Contact: Samuel W. French, M.D., Ph.D.
Harbor-UCLA Medical Center
Terrence M. Donohue, Jr., Ph.D.
Department of Veterans Affairs Medical Center
Alcoholism Clinical and Experimental Research
Alcohol consumption is known to cause liver damage. Yet the specifics of alcohol-induced liver injury can differ depending on the pattern of drinking. New rodent findings show that chronic drinking causes more injury – as measured by gene-expression changes – to the liver than acute or binge drinking.
Results will be published in the April issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View.
"Different patterns of drinking can] produce a different set or pattern of gene expression by the liver because of adaptation by the liver which occurs when the same level of blood alcohol is repeated over and over again," explained Samuel W. French, Distinguished Professor of pathology at the UCLA School of Medicine, and chief of anatomic pathology at Harbor-UCLA Medical Center. Basically, the liver "learns" or "remembers" its response to alcohol.
"Unfortunately, these adaptive changes in gene expression are injurious to the liver and are furthermore persistent in the liver even when alcohol drinking has stopped," French added. "This is why people who develop liver disease after chronic alcohol abuse continue to be sick from liver damage for many months after they have stopped drinking. In fact, they actually get worse when they stop drinking because their liver is programmed epigenetically to work under the influence of alcohol. Think of it as deleterious conditioning and a learning process for the liver."
"Rodents do differ from humans in some of their responses to alcohol because they are rodents, not humans," said Terrence M. Donohue, Jr., a research scientist in the Liver Study Unit at the Department of Veterans Affairs Medical Center and the University of Nebraska Medical Center. "However, overall these results could potentially be applicable to humans and it's likely that they are, as both rodents and humans are mammals."
French and his colleagues used microarray analysis on livers from rats that had been fed an acute/binge dose of alcohol (6 g/kg body weight), enough to intoxicate the animals, and then sacrificed at three and 12 hours after dosage. The gene microarrays were then compared to those from an earlier study of livers from rats that had been fed alcohol for one month (comprising 36 percent of their calories), the equivalent of chronic drinking.
Results showed that chronic exposure to alcohol leads to more gene-expression changes in the liver than does acute exposure to alcohol.
"The liver damage in the two groups was different," said French. "For instance, after chronic abuse the liver cells become swollen and filled with fat stores, some liver cells died and cells in the liver that make scars are activated. These changes do not occur in the liver after an acute or binge dose, as demonstrated by gene expression."
The important lesson that these rodent findings teach us about liver disease in humans, he added, is that daily, excessive drinking can program the liver to become dependent on alcohol. "So when a person stops drinking, their liver will continue to be sick for a while; but if they don't stop drinking, their liver will become even sicker."
Alcoholism: Clinical & Experimental Research (ACER) is the official journal of the Research Society on Alcoholism and the International Society for Biomedical Research on Alcoholism. Co-authors of the ACER paper, "Chronic Ethanol Feeding Alters Hepatocyte Memory Which Is Not Altered by Acute Feeding," were: Fawzia Bardag-Gorce, Joan Oliva, Jennifer Dedes, Jun Li, and Barbara A. French of the Department of Pathology at Harbor-UCLA Medical Center in Torrance, California. The research was conducted at the Los Angeles Biomedical Research Institute. The study was funded by the National Institute of Health.
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