[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:
17-Mar-2008

[ | E-mail ] Share Share

Contact: Josh Eveleth
jeveleth@plos.org
415-624-1234
PLOS

London's HIV epidemic was driven by clusters of sexual contacts

The rapid growth of the HIV/AIDS epidemic in London during the late 1990s was driven in part by transmission of the AIDS virus within clusters of sexual contacts, with individuals frequently passing the virus to others within months after becoming infected themselves, according to research published in PLoS Medicine by Andrew Leigh Brown and colleagues at the University of Edinburgh and London's Chelsea and Westminster Hospital.

These results indicate that growth of the HIV epidemic among men who have sex with men (MSM) in London was not a slow and steady process, but episodic, with multiple clusters of transmission occurring within a few years during the late 1990s, a time when the number of HIV infections in this population doubled.

Information about sexual contact networks can be used for partner notification so that people who may have been unknowingly involved in transmitting the infection can be identified, treated, and advised about disease prevention. Information on network structures can also be used to develop effective community-based prevention strategies.

Traditionally, epidemiologists have reconstructed sexual contact networks by interviewing people with the infection. Interview data has been of limited use in understanding HIV transmission patterns, however, largely because the time over which an infected individual might transmit HIV is long, and the risk of infection from a single sexual contact is low. A more novel way to analyze the spread of HIV is through phylogenetics, which examines the genetic relatedness of viruses obtained from different individuals.

Because genetic data on HIV is routinely obtained in the viral resistance tests used to choose the best HIV medications for an individual patient, Leigh Brown and colleagues were able to compare the sequences of HIV genes from more than 2,000 patients, mainly men who have sex with men (MSM), attending a large London HIV clinic between 1997 and 2003. Of the sequences analyzed, 402 were found to closely match at least one other viral sequence in this group. Further analysis showed that the patients whose viruses showed matches with others formed six clusters of ten or more individuals, as well as many smaller clusters, based on the genetic relatedness of their HIV viruses.

The researchers then used the date when each sample was collected and, taking into account the rates at which changes occur in the viral genes, determined dated phylogenies (essentially family trees of the virus strains) within the clusters. They found that most of the transmissions within each cluster occurred over periods of 3-4 years during the late 1990s, and that at least one in four transmissions between individuals in the large clusters occurred within 6 months following infection of the transmitting partner, suggesting that transmission of the virus during the early stages of HIV infection is likely to be an important driver of the epidemic.

Whether these results apply more generally to MSM at risk for transmitting or acquiring HIV depends on whether the patients in this study are representative of other populations. If additional studies confirm these results more widely, then this quantitative description of HIV transmission patterns should help in the design of strategies to strengthen HIV prevention among MSM.

In an accompanying Perspective, Christopher Pilcher and colleagues at the University of California San Francisco, who were not involved in the study, discuss the implications of this study for public health and clinical practice.

###

Citation: Lewis F, Hughes GJ, Rambaut A, Pozniak A, Leigh Brown AJ (2008) Episodic sexual transmission of HIV revealed by molecular phylodynamics. PLoS Med 5(3): e50.

IN YOUR ARTICLE, PLEASE LINK TO THIS URL, WHICH WILL PROVIDE ACCESS TO THE PUBLISHED PAPER: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050050

PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-05-03-leigh_brown.pdf

CONTACT:
Andrew Leigh Brown
University of Edinburgh
Institute of Evolutionary Biology
Ashworth Laboratories
West Mains Road
Edinburgh, Scotland
United Kingdom
+44-131-650-5523
+44-131-650-6564 (fax)
A.Leigh-Brown@ed.ac.uk

Related PLoS Medicine Perspective:

Citation: Pilcher CD, Wong JK, Pillai SK (2008) Inferring HIV transmission dynamics from phylogenetic sequence relationships. PLoS Med 5(3): e69.

PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050069

PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-05-03-pilcher.pdf

CONTACT:
Christopher Pilcher
University of California San Francisco,
San Francisco,
California
United States of America
+1 415-476-4082 x403
cpilcher@php.ucsf.edu

About PLoS Medicine

PLoS Medicine is an open access, freely available international medical journal. It publishes original research that enhances our understanding of human health and disease, together with commentary and analysis of important global health issues. For more information, visit http://www.plosmedicine.org

About the Public Library of Science

The Public Library of Science (PLoS) is a non-profit organization of scientists and physicians committed to making the world's scientific and medical literature a freely available public resource. For more information, visit http://www.plos.org



[ Back to EurekAlert! ] [ | E-mail Share Share ]

 


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.