[ Back to EurekAlert! ] Public release date: 2-Nov-2009
[ | E-mail Share Share ]

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation

Modifying neural stem cells improves their therapeutic efficacy

Stem cells isolated from the brain of adult mice (adult neural stem cells [aNSCs]) have shown very modest therapeutic effects in a mouse model of the chronic inflammatory neurodegenerative disease multiple sclerosis. But now, Guang-Xian Zhang and colleagues, at Thomas Jefferson University, Philadelphia, have developed an approach to enhance the therapeutic effects of aNSCs in this model of multiple sclerosis. Specifically, the researchers genetically engineered aNSCs to express the anti-inflammatory molecule IL-10 and found that these cells induced more extensive functional and pathological recovery from ongoing disease than did nonengineered aNSCs. Importantly, the IL-10–aNSCs mediated their effects in multiple ways, suppressing immune system attack of nerve cells, promoting nerve cell repair, and promoting production of the nerve cell protective sheath. The authors hope these results might increase the chance that aNSC-based therapies might one day be developed for clinical use.

###

TITLE: Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis

AUTHOR CONTACT:
Guang-Xian Zhang
Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Phone: (215) 955-8935; Fax: (215) 503-5848; E-mail: Guang-Xian.Zhang@jefferson.edu.

View this article at: http://www.jci.org/articles/view/37914?key=NKxgD7l4U2cHdaVxIjn7



[ Back to EurekAlert! ] [ | E-mail Share Share ]

 


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.