In a 28 year study of 261 Japanese-American men who carried Helicobacter pylori belonging to a large family or being born later in the family was associated with a significantly increased risk of developing gastric adenocarcinoma late in life. These results suggest that early-life social environment plays a significant role in risk of microbially induced malignancies expressing five to eight decades later.
Citation: Blaser MJ, Nomura A, Lee J, Stemmerman GN, Perez-Perez GI (2007) Early-life family structure and microbially induced cancer risk. PLoS Med 4(1): e7.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0040007
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-04-01-blaser.pdf
CONTACT:
Martin Blaser
New York University
School of Medicine
550 First Avenue
New York, NY 10016 United States of America
+1 212-263-6394
martin.blaser@nyumc.org
Related PLoS Medicine Perspective article:
Citation: Lagiou P, Trichopoulos D (2007) Parental family structure, Helicobacter pylori, and gastric adenocarcinoma. PLoS Med 4(1): e25.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0040025
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-04-01-lagiou.pdf
CONTACT:
Pagona Lagiou
University of Athens Medical School
Department of Hygiene and Epidemiology
75 M. Asias Street
Goudi
Athens, GR-115 27 Greece
plagiou@hsph.harvard.edu
A Novel Substrate-Based HIV-1 Protease Inhibitor Drug Resistance Mechanism
Changes in the cleavage site of the Gag substrate for the HIV protease can convey resistance to protease inhibitors and might contribute to virologic failure during therapy that includes these drugs.
Citation: Nijhuis M, van Maarseveen NM, Lastere S, Schipper P, Coakley E, et al. (2007) A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism. PLoS Med 4(1): e36.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0040036
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-04-01-boucher.pdf
Related image for press use: http://www.plos.org/press/plme-04-01-boucher.jpg
Caption: Schematic Representation of the Distribution of all Amino Acid Changes Appearing during in vitro Selection Experiments Using RO033-4649
CONTACT:
Charles Boucher
University Medical Centre Utrecht
Eijkman Winkler Centre, Department of Virology
Heidelberglaan 100
Utrecht, Utrecht 3584CX Netherlands
+31 302506526
+31 302505426 (fax)
c.boucher@umcutrecht.nl
About PLoS Medicine
PLoS Medicine is an open access, freely available international medical journal. It publishes original research that enhances our understanding of human health and disease, together with commentary and analysis of important global health issues. For more information, visit http://www.plosmedicine.org
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