Public Release:  Organic & Biomolecular Chemistry

Royal Society of Chemistry

The first issue of Organic & Biomolecular Chemistry, formed from the merger and strategic development of Perkin Transactions 1 & 2, will be published on 10 January 2003. The electronic version will go up on 23 December 2002.

Barbara Imperiali, Francois Diederich, Ben Feringa and Chi-Huey Wong are amongst the first eminent scientists to publish Advance Articles in the journal. Further details are given below. The first issue will also feature contributions from Steve Ley, Jay Siegel and Michael Burkart, these will be available online soon.

Advance Articles Now Available on the Journal Website Include:-

Perspective

    HIV-1 Protease: Mechanism and Drug Discovery
    Chi-Huey Wong, Scripps, USA

Communications
    A donor-acceptor substituted molecular motor: unidirectional rotation driven by visible light.
    Ben Feringa, Groningen, The Netherlands

    A new synthesis of porphobilinogen analogues, inhibitors of hydroxymethylbilane synthase
    Finian Leeper, Cambridge, UK

    Non-steady-state kinetic study of the SN2 reaction between p-nitrophenoxide ion and methyl iodide in aprotic solvents containing water. Evidence for a 2-step mechanism.
    Vernon D. Parker, Utah State, USA

    Facilitated transport of sodium or potassium chloride across vesicle membranes using a ditopic salt-binding macrobicycle
    Bradley D. Smith, Notre Dame, USA

    From central to planar chirality, the first example of atropenantioselective cycloetherification
    Jieping Zhu, CNRS, France

Articles
    Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity
    François Diederich, ETH, Switzerland

    Peptides to peptidomimetics: Towards the design and synthesis of bioavailable inhibitors of oligosaccharyl transferase
    Barbara Imperiali, MIT, USA

    Synthesis of novel chiral phosphinocyrhetrenyloxazoline ligands and their application in asymmetric catalysis
    Carsten Bolm, Aachen, Germany

    Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes
    John Vederas, Alberta, Canada

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Organic & Biomolecular Chemistry will be an essential read for organic chemists. The new journal has attracted contributions from a great number of leading institutions all over the world on topics covering the full breadth of organic chemistry.

These are exciting times for organic chemists, who are at the molecular heart of life science. Synthetic and physical organic chemistry are rapidly gaining importance in the emerging fields of chemical biology and nanotechnology where they play a crucial role in the development of new bioactive substances and novel materials. Organic & Biomolecular Chemistry will be key to the dissemination of these advances.

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