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Contact: Graeme Baldwin
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BioMed Central

Severe, acute maternal stress linked to the development of schizophrenia

Pregnant women who endure the psychological stress of being in a war zone are more likely to give birth to a child who develops schizophrenia. Research published today in the open access journal BMC Psychiatry supports a growing body of literature that attributes maternal exposure to severe stress during the early months of pregnancy to an increased susceptibility to schizophrenia in the offspring.

According to Dolores Malaspina from NYU School of Medicine and lead author of the study, "The stresses in question are those that would be experienced in a natural disaster such as an earthquake or hurricane, a terrorist attack, or a sudden bereavement".

Data from 88,829 people, born in Jerusalem from 1964 to 1976, were collected from the Jerusalem Perinatal Study that linked birth records to Israel's Psychiatric Registry. The NYU authors discovered that the offspring of women who were in their second month of pregnancy during the height of the Arab-Israeli war in June of 1967 (the "Six Day War") displayed a significantly higher incidence of schizophrenia over the following 21-33 years. The study also showed that the pattern was gender-specific, affecting females more than males.

Following the 1967 war, females who had been in their second month of fetal life during the conflict were 4.3 times more likely to develop schizophrenia than females born at other times. Males in their second month of fetal life were 1.2 times more likely to develop schizophrenia. "It's a very striking confirmation of something that has been suspected for quite some time", said Malaspina.

"The placenta is very sensitive to stress hormones in the mother," explains Malaspina, "these hormones were probably amplified during the time of the war."

The authors point out that the study, which assessed ongoing medical records, only supports, rather than proves, the hypothesis that the greatest vulnerability to schizophrenia is in the second month of pregnancy. Limitations to the study include a small sample population as well as the absence of information on the exact length of gestation, which makes it possible that developmental stages were underestimated.

Malaspina also points out that pregnant women in general should not be alarmed about handling daily stressors during pregnancy. "A developing fetus requires some exposure to maternal stress hormones as it normalizes their stress functioning," she says. "But women experiencing anxiety or excessive stress would do well to address it before a planned pregnancy and to have good social support systems."

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Notes to Editors

1. Acute maternal stress in pregnancy and schizophrenia in offspring: a cohort prospective study.
D Malaspina, C Corcoran, K R Kleinhaus, M C Perrin, S Fennig, D Nahon, Y Friedlander and S Harlap
BMC Psychiatry (in press)

During embargo, article available here: http://www.biomedcentral.com/imedia/1449987758183709_article.pdf?random=781190

After the embargo, article available at journal website: http://www.biomedcentral.com/bmcpsychiatry/

Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.

Article citation and URL available on request on day of publication at press@biomedcentral.com

2. The co-authors of this study are: Cheryl Corcoran, Karine R Kleinhaus, Mary C Perrin, Shmuel Fennig, Daniella Nahon and Yechiel Friedlander.

The study was supported by grants from the National Institutes of Health: and from the National Alliance for Research of Schizophrenia and Depression (NARSAD).

3. BMC Psychiatry is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of psychiatric disorders, as well as related molecular genetics, pathophysiology, and epidemiology. BMC Psychiatry (ISSN 1471-244X) is indexed/tracked/covered by PubMed, MEDLINE, CAS, Scopus, EMBASE, Thomson Scientific (ISI) and Google Scholar.

4. BioMed Central (http://www.biomedcentral.com/) is an independent online publishing house committed to providing immediate access without charge to the peer-reviewed biological and medical research it publishes. This commitment is based on the view that open access to research is essential to the rapid and efficient communication of science.



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