[ Back to EurekAlert! ] Public release date: 26-Jun-2008
[ | E-mail Share Share ]

Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-020-763-14804
BioMed Central

A simple therapy for brain injury

Severe brain injury due to blunt force trauma could be reduced by application of a simple polymer, Polyethylene glycol or PEG, mixed in sterile water and injected into the blood stream as reported in BioMed Central's Journal of Biological Engineering.

Andrew Koob and Richard Borgens from Purdue University, Indiana, performed experiments in rats which showed that PEG was effective in limiting damage if administered within four hours after the head injury. However, if treatment was delayed for a further two hours, the beneficial effects were lost. During the experiments, rats were injured with a falling weight and then PEG was administered fifteen minutes, two hours, four hours or six hours later. The authors then carried out a series of behavioural tests on the rats to determine the effectiveness of the PEG treatment.

According to Borgens "These data suggest that PEG may be clinically useful to victims of traumatic brain injury if delivered as rapidly as possible after an injury". Such a treatment could feasibly be carried out at the scene of an accident where PEG could be delivered as a component of IV fluids thus reducing long term brain injury.

###

Media Contact
Graeme Baldwin
Press Office, BioMed Central
Tel: +44 (0) 20 7631 4804
Email: graeme.baldwin@biomedcentral.com

Notes to Editors

1. Behavioral recovery from traumatic brain injury after membrane reconstruction using polyethylene glycol
Andrew O Koob, Julia M Colby and Richard B Borgens
Journal of Biological Engineering (in press)

During embargo, article available here: http://www.jbioleng.org/imedia/2795150117334624_article.pdf?random=510965

After the embargo, article available at journal website: http://www.jbioleng.org/

Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.

Article citation and URL available on request at press@biomedcentral.com on the day of publication.

2. Journal of Biological Engineering, the official journal of the Institute of Biological Engineering, is an open access, online journal that publishes articles on all aspects of biological engineering.

3. BioMed Central (http://www.biomedcentral.com/) is an independent online publishing house committed to providing immediate access without charge to the peer-reviewed biological and medical research it publishes. This commitment is based on the view that open access to research is essential to the rapid and efficient communication of science.



[ Back to EurekAlert! ] [ | E-mail Share Share ]

 


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.