What can we do for prevention and therapy of anaerobe-associated infections?

Body of text: Anaerobic microorganisms are important constituents of both human and animal intestinal microbiota. Infections caused by anaerobic bacteria are increasingly being recognized as major problem in clinical medicine. The commensal anaerobic bacterial flora of the colon may undergo changes during diarrhea, owing to colonization of the intestine by pathogens and to rapid intestinal transit. The major role of endogenous cationic antimicrobial peptides in preventing the onset of infection has been emphasized recently. Such peptides have been found platelets and are designated PMP. Here a group from Institute of Cellular and Intracellular Symbiosis of Russia made an attempt to in vitro detection of SIPMP phenotypes of faecal anaerobic isolates from patients with diarrhea.

A research article to be published on September 21,2008 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Iuri B. Ivanov from Institute of Cellular and Intracellular Symbiosis of Russia studied SIPMP phenotypes of faecal anaerobic isolates from patients with diarrhea.

The article focuses on inhibition of PMP by extracellular bacterial products of faecal anaerobic microorganisms isolated from stool of children with diarrhea. Among anaerobic isolates 80% of B. longum strains, 85.7% of A. israelii strains, 50% of E. lentum strains and 92.86% of B. fragilis strains were SIPMP-positive. The isolated anaerobic organisms demonstrated SIPMP production at a mean level of 13.8% ± 0.7%, 14.7% ± 1.8%, 3.9% ± 0.9% (P < 0.05) and 26.8% ± 7.5% (P < 0.05) for bifidobacteria, A. israelii, E. lentum and B. fragilis, respectively.

Data from the present study may have significant implications in understanding the pathogenesis of microecological disorders in intestine, as well as for future improvement in the prevention and therapy of anaerobe-associated infections.

In this manuscript, the authors reported the detection of secretory inhibitor of platelet microbicidal protein (SIPMP) phenotypes of faecal anaerobic isolates from patients with diarrhea. The study was well performed and interesting.

Reference: Ivanov IB, Gritsenko VA. Distribution of secretory inhibitor of platelet microbicidal protein among anaerobic bacteria isolated from stool of children with diarrhea. World J Gastroenterol 2008; 14(35): 5428-5431
http://www.wjgnet.com/1007-9327/14/5428.asp

Correspondence to: Dr. Iuri B Ivanov, Department of Human Microbiology, Institute of Cellular and Intracellular Symbiosis, Russian Academy of Sciences, Volgogradskaya st., 36/3, of .93, Orenburg 460056, Russia. mil-for@rambler.ru
Telephone: +7-35-32775417 Fax: +7-35-32774463

World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.

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