Identification, isolation and large scale culture of stem cells for potential medical applications is a major challenge in cell biology. In an upcoming PLoS ONE paper, researchers, including Andras Paldi, in Genethon (Evry, France) report, on the basis of experimental observations and computer simulations, that the stem cell identity in culture may strongly depend on the cellular microenvironment.
These observations are in line with the currently emerging view that differentiation is context dependent rather than a pre-programmed attribute of the cells. In practice, this work provide a rationale to research strategies that aim to increase the efficiency of stem cell-related culture methods and, perhaps, even to develop stem cells from already differentiated cells instead of using embryos.
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The paper appears in the April 25th issue of PLoS ONE, the international, peer-reviewed, open-access online journal of the Public Library of Science.
Citation: Stockholm D, Benchaouir R, Picot J, Rameau P, Neildez TMA, et al (2007) The Origin of Phenotypic Heterogeneity in a Clonal Cell Population In Vitro. PLoS ONE 2(4): e394. doi:10.1371/journal.pone.0000394
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://dx.doi.org/10.1371/journal.pone.0000394
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PLoS ONE