This release is available in French.
Montreal, December 10th, 2008 –Insufficient vitamin D can stunt growth and foster weight gain during puberty, according to a new study published in the Journal of Clinical Endocrinology & Metabolism. Even in sun-drenched California, where scientists from the McGill University Health Centre (MUHC) and the University of Southern California conducted their study, vitamin D deficiency was found to cause higher body mass and shorter stature in girls at the peak of their growing spurt.
While lack of vitamin D is common in adults and has been linked to diseases such as osteoporosis, cancer and obesity, until this study, little was known about the consequences of insufficient vitamin D in young people. The research team measured vitamin D in girls aged 16 to 22 using a simple blood test (25-hydroxy vitamin D). They also assessed body fat and height to determine how vitamin D deficiency could affect young women's health.
"The high prevalence of vitamin D insufficiency in young people living in a sun-rich area was surprising," says study lead author, Richard Kremer, co-director of the Musculoskeletal Axis of the MUHC. "We found young women with vitamin D insufficiency were significantly heavier, with a higher body mass index and increased abdominal fat, than young women with normal levels."
Vitamin D fosters growth, healthier weight
The researchers examined 90 Caucasian and Hispanic girls and discovered that young women with normal vitamin D levels were on average taller than peers deficient in vitamin D. Yet in contrast to what's been previously reported in older women, their investigation found no association between lack of vitamin D and bone strength.
"Although vitamin D is now frequently measured in older adults, due to a higher level of awareness in this population, it is rarely measured in young people – especially healthy adolescents," says Dr. Kremer.
"Clinicians need to identify vitamin D levels in younger adults who are at risk by using a simple and useful blood test," says the co-author, Dr. Vicente Gilsanz, head of musculoskeletal imaging at the Children's Hospital Los Angeles of the University of Southern California.
"Because lack of vitamin D can cause fat accumulation and increased risk for chronic disorders later in life, further investigation is needed to determine whether vitamin D supplements could have potential benefits in the healthy development of young people," added Dr. Gilsanz.
About the study:
"Vitamin D Status and its Relationship to Body Fat, Final Height and Peak Bone Mass in Young Women," published in the Journal of Clinical Endocrinology & Metabolism, was authored by Richard Kremer of the McGill University Health Centre, Patricia P. Campbell and Vicente Gilsanz of the Children's Hospital Los Angeles of the University of Southern California, and Timothy Reinhardt of the U.S. Department of Agriculture's National Animal Disease Center.
Partners in research:
This work was supported by the U.S, Department of the Army; the National Institutes of Health (a part of the U.S. Department of Health and Human Services); the Natural Sciences and Engineering Research Council of Canada (NSERC); and the Dimensional Fund Advisors Canada Inc (a subsidiary of U.S.-based Dimensional Fund Advisors).
On the Web:
About the Journal of Clinical Endocrinology & Metabolism: http://jcem.endojournals.org
About the McGill University Health Centre: www.muhc.ca/research
The Research Institute of the McGill University Health Centre (RI MUHC) is a world-renowned biomedical and health-care hospital research centre. Located in Montreal, Quebec, the institute is the research arm of the MUHC, the university health center affiliated with the Faculty of Medicine at McGill University. The institute supports over 600 researchers, nearly 1200 graduate and post-doctoral students and operates more than 300 laboratories devoted to a broad spectrum of fundamental and clinical research. The Research Institute operates at the forefront of knowledge, innovation and technology and is inextricably linked to the clinical programs of the MUHC, ensuring that patients benefit directly from the latest research-based knowledge.
The Research Institute of the MUHC is supported in part by the Fonds de la recherche en santé du Québec. For further details visit: www.muhc.ca/research.
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