New genetic findings in manic-depressive illness

This article presents results of a research study testing the genetic contribution of gamma amino butyric acid receptor 3 (GABRA3) gene as a potential candidate gene in the development of bipolar affective disorder (BPAD). GABRA3 dinucleotide polymorphism was tested in a European multicentric case-control sample, matched for sex and ethnogeographical origin. Allele and genotype (in females) frequencies were compared in 185 BPAD patients and in 370 control participants. Data suggest that the GABRA3 polymorphism may confer susceptibility to the genetic etiology of BPAD.

Citation source: Molecular Psychiatry 2002, Volume 7, number 2, pages 201-207.

For further information on this work, please contact Dr. Isabelle Massat, Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, 808 route de Lennik, B-1070, Brussels, Belgium. Tel.: +32.2.555.37.41, Fax: +32.2.555.4515, E-Mail: imassat@ulb.ac.be

Molecular Psychiatry is published by the Nature Publishing Group. http://www.nature.com/mp

Editor: Julio Licinio, M.D.; phone: +1 310 825-7113; FAX: +1 310 206-6715; e-mail: licinio@ucla.edu

For a copy of this article, please contact Karl Lorenzen, editorial assistant, e-mail: molecularpsychiatry@mednet.ucla.edu.

PLEASE CITE MOLECULAR PSYCHIATRY AS THE SOURCE OF THIS MATERIAL.

ARTICLE: "Excess of allele1 for a3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study"

AUTHORS: I Massat, D Souery, J Del-Favero, L Oruc, MM Nothen, D Blackwood, M Thompson, W Muir, GN Papadimitriou, DG Dikeos, R Kaneva, Vserretti, R Lilli, E Smeraldi, M Jakovljevic, V Flonegovic, M Rietschel, V Milanova, F Valente, C Van Broeckhoven and J Mendlewicz

Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium; Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), University of Antwerp (UIA), Antwerpen, Belgium; Psychiatry Clinic, University of Sarajevo, Sarajevo, Bosnia and Herzogovina; Institute of Human Genetics, University of Bonn, Germany; Department of Psychiatry and the Department of Medical Science, University of Edinburgh, UK; Athens University Medical School, Department of Psychiatry and University of Mental Health Research Institute, Athens, Greece; Laboratory of Molecular Pathology, University Hospital of Obstetrics, Medical University, Sofia, Bulgaria; Institute Scientifico H San Raffaele, Department of Neuroscience, University of Milano School of Medicine, Milan, Italy; Department of Psychiatry, University Hospital ÒREBROÓ, University of Zagreb, Zagreb, Croatia; Department of Psychiatry, University of Bonn, Bonn, Germany; First Psychiatric Clinic, Department of Psychiatry, Alexander University Hospital, Sofia, Bulgaria; Department of Statistics, School of Public Health, Free University of Brussels, Belgium.

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