Colon cancer ranks second of all gastrointestinal malignant tumors, it is one of the leading causes of cancer-related deaths worldwide. Until now, several molecules have been reported to play an important role in gastroenterological tumorigenesis and tumor metastasis, but the molecular mechanisms involved tumor development and progression still remain unclear in colon cancer.
A research article to be published on October 14, 2008 in the World Journal of Gastroenterology addresses this question. In this research, by using the combined methods of laser microdissection (LMD), P27-based RNA amplification, and polypeptide, They evaluated differentially expressed genes between early carcinoma and lymph node metastatic patients. Moreover, They further identified four differentially expressed genes in the progression of colon cancer in another group of 15 patients by means of semiquantitative reverse transcribed polymerase chain.
Their result indicated that the five gene expressions were changed in colon carcinoma cells compared with that of controls. Of the five genes, three genes were downregulated and two were upregulated in invasive submucosal colon carcinoma compared with non-invasive cases. The results were confirmed at the level of RNA and gene expression. Five genes were further identified as differentially expressed genes in the majority of cases (> 50%, 25/40) in progression of colon cancer, and their expression patterns of which were similar to tumor suppressor genes or oncogenes. These results not only reveal the differentially expressed genes in progression of colon cancer, but also provide information that may prove useful for identifying novel diagnostic and therapeutic targets.
Reference: Zhu JS, Guo H, Song MQ, Chen GQ, Sun Q, Zhang Q. Gene profiles between non-invasive and invasive colon cancer using laser microdissection and polypeptide analysis. World J Gastroenterol 2008; 14(38): 5887-5892
Correspondence to: Jin-Shui Zhu, Professor, Department of Gastroenterology, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China. firstname.lastname@example.org Telephone: +86-21-64369181 Fax: +86-21-64837019
About World Journal of Gastroenterology
World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.
About The WJG Press
The WJG Press mainly publishes World Journal of Gastroenterology.