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PUBLIC RELEASE DATE:
3-Aug-2009

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Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-020-319-22165
BioMed Central
@biomedcentral

Big cattle -- the genes that determine carcass weight

An area of chromosome 6 that affects cattle carcass weight has been identified using two different Japanese species. Knowledge of this four-gene region, described in the open access journal BMC Genetics, should be useful in breeding beef cattle.

Akiko Takasuga, from the Shirakawa Institute of Animal Genetics, led a team of researchers who studied Japanese Black and Japanese Brown cattle, two breeds that have survived separately for thousands of years. According to Takasuga, "The 591-kb critical region contains four genes, LOC523874, C6H4orf30, NCAPG, and LOC540095. Interestingly, LOC540095 is the bovine ortholog of the human gene LCORL, and the NCAPG-LCORL region was recently identified as one determinant of human adult height".

The researchers have named the size-determining region CW-2 and have found a single nucleotide polymorphism which can be used as a positional candidate of CW-2 for marker-assisted selection. Takasuga said, "The CW-2 genotype explains a large portion of phenotypic variance. It may be widely distributed among European cattle breeds and not yet be fixed. Selection for this genotype should accelerate the breeding of meatier cattle".

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Notes to Editors

1. Cross-breed comparisons identified a critical 591-kb region for bovine carcass weight QTL (CW-2) on chromosome 6 and the Ile-442-Met substitution in NCAPG as a positional candidate
Kouji Setoguchi, Masako Furuta, Takashi Hirano, Tomoko Nagao, Toshio Watanabe, Yoshikazu Sugimoto and Akiko Takasuga
BMC Genetics (in press)

During embargo, article available here: http://www.biomedcentral.com/imedia/5430039412556064_article.pdf?random=860166

After the embargo, article available at journal website: http://www.biomedcentral.com/bmcgenet/

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Article citation and URL available on request at press@biomedcentral.com on the day of publication

2. BMC Genetics is an open access journal publishing original peer-reviewed research articles in all aspects of inheritance and variation in individuals and among populations. BMC Genetics (ISSN 1471-2156) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, Scopus, EMBASE, Zoological Record, Thomson Reuters (ISI) and Google Scholar.

3. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.



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