Research led by SUNY Downstate Medical Center shows that, at the onset of puberty, the emergence of a novel inhibitory brain receptor, α4βδ (alpha four beta delta), reduces seizure-like activity in a mouse model of epilepsy.
Johns Hopkins neuroscientists believe they have figured out how some rats solve certain navigational problems. If there's a 'reward' at the end of the trip, like the chocolatey drink used in this study, specialized neurons in the hippocampus of the brain 'replay' the route taken to get it, but backward. And the greater the reward, the more often the rats' brains replay it.
Cancer researchers have long observed the value of treating patients with combinations of anti-cancer drugs that work better than single drug treatments. Now, in a new study using laboratory-grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining anti-cancer drugs, including one in a nanoparticle format developed at Johns Hopkins, that specifically target those pathways.
Thanks to new funding from the National Institute on Drug Abuse, researchers at the Lewis Katz School of Medicine at Temple University will explore the effects of the combination of tobacco smoke and opiates on the tissue damage that occurs in many patients infected with HIV.
While even the best wines eventually peak and turn to vinegar, a new study by researchers at University of California, San Diego School of Medicine suggests a paradoxical trend in the mental health of aging adults: they seem to consistently get better over time.
Researchers have developed a new opioid drug candidate that blocks pain without triggering the dangerous side effects of current prescription painkillers. Their secret? Starting from scratch -- with computational techniques that let them explore more than four trillion different chemical interactions.
Researchers trace the roots of this diagnostic disparity to the lack of racial diversity in decades-old studies that misidentified benign genetic variants as disease causing. Benign variants on genes implicated in the disease are far more common in black Americans than in white Americans. The findings underscore a pressing need to reevaluate decades-old genetic studies by using new racially diverse sequencing data.
Researchers found that the use of APMs in pregnancy does not meaningfully increase the risk of congenital malformations or cardiac malformations, with the possible exception of risperidone.
While medications can quickly reduce depressive symptoms, monitoring work productivity can provide unique insight into whether a patient will require additional treatments to achieve long-term remission, a new study through the Peter O'Donnell Jr. Brain Institute finds.
Neurons that fire together really do wire together, says a new study in Science, suggesting that the three-pound computer in our heads may be more malleable than we think.