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PUBLIC RELEASE DATE:
18-Aug-2008

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Contact: Lori Fromm
lfromm@webershandwick.com
312-988-2436
Weber Shandwick Worldwide

Researchers link cocoa flavanols to improved brain blood flow

New study suggests cocoa compounds could hold promise for

McLEAN, VA (August 18, 2008) - Cocoa flavanols, the unique compounds found naturally in cocoa, may increase blood flow to the brain, according to new research published in the Neuropsychiatric Disease and Treatment journal. The researchers suggest that long-term improvements in brain blood flow could impact cognitive behavior, offering future potential for debilitating brain conditions including dementia and stroke.

In a scientific study of healthy, older adults ages 59 to 83, Harvard medical scientists found that study participants who regularly drank a cocoa flavanol-rich beverage made using the Mars, Incorporated Cocoapro® process had an eight percent increase in brain blood flow after one week, and 10 percent increase after two weeks.

In this first-of-its-kind study, the researchers found both short and long-term benefits of cocoa flavanols for brain blood flow, offering future potential for the one in seven older Americans currently living with dementia. When the flow of blood to the brain slows over time, the result may be structural damage and dementia. Scientists speculate that maintaining an increased blood flow to the brain could slow this cognitive decline.

"The totality of the research on cocoa flavanols is impressive. This is just one more study adding to an increasing body of literature connecting regular cocoa flavanol consumption to blood flow and vascular health improvements throughout the body," said Harold Schmitz, Ph.D., chief science officer at Mars, Incorporated, which has supported research on cocoa flavanols for more than 15 years. "Though more research is needed, these findings raise the possibility that flavanol-rich cocoa products could be developed to help slow brain decline in older age."

The Body of Evidence
Contrary to statements often made in the popular media, the collective research demonstrates that the vascular effects of cocoa flavanols are independent of general "antioxidant" effects that cocoa flavanols exhibit in a test tube, outside of the body. While research aimed at studying the potential role of cocoa flavanols in the context of blood vessel and circulatory function continues, a number of previously published studies already suggest that the consumption of cocoa flavanols can have important beneficial effects on the function of the body's network of blood vessels. The body of research not only suggests that cocoa flavanols may provide a dietary approach to maintaining cardiovascular function and health, but also points at new possibilities for cocoa flavanol-based interventions for vascular complications associated with cognitive performance, skin health and age-related blood vessel dysfunction.

Future Cocoa Flavanol Research Directions
For more than 15 years, Mars, Incorporated has conducted and/or supported a significant portion of the research undertaken in the field of cocoa flavanols and reported new insights in peer-reviewed scientific literature. Working in collaboration with top research institutions around the world, Mars, Incorporated continues to lead the way in exploring the nutritional and medical potential of cocoa flavanols. Mars' commitment to rigorous scientific research of cocoa and flavanols is evidenced by more than 100 peer-reviewed research publications and more than 80 patents held by the company. Mars also developed and patented the breakthrough process called Cocoapro® that helps retain more of the naturally occurring flavanols in cocoa. The high-flavanol cocoa powders made using the Mars Cocoapro® process are thoroughly characterized in terms of nutrient content, as well as standardized with respect to flavanol level and flavanol profile. Through the newly created Mars Botanical division, Mars will continue to develop and apply industry-leading analytical techniques and standards to further investigate the biomedical potential of cocoa flavanols. For more information on the many research studies on cocoa flavanols, visit www.healthycocoa.com.

Source: Sorond FA, Lipsitz LA, Hollenberg NK, Fisher NDL. Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans. Neuropsychiatric Disease and Treatment. 2008;4:433-440.

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About Mars, Incorporated
Mars, Incorporated, headquartered in McLean, Virginia is a family-owned company with a strong commitment to science-based research. With more than 15 years of research into the health effects of cocoa flavanols, and decades of research invested into improving the cocoa plant and farming techniques, Mars, Incorporated has become the global leader in cocoa research. For more information, visit www.cocoapro.com. For more information about the Mars, Incorporated cocoa sustainability program, visit www.cocoasustainability.mars.com.

About Mars Botanical
Mars Botanical, headquartered in Rockville, Maryland, is a newly-established division of Mars, Incorporated. The mission of Mars Botanical is to further develop leading edge science and technologies in the field of phytonutrients with the goal of creating new plant-derived products aimed at improving human health, and do so in a sustainable way that helps both farming communities and their local environment. Mars, Incorporated scientists and colleagues at leading research institutions are dedicated to unlocking the full nutritional and medical potential of cocoa flavanols. For more information, visit www.marsbotanical.com.



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