Genetic Findings In Attention Deficit Hyperactivity Disorder

M Gill, G Daly, S Heron, Z Hawi, M Fitzgerald Departments of Psychiatry and Genetics, Trinity College, Trinity Centre for Health Sciences, St James' Hospital, Dublin 2, Ireland

Attention deficit hyperactivity is a common disorder of childhood which has a strong genetic component and which responds to treatment with stimulant drugs which inhibit the dopamine transporter (DAT1). The authors examined the frequency of alleles of a repeat polymorphism in the 3' untranslated region of the DAT1 gene transmitted and not transmitted to ADHD probands from their parents and found a significant excess of transmission of the 480bp allele.The authors have confirmed the association previously found by Cook et al. Further molecular and biochemical analysis will be required to identify the DNA variants/mutations within the DAT1 gene that contribute to susceptibility. For further information, please contact the corresponding author, Dr. Michael Gill, Departments of Psychiatry and Genetics, Trinity College, Trinity Centre for Health Sciences St. James' Hospital, James' Street, Dublin 8, Ireland, Telephone and Fax (353-1)702 2241, e-mail: mgill@mail.tcd.ie

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This article is from the July issue of Molecular Psychiatry, an independent peer-reviewed journal published by Stockton Press/Macmillan Press.

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For information on the scientific aspects of the article please contact the authors. Pre-prints of the articles can be obtained from Ms. Julie Vianello: phone: +1 301 496-6979; FAX: +1 301 402-1561; e-mail: j.vianello@stockton-press.co.uk

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