Researchers at the University of Iowa have used personalized proteomics to devise a successful treatment strategy for a patient with uveitis, a potentially blinding eye disease that can have many causes, making it particularly difficult to diagnose and treat effectively.
A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at The Johns Hopkins University. A report on the study is published in the February issue of Cancer Prevention Research.
When metastatic tumors driven by drug-targetable genetic mutations become resistant to a targeted therapy drug, the usual practice is to test a single metastatic lesion for new mutations that can guide the selection of next-line therapies. But this strategy may miss additional targetable mutations that arise in different metastases, a new study finds.
A new method for detection of infection in wounds could take physicians less than a minute to complete, rather than the current 24 hours it takes for diagnosis, according to research by the George Washington University's Victoria Shanmugam, M.D.
Elastin is a crucial building block in our bodies -- its flexibility allows skin to stretch and twist, blood vessels to expand and relax with every heartbeat, and lungs to swell and contract with each breath. But exactly how this protein-based tissue achieves this flexibility remained an unsolved question -- until now. An international team has carried out an analysis that reveals the details of a hierarchical structure of scissor-shaped molecules that gives elastin its remarkable properties.
An examination of 130 gene expression studies in 10 solid cancers has found that when any of four related genes is overexpressed, patients have much worse outcomes, including reduced survival.
Cells reach a state called senescence when they stop dividing in response to DNA damage. This change can matter greatly to health, but scientists do not yet have a clear picture of how this change impacts the genome. A new Brown University study shows that a cell's chromosomes become physically reconfigured at senescence, leading to significant differences in what genes are expressed.
Georgetown University Medical Center neuroscientists say rest -- for more than a day -- is critical for allowing the brain to reset neural networks and repair any short-term injury. This new study in mice also shows that repeated mild concussions with only a day to recover between injuries leads to mounting damage and brain inflammation that remains evident a year after injury
Using a special profiling technique, a team of researchers at Princeton have determined the mechanism of action of a potent antibiotic, known as tropodithietic acid, leading them to uncover its hidden ability as a potential anticancer agent.
Investigators at Children's Hospital Los Angeles have found that significant bone loss -- a side effect of chemotherapy for acute lymphoblastic leukemia (ALL) - occurs during the first month of treatment, far earlier than previously assumed. Results of the study will be available online Feb. 4, in advance of publication in the journal Bone.