Public Release:  Hayfever hope

Norwich BioScience Institutes

With the peak grass pollen season approaching, scientists can reveal that a daily dose of probiotic can change the immune status of people with hay fever.

In the first human study of its kind, scientists at the Institute of Food Research found that probiotic bacteria in a daily drink can modify the immune system's response to grass pollen, a common cause of seasonal hay fever.

But they are not recommending that sufferers rush to the supermarket shelves just yet. The changes found may not have an immediate effect on symptoms.

"This was a pilot study based on small numbers of patients, but we were fascinated to discover a response", says research leader Professor Claudio Nicoletti. "The probiotic significantly reduced the production of molecules associated with allergy."

Hayfever is an allergic reaction to pollen or fungal spores, most commonly grass pollen. The immune system mistakes the spores for harmful invaders and produces excessive amounts of the antibody IgE to bind to them and fight them off.

IgE stimulates the release of histamine to flush out the spores, and this irritates the airways making them swell and producing the symptoms of hayfever.

In this study, volunteers with a history of seasonal hay fever drank a daily milk drink with or without live bacteria over 5 months. The study was double-blinded and placebo controlled, so neither the volunteers nor the scientists knew who had been assigned the probiotic drinks. The probiotic drinks contained Lactobacillus casei, a bacterial species that has been widely studied for its health promoting properties.

Blood samples were taken before the grass pollen season, then again when it was at its peak (June), and 4 weeks after the end of season. There were no significant differences in levels of IgE in the blood between the two groups at the start of the study, but IgE levels were lower in the probiotic group both at the peak season and afterwards.

At the same times, levels of the antibody IgG were higher, a type of antibody that in contrast to IgE is thought to play a protective role against allergic reactions.

"The probiotic strain we tested changed the way the body's immune cells respond to grass pollen, restoring a more balanced immune response", says Dr Kamal Ivory, a senior member of the group.

The changes observed may also reduce the severity of symptoms, but clinical symptoms were not measured in this study. That is one aim of further research.

"These are really interesting results", says Dr Linda Thomas, head of science at Yakult UK, who provided the drinks and some of the funding. "We are delighted that independent scientists found evidence of this biological activity. The project was part of ongoing research into the benefits of our probiotic strain. The Institute of Food Research is well positioned to do this kind of fundamental research, as it is unique in having the right combination of expertise in microbiology, immunology, flow cytometry and human nutrition research."

Professor Nicoletti's group intend to perform a similar study in the near future to see if the immunological changes translate into a real reduction in the clinical symptoms of hayfever. They would also like to examine the mechanisms involved.



Andy Chapple, Press Office Assistant, Institute of Food Research
t: 01603 251490
m: 07785 766779

Notes to editors

  • Full reference: Clinical and Experimental Allergy, 2008. Oral delivery of Lactobacillus casei Shirota modifies allergen-induced immune responses in allergic rhinitis. Kamal Ivory, Stephen J. Chambers, Carmen Pin, Elena Prieto, Juan L. Arqués, Claudio Nicoletti

  • Funding was provided by Yakult and through IFR's Core Strategic Grant from the BBSRC.

  • The mission of the Institute of Food Research ( is to undertake international quality scientific research relevant to food and human health and to work in partnership with others to provide underpinning science for consumers, policy makers, the food industry and academia. It is a company limited by guarantee, with charitable status, grant aided by the Biotechnology and Biological Sciences Research Council (

  • Flow cytometry allows the rapid analysis of thousands of single cells and can detect rare events. It brings the power of physics to bear on important biological questions by using laser light to measure the characteristics of thousands of individual cells suspended in a stream of fluid.

  • Yakult ( was developed in 1935 by Dr Shirota, at Kyoto University in Japan. Yakult has almost 75 years in bacteriological research and has achieved global recognition in the use of friendly bacteria in foods, cosmetics and pharmaceuticals. Research continues at the Yakult Central Institute in Japan and the company also works closely with scientific and medical communities to increase understanding of the role of friendly bacteria in health. Today Yakult is consumed by 25 million people in 31 countries and territories world-wide.

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