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Showing releases 76-100 out of 3306.

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Public Release: 25-Jul-2013
Nature Methods
Broad-scale genome tinkering with help of an RNA guide
Duke researchers have devised a way to quickly and easily target and tinker with any gene in the human genome. The new tool, which builds on an RNA-guided enzyme they borrowed from bacteria, is being made freely available to researchers who may now apply it to the next round of genome discovery.
National Institutes of Health, National Science Foundation, American Heart Association

Contact: Kendall Morgan
kendall.morgan@duke.edu
919-684-2850
Duke University

Public Release: 25-Jul-2013
PLOS Computational Biology
Analysis of 26 networked autism genes suggests functional role in the cerebellum
A team of scientists has obtained intriguing insights into two groups of autism candidate genes in the mammalian brain that new evidence suggests are functionally and spatially related. The newly published analysis identifies two networked groupings from 26 genes associated with autism that are overexpressed in the cerebellar cortex, in areas dominated by neurons called granule cells.
NIH/National Institute on Drug Abuse

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Public Release: 25-Jul-2013
Journal of Clinical Investigation
Adenosine therapy reduces seizures and progression of epilepsy
In this issue of the Journal of Clinical Investigation, Detlev Boison and colleagues at Legacy Research show an increase of DNA methylation in the hippocampi of epileptic animals.
National Institutes of Health, US Department of Defense

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 25-Jul-2013
Journal of Clinical Investigation
A molecular chaperon prevents antibiotic associated hearing loss
In this issue of the Journal of Clinical Investigation, Lisa Cunningham and colleagues at the National Institutes of Health investigate the mechanism underlying the protective effect of HSP70 on antibiotic induced hair cell loss.
National Institutes of Health

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 24-Jul-2013
Loyola's Alcohol Research Program receives 4 NIH grants totaling more than $3 million
The Alcohol Research Program at Loyola University Chicago Stritch School of Medicine recently received four research grants, totaling more than $3 million, from the National Institutes of Health.
National Institutes of Health

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System

Public Release: 24-Jul-2013
PLOS ONE
Adenoviruses may pose risk for monkey-to-human leap
Adenoviruses commonly infect humans, causing colds, flu-like symptoms and sometimes even death, but now UC San Francisco researchers have discovered that a new species of adenovirus can spread from primate to primate, and potentially from monkey to human.
National Institutes of Health, California National Primate Research Center, Texas Biomedical Research Institute

Contact: Jeffrey Norris
jeff.norris@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 24-Jul-2013
Molecular and Cellular Biology
Potential cause of Parkinson's disease points to new therapeutic strategy
Biologists at The Scripps Research Institute have made a significant discovery that could lead to a new therapeutic strategy for Parkinson's disease. The findings focus on an enzyme known as parkin, whose absence causes an early-onset form of Parkinson's disease.
National Institutes of Health

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute

Public Release: 24-Jul-2013
New England Journal of Medicine
New genetic cause of pulmonary hypertension identified
Scientists have identified new genetic mutations that can cause pulmonary arterial hypertension, a rare fatal disease characterized by high blood pressure in the lungs. The mutations, found in the gene KCNK3, appear to affect potassium channels in the pulmonary artery, a mechanism not previously linked to the condition. Cell culture studies showed that the mutations' effects could be reversed with a drug compound known as a phospholipase inhibitor.
NIH/National Center for Research Resources

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center

Public Release: 24-Jul-2013
Pediatric Blood & Cancer
More central line infections seen in children with cancer once they leave the hospital
Pediatric cancer patients whose central lines are used to treat them at home develop three times as many dangerous bloodstream infections from their devices than their hospitalized counterparts, according to the results of a new Johns Hopkins Children's Center study.
National Institutes of Health

Contact: Ekaterina Pesheva
epeshev1@jhmi.edu
410-502-9433
Johns Hopkins Medicine

Public Release: 24-Jul-2013
Science Translational Medicine
A promising target to treat asthma
A University of Iowa-led team has found a promising, new way to treat asthma: Target an enzyme in airway lining cells. The finding could lead to the development of drugs that block the enzyme, CaMKII, from excessive oxidation, which can trigger asthma attacks.
National Institutes of Health, American Asthma Foundation, Sandler Program for Asthma Research

Contact: Richard Lewis
richard-c-lewis@uiowa.edu
319-384-0012
University of Iowa

Public Release: 24-Jul-2013
Clinical Therapeutics
Improving medicine acceptance in kids: A matter of taste
Many children reject medicines due to an aversion to bitter taste. As such, bitterness presents a key obstacle to the acceptance and effectiveness of beneficial drugs by children worldwide. A new review addresses this critical problem by highlighting recent advances in the scientific understanding of bitter taste, with special attention to the sensory world of children.
NIH/National Institute on Deafness and Other Communication Disorders

Contact: Leslie Stein
stein@monell.org
267-519-4707
Monell Chemical Senses Center

Public Release: 24-Jul-2013
Journal of American Chemical Society
Carnegie Mellon biophysicist obtains first experimental evidence of pressure inside the herpes virus
Scientists have long suspected that herpes viruses were packaged so full of genetic material that they built up an internal pressure so strong it could shoot viral DNA into a host cell during infection. Carnegie Mellon University and University of Pittsburgh researchers have measured, for the first time, the pressure inside human herpes simplex virus 1. The study, published online in the Journal of the American Chemical Society, establishes a new target for antiviral therapies.
National Science Foundation, Swedish Research Council, National Institutes of Health

Contact: Jocelyn Duffy
jhduffy@andrew.cmu.edu
412-268-9982
Carnegie Mellon University

Public Release: 24-Jul-2013
Journal of Adolescent Health
Brothers and sisters learn to build positive relationships in SIBS Program
Little is known about how sibling relationships impact child and family functioning, but Penn State researchers are beginning to shed light on intervention strategies that can cultivate healthy and supportive sibling relationships.
NIH/National Institute on Drug Abuse

Contact: A'ndrea Elyse Messer
aem1@psu.edu
814-865-9481
Penn State

Public Release: 24-Jul-2013
Proceedings of the National Academy of Sciences
Study explains why Africans may be more susceptible to tuberculosis
A researcher from the Perelman School of Medicine at the University of Pennsylvania and colleagues have identified the genetic mutation in Africans with HIV that puts them at a much higher risk for tuberculosis infections.
National Institutes of Health, Burrough Wellcome Fund

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine

Public Release: 24-Jul-2013
Journal of Immunology
Researchers target HER1 receptor for peptide cancer vaccine, therapeutic agents
Small proteins called peptides are being studied as cancer vaccines and as alternatives to antibody-based drugs and inhibitors now used to treat many malignancies. Researchers have identified two regions on the HER1/EGFR receptor, a protein important for cancer-cell growth and metastasis and for poor patient survival, as targets for peptide agents. The findings could lead to novel vaccines and safer more effective therapies for tumors of the breast, lung, colon and head and neck.
NIH/National Cancer Institute

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center

Public Release: 24-Jul-2013
Clinical Cancer Research
Novel gene target shows promise for bladder cancer detection and treatment
Scientists from Virginia Commonwealth University Massey Cancer Center have provided evidence from preclinical experiments that a gene known as melanoma differentiation associated gene-9/syntenin (mda-9/syntenin) could be used as a therapeutic target to kill bladder cancer cells, help prevent metastasis and even be used to non-invasively diagnose the disease and monitor its progression.
NIH/National Cancer Institute

Contact: John Wallace
wallacej@vcu.edu
804-628-1550
Virginia Commonwealth University

Public Release: 24-Jul-2013
Kaiser Permanente receives $8 million grant for novel whole genome sequencing study
The Kaiser Permanente Center for Health Research will receive $8.1 million from the National Institutes of Health to conduct a novel clinical trial using whole genome sequencing to test women and their partners for mutations that could cause rare, but serious diseases in their children.
NIH/National Human Genome Institute

Contact: Catherine Hylas Saunders
csaunders@golinharris.com
202-585-2603
Kaiser Permanente

Public Release: 24-Jul-2013
Journal of General Internal Medicine
Trust in physician eases talks about medical expenses
Strong relationships with physicians are likely to increase patients' openness to talk about health care costs when decisions are being made about their treatment options. According to a new study, rushed visits with insufficient time to talk about important issues can undermine efforts to bring sensitive topics like costs into the doctor-patient relationship and can be counterproductive. The work appears online in the Journal of General Internal Medicine, published by Springer.
NIH/Intramural Research Program, NIH/Clinical Center Department of Bioethics

Contact: Joan Robinson
joan.robinson@springer.com
49-622-148-78130
Springer

Public Release: 24-Jul-2013
Clinical Infectious Diseases
Combo hepatitis C prevention for young drug injectors urged
UC San Francisco researchers are recommending a combination of six comprehensive measures to prevent the spread of hepatitis C, in an effort to address the more than 31,000 young people they estimate may be newly infected with the virus each year in the United States due to injection-drug use.
NIH/National Institute on Drug Abuse, Australian Department of Health and Ageing

Contact: Jeff Sheehy
jsheehy@ari.ucsf.edu
415-597-8165
University of California - San Francisco

Public Release: 24-Jul-2013
Nature
Key molecular pathways leading to Alzheimer's identified
Key molecular pathways that lead to late-onset Alzheimer's disease have been identified by neuroscientists at Columbia University Medical Center. Published in Nature, findings present a new approach to Alzheimer's research and highlight several new potential drug targets.
National Institutes of Health

Contact: Press Office
cumcnews@columbia.edu
212-305-3900
Columbia University Medical Center

Public Release: 24-Jul-2013
JAMA
Women want doctors' help in facing fears about sex after heart attack
Most women want their doctors to give them more information about the safety of resuming sex after a heart attack. Despite fears of another heart attack or dying, many started having sex within a month after their heart attack. Researchers said talking about resuming sex should start with the treating cardiologist while women are in the hospital and should continue through their recovery.
NIH/National Heart, Lung, and Blood Institute, NIH/National Institute on Aging

Contact: Cathy Lewis
cathy.lewis@heart.org
214-706-1324
American Heart Association

Public Release: 24-Jul-2013
Science Translational Medicine
Johns Hopkins researchers reveal genetic glitch at the root of allergies
Newly published research by investigators at Johns Hopkins Children's Center and the Johns Hopkins Institute of Genetic Medicine reveals that a faulty genetic pathway already known for its role in some connective tissue disorders is also a potent player in many types of allergies. Scientists have long understood that allergies are the result of a complex interplay between environment and genes, but now, in what investigators believe is a scientific first, a single genetic pathway has been implicated in an array of allergic disorders.
National Institutes of Health, National Marfan Foundation, Howard Hughes Medical Institute

Contact: Ekaterina Pesheva
epeshev1@jhmi.edu
410-502-9433
Johns Hopkins Medicine

Public Release: 23-Jul-2013
Aggressive Behavior
When bar fights get mean, bystanders intervene
People are more likely to try to break up a bar fight when they believe the conflict is too violent, or has the potential to become more violent, according to an international team of researchers.
NIH/National Institute on Alcohol Abuse and Alcoholism

Contact: Matthew Swayne
mls29@psu.edu
814-865-9481
Penn State

Public Release: 23-Jul-2013
Fred Hutch team receives $4M from NCI to develop precision cancer treatments
A research team headed by Fred Hutchinson Cancer Research Center scientists Christopher Kemp, Ph.D., and Carla Grandori, M.D., Ph.D., has received a $4 million grant from the National Cancer Institute to develop precision therapies that selectively kill cancer cells while sparing normal, healthy tissue.
NIH/National Cancer Institute

Contact: Kristen Woodward
media@fhcrc.org
206-667-2210
Fred Hutchinson Cancer Research Center

Public Release: 23-Jul-2013
Magnetic Resonance in Medicine
Oxygen -- key to most life -- decelerates many cancer tumors when combined with radiation therapy
A multidisciplinary team at UT Southwestern Medical Center has found that measuring the oxygenation of tumors can be a valuable tool in guiding radiation therapy, opening the door for personalized therapies that keep tumors in check with oxygen enhancement.
NIH/National Cancer Institute, Cancer Prevention and Research Institute of Texas

Contact: Alex Lyda
alex.lyda@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Showing releases 76-100 out of 3306.

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