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PUBLIC RELEASE DATE:
28-May-2008

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Contact: Toranj Marphetia
toranj@mcw.edu
414-456-4744
Medical College of Wisconsin
@medicalcollege

New study shows sedentary high school girls are at significant risk for future osteoporosis

Significant numbers of female high school athletes and non-athletes suffer from one or more components of the female athlete triad, a combination of three conditions that can lead to cardiovascular disease, according to a new study by Medical College of Wisconsin researchers in Milwaukee.

The study results were presented today at the American College of Sports Medicine at Indianapolis, by Anne Z. Hoch, D.O., associate professor of orthopedic surgery and physical medicine and rehabilitation at the Medical College, and director of the Froedtert & Medical College Sports Medicine Program. She is also a member of the Medical College's Cardiovascular Center.

Dr. Hoch found that 78 percent of female high school athletes and 65 percent of female high school non-athletes display one or more components of the female athlete triad. The triad is a combination of three conditions - low energy availability, menstrual abnormalities and low bone mineral density - that often leads to the same steroid and hormonal profiles as postmenopausal women.

"We are concerned that non athletic girls have some of the same components of the female athlete triad as athletes and are in fact at greater risk for low bone density," says Dr. Hoch. "These young women are under great pressure to conform to society's standards of body image. In an effort to lose weight, they are restricting their caloric intake and adapting unhealthy nutrition habits."

The study, conducted at Froedtert Hospital, examined eighty varsity athletes and eighty non-athletes at an all-girls school in Milwaukee. Ninety-three percent of non-athletes were found to have calcium deficiencies, compared to 74 percent of athletes.

"Most important and alarming is that 30 percent of the non athletes versus 16 percent of athletes were found to have low bone mineral density putting them at greater risk for developing osteoporosis earlier in life," says Dr. Hoch.

Both groups showed little difference in low energy availability, with 39 percent of non-athletes and 36 percent of athletes reporting this condition. The athletes reported 33 percent more menstrual abnormalities than the non-athletes. Women who have normal periods, and hence normal estrogen levels, are less likely to display changes in the function of the layer of cells that line the interior of blood vessels, called the endothelium.

"Change in endothelial function is the seminal event in cardiovascular disease," says Dr. Hoch.

Dr. Hoch began her studies in the late 1990s to see if young women who have menstrual abnormalities as a result of participating in intense sports are likely to develop cardiovascular disease similar to that seen in postmenopausal women. She and her colleagues were able to show that young women who had the triad also had early vascular change that is a precursor to cardiovascular disease.

"We not only need to educate athletes about the consequences of the triad, now we must educate all students about the harmful effects of a restrictive diet in the adolescent period," says Dr. Hoch.

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The study was funded in part by a grant from the General Clinical Research Center, which has evolved into the Clinical and Translational Science Institute; the Medical College's Cardiovascular Center; and the Steve Cullen Run and Walk.

Other Medical College researchers included Guillermo Carrere, M.D., professor of radiology; Charles Wilson, Ph.D., associate professor of radiology; David Gutterman, M.D., Northwestern Mutual Professor in Cardiology and senior associate dean for research, and Jane Schimke, clinical research coordinator in orthopedic surgery.



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