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Department of Health and Human Services

News from the National Institutes of Health

Funded News


Key: Meeting M      Journal J      Funder F

Showing releases 51-75 out of 3567.

<< < 1 | 2 | 3 | 4 | 5 | 6 | 7 > >>

Public Release: 27-Jan-2015
Journal of Medicinal Chemistry
Scientists find drug candidates can block cell-death pathway associated with Parkinson's
In a pair of related studies, scientists from the Florida campus of The Scripps Research Institute have shown their drug candidates can target biological pathways involved in the destruction of brain cells in Parkinson's disease. The studies suggest it is possible to design highly effective and highly selective (targeted) drug candidates that can protect the function of mitochondria, ultimately preventing brain cell death.
Department of Defense, National Institutes of Health

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute

Public Release: 27-Jan-2015
Journal of Autism and Developmental Disorders
MRIs link impaired brain activity to inability to regulate emotions in autism
Researchers from the UNC School of Medicine have found that -- when it comes to the ability to regulate emotions - brain activity in autistic people is significantly different than is brain activity in people without autism. Using fMRI, the researchers showed that symptoms including tantrums, irritability, anxiety, and depression seem to have a biological, mechanistic basis.
NIH/National Institute of Mental Health, NIH/National Institute of Child Health and Human Development, UNC-CH Graduate School Dissertation Completion Fellowship, Clinical Translational Core of the Carolina Institute for Developmental Disabibilities

Contact: Mark Derewicz
mark.derewicz@unchealth.unc.edu
919-923-0959
University of North Carolina Health Care

Public Release: 27-Jan-2015
Nature Communications
Researchers pinpoint 2 genes that trigger severest form of ovarian cancer
Researchers from the UNC School of Medicine create the first ever mouse model of ovarian clear cell carcinoma using data gleaned from the human cancer genome atlas. They show how when the genes ARID1A and PIK2CA are mutated in specific ways, the result is the most severe form of ovarian cancer 100 percent of the time. In their paper in Nature Communications, they also show that a known drug can suppress tumor growth.
National Institutes of Health, American Cancer Society, Ovarian Cancer Research Fund/Ann Schreiber Mentored Investigator Award

Contact: Mark Derewicz
mark.derewicz@unchealth.unc.edu
919-923-0959
University of North Carolina Health Care

Public Release: 27-Jan-2015
Science Signaling
Lung cancer clues found in downstream pathway
A new study from researchers at the University of Michigan Comprehensive Cancer Center sheds light on the KRAS pathway with a potential target that might have more success at stopping lung cancer growth.
NIH/National Cancer Institute

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 27-Jan-2015
JAMA
Targeted MRI/ultrasound beats standard biopsy to detect high-risk prostate cancer
Targeted biopsy using new fusion technology that combines magnetic resonance imaging with ultrasound is more effective than standard biopsy in detecting high-risk prostate cancer, according to a large-scale study published today in JAMA.
National Institutes of Health

Contact: Karen Lancaster
klancaster@umm.edu
410-328-8919
University of Maryland Medical Center

Public Release: 27-Jan-2015
Structure
New mechanism unlocked for evolution of green fluorescent protein
A primary challenge in the biosciences is to understand the way major evolutionary changes in nature are accomplished. Sometimes the route turns out to be very simple. An example of such simplicity is provided in a new publication by a group of ASU scientists. They show, for the first time, that a hinge migration mechanism, driven solely by long-range dynamic motions, can be the key for evolution of a green-to-red photoconvertible phenotype in a green fluorescent protein.
National Science Foundation, National Institutes of Health postdoctoral fellowship

Contact: Jenny Green
jenny.green@asu.edu
480-965-1430
Arizona State University

Public Release: 27-Jan-2015
Journal of Neurosurgery
Decisions on future childbearing in women diagnosed with a meningioma
Female meningioma survivors were surveyed to ascertain their personal attitudes toward childbearing and what influences may have played a role in their attitudes. The survey revealed that 43 of respondents 25-44 years of age were warned that pregnancy was a risk factor for meningioma recurrence. Nevertheless, these women were more likely to want a baby (70 percent vs. 54 percent) and intend to have a baby (27 percent vs. 12 percent) than same-age women in the general population.
NIH/National Cancer Institute, Moffit Cancer Center

Contact: Jo Ann M. Eliason
jaeliason@thejns.org
434-982-1209
Journal of Neurosurgery Publishing Group

Public Release: 27-Jan-2015
Annals of Clinical and Translational Neurology
Brain region vulnerable to aging is larger in those with longevity gene variant
People who carry a variant of a gene that is associated with longevity also have larger volumes in a front part of the brain involved in planning and decision-making, according to researchers at UC San Francisco.
Larry L. Hillblom Foundation, NIH/National Institutes on Aging, American Federation for Aging Research, Coulter-Weeks Foundation, Bakar Foundation

Contact: Laura Kurtzman
laura.kurtzman@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 26-Jan-2015
Journal of Clinical Oncology
Inherited gene variation helps explain drug toxicity in patients of East Asian ancestry
About 10 percent of young leukemia patients of East Asian ancestry inherit a gene variation that is associated with reduced tolerance of a drug that is indispensable for curing acute lymphoblastic leukemia, the most common childhood cancer. St. Jude Children's Research Hospital scientists led the study, which is being published online today in the Journal of Clinical Oncology.
National Institutes of Health, ALSAC

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Public Release: 26-Jan-2015
Nature Communications
Penn research shows relationship critical for how cells ingest matter
To survive and fulfill their biological functions, cells need to take in material from their environment. In this process, proteins within the cell pull inward on its membrane, forming a pit that eventually encapsulates the material in a bubble called a vesicle. Researchers from the University of Pennsylvania have now revealed a relationship that governs this process, known as endocytosis.
National Institutes of Health, National Science Foundation

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania

Public Release: 26-Jan-2015
Journal of Cell Biology
UGA researchers image and measure tubulin transport in cilia
A new study from the University of Georgia, published in the Journal of Cell Biology, shows the mechanism behind tubulin transport and its assembly into cilia, including the first video imagery of the process. "Cilia are found throughout the body, so defects in cilia formation affect cells that line airways, brain ventricles or the reproductive track," said the study's lead author Julie Craft.
National Institutes of Health

Contact: Karl F. Lechtreck
lechtrek@uga.edu
706-542-0167
University of Georgia

Public Release: 26-Jan-2015
Heart & Lung
More than half of ICU patients on ventilators have the ability to communicate
A new study reveals that more than half of patients in intensive care units using ventilators to help them breathe could benefit from assistive communication tools.
National Institutes of Health, Robert Wood Johnson Foundation

Contact: Meggie Biss
biss.11@osu.edu
614-292-2247
Ohio State University

Public Release: 26-Jan-2015
Neurobiology of Disease
Study of former NFL players reveals specifics of concussive brain damage
Results of the small study of nine men provide further evidence for potential long-term neurological risk to football players who sustain repeated concussions and support calls for better player protections.
National Institutes of Health, Lupus Foundation of America, NFL Charities, GE/NFL Head Health Challenge.

Contact: Marin Hedin
mhedin2@jhmi.edu
410-502-9429
Johns Hopkins Medicine

Public Release: 26-Jan-2015
Sleep Health
Good bedtime habits equal better sleep for kids
Children obtain better and more age-appropriate sleep in the presence of household rules and regular sleep-wake routines, according to sleep researchers.
National Institutes of Health

Contact: A'ndrea Elyse Messer
aem1@psu.edu
814-865-9481
Penn State

Public Release: 26-Jan-2015
Journal of Clinical Investigation
Study finds potential new drug target for lung cancer
A new study by University of Kentucky Markey Cancer Center researchers suggests that targeting a key enzyme and its associated metabolic programming may lead to novel drug development to treat lung cancer.
NIH/National Cancer Institute, NIH/National Institute of Diabetes and Digestive and Kidney Diseases, NIH/Common Fund

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky

Public Release: 26-Jan-2015
Diabetes
Penn Dental Medicine team shows why wound healing is impaired in diabetics
Scientists at the University of Pennsylvania School of Dental Medicine have identified a critical molecule that helps explain why diabetics suffer from this problem and pinpoints a target for therapies that could help boost healing.
NIH/National Institute for Dental and Craniofacial Research

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania

Public Release: 26-Jan-2015
Social Cognitive and Affective Neuroscience
Brain study sheds light on how children with autism process social play
Brain scans confirm significant differences in play behavior, brain activation patterns and stress levels in children with autism spectrum disorder as compared with typically developing children.
NIH/National Institute of Mental Health

Contact: Jennifer Wetzel
Jennifer.wetzel@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center

Public Release: 26-Jan-2015
Cancer Research
An engineering approach from Virginia Tech helps breast cancer researchers at Georgetown
Biologists working with engineers and physicists have found a molecule they say helps determine if breast cancer cells that are resistant to antiestrogen therapy will live or die. Their study, published online earlier this month in Cancer Research, represents a major finding from a unique collaboration between Georgetown Lombardi Comprehensive Cancer Center and Virginia Tech that was designed to study the living cell as an information processing system.
National Institutes of Health, Susan G. Komen Grant

Contact: Karen Teber
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center

Public Release: 26-Jan-2015
Journal of Clinical Oncology
New model better predicts breast cancer risk in African American women
Researchers from Boston University's Slone Epidemiology Center have developed a breast cancer risk prediction model for African American women that found greater accuracy in predicting risk for the disease. The use of this model could result in increased eligibility of African Americans in breast cancer prevention trials.
The Susan G. Komen for the Cure Foundation, NIH/National Cancer Institute

Contact: Gina DiGravio
ginad@bu.edu
617-638-8480
Boston University Medical Center

Public Release: 26-Jan-2015
ChemBioChem
UCI, fellow chemists find a way to unboil eggs
UC Irvine and Australian chemists have figured out how to unboil egg whites -- an innovation that could dramatically reduce costs for cancer treatments, food production and other segments of the $160 billion global biotechnology industry, according to findings published today in the journal ChemBioChem.
NIH/National Institute of General Medical Sciences, Australian Research Council

Contact: Janet Wilson
janethw@uci.edu
949-824-3969
University of California - Irvine

Public Release: 26-Jan-2015
Nature Neuroscience
Support cells in the brain offer a new strategy to boost memory
Researchers from the Gladstone Institutes have uncovered a new memory regulator in the brain involving adenosine receptors, which may offer a potential treatment to improve memory in Alzheimer's disease.
National Institutes of Health, MetLife Foundation, NIH/National Center for Research Resources

Contact: Dana Smith
dana.smith@gladstone.ucsf.edu
415-734-2532
Gladstone Institutes

Public Release: 26-Jan-2015
Nature Structural & Molecular Biology
Scientists identify new mechanism to aid cells under stress
A team of biologists has identified new details in a cellular mechanism that serves as a defense against stress. The findings potentially offer insights into tumor progression and neurodegenerative diseases, such as Parkinson's and Alzheimer's -- the cell's inability to respond to stress is a major cause of these diseases.
National Science Foundation, National Institutes of Health

Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University

Public Release: 26-Jan-2015
Nature
Brain's on-off thirst switch identified
Neurons that trigger our sense of thirst -- and neurons that turn it off -- have been identified by Columbia University Medical Center neuroscientists. The paper was published today in the online edition of Nature.
National Institutes of Health

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center

Public Release: 26-Jan-2015
JAMA Internal Medicine
Even with copayments for nonurgent care, Medicaid patients still rely on ERs
To control costs and encourage Medicaid recipients to get primary care doctors, some states charge copayments to Medicaid patients who got nonurgent care in hospital emergency departments. A Johns Hopkins study based on 2001-2010 data finds copayments did not affect the rate of Medicaid patients' emergency room visits or lead to more primary care doctor's office visits.
Agency for Healthcare Research and Quality, Jayne Koskinas Ted Giovanis Foundation for Health and Policy, NIH/National Cancer Institute, NIH/National Institutes of Health Office of Behavioral and Social Sciences Research

Contact: Heather Dewar
hdewar@jhmi.edu
410-502-9463
Johns Hopkins Medicine

Public Release: 26-Jan-2015
Sleep Health
Flexible work schedules improve health, sleep
Giving employees more control over their work schedules may help curb sleep deficiency, according to health researchers.
National Institutes of Health, Centers for Disease Control, William T. Grant Foundation, Alfred P. Sloan Foundation, Administration for Children and Families

Contact: Victoria M. Indivero
vmi1@psu.edu
814-865-9481
Penn State

Showing releases 51-75 out of 3567.

<< < 1 | 2 | 3 | 4 | 5 | 6 | 7 > >>

     
   

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