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PUBLIC RELEASE DATE:
18-May-2003

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Contact: Elizabeth McDonald
eem6@georgetown.edu
202-687-7707
Georgetown University Medical Center
@Gumedcenter

Was Orton right?

New study examines how the brain works in reading; Offers key to better understanding dyslexia

Washington, DC - Using functional magnetic resonance imaging (fMRI) to study brain activity in children, researchers today confirmed part of an eighty-year-old theory on the neurobiological basis of reading disability, and shed new light on brain regions that change as children become accomplished readers. Their findings were reported in the May 18 online publication of the journal Nature Neuroscience.

In 1925 Dr. Samuel Orton, a clinician and prominent dyslexia researcher, hypothesized that normally developing readers suppress the visual images reported by the right hemisphere of the brain because these images could potentially interfere with input from the left. Advanced technology allowed researchers at Georgetown University Medical Center to discover that children do in fact "turn off" the right side of the visual parts of the brain as they become accomplished readers. This confirms an aspect of Orton's theory--born out of observations of individuals with reading disability--is correct.

For the first time, they also were able to demonstrate that different phonological skills relate to activity in different parts of the brain when children read. Phonological skills allow readers to sound out words by correctly associating sounds with written symbols. They are critical for children learning to read and are often found to be impaired in children with developmental dyslexia.

This observation lends support to the theory that there may be several neurobiological profiles that correspond to different subtypes of dyslexia, each associated with varying deficits in one or more of these different phonological skills.

"Reading is the single most important skill our children learn - it impacts virtually every aspect of a child's life," said Dr. Guinevere Eden, associate professor of pediatrics and director of Georgetown University's Center for the Study of Learning. "Despite the extraordinary effort that goes into teaching children to read, very little is known about the neurobiology of reading acquisition in children. This study is important because we need to understand the brain basis of learning in kids who read well in order to understand why some children, like those with dyslexia, don't."

Eden and her colleagues Peter Turkeltaub, Lynn Gareau, and Dr. Tom Zeffiro of Georgetown, and Dr. Lynn Flowers of Wake Forest University, studied 41 people between the ages of six and 22 using fMRI to examine which parts of the brain they use when they see words. Using a method where subjects were asked to locate tall letters within a word - forcing them to read the words implicitly - the researchers correlated brain activity with scores on reading tests to see if more advanced readers had more activity in certain brain areas than less experienced readers, and vice versa. Then they studied brain activity during reading related to scores on tests of phonological skills.

Supporting Orton's theory, the fMRI scans showed that young children who were just learning to read used the left temporal regions of their brains; increases in age and the associated gains in reading, was characterized by a suppression of the visual areas of the right hemisphere.

The study also showed that the same locus in the left temporal lobe engaged during reading in younger children is also more active if children are good at phonemic awareness, such as understanding that "pop" without "p" is "op." These measures are frequently employed for behavioral evaluation of children at risk for developing reading problems and these new findings provide an anatomical correlate of this ability.

"Work like this can provide important background information to develop new research-based teaching programs that can ultimately help all children to become proficient readers and identify those who are need of specific interventions," said Peter Turkeltaub, primary author of this study. "This is an exciting area of research in which scientists converge with educators and parents to achieve the common goal of helping children achieve the reading skills they need to succeed in life."

Dr. Eden and her team continue to study the neurobiological basis for reading. In related research, supported by the NIH and the International Dyslexia Association - founded in the memory of Samuel Orton, Eden and her colleagues will soon begin the largest national longitudinal study ever undertaken to study brains in children as they develop into readers. A "brain bank" will enable researchers to undertake more comprehensive dyslexia and neurobiological research.

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This research was funded by the National Institutes of Health.

Georgetown University Medical Center is an internationally recognized academic medical center with a three-part mission of research, teaching and patient care (through our partnership with MedStar Health). Our mission is carried out with a strong emphasis on public service and a dedication to the Catholic, Jesuit principle of cura personalis--or "care of the whole person." The Medical Center includes the School of Medicine and the School of Nursing and Health Studies, both nationally ranked, and the world renowned Lombardi Cancer Center.

The Georgetown Center for the Study of Learning, which is funded by the National Institutes of Health, seeks to better understand the neural mechanisms that enable the acquisition of reading skills, and to identify new approaches to assess and treat reading disabilities.



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