[ Back to EurekAlert! ] Public release date: 23-Nov-2009
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Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-203-192-2165
BioMed Central

Road rage

Fuel vapor heightens aggression

Outrageous prices may not be the only thing causing anger at the petrol pumps. A new study, published in the open access journal BMC Physiology, has shown that rats exposed to fumes from leaded and unleaded gasoline become more aggressive.

Amal Kinawy, from Cairo University, Egypt, examined the emotionally incendiary properties of gasoline in three groups of male rats, each exposed to either leaded-gas fumes, unleaded-gas fumes or clean air. As well as observing the animals' behavior, she studied any resulting neurological and physiological changes. She said, "Millions of people every day are exposed to gasoline fumes while refuelling their cars. Exposure can also come from exhaust fumes and, particularly in the developing world, deliberate gasoline sniffing as a means of getting high".

The research demonstrates that rats exposed to either kind of fuel vapor showed increased aggressive behavior, such as more time spent in belligerent postures and increased numbers of actual attacks, in comparison to the clean air group. Examination of the animals' brains after the experiment revealed significant differences between all three groups. According to Kinawy, "Rats exposed to unleaded gasoline showed indications of increased damage caused by free radicals and altered levels of neurotransmitters in the brain cortex region, in comparison with the control or leaded gasoline groups. Furthermore, inhalation of both fuels induced significant fluctuations in neurotransmitters in the hypothalamus, hippocampus and cerebellum".

Kinawy concludes, "Heightened aggression may be yet another risk for the human population chronically exposed to urban air polluted by automobile smoke".

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Notes to Editors:

1. Impact of gasoline inhalation on some neurobehavioural characteristics of male rats
Amal A Kinawy
BMC Physiology (in press)

During embargo, article available here: http://www.biomedcentral.com/imedia/1912784797258915_article.pdf?random=552280

After the embargo, article available at journal website: http://www.biomedcentral.com/bmcphysiol/

Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.

Article citation and URL available on request at press@biomedcentral.com on the day of publication

2. BMC Physiology is an open access journal publishing original peer-reviewed research articles in cellular, tissue-level, organismal, functional, and developmental aspects of physiological processes. BMC Physiology (ISSN 1472-6793) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, EMBASE, Scopus, Zoological Record and Google Scholar.

3. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.



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