Over 100 years have passed since S. aureus was first described as the organism responsible for causing sepsis and abscesses. Today it remains a leading cause of serious infections such as endocarditis, pneumonia, and septicemia and requires intensive antibiotic therapy, which is often unsuccessful due to the rise of antibiotic resistant strains.
Aspirin has previously been shown to reduce the virulence of S. aureus in models of endocarditis. In an earlier study, this same group found that while administration of aspirin or its metabolite, SAL, was capable of reducing the ability of S. aureus to attach to host cells, the effect was significantly enhanced following SAL administration.
In this issue of the JCI, Cheung and colleagues extend these earlier findings and report that treatment with SAL induced activation of the S. aureus stress response gene sigB, resulting in downregulation of regulons sarA and agr, which control the expression of the genes encoding a-hemolysin and fibronectin. This downregulation resulted in decreased ability of the bacteria to adhere to host cells, and reduced S. aureus toxin-mediated hemolysis and thrombolysis of host cells.
"The establishing of a straightforward, unequivocal strategy to downregulate staphylococcal virulence using a cheap, simple, relatively non-toxic, resorbable compound such as SAL may be seen as major progress in the development of intervening strategies in addition to antimicrobial drugs" stated Professor Mathias Herrmann, Director of the Department of Bacteriology and Hygiene at the University of Saarland, Germany in his accompanying commentary. The report is the first description of aspirin-mediated genetic effects against S. aureus and represents an exciting new prospect for this widely used and established drug.
TITLE: Salicylic acid attenuates virulence in endovascular infections by targeting global regulatory pathways in Staphylococcus aureus
AUTHOR CONTACT:
Ambrose L. Cheung
Dartmouth Medical School, Hanover, New Hampshire, USA.
Phone: 603-650-1310
Fax: 603-650-1362
Email: ambrose.cheung@dartmouth.edu
View the PDF of this article at: http://www.jci.org/cgi/content/full/112/2/222
ACCOMPANYING COMMENTARY:
Salicylic acid: an old dog, new tricks, and staphylococcal disease
AUTHOR CONTACT:
Mathias Herrmann
University of Saarland Hospital, Homburg/Saar, Germany.
Phone: 49-6841-162-3900
Fax: 49-6841-162-3985
Email: mathias.herrmann@uniklinik-saarland.de
Journal
Journal of Clinical Investigation