Public Release:  SIDS link: Low blood pressure in preterm infants

Monash University scientists show low blood pressure in premature babies during sleep

Monash University

Scientists from Monash University, Melbourne have shown that infants born prematurely have lower blood pressure during sleep in the first six months of life, compared to healthy, full-term infants.

Scientists at the Ritchie Centre for Baby Health Research, Monash Institute of Medical Research, believe this may be one reason premature infants are at an increased risk of Sudden Infant Death Syndrome (SIDS).

Chief Investigator, Associate Professor Rosemary Horne, said that previous studies have shown that prematurely-born babies are at a significantly increased risk of SIDS; approximately 20 percent of all SIDS cases occur in preterm babies, though preterm babies comprise only 8-10 percent of infants born.

"It has been hypothesised that the underlying mechanism of SIDS involves a fall in blood pressure during sleep combined with a failure of the baby to arouse from sleep which would normally restore blood pressure," Associate Professor Horne said.

"Our study has now provided evidence as to why preterm babies are at a higher risk for SIDS."

The study monitored the blood pressure of 25 preterm and 20 full-term infants at two to four weeks; two to three months and five to six months. Blood pressure was lower during sleep in the preterm infant group at all ages studied, but was lowest in the two to three month age group, when the risk of SIDS is highest.

"Our recommendation is that additional research needs to be undertaken to determine whether preterm infants also have impaired cardiovascular control, as this may also contribute to the higher rate of SIDS in preterm infants, particularly when sleeping face down/on the stomach," said Associate Professor Horne.

"Parents of both term and preterm infants should follow the advice of SIDS and Kids for infant safe sleeping practices and always sleep their infant on his/her back, keep their baby away from cigarette smoke and ensure that the baby's head cannot be covered by bedding," she said.

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More information: Witcombe, Yiallourou, Walker, Horne (2008), Blood pressure and heart rate patterns during sleep are altered in preterm-born infants: implications for Sudden Infant Death Syndrome. Pediatrics 122(6):e1242-8.

Vision opportunities: Footage available in sleep laboratory; mother and young baby

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Monash Institute of Medical Research

The Monash Institute of Medical Research was established by the Governor of Victoria, Emeritus Professor David de Kretser AC in 1991. Since then, the Institute has pioneered research into the characterisation and application of stem cells, the cause and treatment of inflammation and cancer and the improvement of women's, men's and children's health.

Associate Professor Rosemary Horne

Associate Professor Horne's team has been at the forefront of SIDS research for the past 25 years. Her research has been instrumental in providing insights into the underlying physiological mechanisms which are involved in the main risk factors for SIDS, including sleeping infants on their stomachs, maternal smoking, recent infection and prematurity.

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