Knowledge of infection may prevent spread of herpes virus

A new study suggests that the risk of transmitting the virus that causes most cases of genital herpes could be cut in half by more testing and informing sexual partners of infection. The study is published in the July 1 issue of The Journal of Infectious Diseases, now available online.

Until recently, there was little evidence to show that knowledge of infection would lead to decreased transmission of herpes simplex virus (HSV) to others. But Anna Wald, MD, MPH, and colleagues at the University of Washington and the Fred Hutchison Cancer Research Center in Seattle studied 199 patients with newly acquired genital HSV-2 infection and found that patients were about half as likely to transmit the virus when they knew they had genital herpes and informed their sexual partners.

According to Wald, "these findings suggest that testing persons with HSV type-specific serologic assays and encouraging disclosure may result in decreased risk of HSV-2 transmission to sexual partners."

The importance of this finding is described by editorialists Edward Hook III, MD, of the University of Alabama at Birmingham and Peter Leone, MD, of the University of North Carolina at Chapel Hill as one of three effective tools to prevent the spread of this sexually transmitted disease (STD). "Genital herpes is one of the few common STDs for which, at present, there is little coordinated emphasis on control efforts," say Hook and Leone. The two experts also support suppressive antiviral therapy and condom use as the other necessary elements to control the spread of genital herpes nationwide.

This most recent study also found that most people who transmitted HSV did not know that they had genital herpes. Wald, Hook, and Leone suggest that physicians should not only increase testing for HSV, but should also counsel their patients about transmitting the virus and disclosing their HSV status to sex partners.

Founded in 1904, The Journal of Infectious Diseases is the premier publication in the Western Hemisphere for original research on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune mechanisms. Articles in JID include research results from microbiology, immunology, epidemiology, and related disciplines. JID is published under the auspices of the Infectious Diseases Society of America (IDSA). Based in Alexandria, Va., IDSA is a professional society representing about 8,000 physicians and scientists who specialize in infectious diseases. For more information, visit www.idsociety.org.

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