While P. falciparum is a single-celled eukaryotic (nucleated) organism, it leads a fairly complicated life, assuming one form in the mosquito, another when it invades the human liver, and still another in human red blood cells (erythrocytes). The intraerythrocytic developmental cycle (IDC) is the stage of the P. falciparum life cycle associated with the clinical symptoms of malaria. Using data from the recently sequenced P. falciparum genome, the researchers have tracked the expression of all of the parasite's genes during the IDC.
The pattern of gene expression (which can be thought of as the internal operating system of the cell) during the IDC is strikingly simple. It's continuous and clock-like progression of gene activation is reminiscent of much simple life forms – such as a virus or phage – while unprecedented for a free living organism. Virus and phage behave like a "just in time" assembly line: components are made only as needed, and only in the amount that is needed. In this respect, malaria resembles a glorified virus.
Given the remarkable coupling of the timing of gene activation with gene function as shown here, this understanding could help identify the biological function of the 60 percent of genes in P. falciparum that encode proteins of unknown function.
P. falciparum appears to be ultra-streamlined and exquisitely tuned to perform a single job: consume, replicate and invade. The simple program regulating the life of P. falciparum may hold the key to its downfall as any perturbation of the regulatory program will likely have dire consequences for the parasite. This offers renewed hope for the design of inhibitory drugs targeted at the regulatory machinery that would irreparably foul the parasite's regulatory program, ultimately resulting in its death.
Research article: Bozdech Z, Llinás M, Pulliam BL, Wong ED, Zhu J, DeRisi JL (2003). The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum. DOI: 10.1371/journal.pbio.0000005
The following article is published online as a sneak preview to PLoS Biology, the first open-access journal from the Public Library of Science (PLoS). The article will be part of the inaugural issue of the new journal, which will appear online and in print in October 2003. PLoS is a non-profit organization of scientists and physicians committed to making the world's scientific and medical literature a freely available public resource (http://www.plos.org).
Please mention PLoS Biology as the source of this article.
Download article PDF at: http://www.plos.org/downloads/malaria_plosbiology.pdf
UCSF News Office
University of California, San Francisco
Gary Ward (editor)
University of Vermont
Dept. of Microbiology and Molecular Genetics
316 Stafford Hall
95 Carrigan Drive
Burlington, VT 05452
United States of America
802-656-1146 (Alternate Telephone)
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.