The molecular mechanisms of tungstate activity in diabetes have been uncovered. Researchers writing in the open access journal BMC Genomics have identified the pathways through which sodium tungstate improves pancreatic function and beta cell proliferation.
A team led by Professor Ramon Gomis at the Hospital Clinic de Barcelona, Spain, studied the effects of sodium tungstate on pancreatic gene expression in a rat model of diabetes, in order to discover the mechanisms that control the partial pancreatic regeneration induced by this treatment. He said, "A detailed description of the pathways involved in the pancreatic effects of tungstate is provided in our paper. Essentially, tungstate improves pancreatic function through a combination of hyperglycemia-independent pathways and through its own direct and indirect effects. In addition, the MAPK pathway has a key role in the tungstate-induced increase of beta cell proliferation".
Speaking about the results, Professor Gomis said, "We used sodium tungstate treatment of diabetic animals as a tool to search for genes and pathways implicated in pancreatic regeneration after an injury to the pancreas. This study identified genes with a key role in improving pancreatic plasticity, and these could be used as therapeutic targets for the future treatment of diabetes"
Notes to Editors
1. Molecular mechanisms of tungstate-induced pancreatic plasticity: a transcriptomics approach
Jordi Altirriba, Albert Barbera, Hector Del Zotto, Belen Nadal, Sandra Piquer, Alex Sanchez-Pla, Juan J Gagliardino and Ramon Gomis
BMC Genomics (in press)
During embargo, article available here: http://www.biomedcentral.com/imedia/1719040038246009_article.pdf?random=534420
After the embargo, article available at journal website: http://www.biomedcentral.com/bmcgenomics/
Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.
Article citation and URL available on request at email@example.com on the day of publication
2. BMC Genomics is an open access journal publishing original peer-reviewed research articles in all aspects of genome-scale analysis, functional genomics, and proteomics. BMC Genomics (ISSN 1471-2164) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, Scopus, EMBASE, Zoological Record, Thomson Reuters (ISI) and Google Scholar.
3. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.