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Department of Health and Human Services

News from the National Institutes of Health

Funded News

Key: Meeting M      Journal J      Funder F

Showing releases 76-100 out of 3531.

<< < 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 > >>

Public Release: 19-Nov-2014
New England Journal of Medicine
Gene therapy provides safe, long-term relief for patients with severe hemophilia B
Gene therapy developed at St. Jude Children's Research Hospital, University College London and the Royal Free Hospital has transformed life for men with a severe form of hemophilia B by providing a safe, reliable source of the blood clotting protein Factor IX that has allowed some to adopt a more active lifestyle, researchers reported. The results appear in the Nov. 20 edition of the New England Journal of Medicine.
NIH/National Heart, Lung, and Blood Institute, Assisi Foundation of Memphis, Howard Hughes Medical Institute, ALSAC, Medical Research Council, Katharine Dormandy Trust, NHS Blood and Transplant, and others

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

Public Release: 19-Nov-2014
Journal of Biological Chemistry
Researchers identify protein mutation that alters tissue development in males before birth
Case Western Reserve researchers have identified a protein mutation that alters specific gender-related tissue in males before birth and can contribute to the development of cancer as well as other less life-threatening challenges. The findings appear in the Nov. 21 edition of the Journal of Biological Chemistry, whose editors named the article its Paper of the Week.
National Institutes of Health

Contact: Jeannette Spalding
Case Western Reserve University

Public Release: 19-Nov-2014
Major new study reveals new similarities and differences between mice and humans
Powerful clues have been discovered about why the human immune system, metabolism, stress response, and other life functions are so different from those of the mouse. A new, comprehensive study of the mouse genome by an international team reveals striking similarities and differences with the human genome. The study may lead to better use of mouse models in medical research.
NIH/National Human Genome Research Institute

Contact: Barbara K. Kennedy
Penn State

Public Release: 19-Nov-2014
New England Journal of Medicine
MSK team makes key discovery in understanding immunotherapy's successes -- and its failures
A collaborative team of leaders in the field of cancer immunology from Memorial Sloan Kettering Cancer Center has made a key discovery that advances the understanding of why some patients respond to ipilimumab, an immunotherapy drug, while others do not.
Ludwig Cancer Research, Frederick Adler Fund, National Institutes of Health, Swim Across America, Ludwig Trust, Melanoma Research Alliance, Stand Up To Cancer-Cancer Research Institute Immunotherapy Dream Team

Contact: Jeanne D'Agostino
Memorial Sloan-Kettering Cancer Center

Public Release: 19-Nov-2014
New England Journal of Medicine
A signature for success
A team led by Ludwig and Memorial Sloan Kettering researchers has published a landmark study on the genetic basis of response to a powerful cancer therapy known as immune checkpoint blockade. Their paper, in the current issue of the New England Journal of Medicine, describes the precise genetic signatures in melanoma tumors that determine whether a patient will respond to one such therapy.
Ludwig Cancer Research, Frederick Adler Fund, US National Institutes of Health, Swim Across America, Ludwig Trust, Melanoma Research Alliance

Contact: Rachel Steinhardt
Ludwig Institute for Cancer Research

Public Release: 19-Nov-2014
Nature Materials
Spiraling light, nanoparticles and insights into life's structure
As hands come in left and right versions that are mirror images of each other, so do the amino acids and sugars within us. But unlike hands, only the left-oriented amino acids and the right-oriented sugars ever make into life as we know it.
Center for Solar and Thermal Energy Conversion, Energy Frontier Research Center funded by the US Department of Energy, National Science Foundation, National Institutes of Health

Contact: Nicole Casal Moore
University of Michigan

Public Release: 19-Nov-2014
International Journal of Environmental Research and Public Health
UTMB scientist finds marker that predicts cholesterol level changes as people grow older
It's known that cholesterol levels typically rise as people age and that high cholesterol levels are associated with increased risk of cardiovascular disease. What's less known is that cholesterol levels begin to decline the more a person ages. Recently, researchers from the University of Texas Medical Branch at Galveston and the University of Kentucky found that differences in one gene can influence a person's cholesterol levels from midlife to late life.
National Institutes of Health

Contact: Donna Ramirez
University of Texas Medical Branch at Galveston

Public Release: 19-Nov-2014
Humans and mice: So similar but yet so different
An international consortium including researchers from the CRG has presented an exhaustive description of the mouse's functional genome elements and their comparison with the human genome. The work at the CRG was carried out in close collaboration with the group directed by Dr. Thomas R. Gingeras, at CSHL. Comparing humans and mice enables us to better understand mammalian biology and evolution, as well as contributing new information on the use of mice as animal models for looking at human disease.
National Institutes of Health, NIH/National Human Genome Research Institute

Contact: Laia Cendrós
Center for Genomic Regulation

Public Release: 19-Nov-2014
Variation in expression of thousands of genes kept under tight constraint in mice, humans
An international team has identified 6,600 genes whose level of expression varies within a comparatively restricted range in humans and mice. The 6,600 genes represent about one-third of the total set of genes typically active in cells across tissues in both species, irrespective of cell type. The study provides new information that will continue to assist in making the mouse an excellent model organism in which to study human diseases and biology.
NIH/National Human Genome Research Institute, Spanish Plan Nacional, European Research Council, LaCaixa, European Union

Contact: Peter Tarr
Cold Spring Harbor Laboratory

Public Release: 19-Nov-2014
Infant Mental Health Journal
Fathers' engagement with baby depends on mother
Fathers' involvement with their newborns depends on mothers' preparation for parenthood, even for fathers who show the most parenting skills, a new study suggests.
National Science Foundation, NIH/National Institute of Child Health and Human Development

Contact: Sarah Schoppe-Sullivan
Ohio State University

Public Release: 19-Nov-2014
Study finds wide variation in quality, content of clinical cancer guidelines
What's the best way to treat rectal cancer? Consult any of five top clinical guidelines for rectal cancer and you will get a different answer, according to a new study by researchers at the University of Michigan Comprehensive Cancer Center.
Agency for Healthcare Research and Quality, NIH/National Cancer Institute

Contact: Nicole Fawcett
University of Michigan Health System

Public Release: 19-Nov-2014
Drug and Alcohol Dependence
Residential treatment may be first-line option for opioid-dependent young adults
A study from the Massachusetts General Hospital Center for Addiction Services found that a month-long, 12-step-based residential program with strong linkage to community-based follow-up care, enabled almost 30 percent of opioid-dependent young adults to remain abstinent a year later. Another recent study found that 83 percent of young adults entering an office-based opioid treatment program had dropped out a year later.
NIH/National Institute of Alcohol Abuse and Alcoholism, Hazelden Betty Ford Foundation

Contact: Noah Brown
Massachusetts General Hospital

Public Release: 19-Nov-2014
Nature Communications
Power behind 'master' gene for cancer discovered
It's hard to believe, but there are similarities between bean sprouts and human cancer. The same mechanisms that result in bigger bean sprouts also cause cancer metastasis and tumor development.
National Institutes of Health, Fidelity Foundation, Susan G. Komen Breast Cancer Foundation

Contact: Ron Gilmore
University of Texas M. D. Anderson Cancer Center

Public Release: 19-Nov-2014
American Heart Association's Scientific Sessions 2014
High-quality hospitals deliver lowest-cost care for congenital heart surgery patients
US children's hospitals delivering the highest-quality care for children undergoing heart surgery, also appear to provide care most efficiently at a low cost, according to research led by the University of Michigan and presented Tuesday at the American Heart Association Scientific Sessions in Chicago.
NIH/National Heart, Lung, and Blood Institute

Contact: Mary Masson
University of Michigan Health System

Public Release: 19-Nov-2014
UTHealth researchers to study probiotic's effect on deadly pre-term infant condition
Researchers at The University of Texas Health Science Center at Houston have received a $1.6 million grant for a preclinical study investigating whether a probiotic might be helpful in preventing a life-threatening condition in pre-term infants called necrotizing enterocolitis.
NIH/National Center for Complementary & Alternative Medicine

Contact: Hannah Rhodes
University of Texas Health Science Center at Houston

Public Release: 19-Nov-2014
Journal of Health and Social Behavior
Bad marriage, broken heart?
Older couples in a bad marriage -- particularly female spouses -- have a higher risk for heart disease than those in a good marriage, finds the first nationally representative study of its kind.
National Institutes of Health

Contact: Andy Henion
Michigan State University

Public Release: 19-Nov-2014
Neuroscience 2014
Research shows why antidepressant may be effective in postpartum depression
An antidepressant commonly prescribed for women with postpartum depression may restore connections between cells in brain regions that are negatively affected by chronic stress during pregnancy, new research suggests.
NIH/National Institute of Mental Health

Contact: Benedetta Leuner
Ohio State University

Public Release: 19-Nov-2014
Of mice, not men
For more than a century, the laboratory mouse (Mus musculus) has stood in for humans in experiments ranging from deciphering disease and brain function to explaining social behaviors and the nature of obesity. The small rodent has proven to be an indispensable biological tool, the basis for decades of profound scientific discovery and medical progress.
National Institutes of Health, Spanish Plan Nacional, National Science Foundation

Contact: Scott LaFee
University of California - San Diego

Public Release: 19-Nov-2014
Scientists map mouse genome's 'mission control centers'
When the mouse and human genomes were catalogued more than 10 years ago, an international team of researchers set out to understand and compare the 'mission control centers' found throughout the large stretches of DNA flanking the genes. Their long-awaited report suggests why studies in mice cannot always be reproduced in humans. Importantly, their work also sheds light on the function of DNA's regulatory regions, which are often to blame for common chronic human diseases.
NIH/National Human Genome Research Institute, NIH/National Institute of General Medical Sciences, NIH/National Cancer Institute, NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Contact: Catherine Kolf
Johns Hopkins Medicine

Public Release: 19-Nov-2014
Nature Communications
Many older brains have plasticity, but in a different place
Brain scientists have long believed that older people have less of the neural flexibility, or plasticity, required to learn new things. A new study shows that older people learned a visual task just as well as younger ones, but the seniors who showed a strong degree of learning exhibited plasticity in a different part of the brain than younger learners did.
National Institutes of Health

Contact: David Orenstein
Brown University

Public Release: 19-Nov-2014
American Heart Association's Scientific Sessions 2014
Speedy heart transplant for kids better than waiting for perfect match
Survival is predicted to be higher for pediatric heart transplant candidates when the first suitable donor offer is accepted -- even if they have antibodies that may lead to organ rejection. Costs of care are lower for children who don't wait for an antibody-matched heart. Researchers say the decision to perform a heart transplant should not depend solely upon the patient's antibodies.
NIH/National Center for Advancing Translational Sciences, National Institutes of Health

Contact: Bridgette McNeill
American Heart Association

Public Release: 18-Nov-2014
Journal of Neuroscience
Penn-led team prevents memory problems caused by sleep deprivation
In a new study, published in the Journal of Neuroscience, a team led by scientists from the University of Pennsylvania found that a particular set of cells in a small region of the brain are responsible for memory problems after sleep loss. By selectively increasing levels of a signaling molecule in these cells, the researchers prevented mice from having memory deficits.
Netherlands Organization for Scientific Research, University Research Foundation, National Institutes of Health

Contact: Katherine Unger Baillie
University of Pennsylvania

Public Release: 18-Nov-2014
American Heart Association's Scientific Sessions 2014
American Journal of Cardiology
Vanderbilt study finds nationwide decline in one type of serious heart attack
The most emergent form of heart attacks is decreasing nationwide, but this declining incidence could affect emergency departments' quality and timeliness of care.
NIH/National Heart, Lung and Blood Institute

Contact: Jennifer Wetzel
Vanderbilt University Medical Center

Public Release: 18-Nov-2014
Nature Communications
Pain from rejection and physical pain may not be so similar after all
Over the last decade, neuroscientists have largely come to believe that physical pain and social pain are processed by the brain in the same way. But a new study led by the University of Colorado shows that the two kinds of pain actually use distinct neural circuits, a finding that could lead to more targeted treatments and a better understanding of how the two kinds of pain interact.
NIH/National Institute of Mental Health, NIH/National Institute of Biomedical Imaging and Bioengineering

Contact: Choong-Wan Woo
University of Colorado at Boulder

Public Release: 18-Nov-2014
The Anatomical Record
Were Neanderthals a sub-species of modern humans? New research says no
In an extensive, multi-institution study led by SUNY Downstate Medical Center, researchers have identified new evidence supporting the growing belief that Neanderthals were a distinct species separate from modern humans (Homo sapiens), and not a subspecies of modern humans.
National Science Foundation, National Institutes of Health

Contact: Ron Najman
SUNY Downstate Medical Center

Showing releases 76-100 out of 3531.

<< < 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 > >>


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