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Public release date: 26-Jul-2005
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Ken-ichiro Kuwako, Akari Hosokawa, Isao Nishimura, Taichi Uetsuki, Masashi Yamada, Shigeyuki Nada, Masato Okada, and Kazuaki Yoshikawa
Kuwako et al. evaluate mice lacking a paternal copy of the necdin gene (Ndn+m/-p), a maternally imprinted, patternally expressed multifunctional signaling protein. The mice share behavioral and developmental features with Prader-Willi syndrome (PWS), a genomic imprinting-associated developmental disorder. Ndn+m/-p mice displayed a higher tolerance for heat-induced pain, as is also frequent in PWS. The authors speculate that necdin may play an analogous role in brain-derived neurotrophic factor/TrkB signaling in central neurons.
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