Mitochondrial uncoupling demonstrated in human skeletal muscle
With obesity still on the increase, it appears that the main weapon in the fight against it - reducing energy consumption by eating less - is ineffective. There is evident need to search for new treatment strategies dealing with the opposite aspect of the energy balance: increasing energy consumption. Researchers at Maastricht University have now found a way to increase cells’ energy consumption: mitochondrial uncoupling. The findings are published in this week’s PLoS ONE.
PhD candidate Sander Wijers and his colleagues Patrick Schrauwen, Prof. Wim Saris and Wouter van Marken Lichtenbelt have shown that this process occurs naturally in human skeletal muscle cells when exposed to mild cold. They carried out muscle biopsies on 11 lean, healthy male subjects both under normal and mild cold conditions. Their results could lead to the development of drugs that stimulate mitochondrial uncoupling, and thus contribute to obesity treatment.
Fats and sugars are broken down in the mitochondria, or energy factories of the cells. ATP - the energy source used, for example, when muscles contract and for many other cellular processes - is formed using the energy released in this process. In some cases, such as when exposed to cold, not all the energy released from sugars and fats is used to produce ATP; stored energy is used for heat, reducing the availability of ATP for cellular processes. This phenomenon is called mitochondrial uncoupling. Fats and sugars are still broken down in the uncoupled mitochondria, but the energy released is not entirely used for cellular processes. More energy is therefore required to carry out the same physical functions.
Further genomic and proteomic research is required to identify the proteins responsible for uncoupling in skeletal muscle mitochondria. The animal proteins UCP1, UCP2, UCP4 and UCP5 detected in tests appear not to exist in human muscle tissue. And although UCP3 is found in human muscles, it seems to be involved primarily in fatty acid metabolism, not in mitochondrial uncoupling.
Note for the press:
Citation: Wijers SLJ, Schrauwen P, Saris WHM, van Marken Lichtenbelt WD (2008) Human Skeletal Muscle Mitochondrial Uncoupling Is Associated with Cold Induced Adaptive Thermogenesis. PLoS ONE 3(3): e1777. doi:10.1371/journal.pone.0001777
For more information on the content of this press release, please contact Sander Wijers on +31 43 388 4260 or email email@example.com.
The UM Communications & Relations Department can be contacted on +31 43 38 85222 or at firstname.lastname@example.org. For urgent matters outside office hours, please call 06 4602 4992. Press releases issued by Maastricht University can be found at www.pers.unimaas.nl/.
Please refer to the Research Magazine at www.unimaas.nl/researchmagazine for interesting research being carried out at UM.
Leading in Learning
Based in Europe, focused on the world. Maastricht University is a stimulating environment. Where research and teaching are complementary. Where innovation is our focus. Where talent can flourish. A truly student oriented research university.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT (URL live from Mar. 12):
This press release refers to an upcoming article in PLoS ONE. The release has been provided by the article authors and/or their institutions. Any opinions expressed in this are the personal views of the contributors, and do not necessarily represent the views or policies of PLoS. PLoS expressly disclaims any and all warranties and liability in connection with the information found in the release and article and your use of such information.
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.