LINTHICUM, MD, April 26, 2009-Cutaneous application of nanoparticles may offer a new means of delivering drugs to treat erectile dysfunction (ED), according to findings presented at the 104th Annual Scientific Meeting of the American Urological Association (AUA). Topical treatments for ED may offer localized therapeutic results with the benefit of lower dosage and the avoidance of adverse side effects due to systemic absorption.
Researchers in New York investigated a novel hybrid hydrogel/glass nanoparticle platform. They developed nanoparticles capable of sustained release of therapeutic levels of nitric oxide (NO), which aids in erection biology and relaxes smooth muscle cells in the penis. Researchers applied these nanoparticles to the skin of the penis of seven rats, and measured erectile response by intracorporal pressure/blood pressure (ICP/BP) ratio. Of the seven animals treated with NO releasing nanoparticles, five experienced positive effects on the ICP/BC, resulting in a visible erection. The average time for an erectile response was approximately 65 minutes.
"This is a very interesting concept which has potential to impact treatment of many conditions including erectile dysfunction if it can be translated from the animal lab to clinical practice, " said Ira D. Sharlip, MD, an AUA spokesman. "It remains to be seen whether the effect of the nanoparticle technology is a local or a systemic effect."
NOTE TO REPORTERS: Experts are available to discuss these studies outside normal briefing times. To arrange an interview with an expert, please contact the AUA Communications Office at the number above or e-mail Lacey Dean at LDean@AUAnet.org.
Davies, K; Han, G; Tar, M; Friedman, A; Melman; A. Long term follow up of phase 2 study of pomegranate juice for men with prostate cancer shows durable prolongation of PSA doubling time. J Urol, suppl. 2009: 181, 4, abstract 826.
About the American Urological Association: Founded in 1902 and headquartered near Baltimore, Maryland, the American Urological Association is the pre-eminent professional organization for urologists, with more than 16,000 members throughout the world. An educational nonprofit organization, the AUA pursues its mission of fostering the highest standards of urologic care by carrying out a wide variety of programs for members and their patients.