Public Release:  ETH Zurich and IBM improve diagnosis of osteoporosis

Computer simulations help predict fracture risk

ETH Zurich/Swiss Federal Institute of Technology

With the goal of developing an accurate, powerful and fast method to automate the analysis of bone strength, scientists of the ETH Zurich Departments of Mechanical and Process Engineering and Computer Science teamed up with supercomputing experts at IBM's Zurich Research Laboratory. The breakthrough method developed by the team combines density measurements with a large-scale mechanical analysis of the inner-bone microstructure.

Using large-scale, massively parallel simulations, the researchers were able to obtain a dynamic "heat map" of strain, which changes with the load applied to the bone. This map shows the clinician exactly where and under what load a bone is likely to fracture. "With that knowledge, a clinician can also detect osteoporotic damage more precisely and, by adjusting a surgical plate appropriately, can best determine the location of the damage," explains Dr. Costas Bekas of IBM's Computational Sciences team in Zurich. "This work is an excellent showcase of the dramatic potential that supercomputers can have for our everyday lives."

The joint team utilized the massively large-scale capabilities of the 8-rack Blue Gene /L supercomputer to conduct the first simulations on a 5 by 5 mm specimen of real bone. Within 20 minutes, the supercomputer simulation generated 90 Gigabytes of output data. "It is this combination of increased speed and size that will allow solving clinically relevant cases in acceptable time and unprecedented detail", says Professor Ralph Müller, Director of the ETH Zurich Institute for Biomechanics.

Going beyond static bone strength

Ten years ago, the world's most sophisticated supercomputer, called Deep Blue, would not have been able to handle the sheer size of the calculations. Even with sufficient system memory, it would have taken roughly a week of computing time - too long for meaningful impact on diagnosis and treatment.

"Ten years from now, today's supercomputers' performance will be available in desktop systems, making such simulations of bone strength a routine practice in computer tomography," predicts Dr. Alessandro Curioni, manager of the Computational Sciences group at IBM's Zurich Research Laboratory.

ETH Zurich Professor Peter Arbenz, who initiated the collaboration of the involved groups, explains that what was first needed was state of the art in numerical algorithms in order to solve extremely large problems in surprisingly short time, and that it is the first fundamental step towards clinical use of large scale bone simulations. "We are at the beginning of an exciting journey. This line of research must absolutely be continued in order to achieve our goal," he states. Scientists in future aim to advance simulation techniques to go beyond the calculation of static bone strength to the simulation of the actual formation of the fractures for individual patients, in yet another step towards the fast, reliable and early detection of people at high fracture risk.

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Reference

The work "Extreme Scalability Challenges in Analyses of Human Bone Structures" by ETH scientists Peter Arbenz, Cyril Flaig, Harry van Lenthe, Ralph Mueller, Andreas Wirth and ZRL researchers Costas Bekas and Alessandro Curioni was presented at the IACM/ECCOMAS 2008 conference in Venice, Italy, on July 2.

Osteoporosis: the silent enemy

Osteoporosis is the most widespread bone disease worldwide. It affects 75 million people in the US, Europe and Japan alone, incurring health costs second only to those of cardiovascular di-seases. Literally "porous bone", osteoporosis is characterized by loss of bone density, resulting in a high risk of fractures. It is a major cause of pain, disability and death in older persons. Unfortunately, in many cases osteoporosis is not diagnosed until a fracture has occurred. By then the disease is already in an advanced stage, requiring implants or surgical plates to treat or prevent further fractures. The early detection of osteoporosis is crucial so that effective measures can be taken to prevent its progress.

Today, osteoporosis is diagnosed by measuring bone mass and density using specialized X-ray or computer tomography techniques: a highly empirical process. Studies have shown, however, that bone mass measurements are only moderately accurate at determining the strength of the bone because bones are not solid structures. Inside the compact outer shell, bones have a sponge-like center. This complex microstructure accounts for the bone's capability to bear loads and therefore represents a better indicator of a bone's true strength.

ETH Zurich (Swiss Federal Institute of Technology) has a student body of 14,000 students from 80 nations. Nearly 360 professors teach mainly in engineering sciences and architecture, system-oriented sciences, mathematics and natural sciences, as well as carry out research that is highly valued world-wide. On a yearly basis, ETH Zurich applies for 80 -100 patents and directly supports the founding of up to 20 spin-off companies. Distinguished by the successes of 21 Nobel laureates, and with members in the IPCC (Intergovernmental Panel for Climate Control) that was awarded the 2007 Nobel Peace Prize, ETH Zurich is committed to providing its students with unparalleled education and outstanding leader-ship skills.

IBM Zurich Research Laboratory (ZRL)

The IBM Zurich Research Laboratory is the European branch of IBM Research. This worldwide network of more than 3500 employees in eight laboratories around the globe is the largest industrial IT research organization in the world. ZRL, which was established in 1956, currently employs some 330 persons, representing more than 30 nationalities. ZRL's spectrum of research activities includes nanoscience, future chip technology, supercomputing, advanced storage and server technologies, security and privacy, risk and compliance, as well as business optimization and transformation. World-class research and outstanding scientific achievements--most notably two Nobel Prizes--are associated with the Zurich Lab.

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