National Cancer Institute, US Department of Defense

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center

Public Release: 22-Jul-2009
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Close caregiver relationship may slow Alzheimer's decline
A study led by Johns Hopkins and Utah State University researchers suggests that a particularly close relationship with caregivers may give people with Alzheimer's disease a marked edge over those without one in retaining mind and brain function over time. The beneficial effect of emotional intimacy that the researchers saw among participants was on par with some drugs used to treat the disease.
NIH/National Institute on Aging

Contact: Christen Brownlee
cbrownlee@jhmi.edu
410-955-7832
Johns Hopkins Medical Institutions

Public Release: 22-Jul-2009
11th International Congress on Combustion By-Products and Their Health Effects
LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease
Stephania Cormier, Ph.D., associate professor of pharmacology at LSU Health Sciences Center New Orleans, has shown for the first time that early exposure to environmentally persistent free radicals (present in airborne ultrafine particulate matter) affects long-term lung function.
NIH/National Institute of Environmental Health Sciences

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center

Public Release: 22-Jul-2009
Mass. General-based research center will investigate why immune system fails to control hepatitis C
A research consortium based at Massachusetts General Hospital has been awarded $15 million from the National Institute of Allergy and Infectious Diseases to investigate how the hepatitis C virus resists suppression and clearance by the immune system.
NIH/National Institute of Allergy and Infectious Diseases

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital

Public Release: 22-Jul-2009
SRI announces selection by the National Cancer Institute as a Chemical Biology Consortium center
SRI International, an independent nonprofit research and development organization, was selected by the National Cancer Institute for a leading role in the newly formed "Chemical Biology Consortium," a collaborative drug discovery partnership focused on advancing new cancer therapeutics active against novel molecular and genetic cancer targets. Based on its track record of cancer drug discovery and development, SRI was chosen to lead three of the CBC's research and development centers: Comprehensive Chemical Biology Screening, Chemical Diversity and Specialized Applications.
NIH/National Cancer Institute

Contact: Dina Basin
dina.basin@sri.com
650-859-3845
SRI International

Public Release: 21-Jul-2009
Scripps research studies lead to a promising first-in-class drug candidate
Discoveries by Scripps Research Institute scientists have led to a promising new drug candidate -- the first in its class -- for patients with a genetic protein-misfolding disease. In results announced by the biopharmaceutical firm FoldRx Pharmaceuticals Inc. today, the new drug tafamidis significantly halts disease progression for patients with a disease called Transthyretin amyloid polyneuropathy.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases, Skaggs Institute for Chemical Biology at Scripps Research, Lita Annenberg Hazen Foundation

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute

Public Release: 21-Jul-2009
Journal of Youth and Adolescence
Screening for childhood depressive symptoms could start in second grade
New research indicates that screening children for symptoms of depression, the most common mental health disorder in the United States, can begin a lot earlier than previously thought, as early as the second grade.
NIH/National Institute on Drug Abuse

Contact: Joel Schwarz
joels@u.washington.edu
206-543-2580
University of Washington

Public Release: 21-Jul-2009
Columbia leads national effort to develop early intervention for schizophrenia
Columbia University Medical Center's Jeffrey A. Lieberman, M.D., a renowned expert in the field of schizophrenia, has been selected by the National Institute of Mental Health of the National Institutes of Health as principal investigator of a nationwide effort to develop an optimal early intervention strategy for treating people experiencing a first episode of the psychotic symptoms of schizophrenia.
NIH/National Institute of Mental Health

Contact: Elizabeth Streich
eas2125@columbia.edu
212-305-6535
Columbia University Medical Center

Public Release: 21-Jul-2009
$2 million grant aids study of lung cancer in people who never smoked
Researchers at UT Southwestern Medical Center are among an elite group of cancer scientists to share a $2 million grant to find biomarkers for lung cancer that develops in people who have never smoked.
NIH/National Cancer Institute, Canary Foundation

Contact: Connie Piloto
connie.piloto@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 21-Jul-2009
Investigative Ophthalmology and Visual Science
A drug-dispensing contact lens
Taking eye drops multiple times a day can be difficult to do, and as little as 1 to 7 percent of the dose is actually absorbed by the eye. Now, researchers led by Daniel Kohane, M.D., Ph.D., director of the Laboratory for Biomaterials and Drug Delivery at Children's Hospital Boston, have developed special contact lenses that can gradually dispense a constant amount of medication to the eye, at adjustable rates.
NIH/National Institute of General Medical Sciences, Fight for Sight, Johnson & Johnson, Boston KPro Fund, Massachusetts Eye and Ear Infirmary

Contact: Jamie Newton
james.newton@childrens.harvard.edu
617-919-3110
Children's Hospital Boston

Public Release: 21-Jul-2009
Tissue Engineering Part A
Skin-like tissue developed from human embryonic stem cells
Tufts researchers have used pluripotent human embryonic stem cells to create three-dimensional tissues that mimic human skin and the oral mucosa.
NIH/National Institute of Dental and Craniofacial Research

Contact: Siobhan Gallagher
617-636-6586
Tufts University, Health Sciences

Public Release: 21-Jul-2009
Nicotine and Tobacco Research
Rates of secondhand smoke exposure high among college students
Secondhand smoke is not only a nuisance, but a potential health concern for many college students, and administrators should be taking steps to reduce students' exposure, according to a new study by researchers at Wake Forest University School of Medicine.
NIH/National Institute on Alcohol Abuse and Alcoholism

Contact: Jessica Guenzel
jguenzel@wfubmc.edu
336-716-3487
Wake Forest University Baptist Medical Center

Public Release: 20-Jul-2009
Proceedings of the National Academy of Sciences
Sea lamprey jettison one-fifth of their genome
Sea lampreys, which arose from the jawless fish that first appeared a half-billion years ago, dramatically remodel their genomes during embronic development. This is believed to be the first recorded observation of a vertebrate reorganizing its genome during normal development. Evolutionary biologists are interested in how and why the lamprey re-organizes its genome because the animal is a living fossil with millions of years of evolutionary history. Its closest ancestors were among the first vertebrates on earth.
National Institutes of Health, National Science Foundation, National Research Service, NIH/National Institute of General Medical Sciences

Contact: Leila Gray
leilag@uw.edu
206-685-0381
University of Washington

Public Release: 20-Jul-2009
LSUHSC's Nichols to use LSD and fruit flies to identify novel genes for psychosis/schizophrenia
Charles Nichols, Ph.D., assistant professor of pharmacology at LSU Health Sciences Center New Orleans, has been awarded a grant in the amount of $1.4 million over four years by the National Institutes of Health's National Institute of Mental Health to find and characterize novel genes involved in psychosis and schizophrenia, using novel research methods.
NIH/National Institute of Mental Health

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center

Public Release: 20-Jul-2009
Journal of General Internal Medicine
No race disparities in risk of AIDS and death in HIV patients in Kaiser Permanente system
Kaiser Permanente researchers found no disparities by race or ethnicity in risk of AIDS and death among HIV-infected patients in a setting of similar access to care. This is despite lower antiretroviral therapy adherence among Hispanics and African-Americans compared to whites. Researchers also saw a trend toward better outcomes for Hispanics.
NIH/National Institute for Allergy and Infectious Diseases

Contact: Emily Schwartz
eschwartz@golinharris.com
415-274-7926
GolinHarris International

Showing releases 426-450 out of 619 releases.
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