North American researchers have identified drugs that showed promising perspectives in treating cancers, according to a recent study published in Cancer Research. These drugs are normally used to treat other diseases, such as heart failure, cardiac arrhythmia, and infections.
A team of investigators has launched a study of individuals at risk for multiple sclerosis (MS) to better understand the sequence of events that leads some people to develop the disease and set the stage for developing and testing interventions with which to block the onset of MS. The research team introduces the Genes and Environment in Multiple Sclerosis project in the Annals of Neurology.
Vanderbilt engineers have modified the cotton candy machine to create complex microfluidic networks that mimic the capillary system in living tissue and have demonstrated that these networks can keep cells alive and functioning in an artificial three-dimensional matrix.
Mutations in the gene TBX5 have been shown to cause both rare and more prevalent forms of congenital heart disease, yet the underlying mechanisms have remained unclear. A team led by researchers at the University of North Carolina at Chapel Hill has now found evidence pointing to a culprit.
Rice University bioengineers study alternative CRISPR-Cas9 systems for precision genome editing, with a focus on improving its accuracy and limiting 'off-target' errors.
An experimental nanoparticle therapy that combines low-density lipoproteins (LDL) and fish oil preferentially kills primary liver cancer cells without harming healthy cells, UT Southwestern Medical Center researchers report.
A team led by engineers at the University of California, San Diego has 3-D-printed a tissue that closely mimics the human liver's sophisticated structure and function. The new model could be used for patient-specific drug screening and disease modeling. Researchers said the advance could help pharmaceutical companies save time and money when developing new drugs. The work was published the week of Feb. 8 in the online early edition of Proceedings of the National Academy of Sciences.
Taste deficits appear to be more prevalent among multiple sclerosis (MS) patients than previously reported and correlate with brain lesions left by the debilitating disease, a new study from the University of Pennsylvania's Smell and Taste Center and the department of Radiology found.
Using a model blood vessel system built on a polymer microchip, researchers have shown that the relative softness of white blood cells determines whether they remain in a dormant state along vessel walls or enter blood circulation to fight infection.
Researchers uncovered the aberrant mechanism underlying a notoriously treatment-resistant acute lymphoblastic leukemia subtype; findings offer lessons for understanding all cancers.