News Release

Authors warn of inaccuracies concerning use of race in health & social science research

The Gene-Environmental Interaction is what must be studied; but should the study of race be thrown out altogether?

Peer-Reviewed Publication

American Psychological Association

WASHINGTON -- New and sophisticated methods for studying the relationship between human genetic differences, the environment, health and behavior, all made possible by the completion of the Human Genome Project, have made traditional race-based measurements of human differences obsolete, according to numerous authors writing in a special issue of the American Psychologist devoted to Genes, Race, and Psychology in the Genome Era (January, 2005). American Psychologist is the journal of the American Psychological Association (APA).

In a series of articles, leading researchers discuss racial health disparities and the controversial area of intelligence, while also carefully outlining specific instances and ways in which researchers should measure or use race. According to the authors, such research requires a careful examination of both environmental and genetic factors, as well as conceptually sound and methodologically rigorous measures of race at a level not yet universal in all research. The special issue also looks at the construct of race in the 21st century, as well as the historical use of the construct in science, including issues of new genetic markers for race vs. self-reported race, racial vs. ancestral identity, racial disparities, and the interaction between genes and the environment. In separate articles, other authors discuss the long-standing and controversial examination of race and intelligence. The backdrop for each of the articles is the high expectation that the completion of the Human Genome Project will lead to dramatic advances in our understanding of health and behavior.

"This special issue takes a comprehensive look at the concept of race and its usefulness in the genome age," says Norman B. Anderson, PhD, editor of the American Psychologist and CEO of the APA. "It reports on the potential research opportunities afforded by new genetic technologies, while also addressing the ethical and legal complexities presented by these new technologies and the information they produce. Furthermore, it acknowledges the controversial role that psychology has played in past theories about the impact of race on intelligence."

Along a continuum of opinion, the validity of the use of race as a measure in health, social science and genetics research is addressed. Researchers raise the question of whether race measurements can be made in a more nuanced and scientifically sound way, particularly in the light of advances in knowledge due to the Human Genome Project. The question is raised as to whether self-identified race variables, specifically in genetics analyses, should be discarded altogether.

Alexandra Shields, PhD (Georgetown University), and her coauthors suggest the latter. "Given the social risks inherent in using self-identified racial groups in the context of behavioral genetics research and given that more elegant and powerful strategies for controlling for population admixture are now available, we call for an end to the use of self-identified race variables in genetics analyses and for direct measurement of key underlying social and environmental exposures for which race variables have traditionally been used as proxies."

While an article by Smedley (Virginia Commonwealth University) and Smedley (Institute of Medicine), argues the value of retaining the use of race categories for some purposes including some social policies.

The issue is made up of a series of 10 articles. Highlights are summarized below.

Race and Ethnicity in the Genome Era: The Complexity of the Constructs. Authors Vence L. Bonham, PhD (National Human Genome Research Institute, National Institutes of Health), Esther Warshauer-Baker, PhD (National Human Genome Research Institute, National Institutes of Health), and Francis S. Collins, PhD (National Human Genome Research Institute, National Institutes of Health), write, "We remain optimistic about the benefits that genomic advances will provide for those suffering from psychological disorders, and there is good reason to believe that the incorporation of genomics into behavioral research will generate new insights and areas of investigation. While retaining this enthusiasm, we remain wary of the abuses of the past and the potential for genomic research to harm those who have historically been most vulnerable. We hope that by forging ahead with scientifically rigorous research and accompanying that research with deep inquiry into social, ethical, and legal implications, the promise of genomics will become a reality for all peoples."

Race as Biology Is Fiction, Racism as a Social Problem Is Real: Anthropological and Historical Perspectives on the Social Construction of Race. In this article, Anthropologist Audrey Smedley, PhD (Virginia Commonwealth University), and Psychologist Brian D. Smedley, PhD (Institute of Medicine), submit that racialized science--science distinctions based on race--are imprecise and distort human differences. However, while race is a poor construct in science, it is a very relevant construct for social policy concerns. "Race remains a significant predictor of which groups will have greater access to societal goods and resources and which groups will face barriers...the fact of inequality renders race an important social policy concern."

The Meaning of Race in Psychology and How To Change It: A Methodological Perspective. Authors Janet E. Helms, PhD (Boston College), Maryam Jernigan, PhD (Boston College), and Jackquelyn Mascher, PhD (Boston College), state that the use of race categories within psychological research and theory lend credibility to a "conceptually meaningless concept" and should be replaced. They suggest substituting concepts of ethnicity, ethnic group, or ethnic identity for race or racial group, saying this approach would "consider such factors as values, customs, and traditions."

In the Eye of the Storm: Race and Genomics in Research and Practice. Authors Vivian Ota Wang, PhD (National Human Genome Research Institute, National Institutes of Health), and Stanley Sue, PhD (University of California, Davis), warn of the danger of the imprecise measure of race as a research determinate. "Geneticists and social and behavioral scientists and clinicians must recognize how their own unclear use of race creates havoc for scientific, clinical, and health policy enterprises," state the authors. Race, according to the authors, is a "second-order construct" that is too often used as a proxy for assumed biological, genetic, social, psychological, and other phenotypic factors, including people's beliefs about ancestry, nationality, language(s)/accent, religion, skin color, and racial identity, and, as such, limits the value of the research.

"Until population (and race) variables are more methodologically robust and used more consistently, social, behavioral, and genetic research will be limited in answering the questions related to biological and psychological differences, treatment efficiency, diagnostic bias, and service delivery."

Intelligence, Race, and Genetics. Authors Robert J. Sternberg, PhD (Yale University), Elena L. Grigorenko, PhD (Yale University), and Kenneth K. Kidd, PhD (Yale University), submit that research that attempts to link genetics and race with intelligence is invalid--based in folklore and not in science. Race is a social construction, not a scientific one, according to the authors, and studies of the relationship between race and other constructs may serve (or harm) social ends, but they do not serve science well. "There is nothing special about the skin color that serves as a basis for differentiating humans into so-called "races," the authors state.

Under the Skin: On the Impartial Treatment of Genetic and Environmental Hypotheses of Racial Differences" Author David C. Rowe, PhD (University of Arizona), proposes that studying racial differences in various human traits does have scientific merit. Further, he suggests that the appropriate scientific approach to studying race differences is to give environmental and genetic explanations equal prior weights. He proposes new research methods and designs -- based on both molecular and behavioral genetic data – to study race differences. These methods are discussed in relation to their potential to help evaluate the status of both genetic and environmental explanations.

Race and IQ: Molecular Genetics as Deus ex Machina. In a rebuttal to Rowe, Author Richard S. Cooper, MD (Loyola University Chicago), writes, "it is premature to argue that we should expect useful answers from research on whether there is a molecular basis for racial differences in IQ scores. Until the DNA-phenotype relationship is understood such questions should remain in the realm of nescience – the unknown and the unknowable – not science. Rather than providing useful answers, further research on race and IQ…will instead add to the existing morass of Type I error and willful falsification." According to Cooper, any discussion of race that ignores the cultural meaning and context of race fails the test of good science.

The Use of Race Variables in Genetic Studies of Complex Traits and the Goal of Reducing Health Disparities: A Transdisciplinary Perspective. Alexandra E. Shields, PhD (Georgetown University), Michael Fortun, PhD (Rensselaer Polytechnic Institute), Evelynn M. Hammonds, PhD (Harvard University), Patricia A. King, JD (Georgetown University Law Center), Caryn Lerman, PhD (University of Pennsylvania), Rayna Rapp, PhD (New York University), Patrick F. Sullivan, PhD (University of North Carolina at Chapel Hill). Using the case of new genetics research on smoking to illustrate their arguments, Shields, et. al. submit that the use of self-identified race categories in genetic analyses is no longer an appropriate research technique. According to the authors, there are more precise and effective measures now available to address methodological concerns. Furthermore, the use of self-identified race categories as proxies for a host of underlying social and environmental factors that track with race fail to produce knowledge of complex gene-environment interactions, knowledge that is needed to understand disease etiology and address racial health disparities.

The authors believe that new genetic investigations should spur the field to identify more refined measurements of social and environmental factors that traditionally have been measured only grossly and indirectly by race. Doing so, the authors submit, may achieve a breakthrough in producing the kind of data needed to begin to solve the health disparities problem in the United States. The interdisciplinary Georgetown University Ethics Research Consortium on Smoking is funded by the Robert Wood Johnson Foundation.

Genes, Environment, and Race: Quantitative Genetic Approaches. Authors Keith E. Whitfield, PhD (Penn State University), and Gerald McClearn, PhD (Penn State University), caution against explanations of racial health disparities that are based exclusively on either genetic or environmental explanations. They emphasize the co-action and interaction of genes and environments in health and offer example of twin-studies and quantitative genetic approaches as alternatives.

Race and Genetics: Controversies in Biomedical, Behavioral, and Forensic Sciences. Authors Pilar Ossorio, PhD (University of Wisconsin-Madison), and Troy Duster, PhD (New York University), suggest that much of the criticism of the use of race as a dividing category in science is well founded. But, rather than categorically rejecting the use of race variables in all science, they call for a "more nuanced discussion of when and how to use race variables in research." The authors point to the field of criminal justice as an area in which the use of genetic markers for race is gaining popularity. However genetic information that might be used in an attempt to explain behavior or link suspects to crimes can be highly inaccurate and will not necessarily lead to an increase in public safety.

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Full text articles can be found at: http://www.apa.org/releases/jan05ap_articles.html (For media use only! - please do not publish this link)

A list of lead authors and their contact information is attached.

The American Psychological Association (APA), in Washington, DC, is the largest scientific and professional organization representing psychology in the United States and is the world's largest association of psychologists. APA's membership includes more than 150,000 researchers, educators, clinicians, consultants and students. Through its divisions in 53 subfields of psychology and affiliations with 60 state, territorial, and Canadian provincial associations, APA works to advance psychology as a science, as a profession, and as a means of promoting health, education, and human welfare.

Contact: Rhea Farberman Public Affairs Office
202-336-5700
public.affairs@apa.org

January 2005 American Psychologist
Lead Author Contact Information

Genes, Race, and Psychology in the Genome Era: An Introduction
Norman B. Anderson and Kim J. Nickerson, American Psychological Association

Contact: APA Public Affairs Office
Phone: 202-336-5700
Email: public.affairs@apa.org

Race and Ethnicity in the Genome Era: The Complexity of the Constructs
Vence L. Bonham, Esther Warshauer-Baker, and Francis S. Collins, National Institutes of Health

Contact: Vence L. Bonham, PhD, National Human Genome Research Institute, National Institutes of Health.
Phone: 301-402-7229
Email: bonhamv@mail.nih.gov

Race as Biology Is Fiction, Racism as a Social Problem Is Real: Anthropological and Historical Perspectives on the Social Construction of Race
Audrey Smedley, Virginia Commonwealth University, and Brian D. Smedley, Institute of Medicine

Contact: Audrey Smedley, PhD, Anthropology, School of World Studies, Virginia Commonwealth University
Phone: 804-828-2585
Email: asmedley@mail1.vcu.edu

The Meaning of Race in Psychology and How to Change It: A Methodological Perspective
Janet E. Helms, Maryam Jernigan, and Jackquelyn Mascher, Boston College

Contact: Janet E. Helms, PhD, Department of Counseling, Developmental and Educational Psychology, Boston College Phone: 617-552-4080
Email: helmsja@bc.edu

In the Eye of the Storm: Race and Genomics Research and Practice
Vivian Ota Wang, National Human Genome Research Institute, National Institutes of Health and Stanley Sue, University of California, Davis

Contact: Vivian Ota Wang, PhD, Ethical, Legal, and Social Implications Program, National Human Genome Research Institute, National Institutes of Health, U.S. Department of Health and Human Services
Phone: 301 496-7531
Email: otawangv@mail.nih.gov

Intelligence, Race, and Genetics
Robert J. Sternberg, Elena L. Grigorenko, and Kenneth K. Kidd, Yale University

Contact: Robert J. Sternberg, PhD, PACE Center, Yale University
Phone: 203-432-4633
Email: Robert.Sternberg@yale.edu

Under the Skin: On the Impartial Treatment of Genetic and Environmental Hypotheses of Racial Differences
David C. Rowe (Deceased), University of Arizona.

NOTE: Sadly, Dr. Rowe died in 2003 of cancer. Dr. Joseph Rodgers made final revisions to this article.

Contact: Joseph Rodgers, Department of Psychology, University of Oklahoma
Phone: 405-325-4591
Email: jrodgers@ou.edu

Race and IQ: Molecular Genetics as Deus ex Machina
Richard S. Cooper, Loyola University Chicago Stritch School of Medicine

Contact: Richard S. Cooper, MD, Department of Preventive Medicine and Epidemiology, Loyola University Chicago Stritch School of Medicine
Phone: 708-327-9010
Email: rcooper@lumc.edu

The Use of Race Variables in Genetic Studies of Complex Traits and the Goal of Reducing Health Disparities: A Transdisciplinary Perspective
Alexandra E. Shields, Georgetown University, Michael Fortun, Rensselaer Polytechnic Institute, Evelynn M. Hammonds, Harvard University, Patricia A. King, Georgetown University Law Center, Caryn Lerman, University of Pennsylvania, Rayna Rapp, New York University, and Patrick F. Sullivan, University of North Carolina at Chapel Hill

Contact: Alexandra E. Shields, PhD, Health Policy Institute, Georgetown Public Policy Institute, Georgetown University
Phone: 617 724-1084 (Dr. Shields is spending a semester at Harvard University)
Email: shieldsa@georgetown.edu

Genes, Environment, and Race: Quantitative Genetic Approaches
Keith E. Whitfield and Gerald McClearn, Pennsylvania State University

Contact: Keith E. Whitfield, PhD, Department of Biobehavioral Health, Pennsylvania State University
Phone: 814-863-1840
Email: kew5@psu.edu

Race and Genetics: Controversies in Biomedical, Behavioral, and Forensic Sciences
Pilar Ossorio, University of Wisconsin-Madison and Troy Duster, New York University

Contact: Pilar Ossorio, PhD, University of Wisconsin Law School
Phone: 608-263-4387
Email: pnossorio@wisc.edu


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